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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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sciencedirect.com/science/article/pii/S2211124725012045
Oct 2025
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Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

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1. scibot 03 Oct 2025
  
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  DOI: 10.7554/eLife.97151
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12488188/
Sep 2025
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A novel MAP7D1 mutation causes mitotic defects and RPS14 accumulation in Shwachman−Diamond syndrome patient cells

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1. scibot 20 Sep 2025
  
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  DOI: 10.1242/dmm.052409
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12421802/
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UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma

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1. scibot 20 Sep 2025
  
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  DOI: 10.1158/1078-0432.CCR-25-0261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12434397/
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Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function

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1. scibot 09 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116252
  
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sciencedirect.com/science/article/pii/S221112472501023X
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Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116225
  
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sciencedirect.com/science/article/pii/S2211124725009969
Aug 2025
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YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116188
  
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sciencedirect.com/science/article/pii/S2211124725009593
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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  DOI: 10.1016/j.devcel.2025.07.016
  
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sciencedirect.com/science/article/pii/S1534580725004733
Jul 2025
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Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.cub.2025.07.011
  
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sciencedirect.com/science/article/pii/S0960982225008772
Jun 2025
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GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity

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1. scibot 24 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.042
  
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sciencedirect.com/science/article/pii/S0092867425006300
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Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115810
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00581-9
52.53.155.43 52.53.155.43

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.xhgg.2025.100461
  
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2. scibot 05 Jun 2025
  
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  DOI: 10.1016/j.xhgg.2025.100461
  
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52.53.155.43/de242f5c9d14208174da1148bf800061ebe1b9cf/1-s2.0-S2666247725000648-main-html.html
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Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.xgen.2025.100917
  
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sciencedirect.com/science/article/pii/S2666979X25001739
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225008983-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112637
  
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52.53.155.43/6b559eaf1ba237e9261e221105645573c7e60c53/1-s2.0-S2589004225008983-main-html.html
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NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115701
  
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sciencedirect.com/science/article/pii/S2211124725004723
Apr 2025
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1097276525002011
Mar 2025
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Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

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1. scibot 28 Mar 2025
  
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  RRID:AB_490778
  
  DOI: 10.1083/jcb.202310157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11450323/
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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115426
  
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sciencedirect.com/science/article/pii/S2211124725001974
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 14 Mar 2025
  
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  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
Feb 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225003785-main-html.html

1
1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.112118
  
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52.53.155.43/d1f964056b3dd00ef17176fded1971b6e20e47a3/1-s2.0-S2589004225003785-main-html.html
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115340
  
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sciencedirect.com/science/article/pii/S2211124725001111
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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1. scibot 08 Feb 2025
  
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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
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Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass

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1. scibot 07 Feb 2025
  
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  DOI: 10.1016/j.devcel.2025.01.011
  
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sciencedirect.com/science/article/pii/S1534580725000310
Jan 2025
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A conserved acetylation switch enables pharmacological control of tubby-like protein stability

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1. scibot 10 Jan 2025
  
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  rabbit anti-Myc tag
  
  DOI: 10.1074/jbc.RA120.015839
  
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jbc.org/article/S0021-9258(20)00061-7/fulltext
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Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O

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  DOI: 10.1016/j.str.2024.12.002
  
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sciencedirect.com/science/article/pii/S0969212624005379
Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
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A function of TPL/TBL1-type corepressors is to nucleate the assembly of the preinitiation complex

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1. scibot 13 Dec 2024
  
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  DOI: 10.1083/jcb.202404103
  
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rupress.org/jcb/article/224/2/e202404103/277146/A-function-of-TPL-TBL1-type-corepressors-is-to
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TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture

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  DOI: 10.1016/j.molcel.2024.11.019
  
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sciencedirect.com/science/article/pii/S1097276524009444
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

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  DOI: 10.1016/j.cmet.2024.11.005
  
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sciencedirect.com/science/article/pii/S1550413124004510
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DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

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1. scibot 05 Dec 2024
  
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  AB_490778
  
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sciencedirect.com/science/article/pii/S1097276524009146
Nov 2024
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SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release

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  DOI: 10.1038/s44319-024-00250-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11549447/
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A functional connection between the Microprocessor and a variant NEXT complex

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  DOI: 10.1016/j.molcel.2024.10.015
  
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sciencedirect.com/science/article/pii/S1097276524008554
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits

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1. scibot 23 Aug 2024
  
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  DOI: 10.1126/sciadv.adn6016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11338267/
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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1. scibot 19 Aug 2024
  
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  AB_490778
  
  DOI: 10.1016/j.immuni.2024.07.010
  
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sciencedirect.com/science/article/pii/S1074761324003595
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SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

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1. scibot 02 Aug 2024
  
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  MYC-tag
  
  DOI: 10.1007/s00395-021-00865-9
  
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link.springer.com/article/10.1007/s00395-021-00865-9/tables/2
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Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

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  Rabbit anti-myc tag
  
  DOI: 10.1016/j.molcel.2020.11.047
  
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities

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ROS are required for the germinative cell proliferation and metacestode larval growth of Echinococcus multilocularis

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Structural transitions enable interleukin-18 maturation and signaling

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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins

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Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss

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All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex

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Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer

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Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk

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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways

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Acylation of MLKL impacts its function in necroptosis

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NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages

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E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

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MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC

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ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis

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Jul 2023
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Structural basis for membrane-proximal proteolysis of substrates by ADAM10

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Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery

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Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

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Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

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Calcineurin associates with centrosomes and regulates cilia length maintenance

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Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition

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Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

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The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells

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FAM193A is a positive regulator of p53 activity

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  DOI: 10.1016/j.celrep.2023.112230
  
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EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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  DOI: 10.1016/j.isci.2022.105184
  
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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

1
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Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL

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  2278
  
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

1
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EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

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TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation

1
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Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

1
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Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells

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A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand

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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

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HIV-1 exploits the Fanconi anemia pathway for viral DNA integration

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Chl1 coordinates with H3K9 methyltransferase Clr4 to reduce the accumulation of RNA-DNA hybrids and maintain genome stability

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A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants

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Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats

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Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

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Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

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TMEM106A inhibits enveloped virus release from cell surface

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Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

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Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

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Biosensors based on peptide exposure show single molecule conformations in live cells

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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

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A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication

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Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection

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Untitled document

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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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  DOI: 10.1038/s41467-021-24687-4
  
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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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Untitled document

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Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel

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  DOI: 10.1016/j.neuron.2019.08.041
  
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Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action

1
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TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.

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Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication

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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

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  DOI: 10.1016/j.celrep.2018.10.049
  
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The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

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CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells

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Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment

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CREG1 promotes lysosomal biogenesis and function

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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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  rabbit anti-Myc-Tag
  
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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

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Bioorthogonal dissection of the replicase assembly of hepatitis C virus

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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

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Live Imaging Reveals Listeria Hijacking of E-Cadherin Recycling as It Crosses the Intestinal Barrier

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Diverse viral proteases activate the NLRP1 inflammasome

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Distinct Roles and Synergistic Function of FruM Isoforms in Drosophila Olfactory Receptor Neurons

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The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

1
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Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17

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CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching

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faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1

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  DOI: 10.1096/fj.202001544R
  
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A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling

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Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

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TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells

1
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  DOI: 10.1016/j.neuron.2020.03.033
  
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Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

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Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

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The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

1
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  DOI: 10.7554/eLife.38181
  
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HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

1
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C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms

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  DOI: 10.1111/jnc.14840
  
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Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation

1
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  DOI: 10.1016/j.devcel.2019.11.019
  
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A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

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Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel

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  DOI: 10.1016/j.neuron.2019.08.041
  
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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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  RRID:AB_10693332
  
  DOI: 10.1016/j.celrep.2019.08.076
  
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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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  RRID:AB_490778
  
  DOI: 10.1016/j.ccell.2019.10.002
  
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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  RRID:AB_490778
  
  DOI: 10.1016/j.immuni.2019.11.015
  
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  DOI: 10.1016/j.celrep.2018.12.106
  
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Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation

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  RRID:AB_490778
  
  DOI: 10.1016/j.celrep.2019.05.004
  
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  RRID:AB_490778
  
  DOI: 10.1016/j.celrep.2019.01.018
  
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  RRID:AB_490778
  
  DOI: 10.1016/j.celrep.2019.02.035
  
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  DOI: 10.1016/j.ccell.2019.01.009
  
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  DOI: 10.1016/j.celrep.2019.01.030
  
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sciencedirect.com/science/article/pii/S2211124719300397
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  DOI: 10.1016/j.cmet.2019.01.002
  
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  DOI: 10.1016/j.cell.2018.12.030
  
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  DOI: 10.1016/j.celrep.2019.01.029
  
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Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

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  RRID:AB_490778
  
  DOI: 10.1016/j.ebiom.2019.03.034
  
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  DOI: 10.1016/j.cell.2019.02.030
  
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sciencedirect.com/science/article/pii/S0092867419302132
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Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

1
1. scibot 05 Nov 2018
  
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  2278
  
  Curator: @evieth
  
  Curator note: Cell Signaling Technology Cat# 2278, Rabbit Anti-Myc-Tag Monoclonal Antibody, Unconjugated, Clone 71D10
  
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Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development

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Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain

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sciencedirect.com/science/article/pii/S0896627317309339
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Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium

1
1. scibot 08 Nov 2017
  
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  RRID:AB_490778
  
  Curator: @Jmenke
  
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Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

1
1. scibot 08 Nov 2017
  
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  AB_490778
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S109727651730360X
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eIF4A inactivates TORC1 in response to amino acid starvation

1
1. scibot 08 Nov 2017
  
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  2278
  
  Curator: @bandrow
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4868951/
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Dlg5 Regulates Dendritic Spine Formation and Synaptogenesis by Controlling Subcellular N-Cadherin Localization

1
1. scibot 08 Nov 2017
  
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  AB_490778
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4166160/

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