126 Matching Annotations
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    KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13369686/
  3. May 2026
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    It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages
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    biorxiv.org/content/10.64898/2026.04.23.719926v1
  5. Apr 2026
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    Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1
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  8. Feb 2026
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    SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism
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    Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation
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  11. Dec 2025
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  14. Oct 2025
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    Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration
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    Dishevelled drives Wnt-stimulated disassembly of primary cilia through a unique PDZ-mediated binding mode with Daple and Girdin
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    biorxiv.org/content/10.1101/2025.09.26.678488v1
  17. Sep 2025
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    Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice
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    GPR65 Functions as a Key Factor of Bone Aging and a Novel Therapeutic Target for Osteoporosis
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  21. Jul 2025
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    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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  26. May 2025
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    Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
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  28. Mar 2025
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    PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  36. Oct 2024
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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  38. Aug 2024
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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  43. Jul 2024
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  45. May 2024
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  47. Apr 2024
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    Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis
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  50. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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  52. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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  54. Jun 2023
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    Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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  58. May 2023
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    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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  62. Apr 2023
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    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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  64. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  67. Feb 2023
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    Hexane fraction of Prunus japonica thunb. Seed extract enhances boar sperm motility via CatSper ion channel
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  69. Jan 2023
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    Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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  72. Dec 2022
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop
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  75. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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  78. Aug 2022
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    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  80. Jul 2022
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    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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  83. Jun 2022
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  85. May 2022
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  89. Apr 2022
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    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
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  91. Feb 2022
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    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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  94. Sep 2021
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    Doxazosin and erlotinib have anticancer effects in the endometrial cancer cell and important roles in ERα and Wnt/β-catenin signaling pathways
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  96. Aug 2021
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner
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  102. Jul 2021
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    Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
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    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8245133/
  109. May 2021
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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  115. Mar 2021
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  117. Feb 2021
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
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  120. Jan 2021
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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    ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
  122. Dec 2020
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    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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  124. Nov 2020
  125. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model
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  126. Oct 2020
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    Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  129. Sep 2020
  130. dev.biologists.org dev.biologists.org
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  133. www.mdpi.com www.mdpi.com
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  134. www.sciencedirect.com www.sciencedirect.com
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  139. Jan 2020
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  151. Nov 2018
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  161. Nov 2017
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