114 Matching Annotations
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    GPR65 Functions as a Key Factor of Bone Aging and a Novel Therapeutic Target for Osteoporosis
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    onlinelibrary.wiley.com/doi/10.1111/acel.70212
  3. Jul 2025
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    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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  5. Jun 2025
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    EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
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  8. May 2025
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    Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
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  10. Mar 2025
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    PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
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  14. Dec 2024
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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  18. Oct 2024
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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  20. Aug 2024
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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  25. Jul 2024
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    Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
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  27. May 2024
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    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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  29. Apr 2024
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    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis
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  32. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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  34. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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  36. Jun 2023
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    Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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  40. May 2023
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    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
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  44. Apr 2023
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    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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  46. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  49. Feb 2023
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    Hexane fraction of Prunus japonica thunb. Seed extract enhances boar sperm motility via CatSper ion channel
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  51. Jan 2023
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    Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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  54. Dec 2022
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop
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  57. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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  60. Aug 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  62. Jul 2022
  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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    Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
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  65. Jun 2022
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    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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  67. May 2022
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    c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
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  71. Apr 2022
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    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
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  73. Feb 2022
  74. www.sciencedirect.com www.sciencedirect.com
    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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  76. Sep 2021
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    Doxazosin and erlotinib have anticancer effects in the endometrial cancer cell and important roles in ERα and Wnt/β-catenin signaling pathways
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  78. Aug 2021
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner
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  84. Jul 2021
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    Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
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    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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  91. May 2021
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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  97. Mar 2021
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  99. Feb 2021
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
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  102. Jan 2021
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  104. Dec 2020
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    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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  106. Nov 2020
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    Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model
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  108. Oct 2020
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    Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β
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  111. Sep 2020
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    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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    A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
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    Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
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    Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus
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    FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer
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  121. Jan 2020
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    Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development
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    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor
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