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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

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  DOI: 10.1038/s41418-026-01846-y
  
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nature.com/articles/s41418-026-01846-y
Jul 2026
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PD-1 blockade unleashes local hepatitis B virus-related B cell response inhibiting hepatocellular carcinoma

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sciencedirect.com/science/article/pii/S1535610826002977
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Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth

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sciencedirect.com/science/article/pii/S2666379126003381
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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sciencedirect.com/science/article/pii/S2211124726004870
Apr 2026
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Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity

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sciencedirect.com/science/article/pii/S1074761326001408
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STAT5 activation enhances adoptive therapy combined with peptide vaccination by preventing PD-1 inhibition

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  DOI: 10.1158/1535-7163.MCT-24-0505
  
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aacrjournals.org/mct/article/24/3/419/752080/STAT5-Activation-Enhances-Adoptive-Therapy
Mar 2026
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A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy

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sciencedirect.com/science/article/pii/S0092867426002692
Jan 2026
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1-s2.0-S2589004226001513-main-html.html

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54.241.53.176/98fce87961b486739ffccb2301810ebb417a10a7/1-s2.0-S2589004226001513-main-html.html
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
Sep 2025
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A mosaic H3 subtype live attenuated influenza vaccine elicits broad immune responses to influenza a viruses

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  DOI: 10.1016/j.vaccine.2025.127776
  
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sciencedirect.com/science/article/pii/S0264410X25010734
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GD2TIF cells as a platform for single-dose and long-term delivery of biologics

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  DOI: 10.1038/s41467-025-63427-w
  
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nature.com/articles/s41467-025-63427-w
Aug 2025
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Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis

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  DOI: 10.1158/0008-5472.CAN-24-4317
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12352130/
Jul 2025
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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  DOI: 10.1016/j.ccell.2025.07.002
  
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sciencedirect.com/science/article/pii/S1535610825002739
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CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo

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  DOI: 10.1016/j.immuni.2025.06.011
  
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Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans

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  DOI: 10.1016/j.celrep.2025.115933
  
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sciencedirect.com/science/article/pii/S2211124725007041
Jun 2025
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BPS Publications

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  DOI: 10.1111/bph.17473
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17473
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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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  DOI: 10.1016/j.xcrm.2025.102141
  
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sciencedirect.com/science/article/pii/S2666379125002149
May 2025
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IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.004
  
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sciencedirect.com/science/article/pii/S1074761325001670
Mar 2025
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Translation dysregulation in cancer as a source for targetable antigens

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  DOI: 10.1016/j.ccell.2025.03.003
  
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sciencedirect.com/science/article/pii/S1535610825000820
Feb 2025
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Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection

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  DOI: 10.1186/s12974-025-03376-9
  
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jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03376-9
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Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

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sciencedirect.com/science/article/pii/S1535610825000224
Dec 2024
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Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

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  DOI: 10.1016/j.isci.2024.111248
  
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sciencedirect.com/science/article/pii/S2589004224024738
Jul 2024
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Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine

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  DOI: 10.1016/j.chom.2024.06.003
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00197-5
May 2024
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Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies

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ncbi.nlm.nih.gov/pmc/articles/PMC11126743/
Apr 2024
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection

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  DOI: 10.1016/j.celrep.2024.114156
  
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The diversity of inhibitory receptor co-expression patterns of exhausted CD8+ T cells in oropharyngeal carcinoma

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  DOI: 10.1016/j.isci.2024.109668
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11035373/
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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  DOI: 10.1016/j.cell.2024.03.039
  
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sciencedirect.com/science/article/pii/S0092867424003556
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Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling

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  DOI: 10.1126/scisignal.adh0439
  
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science.org/doi/10.1126/scisignal.adh0439
Jan 2024
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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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  DOI: 10.1016/j.xcrm.2023.101377
  
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sciencedirect.com/science/article/pii/S2666379123006067
Dec 2023
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Immunotherapy targeting B cells and long-lived plasma cells effectively eliminates pre-existing donor-specific allo-antibodies

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  DOI: 10.1016/j.xcrm.2023.101336
  
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sciencedirect.com/science/article/pii/S2666379123005530
Oct 2023
www.cell.com www.cell.com

The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells

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  DOI: 10.1016/j.isci.2023.108087
  
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cell.com/iscience/abstract/S2589-0042(23)02164-8
Sep 2023
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Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration

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  DOI: 10.1016/j.cmet.2023.08.010
  
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sciencedirect.com/science/article/pii/S1550413123003315
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Interferon-g-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit acute contact dermatitis

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.jaci.2023.07.015
  
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sciencedirect.com/science/article/pii/S0091674923009818
May 2023
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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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  DOI: 10.1016/j.cmet.2023.04.017
  
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Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection

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1. scibot 10 May 2023
  
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  DOI: 10.1016/j.immuni.2023.04.010
  
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sciencedirect.com/science/article/pii/S1074761323001796
Dec 2022
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Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity

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cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

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Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells

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Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models

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Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity

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Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP

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Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

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Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation

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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

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Untitled document

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Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

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Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers

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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

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Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology

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NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

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The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

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Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate

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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

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Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever

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L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

3
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