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GPR161–GLI3 repressor signaling at cilia directs apical constriction and cell fate during cranial neural tube closure

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1. scibot 23 Dec 2025
  
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  DOI: 10.1242/dev.205171
  
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dx.doi.org/10.1242/dev.205171
Aug 2025
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Generation of human iPSC-derived pancreatic organoids to study pancreas development and disease

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  DOI: 10.12688/f1000research.162496.1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314479/
Jun 2025
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulation

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sciencedirect.com/science/article/pii/S2352396425002610
May 2025
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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

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hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation

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pmc.ncbi.nlm.nih.gov/articles/PMC12087151/
Dec 2024
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Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells

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sciencedirect.com/science/article/pii/S2211124724013457
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Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling

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sciencedirect.com/science/article/pii/S1534580724006646
Oct 2024
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The chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin

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sciencedirect.com/science/article/pii/S2211124724011653
Jul 2024
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Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation

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sciencedirect.com/science/article/pii/S2666379124003732
May 2024
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Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition

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sciencedirect.com/science/article/pii/S1534580724002971
Apr 2024
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Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids

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sciencedirect.com/science/article/pii/S1934590924000894
Jan 2024
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Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner

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  DOI: 10.1016/j.devcel.2023.12.011
  
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sciencedirect.com/science/article/pii/S1534580723006913
Nov 2023
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Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia

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1. scibot 10 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108364
  
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sciencedirect.com/science/article/pii/S2589004223024410
Sep 2023
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Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

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1. scibot 08 Sep 2023
  
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  DOI: 10.7554/eLife.90006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10482429/
Apr 2023
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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.neuron.2023.01.010
  
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sciencedirect.com/science/article/pii/S089662732300034X
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Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes

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sciencedirect.com/science/article/pii/S1534580723001077
Mar 2023
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Protocol to generate human pluripotent stem cell-derived pancreatic β cells through methionine and zinc deprivation

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.xpro.2023.102183
  
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sciencedirect.com/science/article/pii/S2666166723001417
Aug 2022
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Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

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1. scibot 23 Aug 2022
  
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  DOI: 10.1016/j.devcel.2022.07.014
  
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sciencedirect.com/science/article/pii/S1534580722005317
Jul 2022
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Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization

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sciencedirect.com/science/article/pii/S2211124722009263
Jun 2022
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SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis

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ncbi.nlm.nih.gov/pmc/articles/PMC9212970/
Mar 2022
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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sciencedirect.com/science/article/pii/S2211124722001498
Nov 2021
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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

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ncbi.nlm.nih.gov/pmc/articles/PMC8554488/
Sep 2021
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The postnatal pancreatic microenvironment guides β cell maturation through BMP4 production

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Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

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Aug 2021
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Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

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ncbi.nlm.nih.gov/pmc/articles/PMC8378848/
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RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish

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Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes

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  DOI: 10.1210/js.2017-00081
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5542010/
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Untitled document

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academic.oup.com/jes/article/1/5/385/3084588
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Untitled document

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  DOI: 10.3389/fendo.2018.00791
  
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frontiersin.org/article/10.3389/fendo.2018.00791/full
Jul 2021
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Untitled document

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  DOI: 10.1016/j.cell.2017.11.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5786493/
May 2021
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A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

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  DOI: 10.1016/j.devcel.2020.08.003
  
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sciencedirect.com/science/article/pii/S1534580720306274
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Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

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  DOI: 10.1016/j.devcel.2020.06.034
  
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sciencedirect.com/science/article/pii/S1534580720305426
Apr 2021
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Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma

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sciencedirect.com/science/article/pii/S1934590921000539
Feb 2021
elifesciences.org elifesciences.org

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

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  DOI: 10.7554/eLife.59067
  
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elifesciences.org/articles/59067
Dec 2020
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Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

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Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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ARL13B regulates Sonic hedgehog signaling from outside primary cilia

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Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal

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Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

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TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation

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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

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Untitled document

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E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

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https://www.ncbi.nlm.nih.gov/pubmed/29290584

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Intrinsic Immunity Shapes Viral Resistance of Stem Cells

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Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord

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Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes

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Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

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