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  1. Last 7 days
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    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    1. scibot 03 Jul 2024
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      DOI: 10.3389/fonc.2024.1394653

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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  3. Jun 2024
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    sciencedirect.com/science/article/pii/S1550413124001918
  5. May 2024
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    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    1. scibot 23 May 2024
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      DOI: 10.1101/2024.05.13.593567

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    biorxiv.org/content/10.1101/2024.05.13.593567v1
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    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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    sciencedirect.com/science/article/pii/S1074761324002292
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    sciencedirect.com/science/article/pii/S1550413124001359
  9. Apr 2024
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724004777
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    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  14. Mar 2024
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    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
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    sciencedirect.com/science/article/pii/S1535610824000606
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124724002638
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  18. Feb 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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      DOI: 10.1016/j.stem.2024.01.013

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    sciencedirect.com/science/article/pii/S1934590924000432
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    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830876/
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    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  23. Jan 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839450/
  25. Dec 2023
  26. www.sciencedirect.com www.sciencedirect.com
    An oncogenic phenoscape of colonic stem cell polarization
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    sciencedirect.com/science/article/pii/S0092867423012217
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    sciencedirect.com/science/article/pii/S0092867423012205
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    sciencedirect.com/science/article/pii/S1534580723006196
  29. Nov 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Tsc2 coordinates neuroprogenitor differentiation
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    sciencedirect.com/science/article/pii/S2589004223025191
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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    sciencedirect.com/science/article/pii/S2211124723012810
  32. Oct 2023
  33. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  34. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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      DOI: 10.1038/s41586-023-06657-6

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    52.53.155.43/0f3eb7b8d15ef36be47b7c18ecdf1d19ad34ca1a/s41586-023-06657-6_reference-html.html
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  36. Sep 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes
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      DOI: 10.1016/j.jlr.2023.100450

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    sciencedirect.com/science/article/pii/S0022227523001232
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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      DOI: 10.1016/j.molcel.2023.08.032

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    sciencedirect.com/science/article/pii/S1097276523006950
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    WNK1 is required during male pachynema to sustain fertility.
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    sciencedirect.com/science/article/pii/S2589004223016930
  40. Aug 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter
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    sciencedirect.com/science/article/pii/S2589004223015675
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
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      DOI: 10.1158/1940-6207.CAPR-22-0275

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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10405072/
  44. Jul 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    sciencedirect.com/science/article/pii/S2589004223012087
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    sciencedirect.com/science/article/pii/S2211124723007751
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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    sciencedirect.com/science/article/pii/S221112472300760X
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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      DOI: 10.1158/0008-5472.CAN-22-0945

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  49. Jun 2023
  50. www.embopress.org www.embopress.org
    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
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      DOI: 10.15252/emmm.202216951

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    embopress.org/doi/full/10.15252/emmm.202216951
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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  102. Jun 2022
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development
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    Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice
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  118. Mar 2022
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  122. Feb 2022
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  126. Jan 2022
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  130. Dec 2021
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    Translational and post-translational control of human naïve versus primed pluripotency
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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  134. Nov 2021
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  136. 52.53.155.43 52.53.155.43
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  138. Oct 2021
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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  143. Sep 2021
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  148. Aug 2021
  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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      anti-phospho-4E-BP1Thr37/45

      DOI: 10.1038/s42255-020-0256-z

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  200. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  201. Oct 2020
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    Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway
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      DOI: 10.1016/j.celrep.2020.108211

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    Metabolic Control over mTOR-Dependent Diapause-like State
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      DOI: 10.1016/j.devcel.2019.12.018

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    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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    Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP
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    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
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    Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome
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    mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex
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    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      phosphor‐4E‐BP1

      DOI: 10.15252/embr.201949898

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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Environmental arginine controls multinuclear giant cell metabolism and formation
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      p-4EBP1 Thr37/46

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      DOI: 10.1126/sciadv.aaz6699

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  218. Jan 2020
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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      RRID:AB_560835

      DOI: 10.1016/j.immuni.2019.06.007

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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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      DOI: 10.1016/j.chembiol.2019.05.009

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    sciencedirect.com/science/article/pii/S2451945619301783
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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      RRID:AB_560835

      DOI: 10.1016/j.cmet.2019.07.010

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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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      RRID:AB_560835

      DOI: 10.1016/j.celrep.2019.08.084

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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      DOI: 10.1016/j.celrep.2019.07.027

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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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      DOI: 10.1016/j.celrep.2019.10.038

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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses
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      DOI: 10.1002/jcp.28923

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    Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
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      DOI: 10.1016/j.immuni.2019.10.001

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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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