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Coiled-coil interactions drive the ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cells

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1. scibot 15 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113638
  
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sciencedirect.com/science/article/pii/S2589004225018991
Oct 2025
54.241.53.176 54.241.53.176

hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html

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1. scibot 08 Oct 2025
  
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  DOI: 10.1038/s44320-025-00141-1
  
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  DOI: 10.1038/s44320-025-00141-1
  
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54.241.53.176/9c78a41645fcc9eb1ef3871f95e64fd70faf70c8/hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html
www.embopress.org www.embopress.org

Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

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1. scibot 07 Oct 2025
  
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  DOI: 10.1038/s44320-025-00141-1
  
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embopress.org/doi/10.1038/s44320-025-00141-1
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Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma

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  DOI: 10.1016/j.isci.2025.113456
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12496224/
Aug 2025
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Beauvericin disrupts G2/M transition and induces meiotic arrest during mouse oocyte maturation

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.reprotox.2025.109032
  
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sciencedirect.com/science/article/pii/S0890623825002035
Jul 2025
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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sciencedirect.com/science/article/pii/S2666379125002848
May 2025
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
Mar 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

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1. scibot 06 Mar 2025
  
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  DOI: 10.1111/bph.17464
  
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  DOI: 10.1111/bph.17464
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Nov 2024
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CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00240-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
Aug 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 21 Aug 2024
  
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  DOI: 10.1126/science.adk0775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
Jul 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 18 Jul 2024
  
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  DOI: 10.1126/science.adk0775
  
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science.org/doi/10.1126/science.adk0775
May 2024
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
May 2023
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p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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1. scibot 13 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112479
  
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sciencedirect.com/science/article/pii/S2211124723004904
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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.celrep.2022.111077
  
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sciencedirect.com/science/article/pii/S2211124722008750
Jan 2023
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ER-001259851-000, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs

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1. scibot 14 Jan 2023
  
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  DOI: 10.1158/1535-7163.MCT-21-0879
  
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aacrjournals.org/mct/article/22/1/12/711996/ER-851-a-Novel-Selective-Inhibitor-of-AXL
May 2022
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110814
  
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sciencedirect.com/science/article/pii/S221112472200585X
Mar 2022
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Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

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1. scibot 09 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110468
  
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sciencedirect.com/science/article/pii/S2211124722002017
Jan 2022
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Compartmentalized control of Cdk1 drives mitotic spindle assembly

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.celrep.2022.110305
  
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sciencedirect.com/science/article/pii/S2211124722000171
Oct 2021
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A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

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1. scibot 19 Oct 2021
  
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  DOI: 10.1016/j.cub.2021.09.050
  
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sciencedirect.com/science/article/pii/S0960982221012902
Aug 2021
europepmc.org europepmc.org

Untitled document

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  DOI: 10.7554/eLife.40856
  
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europepmc.org/articles/PMC6292694/
Jul 2021
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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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1. scibot 01 Jul 2021
  
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  DOI: 10.1016/j.biocel.2021.106028
  
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sciencedirect.com/science/article/pii/S1357272521001060
Jan 2020
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Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.48943
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6887120/
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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.05.001
  
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sciencedirect.com/science/article/pii/S1535610819302247
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Development and Characterization of a Wee1 Kinase Degrader

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2019.10.013
  
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sciencedirect.com/science/article/pii/S2451945619303587
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
Nov 2018
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Untitled document

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sciencedirect.com/science/article/pii/S2211124718314116
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic Functional Annotation of Somatic Mutations in Cancer

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1. scibot 05 Nov 2018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5926201/