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  1. Last 7 days
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    sciencedirect.com/science/article/pii/S2211124724014554
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    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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  4. Dec 2024
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC134 controls TLR biogenesis through the ER chaperone Gp96
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    pmc.ncbi.nlm.nih.gov/articles/PMC11629888/
  6. Nov 2024
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11570319/
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    IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy
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    sciencedirect.com/science/article/pii/S2666379124005974
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    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11550584/
  10. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  12. Jul 2024
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    A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1
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    sciencedirect.com/science/article/pii/S1931312824002622
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    Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269928/
  15. Jun 2024
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    Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer
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    sciencedirect.com/science/article/pii/S155041312400189X
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    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
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    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  19. May 2024
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    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
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    sciencedirect.com/science/article/pii/S1074761324002218
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    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
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  23. Apr 2024
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    6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16374
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
  28. Mar 2024
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    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960275/
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer’s disease
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  33. Feb 2024
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    Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses
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    The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
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    sciencedirect.com/science/article/pii/S2211124724001232
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    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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  38. Jan 2024
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    PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis
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  40. Nov 2023
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    Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis
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  42. Oct 2023
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    CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling
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    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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      DOI: 10.3892/ol.2023.14067

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    ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
  45. www.cell.com www.cell.com
    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    cell.com/iscience/abstract/S2589-0042(23)02074-6
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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  47. Aug 2023
  48. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2
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    ncbi.nlm.nih.gov/pmc/articles/PMC10374607/
  51. Jul 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10358659/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
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      DOI: 10.1158/2159-8290.CD-22-0561

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  54. Jun 2023
  55. www.microbiologyresearch.org www.microbiologyresearch.org
    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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  56. www.sciencedirect.com www.sciencedirect.com
    NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
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  57. May 2023
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
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  60. www.mdpi.com www.mdpi.com
    Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury
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  61. Apr 2023
  62. www.cell.com www.cell.com
    Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
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  63. Feb 2023
  64. www.sciencedirect.com www.sciencedirect.com
    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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  65. Jan 2023
  66. academic.oup.com academic.oup.com
    ERRα attenuates vascular inflammation via enhanced NFκB degradation pathway
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
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  69. Dec 2022
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor necrosis factor is a necroptosis-associated alarmin
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  71. www.karger.com www.karger.com
    Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
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  72. 52.53.155.43 52.53.155.43
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vagus nerve stimulation is a potential treatment for ischemic stroke
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  74. Aug 2022
  75. www.sciencedirect.com www.sciencedirect.com
    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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  76. Jun 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat
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  78. journals.lww.com journals.lww.com
    Muse cells decrease the neuroinflammatory response by... : Neural Regeneration Research
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast
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  80. May 2022
  81. www.sciencedirect.com www.sciencedirect.com
    Ripple-selective GABAergic projection cells in the hippocampus
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  82. Apr 2022
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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  84. Mar 2022
  85. www.sciencedirect.com www.sciencedirect.com
    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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  87. Feb 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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  89. Dec 2021
  90. www.sciencedirect.com www.sciencedirect.com
    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  92. Nov 2021
  93. www.sciencedirect.com www.sciencedirect.com
    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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  94. Oct 2021
  95. www.sciencedirect.com www.sciencedirect.com
    Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior
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  96. www.embopress.org www.embopress.org
    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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  97. Aug 2021
  98. www.sciencedirect.com www.sciencedirect.com
    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  102. Jul 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death
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      Rabbit monoclonal anti-p-IκBα

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  104. www.sciencedirect.com www.sciencedirect.com
    LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
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  105. www.jneurosci.org www.jneurosci.org
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
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  108. Jun 2021
  109. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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  110. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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  111. www.sciencedirect.com www.sciencedirect.com
    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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      DOI: 10.1016/j.celrep.2021.109272

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  112. www.cell.com www.cell.com
    Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior
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      DOI: 10.1016/j.celrep.2021.109249

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    cell.com/cell-reports/fulltext/S2211-1247(21)00614-8
  113. May 2021
  114. www.sciencedirect.com www.sciencedirect.com
    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    sciencedirect.com/science/article/pii/S1074761321001898
  115. www.sciencedirect.com www.sciencedirect.com
    SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis
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      DOI: 10.1016/j.isci.2021.102510

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  116. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
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      DOI: 10.1111/bph.15384

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15384
  117. www.sciencedirect.com www.sciencedirect.com
    Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
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      pIκB (Ser23; 14D4)

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  118. www.sciencedirect.com www.sciencedirect.com
    Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells
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    sciencedirect.com/science/article/pii/S1534580721000708
  119. Apr 2021
  120. www.sciencedirect.com www.sciencedirect.com
    Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation
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      DOI: 10.1016/j.chembiol.2020.08.010

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  121. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  122. Mar 2021
  123. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15396

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  124. www.sciencedirect.com www.sciencedirect.com
    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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      DOI: 10.1016/j.celrep.2021.108891

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    sciencedirect.com/science/article/pii/S2211124721002059
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7957119/
  126. Feb 2021
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits
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      DOI: 10.7554/eLife.57000

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  128. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression
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      DOI: 10.1111/jnc.15184

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  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Iron Potentiates Microglial Interleukin‐1β Secretion Induced by Amyloid‐β
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      DOI: 10.1111/jnc.14906

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  130. Sep 2020
  131. www.sciencedirect.com www.sciencedirect.com
    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
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    sciencedirect.com/science/article/pii/S2211124720303521
  132. www.sciencedirect.com www.sciencedirect.com
    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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      DOI: 10.1016/j.cell.2020.03.040

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  133. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses RANKL‐induced osteoclastogenesis and attenuates inflammatory bone destruction
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      DOI: 10.1111/bph.15179

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  134. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.14972

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  135. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
  136. Jan 2020
  137. www.sciencedirect.com www.sciencedirect.com
    In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected with CRISPR/Cas9
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      RRID:AB_561111

      DOI: 10.1016/j.celrep.2019.06.038

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    sciencedirect.com/science/article/pii/S2211124719308046
  138. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
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      RRID:AB_561111

      DOI: 10.1016/j.cmet.2019.08.003

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    sciencedirect.com/science/article/pii/S1550413119304322
  139. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin-Editing Enzyme A20 Regulates Synapse Remodeling and Efficacy
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      DOI: 10.1016/j.brainres.2019.146569

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    sciencedirect.com/science/article/pii/S0006899319306237
  140. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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      RRID:AB_561111

      DOI: 10.1016/j.immuni.2019.01.007

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  141. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.02.024

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    sciencedirect.com/science/article/pii/S2211124719301949
  142. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_561111

      DOI: 10.1016/j.cell.2018.12.038

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    sciencedirect.com/science/article/pii/S0092867418316520
  143. www.sciencedirect.com www.sciencedirect.com
    Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis
    1
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      DOI: 10.1016/j.ebiom.2018.12.037

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    sciencedirect.com/science/article/pii/S2352396418306145
  144. Nov 2018
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  146. www.sciencedirect.com www.sciencedirect.com
    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling
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  148. molmed.biomedcentral.com molmed.biomedcentral.com
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  149. link.springer.com link.springer.com
    IDH2 Deficiency in Microglia Decreases the Pro-inflammatory Response <Emphasis Type="Italic">via</Emphasis> the ERK and NF-κB Pathways
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    Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
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    Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors
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  152. elifesciences.org elifesciences.org
    Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
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    Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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    Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation
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    β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
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  157. Nov 2017
  158. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein kinase D exerts neuroprotective functions during oxidative stress via Nuclear Factor kappaB‐independent signaling pathways
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  159. elifesciences.org elifesciences.org
    Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
    1
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    elifesciences.org/articles/24425
  160. www.sciencedirect.com www.sciencedirect.com
    The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior
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    1. scibot 08 Nov 2017
      AB_561111

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S2352396417301585
  161. www.sciencedirect.com www.sciencedirect.com
    Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2 +-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons
    1
    1. scibot 08 Nov 2017
      AB_561111

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1044743116300987
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NF-κB regulates neuronal ankyrin-G via a negative feedback loop
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    1. scibot 08 Nov 2017
      AB_561111

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    ncbi.nlm.nih.gov/pmc/articles/PMC5299403/
  163. www.sciencedirect.com www.sciencedirect.com
    Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
    1
    1. scibot 08 Nov 2017
      AB_561111

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 2859, RRID:AB_561111)

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    sciencedirect.com/science/article/pii/S0092867416310832
  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
    1
    1. scibot 08 Nov 2017
      AB_561111

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC4160779/
  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders
    1
    1. scibot 08 Nov 2017
      AB_561111

      Curator: @jcabotaj

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    ncbi.nlm.nih.gov/pmc/articles/PMC4145180/