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Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
Sep 2025
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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

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  DOI: 10.1016/j.molcel.2025.08.021
  
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sciencedirect.com/science/article/pii/S1097276525007063
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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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  DOI: 10.1158/1541-7786.MCR-24-1045
  
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aacrjournals.org/mcr/article/23/9/765/764255/Novel-Metastasis-Suppressor-PI3KC2-Is-Mediated-by
Aug 2025
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1-s2.0-S2589004225015664-main-html.html

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  DOI: 10.1016/j.isci.2025.113305
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
Jul 2025
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/science.adm9805
  
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  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
Jun 2025
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma

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  DOI: 10.1016/j.isci.2025.112750
  
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sciencedirect.com/science/article/pii/S2589004225010119
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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  DOI: 10.1091/mbc.E24-11-0512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974963/
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

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  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
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mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos

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  DOI: 10.1016/j.devcel.2024.12.039
  
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cell.com/developmental-cell/abstract/S1534-5807(24)00778-0
Mar 2025
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

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1. scibot 21 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
Feb 2025
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RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis

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1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s44318-024-00353-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
Jan 2025
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Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis

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  DOI: 10.1016/j.celrep.2024.115119
  
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sciencedirect.com/science/article/pii/S2211124724014700
Dec 2024
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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115101
  
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sciencedirect.com/science/article/pii/S2211124724014529
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
Oct 2024
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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1. scibot 05 Oct 2024
  
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  AB_561245
  
  DOI: 10.1101/2024.09.09.612106
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
Sep 2024
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2020.108223
  
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sciencedirect.com/science/article/pii/S2211124720312122
Aug 2024
journals.physiology.org journals.physiology.org

mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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  DOI: 10.1152/ajpcell.00385.2020
  
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journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
May 2024
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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

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  DOI: 10.1016/j.celrep.2024.114173
  
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  DOI: 10.1016/j.celrep.2024.114173
  
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52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
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BPS Publications

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  DOI: 10.1111/bph.16391
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
Feb 2024
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mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms

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  DOI: 10.1210/endocr/bqae015
  
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52.53.155.43/6951e0010ae4c14df11b3315f954e81c6a9c88a4/bqae015-html.html
Jan 2024
www.mdpi.com www.mdpi.com

BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation

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1. scibot 07 Jan 2024
  
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  DOI: 10.3390/ijms25010453
  
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mdpi.com/1422-0067/25/1/453
Dec 2023
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Nutrient-regulated control of lysosome function by signaling lipid conversion

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  DOI: 10.1016/j.cell.2023.09.027
  
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sciencedirect.com/science/article/pii/S0092867423010814
Nov 2023
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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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  DOI: 10.1016/j.cmet.2023.10.016
  
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sciencedirect.com/science/article/abs/pii/S1550413123003856
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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  DOI: 10.1016/j.molcel.2021.03.010
  
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sciencedirect.com/science/article/pii/S1097276521001787
Oct 2023
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.molcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1097276521001775
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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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  DOI: 10.15252/embr.202356815
  
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embopress.org/doi/10.15252/embr.202356815
Jul 2023
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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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  DOI: 10.1016/j.celrep.2023.112764
  
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  DOI: 10.1016/j.celrep.2023.112764
  
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sciencedirect.com/science/article/pii/S2211124723007751
Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.neuron.2023.04.006
  
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Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel

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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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mTOR inhibition decreases angiotensin II-induced steroidogenesis in HAC15 human adrenocortical carcinoma cells

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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus

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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma

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The mTOR chromatin-bound interactome in prostate cancer

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Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model

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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

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Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding

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The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

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Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

1
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  RRID:AB_5612451
  
  DOI: 10.1016/j.devcel.2020.11.016
  
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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

1
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  DOI: 10.1016/j.immuni.2020.06.016
  
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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

1
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  RRID:AB_561245
  
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

1
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  DOI: 10.1016/j.molcel.2021.03.009
  
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

1
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

1
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  RRID:AB_561245
  
  DOI: 10.1016/j.cell.2020.12.024
  
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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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Mitochondrial Regulation of the 26S Proteasome

1
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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

1
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Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

1
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  DOI: 10.1016/j.celrep.2020.03.068
  
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Mechanism of Activation of AMPK by Cordycepin

1
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

1
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  DOI: 10.1016/j.celrep.2020.01.080
  
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Regulation of Hippocampal Memory by mTORC1 in Somatostatin Interneurons

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  DOI: 10.1523/JNEUROSCI.0728-19.2019
  
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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

1
1. scibot 04 Sep 2020
  
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  DOI: 10.15252/embr.201949898
  
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rupress.org rupress.org

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

1
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  DOI: 10.1084/jem.20191787
  
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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

1
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  RRID:AB_561245
  
  DOI: 10.7554/eLife.51440
  
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mcr.aacrjournals.org mcr.aacrjournals.org

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

1
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  DOI: 10.1158/1541-7786.MCR-20-0024
  
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mcr.aacrjournals.org/content/18/8/1142
academic.oup.com academic.oup.com

Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1

1
1. scibot 03 Sep 2020
  
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  Raptor
  
  DOI: 10.1093/jb/mvaa076
  
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academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
Jan 2020
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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

1
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  RRID:AB_561245
  
  DOI: 10.1016/j.molcel.2019.10.016
  
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

1
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  RRID:AB_561245
  
  DOI: 10.1016/j.celrep.2019.07.084
  
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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

1
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  RRID:AB_561245
  
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
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  RRID:AB_561245
  
  DOI: 10.1016/j.molcel.2019.07.023
  
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

1
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  RRID:AB_10694695
  
  DOI: 10.1016/j.immuni.2019.06.007
  
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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

1
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  RRID:AB_561245
  
  DOI: 10.1016/j.immuni.2019.10.001
  
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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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  DOI: 10.1016/j.molcel.2019.08.021
  
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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

1
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  DOI: 10.1016/j.celrep.2019.09.047
  
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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

1
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  DOI: 10.1016/j.celrep.2019.10.117
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.062
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.052
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.036
  
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Untitled document

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  DOI: 10.1210/en.2018-01097
  
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Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

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  DOI: 10.1016/j.cmet.2019.03.005
  
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Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.02.096
  
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mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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1. scibot 05 Nov 2018
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

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1. scibot 05 Nov 2018
  
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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

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1. scibot 08 Nov 2017
  
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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1. scibot 08 Nov 2017
  
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An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

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1. scibot 08 Nov 2017
  
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  Rabbit monoclonal anti-Raptor (24C12)
  
  Curator: @chewbeccax
  
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