96 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    1. scibot 21 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115101

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    sciencedirect.com/science/article/pii/S2211124724014529
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
  5. Oct 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
    1
    1. scibot 05 Oct 2024
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      DOI: 10.1101/2024.09.09.612106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  7. Sep 2024
  8. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2020.108223

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    sciencedirect.com/science/article/pii/S2211124720312122
  9. Aug 2024
  10. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    1. scibot 02 Aug 2024
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      DOI: 10.1152/ajpcell.00385.2020

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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  11. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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    1. scibot 02 Aug 2024
      Raptor

      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  12. May 2024
  13. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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    1. scibot 09 May 2024
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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  14. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 03 May 2024
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      DOI: 10.1111/bph.16391

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
  15. Feb 2024
  16. 52.53.155.43 52.53.155.43
    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    1. scibot 15 Feb 2024
      AB_561245

      DOI: 10.1210/endocr/bqae015

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  17. Jan 2024
  18. www.mdpi.com www.mdpi.com
    BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation
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    1. scibot 07 Jan 2024
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      DOI: 10.3390/ijms25010453

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    mdpi.com/1422-0067/25/1/453
  19. Dec 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  21. Nov 2023
  22. www.sciencedirect.com www.sciencedirect.com
    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.cmet.2023.10.016

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    sciencedirect.com/science/article/abs/pii/S1550413123003856
  23. www.sciencedirect.com www.sciencedirect.com
    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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    1. scibot 16 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276521001787
  24. Oct 2023
  25. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  26. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  27. Jul 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    sciencedirect.com/science/article/pii/S2211124723007751
  29. Apr 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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      DOI: 10.1016/j.neuron.2023.04.006

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    sciencedirect.com/science/article/pii/S0896627323002684
  31. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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      DOI: 10.1002/iub.2722

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
  32. Dec 2022
  33. www.sciencedirect.com www.sciencedirect.com
    Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
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      DOI: 10.1016/j.celrep.2022.111862

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    sciencedirect.com/science/article/pii/S2211124722017582
  34. Nov 2022
  35. academic.oup.com academic.oup.com
    mTOR inhibition decreases angiotensin II-induced steroidogenesis in HAC15 human adrenocortical carcinoma cells
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    1. scibot 19 Nov 2022
      AB_561245

      DOI: 10.1210/endocr/bqac185

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    academic.oup.com/endo/article/164/1/bqac185/6793711
  36. www.sciencedirect.com www.sciencedirect.com
    Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
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      DOI: 10.1016/j.molcel.2022.10.030

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    sciencedirect.com/science/article/pii/S1097276522010589
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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      DOI: 10.1016/j.molcel.2022.10.026

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    sciencedirect.com/science/article/pii/S1097276522010541
  38. May 2022
  39. link.springer.com link.springer.com
    Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus
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      DOI: 10.1007/s12031-022-02030-w

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    link.springer.com/article/10.1007/s12031-022-02030-w
  40. Apr 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110712

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    sciencedirect.com/science/article/pii/S2211124722004739
  42. Mar 2022
  43. www.sciencedirect.com www.sciencedirect.com
    The mTOR chromatin-bound interactome in prostate cancer
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    1. scibot 23 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110534

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    sciencedirect.com/science/article/pii/S2211124722002753
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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      DOI: 10.1152/ajpendo.00236.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
  45. Feb 2022
  46. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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      DOI: 10.15252/embj.2021108119

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    embopress.org/doi/abs/10.15252/embj.2021108119
  47. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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      DOI: 10.1016/j.molcel.2022.01.002

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    sciencedirect.com/science/article/pii/S1097276522000028
  48. www.sciencedirect.com www.sciencedirect.com
    Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly
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      DOI: 10.1016/j.celrep.2022.110307

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    sciencedirect.com/science/article/pii/S2211124722000195
  49. Dec 2021
  50. reader.elsevier.com reader.elsevier.com
    Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells
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      DOI: 10.1016/j.celrep.2021.110063

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    reader.elsevier.com/reader/sd/pii/S2211124721015497
  51. Nov 2021
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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      DOI: 10.7554/eLife.71575

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    ncbi.nlm.nih.gov/pmc/articles/PMC8598234/
  53. 52.53.155.43 52.53.155.43
    ajpcell.00385.2020-html.html
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    52.53.155.43/fcc41b1e6a5d6b11282a20b711b4d6b99930c8bb/ajpcell.00385.2020-html.html
  54. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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      DOI: 10.1007/s00213-021-06015-2

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    link.springer.com/article/10.1007/s00213-021-06015-2
  55. Oct 2021
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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      DOI: 10.7554/eLife.72328

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    ncbi.nlm.nih.gov/pmc/articles/PMC8523161/
  57. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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      DOI: 10.1016/j.celrep.2021.109785

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    sciencedirect.com/science/article/pii/S2211124721012444
  58. Sep 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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      DOI: 10.1016/j.molcel.2021.08.025

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    sciencedirect.com/science/article/pii/S1097276521006924
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    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    sciencedirect.com/science/article/pii/S1097276521007358
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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  62. Aug 2021
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  67. www.sciencedirect.com www.sciencedirect.com
    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  68. Jul 2021
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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  74. May 2021
  75. www.sciencedirect.com www.sciencedirect.com
    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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  76. academic.oup.com academic.oup.com
    The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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      DOI: 10.1210/endocr/bqaa133

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  78. www.sciencedirect.com www.sciencedirect.com
    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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      RRID:AB_5612451

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  81. www.sciencedirect.com www.sciencedirect.com
    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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  83. Apr 2021
  84. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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  86. Jan 2021
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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      DOI: 10.1016/j.cell.2020.12.024

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  88. Sep 2020
  89. www.cell.com www.cell.com
    A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation
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    Mitochondrial Regulation of the 26S Proteasome
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1
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    Mechanism of Activation of AMPK by Cordycepin
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      DOI: 10.1016/j.cell.2020.05.053

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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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  96. www.jneurosci.org www.jneurosci.org
    Regulation of Hippocampal Memory by mTORC1 in Somatostatin Interneurons
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      DOI: 10.1523/JNEUROSCI.0728-19.2019

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    jneurosci.org/content/39/43/8439
  97. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      DOI: 10.15252/embr.201949898

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  98. rupress.org rupress.org
    Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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      DOI: 10.1084/jem.20191787

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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
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      DOI: 10.7554/eLife.51440

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  100. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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      DOI: 10.1158/1541-7786.MCR-20-0024

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  101. academic.oup.com academic.oup.com
    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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      DOI: 10.1093/jb/mvaa076

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  102. Jan 2020
  103. www.sciencedirect.com www.sciencedirect.com
    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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      RRID:AB_561245

      DOI: 10.1016/j.molcel.2019.10.016

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  104. www.sciencedirect.com www.sciencedirect.com
    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
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      RRID:AB_561245

      DOI: 10.1016/j.celrep.2019.07.084

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    sciencedirect.com/science/article/pii/S2211124719310009
  105. www.sciencedirect.com www.sciencedirect.com
    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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      RRID:AB_561245

      DOI: 10.1016/j.celrep.2019.06.085

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    sciencedirect.com/science/article/pii/S2211124719308654
  106. www.sciencedirect.com www.sciencedirect.com
    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    1. scibot 13 Jan 2020
      RRID:AB_561245

      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
  107. www.sciencedirect.com www.sciencedirect.com
    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
    1
    1. scibot 13 Jan 2020
      RRID:AB_10694695

      DOI: 10.1016/j.immuni.2019.06.007

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    Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
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      DOI: 10.1016/j.immuni.2019.10.001

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    Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase
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      DOI: 10.1016/j.molcel.2019.08.021

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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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      DOI: 10.1016/j.celrep.2019.09.047

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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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      DOI: 10.1016/j.celrep.2019.10.117

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      DOI: 10.1016/j.celrep.2019.01.062

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      DOI: 10.1016/j.celrep.2018.12.036

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    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
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  118. Nov 2018
  119. www.sciencedirect.com www.sciencedirect.com
    mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
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  123. Nov 2017
  124. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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      AB_561245

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    An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
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      Rabbit monoclonal anti-Raptor (24C12)

      Curator: @chewbeccax

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