166 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
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    1. scibot 08 Jun 2024
      RRID:AB_561284

      DOI: 10.1038/s44318-024-00092-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
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    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
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    1. scibot 04 Jun 2024
      RRID:AB_561284

      DOI: 10.1016/j.celrep.2024.114289

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    sciencedirect.com/science/article/pii/S221112472400617X
  4. May 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Distinct roles of TREM2 in central nervous system cancers and peripheral cancers
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    sciencedirect.com/science/article/pii/S1535610824001624
  6. aacrjournals.org aacrjournals.org
    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
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    1. scibot 23 May 2024
      RRID:AB_561284

      DOI: 10.1158/2159-8290.CD-23-0700

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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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    Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.celrep.2024.114246

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    sciencedirect.com/science/article/pii/S2211124724005746
  8. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    1. scibot 16 May 2024
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      DOI: 10.1101/2024.05.07.592875

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    biorxiv.org/content/10.1101/2024.05.07.592875v1
  9. www.biorxiv.org www.biorxiv.org
    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.01.24.577107

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    biorxiv.org/content/10.1101/2024.01.24.577107v1
  10. Apr 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001976
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
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    ISGylation by HERCs facilitates STING activation
    1
    1. scibot 23 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004637
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    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
    1
    1. scibot 19 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004236
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
    1
    1. scibot 16 Apr 2024
      RRID:AB_3096118

      DOI: 10.1016/j.celrep.2024.114111

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    sciencedirect.com/science/article/pii/S221112472400439X
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.isci.2024.109533

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000115/
  17. Mar 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
    1
    1. scibot 15 Mar 2024
      RRID:AB_561284

      DOI: 10.1016/j.celrep.2024.113945

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    sciencedirect.com/science/article/pii/S2211124724002730
  19. Feb 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
    1. scibot 27 Feb 2024
      Cell Signaling9167S

      DOI: 10.1016/j.celrep.2024.113816

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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1080/21505594.2024.2303853

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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
  22. www.sciencedirect.com www.sciencedirect.com
    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
    1
    1. scibot 13 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113751

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    sciencedirect.com/science/article/pii/S2211124724000792
  23. 52.53.155.43 52.53.155.43
    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.isci.2024.109100

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  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
    1
    1. scibot 02 Feb 2024
      RRID:AB_561284

      DOI: 10.1158/1078-0432.CCR-23-0215

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524955/
  25. www.sciencedirect.com www.sciencedirect.com
    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
    1
    1. scibot 01 Feb 2024
      RRID:AB_561284

      DOI: 10.1101/2024.01.04.574136

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
  27. Jan 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
    1
    1. scibot 23 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113600

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    ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pdgfrβ is required for embryonic specification and confinement of the adult white adipose lineage
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    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108682

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792241/
  30. www.sciencedirect.com www.sciencedirect.com
    Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
    1
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      DOI: 10.1016/j.cels.2023.12.006

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    sciencedirect.com/science/article/pii/S2405471223003605
  31. Dec 2023
  32. www.sciencedirect.com www.sciencedirect.com
    IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
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    1. scibot 21 Dec 2023
      RRID:AB_561284

      DOI: 10.1016/j.isci.2023.108597

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    sciencedirect.com/science/article/pii/S2589004223026743
  33. www.sciencedirect.com www.sciencedirect.com
    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.immuni.2023.11.002

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    sciencedirect.com/science/article/pii/S1074761323004831
  34. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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    1. scibot 01 Dec 2023
      RRID:AB_561284

      DOI: 10.1126/sciimmunol.adj5097

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    science.org/doi/10.1126/sciimmunol.adj5097
  35. Nov 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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      DOI: 10.1158/2767-9764.CRC-23-0265

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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
  37. www.sciencedirect.com www.sciencedirect.com
    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
    1
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      DOI: 10.1016/j.immuni.2023.09.012

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    sciencedirect.com/science/article/abs/pii/S107476132300417X
  38. Oct 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Serotonin reduction in post-acute sequelae of viral infection
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      DOI: 10.1016/j.cell.2023.09.013

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    sciencedirect.com/science/article/pii/S0092867423010346
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer
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      DOI: 10.1158/0008-5472.CAN-23-1711

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    ncbi.nlm.nih.gov/pmc/articles/PMC10543960/
  41. Sep 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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      DOI: 10.1016/j.devcel.2023.08.013

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    sciencedirect.com/science/article/pii/S1534580723004094
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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      DOI: 10.1158/2643-3230.BCD-22-0082

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    ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
  45. Aug 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages
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      DOI: 10.1126/sciimmunol.abo4767

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    ncbi.nlm.nih.gov/pmc/articles/PMC10443087/
  47. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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      DOI: 10.1016/j.celrep.2023.112937

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      DOI: 10.1016/j.celrep.2023.112937

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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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      DOI: 10.1016/j.celrep.2023.112929

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    sciencedirect.com/science/article/pii/S2211124723009403
  49. Jul 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
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      DOI: 10.1016/j.celrep.2023.112841

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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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  54. Jun 2023
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    Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling
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  56. May 2023
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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    Intracellular infection and immune system cues rewire adipocytes to acquire immune function
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    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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  105. Mar 2022
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    Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
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  110. Feb 2022
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  113. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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  117. Dec 2021
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    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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  120. Nov 2021
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  123. Oct 2021
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  125. Sep 2021
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    Activating a collaborative innate-adaptive immune response to control metastasis
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  129. Aug 2021
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    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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  138. Jul 2021
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    Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
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  145. Jun 2021
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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  147. www.frontiersin.org www.frontiersin.org
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    Translation stress and collided ribosomes are co-activators of cGAS
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  149. May 2021
  150. www.sciencedirect.com www.sciencedirect.com
    Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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  155. Apr 2021
  156. www.sciencedirect.com www.sciencedirect.com
    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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    1. scibot 05 Nov 2018
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    europepmc.org/articles/PMC5915735/
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1931312818300477
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    Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
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    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1074761318300840
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1535610818301223
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    The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
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    1. scibot 05 Nov 2018
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      Curator: @evieth

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    sciencedirect.com/science/article/pii/S0165572817303703
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    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6427047/
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    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
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    1. scibot 08 Nov 2017
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    sciencedirect.com/science/article/pii/S1535610817302982
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    Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation
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    1. scibot 08 Nov 2017
      Monoclonal anti-mouse pSTAT1 pY701 (clone 58D6)Cell Signaling TechnologiesCat: 9167

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