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    RNA sensing induced by chromosome missegregation augments anti-tumor immunity
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    Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution
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  4. Dec 2024
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    Regulation of human interferon signaling by transposon exonization
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  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway
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  7. 52.53.155.43 52.53.155.43
    1-s2.0-S2352345X24001905-main-html.html
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  8. Nov 2024
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis
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  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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  11. Oct 2024
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    sciencedirect.com/science/article/pii/S1550413124003668
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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  15. Sep 2024
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    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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    PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2
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    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
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  21. Aug 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    sciencedirect.com/science/article/pii/S2211124724009379
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    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
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    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
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  26. Jul 2024
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S1074761324002796
  28. Jun 2024
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    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
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  31. May 2024
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    Distinct roles of TREM2 in central nervous system cancers and peripheral cancers
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    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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    Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
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  35. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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  37. Apr 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
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    ISGylation by HERCs facilitates STING activation
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    sciencedirect.com/science/article/pii/S2211124724004637
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    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
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    sciencedirect.com/science/article/pii/S2211124724004236
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000115/
  44. Mar 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    sciencedirect.com/science/article/pii/S2211124724002730
  46. Feb 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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      DOI: 10.1080/21505594.2024.2303853

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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
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  54. Jan 2024
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    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer
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    Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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  102. Jan 2023
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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  108. Dec 2022
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  110. Nov 2022
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    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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  114. Oct 2022
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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  121. Sep 2022
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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  123. Aug 2022
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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  126. Jul 2022
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    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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  128. May 2022
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    Intracellular infection and immune system cues rewire adipocytes to acquire immune function
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  130. Apr 2022
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    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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  132. Mar 2022
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    Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
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  137. Feb 2022
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  140. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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  144. Dec 2021
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  147. Nov 2021
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    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
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  150. Oct 2021
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  152. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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  156. Aug 2021
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    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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  185. Mar 2021
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  192. Jan 2021
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
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    Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
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    RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer
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    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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    Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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  224. Nov 2018
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    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
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    Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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    The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
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    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
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    Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation
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