98 Matching Annotations
  1. Jul 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
    1
    1. scibot 14 Jul 2024
      RRID:AB_615042

      DOI: 10.1016/j.isci.2024.110109

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233918/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration
    1
    1. scibot 07 Jul 2024
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      DOI: 10.1016/j.celrep.2024.113999

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    ncbi.nlm.nih.gov/pmc/articles/PMC11216409/
  4. Jun 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.011

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    sciencedirect.com/science/article/pii/S1534580724003289
  6. May 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LncRNA Hsrω nucleates TBPH and promotes intestinal stem cell differentiation upon heat shock
    1
    1. scibot 08 May 2024
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      DOI: 10.1016/j.isci.2024.109732

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    ncbi.nlm.nih.gov/pmc/articles/PMC11067334/
  8. 52.53.155.43 52.53.155.43
    TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis
    1
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.01.07.574541

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    52.53.155.43/52328d22433e68f24f1d36a54def69a5a5ed912e/2024.01.07.574541v2.full-html.html
  9. Apr 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle
    2
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.012

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    2. scibot 09 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.012

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    sciencedirect.com/science/article/pii/S1097276524002223
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.004

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    sciencedirect.com/science/article/pii/S1934590924000857
  12. Mar 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
    1
    1. scibot 31 Mar 2024
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      DOI: 10.1038/s42003-024-06071-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10978903/
  14. Feb 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons
    2
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.isci.2024.109166

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    2. scibot 29 Feb 2024
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      DOI: 10.1016/j.isci.2024.109166

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    sciencedirect.com/science/article/pii/S2589004224003870
  16. www.sciencedirect.com www.sciencedirect.com
    hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113769

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    sciencedirect.com/science/article/pii/S2211124724000974
  17. jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com
    Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1186/s12974-024-03039-1

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    2. scibot 15 Feb 2024
      RRID:AB_615042

      DOI: 10.1186/s12974-024-03039-1

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    jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03039-1
  18. www.sciencedirect.com www.sciencedirect.com
    Mouse oocytes sequester aggregated proteins in degradative super-organelles
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.031

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    sciencedirect.com/science/article/pii/S0092867424000680
  19. www.sciencedirect.com www.sciencedirect.com
    Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.022

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    sciencedirect.com/science/article/pii/S0896627324000485
  20. Jan 2024
  21. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 18 Jan 2024
      AB_615042

      DOI: 10.1126/sciadv.ade1282

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    science.org/doi/10.1126/sciadv.ade1282
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113662

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857847/
  23. Dec 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113509

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    sciencedirect.com/science/article/pii/S2211124723015218
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Targeted perturbation of signaling-driven condensates
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.023

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    sciencedirect.com/science/article/pii/S1097276523008602
  27. Sep 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43
    1
    1. scibot 30 Sep 2023
      RRID:AB_615042

      DOI: 10.1016/j.jbc.2023.105272

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    sciencedirect.com/science/article/pii/S0021925823023001
  29. Aug 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients
    1
    1. scibot 26 Aug 2023
      AB_615042

      DOI: 10.3389/fnmol.2023.1243277

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    ncbi.nlm.nih.gov/pmc/articles/PMC10445132/
  31. www.sciencedirect.com www.sciencedirect.com
    Tuning Hsp104 specificity to selectively detoxify α-synuclein
    1
    1. scibot 25 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.029

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    sciencedirect.com/science/article/abs/pii/S1097276523006044
  32. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal
    1
    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112998

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    sciencedirect.com/science/article/pii/S2211124723010094
  33. 52.53.155.43 52.53.155.43
    Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1093/brain/awad264

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    52.53.155.43/5178e3b5a29ba09ab2106f8993d42d5e0411ae62/awad264 (1)-html.html
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112841

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    sciencedirect.com/science/article/pii/S2211124723008525
  36. Jun 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence
    1
    1. scibot 24 Jun 2023
      AB_615042

      DOI: 10.12688/f1000research.131852.2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10285334/
  38. May 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.isci.2023.106645

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    sciencedirect.com/science/article/pii/S2589004223007228
  40. www.sciencedirect.com www.sciencedirect.com
    Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.celrep.2022.111086

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    sciencedirect.com/science/article/pii/S2211124722008889
  41. Apr 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 27 Apr 2023
      AB_615042

      DOI: 10.1126/sciadv.ade1282

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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  43. Mar 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ILF3 prion-like domain regulates gene expression and fear memory under chronic stress
    1
    1. scibot 09 Mar 2023
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      DOI: 10.1016/j.isci.2023.106229

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    ncbi.nlm.nih.gov/pmc/articles/PMC9982275/
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
    1
    1. scibot 24 Feb 2023
      RRID:AB_615042

      DOI: 10.1016/j.celrep.2023.112134

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    sciencedirect.com/science/article/pii/S2211124723001456
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC10062012/
  48. www.sciencedirect.com www.sciencedirect.com
    SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
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      DOI: 10.1016/j.stem.2023.01.005

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    sciencedirect.com/science/article/pii/S193459092300005X
  49. Oct 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
    1
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      DOI: 10.1016/j.celrep.2022.111508

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    sciencedirect.com/science/article/pii/S2211124722013584
  51. Aug 2022
  52. www.embopress.org www.embopress.org
    Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons
    1
    1. scibot 26 Aug 2022
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      DOI: 10.15252/embj.2021110486

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    embopress.org/doi/10.15252/embj.2021110486
  53. May 2022
  54. link.springer.com link.springer.com
    Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
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      DOI: 10.1186/s40478-022-01352-5

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    link.springer.com/article/10.1186/s40478-022-01352-5
  55. Mar 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
    1
    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.devcel.2022.02.022

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    sciencedirect.com/science/article/pii/S1534580722001241
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
    1
    1. scibot 26 Mar 2022
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      DOI: 10.1038/s41586-022-04424-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8891019/
  58. www.sciencedirect.com www.sciencedirect.com
    Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases
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    1. scibot 06 Mar 2022
      RRID:AB_615042

      DOI: 10.1016/j.cell.2022.02.026

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    sciencedirect.com/science/article/pii/S0092867422002598
  59. Dec 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS
    1
    1. scibot 08 Dec 2021
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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  62. Aug 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
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    TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
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    Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability
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  68. Jul 2021
  69. www.nature.com www.nature.com
    Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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  71. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phosphorylation of Trans-active response DNA binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing
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  73. journals.plos.org journals.plos.org
    DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro
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    Neuronal VCP loss of function recapitulates FTLD-TDP pathology
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  75. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
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  76. Jun 2021
  77. elifesciences.org elifesciences.org
    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
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  78. May 2021
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    UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
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    Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
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    G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
    1
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    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
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  83. Mar 2021
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
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      DOI: 10.7554/eLife.64456

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  85. Jan 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic genetic variation revealed in diverse Hsp104 homologs
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  87. Dec 2020
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
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    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
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  90. Nov 2020
  91. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Amyotrophic lateral sclerosis associated mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
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      rabbit polyclonal α‐TDP‐43

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  92. Sep 2020
  93. www.sciencedirect.com www.sciencedirect.com
    Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
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    Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network
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    Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
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  96. jcs.biologists.org jcs.biologists.org
    TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2
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      DOI: 10.1242/jcs.245811

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  97. www.sciencedirect.com www.sciencedirect.com
    An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
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      rabbit anti-TDP-43

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  98. Jan 2020
  99. www.sciencedirect.com www.sciencedirect.com
    Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
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      DOI: 10.7554/eLife.40811

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    Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
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      RRID:AB_615042

      DOI: 10.1016/j.neuron.2019.02.038

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    Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
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    Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS
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  105. link.springer.com link.springer.com
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  106. Nov 2018
  107. www.sciencedirect.com www.sciencedirect.com
    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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  108. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
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    Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
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  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP‐43 tissue pathology
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  112. Nov 2017
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread
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    TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
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    TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
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  116. www.sciencedirect.com www.sciencedirect.com
    Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
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    A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
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    C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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