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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
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    1. scibot 21 Dec 2024
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      DOI: 10.1158/2767-9764.CRC-24-0408

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    pmc.ncbi.nlm.nih.gov/articles/PMC11586712/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and Their Zebrafish Homologs at the Blood-Brain Barrier
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    1. scibot 21 Dec 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11585257/
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    Intron retention of an adhesion GPCR generates 1TM isoforms required for 7TM-GPCR function
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014293
  5. Dec 2024
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    Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells
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    1. scibot 14 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724013378
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells
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    1. scibot 13 Dec 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617193/
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    Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles
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    1. scibot 12 Dec 2024
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    sciencedirect.com/science/article/pii/S1097276524009201
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    Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
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    sciencedirect.com/science/article/pii/S2211124724014074
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    m6A sites in the coding region trigger translation-dependent mRNA decay
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    sciencedirect.com/science/article/pii/S1097276524008736
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    Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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    1. scibot 02 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724013408
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    Thyroid hormones are required for thermogenesis of beige adipocytes induced by Zfp423 inactivation
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    1. scibot 02 Dec 2024
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    sciencedirect.com/science/article/pii/S221112472401338X
  13. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    1. scibot 28 Nov 2024
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    sciencedirect.com/science/article/pii/S2211124724013524
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    Plausible, robust biological oscillations through allelic buffering
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    1. scibot 15 Nov 2024
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    sciencedirect.com/science/article/pii/S2405471224002990
  16. 52.53.155.43 52.53.155.43
    glae258-html.html
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    1. scibot 08 Nov 2024
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    can-24-0529-html.html
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  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma
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    1. scibot 07 Nov 2024
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      DOI: 10.1002/mc.23610

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  19. Oct 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors
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    1. scibot 04 Oct 2024
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      DOI: 10.1158/1535-7163.MCT-23-0865

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443198/
  21. Sep 2024
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    EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization
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    sciencedirect.com/science/article/pii/S221112472401132X
  23. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    1. scibot 27 Sep 2024
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286715
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    Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
    1
    1. scibot 25 Sep 2024
      RRID:AB_2651127

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    sciencedirect.com/science/article/pii/S2211124721003326
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2020.108201

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    sciencedirect.com/science/article/pii/S2211124720311906
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    Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
    1
    1. scibot 25 Sep 2024
      RRID:AB_621842

      DOI: 10.1016/j.ebiom.2020.102878

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    sciencedirect.com/science/article/pii/S235239642030253X
  27. elifesciences.org elifesciences.org
    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
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    1. scibot 25 Sep 2024
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      DOI: 10.7554/eLife.50519

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    elifesciences.org/articles/50519
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610819305239
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Corticosterone primes the neuroinflammatory response to Gulf War Illness‐relevant organophosphates independently of acetylcholinesterase inhibition
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      DOI: 10.1111/jnc.14071

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14071/full
  30. www.sciencedirect.com www.sciencedirect.com
    Protein UFMylation regulates early events during ribosomal DNA-damage response
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    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010891
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    Protofilament-specific nanopatterns of tubulin post-translational modifications regulate the mechanics of ciliary beating
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    1. scibot 13 Sep 2024
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      DOI: 10.1016/j.cub.2024.08.021

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    sciencedirect.com/science/article/pii/S0960982224011333
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis
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      DOI: 10.1016/j.isci.2024.110683

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    ncbi.nlm.nih.gov/pmc/articles/PMC11382127/
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    Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin
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    sciencedirect.com/science/article/pii/S1931312824003196
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    mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S2666379124004385
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    sciencedirect.com/science/article/pii/S009286742400905X
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    Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ
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    sciencedirect.com/science/article/pii/S2211124724010465
  37. 52.53.155.43 52.53.155.43
    o-guinn-et-al-2024-fxr-deletion-attenuates-intestinal-barrier-dysfunction-in-murine-acute-intestinal-inflammation-html.html
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    52.53.155.43/38c001291b888dcf9d96e78ed9f3c0ee31989d96/o-guinn-et-al-2024-fxr-deletion-attenuates-intestinal-barrier-dysfunction-in-murine-acute-intestinal-inflammation-html.html
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
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      DOI: 10.1152/ajpcell.00654.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC11371365/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes
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      DOI: 10.1038/s41467-024-51676-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11362472/
  40. Aug 2024
  41. www.sciencedirect.com www.sciencedirect.com
    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
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      DOI: 10.1016/j.xcrm.2024.101700

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    sciencedirect.com/science/article/pii/S266637912400421X
  42. www.sciencedirect.com www.sciencedirect.com
    Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
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      DOI: 10.1016/j.celrep.2024.114681

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    sciencedirect.com/science/article/pii/S2211124724010325
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
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      DOI: 10.1016/j.chembiol.2023.06.018

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    ncbi.nlm.nih.gov/pmc/articles/PMC10530441/
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    Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans
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      DOI: 10.1016/j.cmet.2024.07.020

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    Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1
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      D. Secondary antibodies used for immunoblotting or confocal imaging

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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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  91. www.nature.com www.nature.com
    Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
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    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
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    Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT
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    Alternative mRNA splicing events and regulators in epidermal differentiation
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    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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  114. link.springer.com link.springer.com
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  115. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide
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    Mechanistic and structural studies reveal NRAP-1-dependent coincident activation of NMDARs
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents
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    Influenza A virus selectively elevates prostaglandin E2 formation in pro-resolving macrophages
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation
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    A naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease
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  128. Dec 2023
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    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
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    MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
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    Proteomics from compartment-specific APEX2 labeling in Mycobacterium tuberculosis reveals Type VII secretion substrates in the cell wall
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    Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Recruitment of FBXO22 for Targeted Degradation of NSD2
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    Divergence of TORC1-mediated stress response leads to novel acquired stress resistance in a pathogenic yeast
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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  153. Oct 2023
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    Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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  157. 52.53.155.43 52.53.155.43
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    Neuronal activity drives IGF2 expression from pericytes to form long-term memory
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
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  161. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
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    Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury
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    The C2 domain of calpain 5 contributes to enzyme activation and membrane localization
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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  168. Aug 2023
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    Divergence of TORC1-mediated Stress Response Leads to Novel Acquired Stress Resistance in a Pathogenic Yeast
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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    Exercise improves homeostasis of the intestinal epithelium by activation of APJ-AMPK signaling
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Sex-specific Phenotypes in the Aging Mouse Heart and Consequences for Chronic Fibrosis
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    LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling
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    Organism-wide, cell-type-specific secretome mapping of exercise training in mice
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    Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling
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      SciCrunch record: RRID:AB_621843

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      RRIDCUR:Unresolved RRID:AB_621843
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    ncbi.nlm.nih.gov/pmc/articles/PMC9145266/
  211. www.nature.com www.nature.com
    Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
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    1. scibot 02 May 2023
      RRID:AB_621843

      DOI: 10.1038/s41594-023-00981-1

      Resource: (LI-COR Biosciences Cat# 926-32211, RRID:AB_621843)

      Curator: @scibot

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    nature.com/articles/s41594-023-00981-1
  212. Apr 2023
  213. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    1. scibot 29 Apr 2023
      RRID:AB_621843

      DOI: 10.1016/j.celrep.2023.112436

      Resource: (LI-COR Biosciences Cat# 926-32211, RRID:AB_621843)

      Curator: @scibot

      SciCrunch record: RRID:AB_621843

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      RRID:AB_621843
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    sciencedirect.com/science/article/pii/S2211124723004473