564 Matching Annotations
  1. Last 7 days
  2. www.pnas.org www.pnas.org
    Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity
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    1. scibot 29 Dec 2024
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      DOI: 10.1073/pnas.2407225121

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    pnas.org/doi/10.1073/pnas.2407225121
  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution
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    1. scibot 21 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115115

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    sciencedirect.com/science/article/pii/S2211124724014669
  5. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224028086-main-html.html
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    1. scibot 19 Dec 2024
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      DOI: 10.1016/j.isci.2024.111581

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    The role of osteocrin in memory formation during early learning, as revealed by visual imprinting in chicks
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    1. scibot 19 Dec 2024
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      DOI: 10.1016/j.isci.2024.111195

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    sciencedirect.com/science/article/pii/S2589004224024209
  7. www.sciencedirect.com www.sciencedirect.com
    Enhanced antitumor immunity in breast cancer: Synergistic effects of ADAM10/ADAM17 inhibition, metabolic modulation, and camptothecin-loaded selenium nanoparticles
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    1. scibot 14 Dec 2024
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      DOI: 10.1016/j.ijpharm.2024.125037

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    sciencedirect.com/science/article/pii/S0378517324012717
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
    1
    1. scibot 13 Dec 2024
      sc-47778, Santa Cruz

      DOI: 10.1002/advs.202406191

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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202406191
  9. www.sciencedirect.com www.sciencedirect.com
    Maternal gut microbiota influence stem cell function in offspring
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    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.stem.2024.10.003

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    sciencedirect.com/science/article/pii/S1934590924003655
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    Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolism
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    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.ebiom.2024.105487

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    sciencedirect.com/science/article/pii/S2352396424005231
  11. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle
    1
    1. scibot 05 Dec 2024
      RRID:AB_626632

      DOI: 10.1096/fj.202401145RR

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    Covalent targeting of splicing in T cells
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.chembiol.2024.10.010

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    sciencedirect.com/science/article/pii/S2451945624004458
  13. Nov 2024
  14. www.sciencedirect.com www.sciencedirect.com
    ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss
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    1. scibot 17 Nov 2024
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      DOI: 10.1016/j.molcel.2024.10.020

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    sciencedirect.com/science/article/pii/S1097276524008608
  15. www.sciencedirect.com www.sciencedirect.com
    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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    1. scibot 16 Nov 2024
      RRID:AB_626632

      DOI: 10.1016/j.devcel.2024.10.008

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    sciencedirect.com/science/article/pii/S1534580724006270
  16. www.sciencedirect.com www.sciencedirect.com
    Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.bbadis.2024.167572

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    sciencedirect.com/science/article/pii/S0925443924005660
  17. www.sciencedirect.com www.sciencedirect.com
    Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis
    1
    1. scibot 11 Nov 2024
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      DOI: 10.1016/j.celrep.2024.114966

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    sciencedirect.com/science/article/pii/S2211124724013172
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice
    1
    1. scibot 10 Nov 2024
      RRID:AB_626632

      DOI: 10.1210/endocr/bqae141

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    pmc.ncbi.nlm.nih.gov/articles/PMC11538792/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction
    1
    1. scibot 08 Nov 2024
      RRID:AB_626632

      DOI: 10.1038/s44318-024-00233-y

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    pmc.ncbi.nlm.nih.gov/articles/PMC11535212/
  20. journals.lww.com journals.lww.com
    Reduced mesencephalic astrocyte-derived neurotrophic factor ... : Neural Regeneration Research
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      DOI: 10.4103/NRR.NRR-D-23-01666

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    journals.lww.com/nrronline/fulltext/2025/09000/reduced_mesencephalic_astrocyte_derived.27.aspx
  21. Oct 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
    1
    1. scibot 05 Oct 2024
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      DOI: 10.1016/j.chembiol.2023.06.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
  23. Sep 2024
  24. www.sciencedirect.com www.sciencedirect.com
    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1016/j.ccell.2020.05.022

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    sciencedirect.com/science/article/pii/S1535610820302725
  25. www.sciencedirect.com www.sciencedirect.com
    NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1016/j.celrep.2021.108689

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    sciencedirect.com/science/article/pii/S2211124721000024
  26. www.sciencedirect.com www.sciencedirect.com
    Critical role of Syk-dependent STAT1 activation in innate antiviral immunity
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1016/j.celrep.2020.108627

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    sciencedirect.com/science/article/pii/S2211124720316168
  27. www.sciencedirect.com www.sciencedirect.com
    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1016/j.celrep.2020.108625

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    sciencedirect.com/science/article/pii/S2211124720316144
  28. www.sciencedirect.com www.sciencedirect.com
    Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1016/j.tranon.2020.101000

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    sciencedirect.com/science/article/pii/S1936523320304927
  29. academic.oup.com academic.oup.com
    Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1210/jendso/bvaa054

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    academic.oup.com/jes/article/4/7/bvaa054/5837712
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    GLAST‐CreERT2 mediated deletion of GDNF increases brain damage and exacerbates long‐term stroke outcomes after focal ischemic stroke in mouse model
    1
    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1002/glia.23848

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    onlinelibrary.wiley.com/doi/10.1002/glia.23848
  31. mcr.aacrjournals.org mcr.aacrjournals.org
    Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth
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    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1158/1541-7786.MCR-19-0934

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  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of transcription factor SP1 produces neuroprotective effects through decreasing MAO B activity in MPTP/MPP+ Parkinson's disease models
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    1. scibot 25 Sep 2024
      RRID:AB_2714189

      DOI: 10.1002/jnr.24266

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  33. www.sciencedirect.com www.sciencedirect.com
    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
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      DOI: 10.1016/j.celrep.2024.114751

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    sciencedirect.com/science/article/pii/S2211124724011021
  34. www.sciencedirect.com www.sciencedirect.com
    Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation
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      DOI: 10.1016/j.celrep.2024.114734

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    sciencedirect.com/science/article/pii/S2211124724010854
  35. www.nature.com www.nature.com
    ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer
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      DOI: 10.1038/s41388-024-03154-6

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    nature.com/articles/s41388-024-03154-6
  36. www.sciencedirect.com www.sciencedirect.com
    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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      DOI: 10.1016/j.celrep.2024.114689

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    sciencedirect.com/science/article/pii/S2211124724010404
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
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      DOI: 10.1038/s41598-024-72024-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377710/
  38. www.sciencedirect.com www.sciencedirect.com
    FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants
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      DOI: 10.1016/j.isci.2024.110814

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    sciencedirect.com/science/article/pii/S258900422402039X
  39. www.sciencedirect.com www.sciencedirect.com
    Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
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      DOI: 10.1016/j.cell.2024.08.007

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    sciencedirect.com/science/article/pii/S0092867424008985
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    Osteocalcin-expressing neutrophils from skull bone marrow exert immunosuppressive and neuroprotective effects after TBI
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      DOI: 10.1016/j.celrep.2024.114670

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    sciencedirect.com/science/article/pii/S2211124724010210
  41. Aug 2024
  42. www.sciencedirect.com www.sciencedirect.com
    BBOX1 mediates metabolic reprogramming driven by hypoxia and participates in the malignant progress of high-grade serous ovarian cancer
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      DOI: 10.1016/j.bbamcr.2024.119830

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    sciencedirect.com/science/article/pii/S0167488924001733
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    RNA interacts with topoisomerase I to adjust DNA topology
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    1. scibot 23 Aug 2024
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      DOI: 10.1016/j.molcel.2024.07.032

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    sciencedirect.com/science/article/pii/S1097276524006300
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    TRIM24 upregulates ORM2 to alleviate abnormal lipid metabolism, inflammation, and oxidative stress in mice with obstructive sleep apnea syndrome & metabolic dysfunction-associated steatotic liver disease
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network
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    Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer’s disease
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    The extract of Ilex kudingcha inhibits atherosclerosis in apoE-deficient mice by suppressing cholesterol accumulation in macrophages
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  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Localization of α‐Synuclein in Teleost Central Nervous System: Immunohistochemical and Western Blot Evidence by 3D5 Monoclonal Antibody in the Common Carp, Cyprinus carpio
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  53. www.sciencedirect.com www.sciencedirect.com
    Blending and separating dynamics of RNA-binding proteins develop architectural splicing networks spreading throughout the nucleus
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    Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis
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    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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    Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson’s disease
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    The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation
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    CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection
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    Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver
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    Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
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    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers
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  68. Jun 2024
  69. www.cell.com www.cell.com
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    Protein-energy restriction-induced lipid metabolism disruption causes stable-to-progressive disease shift in Mycobacterium avium-infected female mice
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    Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
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    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
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    Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
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    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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    Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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    Hypoxia modulates P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) drug transporters in brain endothelial cells of the developing human blood-brain barrier
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer
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    Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells
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    Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition
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  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
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    Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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  97. Mar 2024
  98. www.sciencedirect.com www.sciencedirect.com
    A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
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    A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
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    OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
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    Dual effects of TGF-β inhibitor in ALS - inhibit contracture and neurodegeneration
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    Non-random spatial organization of telomere varies during the cell cycle and requires LAP2 and BAF
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    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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    Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption
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    Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia
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    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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    Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease
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    Liver Androgen Receptor Knockout Improved High-fat Diet Induced Glucose Dysregulation in Female Mice But Not Male Mice
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  112. Feb 2024
  113. www.sciencedirect.com www.sciencedirect.com
    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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  115. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer
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  119. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway
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    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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    Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization
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  166. 52.53.155.43 52.53.155.43
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    CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance
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    Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease
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    Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
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    Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
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    Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
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    Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome
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    Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis
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    Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
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    Silencing of CDC42 inhibits contraction and growth-related functions in prostate stromal cells, which is mimicked by ML141
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    Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
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    Muscle glycome in Idiopathic Inflammatory Myopathies: impact in IL-6 production and disease prognosis.
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    Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
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    SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury
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  201. www.sciencedirect.com www.sciencedirect.com
    YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
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    Modeling breast cancer proliferation, drug synergies, and alternating therapies
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    Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response
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    Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells
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    Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
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    1. scibot 16 May 2023
      RRID:AB_626632

      DOI: 10.3389/fphar.2023.1105427

      Resource: (Santa Cruz Biotechnology Cat# sc-47778, RRID:AB_626632)

      Curator: @scibot

      SciCrunch record: RRID:AB_626632

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      RRID:AB_626632
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    ncbi.nlm.nih.gov/pmc/articles/PMC10175612/