53 Matching Annotations
  1. May 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
  3. Apr 2024
  4. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
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      RRID:AB_626761

      DOI: 10.1083/jcb.202303141

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      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  5. www.nature.com www.nature.com
    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
    3
    1. scibot 03 Apr 2024
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      DOI: 10.1038/s41467-024-47069-y

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      DOI: 10.1038/s41467-024-47069-y

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    3. scibot 03 Apr 2024
      RRID:AB_626761

      DOI: 10.1038/s41467-024-47069-y

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    nature.com/articles/s41467-024-47069-y
  6. Jan 2024
  7. www.sciencedirect.com www.sciencedirect.com
    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.040

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    sciencedirect.com/science/article/pii/S1097276523010869
  8. Apr 2023
  9. www.sciencedirect.com www.sciencedirect.com
    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.molcel.2023.02.004

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    sciencedirect.com/science/article/pii/S1097276523000837
  10. Feb 2023
  11. www.sciencedirect.com www.sciencedirect.com
    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
    1
    1. scibot 17 Feb 2023
      RRID:AB_626761

      DOI: 10.1016/j.isci.2023.106107

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    sciencedirect.com/science/article/pii/S2589004223001840
  12. Jan 2023
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
    1
    1. scibot 11 Jan 2023
      RRID:AB_626761

      DOI: 10.1016/j.isci.2022.105806

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
  14. Dec 2022
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
    1
    1. scibot 08 Dec 2022
      RRID:AB_626761

      DOI: 10.1016/j.isci.2022.105626

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    ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
  16. Nov 2022
  17. www.sciencedirect.com www.sciencedirect.com
    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
    1
    1. scibot 18 Nov 2022
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2022.111716

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    sciencedirect.com/science/article/pii/S2211124722015947
  18. Sep 2022
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
    1
    1. scibot 02 Sep 2022
      RRID:AB_626761

      DOI: 10.1158/0008-5472.CAN-21-1843

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
  20. Apr 2022
  21. www.sciencedirect.com www.sciencedirect.com
    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
    1
    1. scibot 21 Apr 2022
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2022.03.030

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    sciencedirect.com/science/article/pii/S1097276522002684
  22. Mar 2022
  23. www.sciencedirect.com www.sciencedirect.com
    BMI-1 regulates DNA end resection and homologous recombination repair
    1
    1. scibot 23 Mar 2022
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2022.110536

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    sciencedirect.com/science/article/pii/S2211124722002777
  24. www.sciencedirect.com www.sciencedirect.com
    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
    1
    1. scibot 02 Mar 2022
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2022.01.020

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    sciencedirect.com/science/article/pii/S1097276522000855
  25. Dec 2021
  26. www.sciencedirect.com www.sciencedirect.com
    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
    1
    1. scibot 22 Dec 2021
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2021.110138

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    sciencedirect.com/science/article/pii/S221112472101634X
  27. Nov 2021
  28. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
    1
    1. scibot 18 Nov 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2021.10.017

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    sciencedirect.com/science/article/pii/S1097276521009096
  29. Sep 2021
  30. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
    1
    1. scibot 11 Sep 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2021.08.016

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    sciencedirect.com/science/article/pii/S1097276521006833
  31. Jul 2021
  32. www.sciencedirect.com www.sciencedirect.com
    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
    2
    1. scibot 28 Jul 2021
      AB_626761

      DOI: 10.1016/j.molcel.2017.08.021

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    2. scibot 28 Jul 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2017.08.021

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    sciencedirect.com/science/article/pii/S1097276517306184
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response
    1
    1. scibot 17 Jul 2021
      RRID:AB_626761

      DOI: 10.7554/eLife.61407

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    ncbi.nlm.nih.gov/pmc/articles/PMC8279762/
  34. Jun 2021
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
    1
    1. scibot 18 Jun 2021
      RRID:AB_626761

      DOI: 10.1016/j.isci.2021.102534

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    ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
  36. www.sciencedirect.com www.sciencedirect.com
    Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin
    1
    1. scibot 08 Jun 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2021.05.010

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    sciencedirect.com/science/article/pii/S1097276521003671
  37. May 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
    1
    1. scibot 14 May 2021
      RRID:AB_626761

      DOI: 10.1016/j.chom.2021.04.006

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    sciencedirect.com/science/article/pii/S1931312821001827
  39. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
    1
    1. scibot 07 May 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2020.09.017

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    sciencedirect.com/science/article/pii/S109727652030647X
  40. Apr 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
    1
    1. scibot 22 Apr 2021
      RRID:AB_626761

      DOI: 10.1016/j.ccell.2020.10.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
  42. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
    1
    1. scibot 12 Apr 2021
      RRID:AB_626761

      DOI: 10.1016/j.cell.2021.01.041

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    sciencedirect.com/science/article/pii/S0092867421000842
  43. www.sciencedirect.com www.sciencedirect.com
    SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
    1
    1. scibot 01 Apr 2021
      BRCA1

      DOI: 10.1016/j.celrep.2021.108921

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    sciencedirect.com/science/article/pii/S2211124721002357
  44. Feb 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
    1
    1. scibot 25 Feb 2021
      RRID:AB_626761

      DOI: 10.1016/j.molcel.2021.01.004

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    sciencedirect.com/science/article/pii/S1097276521000046
  46. Jan 2021
  47. www.sciencedirect.com www.sciencedirect.com
    DCAF14 promotes stalled fork stability to maintain genome integrity
    1
    1. scibot 28 Jan 2021
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2020.108669

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    sciencedirect.com/science/article/pii/S2211124720316582
  48. www.sciencedirect.com www.sciencedirect.com
    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
    1
    1. scibot 21 Jan 2021
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      DOI: 10.1016/j.molcel.2020.12.025

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    sciencedirect.com/science/article/pii/S1097276520309461
  49. Nov 2020
  50. www.sciencedirect.com www.sciencedirect.com
    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
    1
    1. scibot 07 Nov 2020
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2020.108347

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    sciencedirect.com/science/article/pii/S221112472031336X
  51. Sep 2020
  52. www.sciencedirect.com www.sciencedirect.com
    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
    1
    1. scibot 16 Sep 2020
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2020.107884

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    sciencedirect.com/science/article/pii/S2211124720308652
  53. www.sciencedirect.com www.sciencedirect.com
    BRCA1 Mutational Complementation Induces Synthetic Viability
    1
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      RRID:AB_626761

      DOI: 10.1016/j.molcel.2020.04.006

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    sciencedirect.com/science/article/pii/S109727652030232X
  54. www.sciencedirect.com www.sciencedirect.com
    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
    1
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      RRID:AB_626761

      DOI: 10.1016/j.celrep.2020.107745

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    sciencedirect.com/science/article/pii/S2211124720307257
  55. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
    1
    1. scibot 04 Sep 2020
      BRCA1

      DOI: 10.1101/gad.332395.119

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      Curator comments: Mouse Anti-Human BRCA1 (D-9) Monoclonal, Unconjugated, Clone D-9 antibody Santa Cruz Biotechnology Cat# sc-6954

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    genesdev.cshlp.org/content/33/23-24/1702.full
  56. Aug 2020
  57. www.sciencedirect.com www.sciencedirect.com
    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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      AB_626761

      DOI: 10.1016/j.celrep.2020.108018

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    sciencedirect.com/science/article/pii/S2211124720310032
  58. Jan 2020
  59. www.sciencedirect.com www.sciencedirect.com
    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
    1
    1. scibot 13 Jan 2020
      RRID:AB_626761

      DOI: 10.1016/j.celrep.2019.11.012

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    sciencedirect.com/science/article/pii/S2211124719314834
  60. www.sciencedirect.com www.sciencedirect.com
    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
    1
    1. scibot 13 Jan 2020
      RRID:AB_626761

      DOI: 10.1016/j.ccell.2019.07.007

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    sciencedirect.com/science/article/pii/S1535610819303344
  61. www.sciencedirect.com www.sciencedirect.com
    Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
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      RRID:AB_626761

      DOI: 10.1016/j.cell.2019.06.002

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    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
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    EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
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    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
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    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse
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  67. Nov 2018
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    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
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    The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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  73. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
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    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
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