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Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma

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sciencedirect.com/science/article/pii/S2211124726010752
Aug 2026
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DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development

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  DOI: 10.1016/j.cell.2026.07.041
  
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sciencedirect.com/science/article/pii/S0092867426008731
Jul 2026
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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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pmc.ncbi.nlm.nih.gov/articles/PMC13307467/
Feb 2026
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Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade

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1. scibot 12 Feb 2026
  
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nature.com/articles/s41418-026-01672-2
Jan 2026
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The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair

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sciencedirect.com/science/article/pii/S221112472501602X
Nov 2025
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HSP90 buffers deleterious genetic variations in BRCA1

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sciencedirect.com/science/article/pii/S1097276525008676
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MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer

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sciencedirect.com/science/article/pii/S2211124725013762
Oct 2025
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BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR

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sciencedirect.com/science/article/pii/S221112472501232X
Jul 2025
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Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

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52.53.155.43/afb5e6b037ad2f349bd7a3112c88e9d2144c43dd/2023.03.16.533020v1.full-html.html
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TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

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Apr 2025
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Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

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1. scibot 16 Apr 2025
  
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  DOI: 10.7554/eLife.96722
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11996177/
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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1. scibot 16 Apr 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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  DOI: 10.1016/j.celrep.2025.115452
  
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sciencedirect.com/science/article/pii/S2211124725002232
Mar 2025
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Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

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  DOI: 10.1002/advs.202410718
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
Feb 2025
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Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence

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  DOI: 10.1016/j.xcrm.2025.101937
  
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sciencedirect.com/science/article/pii/S2666379125000102
Dec 2024
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Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer

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1. scibot 21 Dec 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-1703
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
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CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation

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1. scibot 13 Dec 2024
  
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  Santa Cruz Biotechnology sc-6954
  
  DOI: 10.1093/nar/gkae1068
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
Nov 2024
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can-24-1703-html.html

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1. scibot 14 Nov 2024
  
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  DOI: 10.1158/0008-5472.can-24-1703
  
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52.53.155.43/8b203bbc7fbd88b2067024854eff5a07e6929833/can-24-1703-html.html
Jul 2024
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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

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cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
May 2024
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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

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sciencedirect.com/science/article/pii/S2211124724005333
Apr 2024
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DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
Jan 2024
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

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  DOI: 10.1016/j.molcel.2023.12.040
  
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sciencedirect.com/science/article/pii/S1097276523010869
Apr 2023
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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

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  DOI: 10.1016/j.molcel.2023.02.004
  
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Feb 2023
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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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  DOI: 10.1016/j.isci.2023.106107
  
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sciencedirect.com/science/article/pii/S2589004223001840
Jan 2023
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Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

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  DOI: 10.1016/j.isci.2022.105806
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
Dec 2022
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BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

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  DOI: 10.1016/j.isci.2022.105626
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
Nov 2022
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

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  DOI: 10.1016/j.celrep.2022.111716
  
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sciencedirect.com/science/article/pii/S2211124722015947
Sep 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS

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  DOI: 10.1158/0008-5472.CAN-21-1843
  
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pubmed.ncbi.nlm.nih.gov/35027467/
Apr 2022
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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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  DOI: 10.1016/j.molcel.2022.03.030
  
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sciencedirect.com/science/article/pii/S1097276522002684
Mar 2022
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BMI-1 regulates DNA end resection and homologous recombination repair

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  DOI: 10.1016/j.celrep.2022.110536
  
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sciencedirect.com/science/article/pii/S2211124722002777
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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

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  DOI: 10.1016/j.molcel.2022.01.020
  
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sciencedirect.com/science/article/pii/S1097276522000855
Dec 2021
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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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1. scibot 22 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110138
  
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sciencedirect.com/science/article/pii/S221112472101634X
Nov 2021
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

2
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  AB_626761
  
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Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

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Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

1
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Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

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Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

1
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Functional interrogation of DNA damage response variants with base editing screens

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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

1
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

1
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DCAF14 promotes stalled fork stability to maintain genome integrity

1
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

1
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PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage

1
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Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

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BRCA1 Mutational Complementation Induces Synthetic Viability

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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

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Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne

1
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  BRCA1
  
  DOI: 10.1101/gad.332395.119
  
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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

1
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LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

1
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Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer

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Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

1
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EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

1
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The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

1
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  DOI: 10.15252/embj.2019102361
  
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embopress.org/doi/10.15252/embj.2019102361
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Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

1
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DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse

1
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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

1
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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

1
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The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures

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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling

1
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pubmed.ncbi.nlm.nih.gov/29606576/
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Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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1. scibot 05 Nov 2018
  
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  RRID:AB_626761
  
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  (Santa Cruz Biotechnology Cat# sc-6954, RRID:AB_626761)
  
  SciCrunch record: RRID:AB_626761
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_626761
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sciencedirect.com/science/article/pii/S1097276517308808

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