70 Matching Annotations
  1. Jul 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13307467/
  3. Feb 2026
  4. www.nature.com www.nature.com
    Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade
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    nature.com/articles/s41418-026-01672-2
  5. Jan 2026
  6. www.sciencedirect.com www.sciencedirect.com
    The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair
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    sciencedirect.com/science/article/pii/S221112472501602X
  7. Nov 2025
  8. www.sciencedirect.com www.sciencedirect.com
    HSP90 buffers deleterious genetic variations in BRCA1
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    sciencedirect.com/science/article/pii/S1097276525008676
  9. www.sciencedirect.com www.sciencedirect.com
    MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer
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    sciencedirect.com/science/article/pii/S2211124725013762
  10. Oct 2025
  11. www.sciencedirect.com www.sciencedirect.com
    BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR
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    sciencedirect.com/science/article/pii/S221112472501232X
  12. Jul 2025
  13. 52.53.155.43 52.53.155.43
    Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
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    52.53.155.43/afb5e6b037ad2f349bd7a3112c88e9d2144c43dd/2023.03.16.533020v1.full-html.html
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    TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
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    sciencedirect.com/science/article/pii/S109727652500509X
  15. Apr 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11996177/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
  18. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  19. Mar 2025
  20. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  21. Feb 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence
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    sciencedirect.com/science/article/pii/S2666379125000102
  23. Dec 2024
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617242/
  25. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  26. Nov 2024
  27. 52.53.155.43 52.53.155.43
    can-24-1703-html.html
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    52.53.155.43/8b203bbc7fbd88b2067024854eff5a07e6929833/can-24-1703-html.html
  28. Jul 2024
  29. www.cell.com www.cell.com
    ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
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    cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
  30. May 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
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    sciencedirect.com/science/article/pii/S2211124724005333
  32. Apr 2024
  33. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  34. www.nature.com www.nature.com
    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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    nature.com/articles/s41467-024-47069-y
  35. Jan 2024
  36. www.sciencedirect.com www.sciencedirect.com
    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    sciencedirect.com/science/article/pii/S1097276523010869
  37. Apr 2023
  38. www.sciencedirect.com www.sciencedirect.com
    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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    sciencedirect.com/science/article/pii/S1097276523000837
  39. Feb 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
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    sciencedirect.com/science/article/pii/S2589004223001840
  41. Jan 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
  43. Dec 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
  45. Nov 2022
  46. www.sciencedirect.com www.sciencedirect.com
    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    sciencedirect.com/science/article/pii/S2211124722015947
  47. Sep 2022
  48. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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    pubmed.ncbi.nlm.nih.gov/35027467/
  49. Apr 2022
  50. www.sciencedirect.com www.sciencedirect.com
    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    sciencedirect.com/science/article/pii/S1097276522002684
  51. Mar 2022
  52. www.sciencedirect.com www.sciencedirect.com
    BMI-1 regulates DNA end resection and homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124722002777
  53. www.sciencedirect.com www.sciencedirect.com
    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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    sciencedirect.com/science/article/pii/S1097276522000855
  54. Dec 2021
  55. www.sciencedirect.com www.sciencedirect.com
    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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    sciencedirect.com/science/article/pii/S221112472101634X
  56. Nov 2021
  57. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    sciencedirect.com/science/article/pii/S1097276521009096
  58. Sep 2021
  59. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521006833
  60. Jul 2021
  61. www.sciencedirect.com www.sciencedirect.com
    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    sciencedirect.com/science/article/pii/S1097276517306184
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8279762/
  63. Jun 2021
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
  65. www.sciencedirect.com www.sciencedirect.com
    Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin
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    sciencedirect.com/science/article/pii/S1097276521003671
  66. May 2021
  67. www.sciencedirect.com www.sciencedirect.com
    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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    sciencedirect.com/science/article/pii/S1931312821001827
  68. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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    sciencedirect.com/science/article/pii/S109727652030647X
  69. Apr 2021
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
  71. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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    sciencedirect.com/science/article/pii/S0092867421000842
  72. www.sciencedirect.com www.sciencedirect.com
    SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
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    sciencedirect.com/science/article/pii/S2211124721002357
  73. Feb 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    sciencedirect.com/science/article/pii/S1097276521000046
  75. Jan 2021
  76. www.sciencedirect.com www.sciencedirect.com
    DCAF14 promotes stalled fork stability to maintain genome integrity
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    sciencedirect.com/science/article/pii/S2211124720316582
  77. www.sciencedirect.com www.sciencedirect.com
    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
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    sciencedirect.com/science/article/pii/S1097276520309461
  78. Nov 2020
  79. www.sciencedirect.com www.sciencedirect.com
    PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
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    sciencedirect.com/science/article/pii/S221112472031336X
  80. Sep 2020
  81. www.sciencedirect.com www.sciencedirect.com
    Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment
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    sciencedirect.com/science/article/pii/S2211124720308652
  82. www.sciencedirect.com www.sciencedirect.com
    BRCA1 Mutational Complementation Induces Synthetic Viability
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    sciencedirect.com/science/article/pii/S109727652030232X
  83. www.sciencedirect.com www.sciencedirect.com
    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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    sciencedirect.com/science/article/pii/S2211124720307257
  84. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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    genesdev.cshlp.org/content/33/23-24/1702.full
  85. Aug 2020
  86. www.sciencedirect.com www.sciencedirect.com
    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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    sciencedirect.com/science/article/pii/S2211124720310032
  87. Jan 2020
  88. www.sciencedirect.com www.sciencedirect.com
    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    sciencedirect.com/science/article/pii/S2211124719314834
  89. www.sciencedirect.com www.sciencedirect.com
    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    sciencedirect.com/science/article/pii/S1535610819303344
  90. www.sciencedirect.com www.sciencedirect.com
    Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
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    sciencedirect.com/science/article/pii/S0092867419306300
  91. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
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    sciencedirect.com/science/article/pii/S1097276519304356
  92. www.sciencedirect.com www.sciencedirect.com
    EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
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    sciencedirect.com/science/article/pii/S1097276519303983
  93. www.embopress.org www.embopress.org
    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
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    embopress.org/doi/10.15252/embj.2019102361
  94. www.sciencedirect.com www.sciencedirect.com
    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    sciencedirect.com/science/article/pii/S1097276519308044
  95. www.sciencedirect.com www.sciencedirect.com
    DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse
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    sciencedirect.com/science/article/pii/S1097276519301765
  96. Nov 2018
  97. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    sciencedirect.com/science/article/pii/S1097276518307858
  98. www.sciencedirect.com www.sciencedirect.com
    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    sciencedirect.com/science/article/pii/S0092867418311176
  99. www.sciencedirect.com www.sciencedirect.com
    The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
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    sciencedirect.com/science/article/pii/S2211124718313330
  100. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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    sciencedirect.com/science/article/pii/S109727651830100X
  101. www.sciencedirect.com www.sciencedirect.com
    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    sciencedirect.com/science/article/pii/S1535610818300199
  102. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
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    pubmed.ncbi.nlm.nih.gov/29606576/
  103. www.sciencedirect.com www.sciencedirect.com
    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
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    sciencedirect.com/science/article/pii/S1097276517308808