63 Matching Annotations
  1. Last 7 days
  2. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511734
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CPNE5 Overexpression Inhibits Cardiomyocytes Apoptosis by Promoting the Degradation of FAS Receptor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398889/
  5. Jul 2025
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    TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy
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    sciencedirect.com/science/article/pii/S2211124725007727
  7. Apr 2025
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    RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity
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    sciencedirect.com/science/article/pii/S2211124725003705
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    STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders
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    sciencedirect.com/science/article/pii/S1097276525002011
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    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  11. Mar 2025
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    7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
  13. Jan 2025
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    Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11770068/
  15. Dec 2024
  16. 52.53.155.43 52.53.155.43
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    Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels
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    sciencedirect.com/science/article/pii/S0021925824025250
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    Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo
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    sciencedirect.com/science/article/pii/S2211124724013767
  19. Nov 2024
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11570319/
  21. Aug 2024
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    sciencedirect.com/science/article/pii/S1097276524006191
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    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
  24. May 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  26. Apr 2024
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    Candesartan upregulates angiotensin-converting enzyme 2 in kidneys of male animals by decreased ubiquitination
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202302707R
  28. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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  30. Feb 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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  32. Jul 2023
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    Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment
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    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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    sciencedirect.com/science/article/pii/S0092867423006451
  35. Jun 2023
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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  38. May 2023
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    The ultrastructural function of MLN64 in the late endosome–mitochondria membrane contact sites in placental cells
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  40. Apr 2023
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    Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis
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  42. Feb 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRF3 activates mTORC1 arginine-dependently for cancer cell viability
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  45. Jan 2023
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    Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
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    sciencedirect.com/science/article/pii/S2211124722018733
  47. Dec 2022
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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  49. Nov 2022
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9450962/
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    Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9656695/
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
  53. Sep 2022
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    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
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    sciencedirect.com/science/article/pii/S2211124722011779
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    Autophagy modulates cell fate decisions during lineage commitment
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    ncbi.nlm.nih.gov/pmc/articles/PMC9450964/
  56. Jul 2022
  57. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    nature.com/articles/s41531-022-00354-3
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    Measurement of autophagy via LC3 western blotting following DNA-damage-induced senescence
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  59. Jun 2022
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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  61. Apr 2022
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    Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
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    link.springer.com/article/10.1007/s00018-022-04251-z
  63. Mar 2022
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    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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    sciencedirect.com/science/article/pii/S2211124722001711
  65. Feb 2022
  66. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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  67. Aug 2021
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  70. Jul 2021
  71. onlinelibrary.wiley.com onlinelibrary.wiley.com
    THE neuronal ceroid lipofuscinosis-related protein CLN8 regulates endo-lysosomal dynamics and dendritic morphology
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    onlinelibrary.wiley.com/doi/10.1111/boc.202000016
  72. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz255/5613690
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    Delivering progranulin to neuronal lysosomes protects against excitotoxicity
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    sciencedirect.com/science/article/pii/S002192582100795X
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43
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    ncbi.nlm.nih.gov/pmc/articles/PMC8259439/
  75. Apr 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2
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    sciencedirect.com/science/article/pii/S0092867420306152
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    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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  78. Jan 2021
  79. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202001886R
  80. Nov 2020
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  82. Sep 2020
  83. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
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    Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
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  87. Jan 2020
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    Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
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    sciencedirect.com/science/article/pii/S0896627319307743
  91. www.embopress.org www.embopress.org
    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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    embopress.org/doi/full/10.15252/embr.201947728
  92. Nov 2018
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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    sciencedirect.com/science/article/pii/S0896627318300564