67 Matching Annotations
  1. Jul 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell type-specific expression and subcellular localization of the human insulin upstream open reading frame (INSU) protein in pancreatic β-cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13314798/
  3. Apr 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13104734/
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    2026.04.09.717238.full-html.html
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    biorxiv.org/content/10.64898/2026.04.09.717238v1
  6. Mar 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13016079/
  8. Oct 2025
  9. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511734
  10. Sep 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CPNE5 Overexpression Inhibits Cardiomyocytes Apoptosis by Promoting the Degradation of FAS Receptor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398889/
  12. Jul 2025
  13. www.sciencedirect.com www.sciencedirect.com
    TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy
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    sciencedirect.com/science/article/pii/S2211124725007727
  14. Apr 2025
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    RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity
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    sciencedirect.com/science/article/pii/S2211124725003705
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    STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders
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    sciencedirect.com/science/article/pii/S1097276525002011
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    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  18. Mar 2025
  19. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
  20. Jan 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11770068/
  22. Dec 2024
  23. 52.53.155.43 52.53.155.43
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    Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels
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    sciencedirect.com/science/article/pii/S0021925824025250
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    Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo
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    sciencedirect.com/science/article/pii/S2211124724013767
  26. Nov 2024
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11570319/
  28. Aug 2024
  29. www.sciencedirect.com www.sciencedirect.com
    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    sciencedirect.com/science/article/pii/S1097276524006191
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
  31. May 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  33. Apr 2024
  34. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Candesartan upregulates angiotensin-converting enzyme 2 in kidneys of male animals by decreased ubiquitination
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202302707R
  35. Mar 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    sciencedirect.com/science/article/pii/S1097276524001722
  37. Feb 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  39. Jul 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment
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    sciencedirect.com/science/article/pii/S2211124723007854
  41. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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    sciencedirect.com/science/article/pii/S0092867423006451
  42. Jun 2023
  43. www.sciencedirect.com www.sciencedirect.com
    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    sciencedirect.com/science/article/pii/S2211124723006666
  44. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  45. May 2023
  46. www.sciencedirect.com www.sciencedirect.com
    The ultrastructural function of MLN64 in the late endosome–mitochondria membrane contact sites in placental cells
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    sciencedirect.com/science/article/pii/S001448272300215X
  47. Apr 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis
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    sciencedirect.com/science/article/pii/S1550413123000037
  49. Feb 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRF3 activates mTORC1 arginine-dependently for cancer cell viability
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    ncbi.nlm.nih.gov/pmc/articles/PMC9932127/
  51. 52.53.155.43 52.53.155.43
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  52. Jan 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
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    sciencedirect.com/science/article/pii/S2211124722018733
  54. Dec 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    sciencedirect.com/science/article/pii/S1534580722008103
  56. Nov 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9450962/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9656695/
  59. www.sciencedirect.com www.sciencedirect.com
    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
  60. Sep 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
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    sciencedirect.com/science/article/pii/S2211124722011779
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy modulates cell fate decisions during lineage commitment
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    ncbi.nlm.nih.gov/pmc/articles/PMC9450964/
  63. Jul 2022
  64. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    nature.com/articles/s41531-022-00354-3
  65. www.sciencedirect.com www.sciencedirect.com
    Measurement of autophagy via LC3 western blotting following DNA-damage-induced senescence
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    sciencedirect.com/science/article/pii/S2666166722004191
  66. Jun 2022
  67. www.sciencedirect.com www.sciencedirect.com
    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    sciencedirect.com/science/article/pii/S2589004222007477
  68. Apr 2022
  69. link.springer.com link.springer.com
    Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
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    link.springer.com/article/10.1007/s00018-022-04251-z
  70. Mar 2022
  71. www.sciencedirect.com www.sciencedirect.com
    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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    sciencedirect.com/science/article/pii/S2211124722001711
  72. Feb 2022
  73. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    pubmed.ncbi.nlm.nih.gov/35139382/
  74. Aug 2021
  75. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1934590918305046
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6327112/
  77. Jul 2021
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    THE neuronal ceroid lipofuscinosis-related protein CLN8 regulates endo-lysosomal dynamics and dendritic morphology
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    onlinelibrary.wiley.com/doi/10.1111/boc.202000016
  79. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz255/5613690
  80. www.sciencedirect.com www.sciencedirect.com
    Delivering progranulin to neuronal lysosomes protects against excitotoxicity
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    sciencedirect.com/science/article/pii/S002192582100795X
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43
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    ncbi.nlm.nih.gov/pmc/articles/PMC8259439/
  82. Apr 2021
  83. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2
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    sciencedirect.com/science/article/pii/S0092867420306152
  84. www.sciencedirect.com www.sciencedirect.com
    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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    sciencedirect.com/science/article/pii/S1535610821001185
  85. Jan 2021
  86. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202001886R
  87. Nov 2020
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  89. Sep 2020
  90. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15131
  91. elifesciences.org elifesciences.org
    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
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    elifesciences.org/articles/35012
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
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    ncbi.nlm.nih.gov/pmc/articles/PMC7145425/
  93. www.sciencedirect.com www.sciencedirect.com
    Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
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    sciencedirect.com/science/article/pii/S1934590920300138
  94. Jan 2020
  95. www.sciencedirect.com www.sciencedirect.com
    Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling
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    sciencedirect.com/science/article/pii/S153458071930944X
  96. www.sciencedirect.com www.sciencedirect.com
    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    sciencedirect.com/science/article/pii/S2211124719310022
  97. www.sciencedirect.com www.sciencedirect.com
    Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
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    sciencedirect.com/science/article/pii/S0896627319307743
  98. www.embopress.org www.embopress.org
    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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    embopress.org/doi/full/10.15252/embr.201947728
  99. Nov 2018
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6042961/
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    sciencedirect.com/science/article/pii/S1931312818302038
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    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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    sciencedirect.com/science/article/pii/S0896627318300564