50 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels
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      DOI: 10.1016/j.jbc.2024.108023

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    sciencedirect.com/science/article/pii/S0021925824025250
  3. Nov 2024
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    sciencedirect.com/science/article/pii/S096098222401457X
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
  7. Jul 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215108/
  9. May 2024
  10. www.sciencedirect.com www.sciencedirect.com
    A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
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    1. scibot 31 May 2024
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    sciencedirect.com/science/article/pii/S0092867424004677
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
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    1. scibot 16 May 2024
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      DOI: 10.1111/tra.12936

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    onlinelibrary.wiley.com/doi/10.1111/tra.12936
  12. Mar 2024
  13. rupress.org rupress.org
    Rab32 family proteins regulate autophagosomal components recycling
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      DOI: 10.1083/jcb.202306040

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    rupress.org/jcb/article/223/3/e202306040/276549/Rab32-family-proteins-regulate-autophagosomal
  14. www.sciencedirect.com www.sciencedirect.com
    Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease
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    1. scibot 06 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001254
  15. Dec 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
    1
    1. scibot 22 Dec 2023
      RRID:AB_626858

      DOI: 10.1038/s41467-023-44033-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  17. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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    sciencedirect.com/science/article/pii/S1097276523009681
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
    1. scibot 16 Dec 2023
      RRID:AB_626858

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  19. www.sciencedirect.com www.sciencedirect.com
    P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113501

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    sciencedirect.com/science/article/pii/S2211124723015139
  20. Aug 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Staphylococcus aureus phagocytosis is affected by senescence
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    1. scibot 19 Aug 2023
      RRID:AB_626858

      DOI: 10.3389/fragi.2023.1198241

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    ncbi.nlm.nih.gov/pmc/articles/PMC10423838/
  22. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal
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    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112998

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    sciencedirect.com/science/article/pii/S2211124723010094
  23. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.011

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    sciencedirect.com/science/article/abs/pii/S1097276523005269
  24. Jun 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
    1
    1. scibot 09 Jun 2023
      RRID:AB_626858

      DOI: 10.1016/j.celrep.2023.112616

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    sciencedirect.com/science/article/pii/S2211124723006277
  26. www.sciencedirect.com www.sciencedirect.com
    Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2
    1
    1. scibot 07 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112601

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    sciencedirect.com/science/article/pii/S2211124723006125
  27. Apr 2023
  28. www.science.org www.science.org
    An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation
    2
    1. scibot 27 Apr 2023
      RRID:AB_626858

      DOI: 10.1126/sciadv.adf8966

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      DOI: 10.1126/sciadv.adf8966

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    science.org/doi/10.1126/sciadv.adf8966
  29. www.sciencedirect.com www.sciencedirect.com
    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
    1
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      RRID:AB_626858

      DOI: 10.1016/j.celrep.2023.112316

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    sciencedirect.com/science/article/pii/S2211124723003273
  30. Oct 2022
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
    1
    1. scibot 02 Oct 2022
      RRID:AB_626858

      DOI: 10.1016/j.isci.2022.105118

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    ncbi.nlm.nih.gov/pmc/articles/PMC9519628/
  32. Sep 2022
  33. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
    1
    1. scibot 29 Sep 2022
      RRID:AB_626858

      DOI: 10.1016/j.celrep.2022.111428

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    sciencedirect.com/science/article/pii/S2211124722012694
  34. www.sciencedirect.com www.sciencedirect.com
    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
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    1. scibot 15 Sep 2022
      RRID:AB_626858

      DOI: 10.1016/j.celrep.2022.111349

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    sciencedirect.com/science/article/pii/S2211124722011779
  35. Jul 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide
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      RRID:AB_626858

      DOI: 10.1016/j.isci.2022.104624

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    sciencedirect.com/science/article/pii/S2589004222008963
  37. Apr 2022
  38. www.nature.com www.nature.com
    Recycling of autophagosomal components from autolysosomes by the recycler complex
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    1. scibot 01 Apr 2022
      RRID:AB_626858

      DOI: 10.1038/s41556-022-00861-8

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    nature.com/articles/s41556-022-00861-8
  39. Mar 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
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      DOI: 10.1016/j.isci.2022.103869

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    sciencedirect.com/science/article/pii/S2589004222001390
  41. Feb 2022
  42. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
    1
    1. scibot 12 Feb 2022
      RRID:AB_626858

      DOI: 10.15252/embj.2021108119

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    embopress.org/doi/abs/10.15252/embj.2021108119
  43. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    1. scibot 04 Feb 2022
      RRID:AB_626858

      DOI: 10.1016/j.molcel.2022.01.002

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    sciencedirect.com/science/article/pii/S1097276522000028
  44. Aug 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis
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      DOI: 10.1016/j.xcrm.2021.100370

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    sciencedirect.com/science/article/pii/S266637912100224X
  46. elifesciences.org elifesciences.org
    Untitled document
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    1. scibot 07 Aug 2021
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      DOI: 10.7554/eLife.31326

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    elifesciences.org/articles/31326
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.31326

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    ncbi.nlm.nih.gov/pmc/articles/PMC5780041/
  48. Jul 2021
  49. www.sciencedirect.com www.sciencedirect.com
    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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    1. scibot 31 Jul 2021
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      DOI: 10.1016/j.cmet.2019.03.005

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    sciencedirect.com/science/article/pii/S1550413119301330
  50. www.sciencedirect.com www.sciencedirect.com
    Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
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      :AB_626858

      DOI: 10.1016/j.cell.2016.07.040

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    sciencedirect.com/science/article/pii/S0092867416309904
  51. www.sciencedirect.com www.sciencedirect.com
    Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release
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      DOI: 10.1016/j.cub.2021.06.022

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    sciencedirect.com/science/article/pii/S0960982221008174
  52. May 2021
  53. www.sciencedirect.com www.sciencedirect.com
    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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      DOI: 10.1016/j.devcel.2020.11.016

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    sciencedirect.com/science/article/pii/S1534580720309254
  54. www.sciencedirect.com www.sciencedirect.com
    Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation
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      DOI: 10.1016/j.devcel.2020.08.008

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    sciencedirect.com/science/article/pii/S1534580720306663
  55. Feb 2021
  56. www.nature.com www.nature.com
    Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress
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    1. scibot 26 Feb 2021
      anti-LAMP2

      DOI: 10.1038/s42255-020-00325-z

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    nature.com/articles/s42255-020-00325-z
  57. Jan 2021
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    1
    1. scibot 26 Jan 2021
      RRID:AB_626858

      DOI: 10.1016/j.cell.2020.12.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  59. Jan 2020
  60. www.sciencedirect.com www.sciencedirect.com
    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
    1
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      RRID:AB_626858

      DOI: 10.1016/j.celrep.2019.07.084

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    sciencedirect.com/science/article/pii/S2211124719310009
  61. elifesciences.org elifesciences.org
    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
    1
    1. scibot 13 Jan 2020
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      DOI: 10.7554/eLife.46188

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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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      DOI: 10.1016/j.ccell.2019.01.018

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  63. www.sciencedirect.com www.sciencedirect.com
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  64. www.sciencedirect.com www.sciencedirect.com
    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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      DOI: 10.1016/j.cmet.2019.03.005

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  65. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
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      DOI: 10.1113/JP276022

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  66. Nov 2018
  67. elifesciences.org elifesciences.org
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    Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain
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  69. Nov 2017
  70. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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      Curator: @gabimpine

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