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79 Matching Annotations

Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

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  DOI: 10.1016/j.celrep.2025.116745
  
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sciencedirect.com:5037/science/article/pii/S2211124725015177
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability

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1. scibot 20 Nov 2025
  
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  DOI: 10.1038/s44318-025-00602-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12623888/
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

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  DOI: 10.1016/j.celrep.2025.116495
  
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sciencedirect.com/science/article/pii/S2211124725012665
Oct 2025
54.241.53.176 54.241.53.176

2025.09.25.678487v1.full-html.html

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  DOI: 10.1101/2025.09.25.678487
  
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54.241.53.176/6242d0964f3f11ac8334753a1121987506367c6b/2025.09.25.678487v1.full-html.html
Feb 2025
52.53.155.43 52.53.155.43

A non-catalytic function for Rad18 in sustaining glioblastoma proliferation

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  DOI: 10.1101/2024.09.05.611406
  
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52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
Dec 2024
www.cell.com www.cell.com

The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.cub.2024.11.035
  
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cell.com/current-biology/abstract/S0960-9822(24)01575-6
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

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sciencedirect.com/science/article/pii/S1097276524009894
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

1
1. scibot 21 Aug 2024
  
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  DOI: 10.1038/s41388-024-03094-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
Jun 2024
www.cell.com www.cell.com

CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

1
1. scibot 29 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109978
  
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cell.com/iscience/abstract/S2589-0042(24)01200-8
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DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

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1. scibot 22 Jun 2024
  
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  DOI: 10.1083/jcb.202402144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

2
1. scibot 25 Apr 2024
  
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  DOI: 10.1083/jcb.202303141
  
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  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

2
1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114064
  
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  DOI: 10.1016/j.celrep.2024.114064
  
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sciencedirect.com/science/article/pii/S2211124724003929
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A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation

1
1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114024
  
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sciencedirect.com/science/article/pii/S2211124724003528
Feb 2024
aacrjournals.org aacrjournals.org

A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients

1
1. scibot 24 Feb 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-2005
  
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aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

1
1. scibot 13 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113778
  
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sciencedirect.com/science/article/pii/S2211124724001062
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

1
1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108925
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
Jan 2024
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EXO1 protects BRCA1-deficient cells against toxic DNA lesions

1
1. scibot 25 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.12.039
  
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sciencedirect.com/science/article/pii/S1097276523010857
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In silico protein interaction screening uncovers DONSON’s role in replication initiation

1
1. scibot 24 Jan 2024
  
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  DOI: 10.1126/science.adi3448
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
Dec 2023
52.53.155.43 52.53.155.43

ccr-23-2005-html.html

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  DOI: 10.1158/1078-0432.ccr-23-2005
  
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52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

1
1. scibot 29 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108278
  
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sciencedirect.com/science/article/pii/S2589004223023556
Aug 2023
www.science.org www.science.org

A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

1
1. scibot 29 Aug 2023
  
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  DOI: 10.1126/scisignal.ade6737
  
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science.org/doi/10.1126/scisignal.ade6737
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In silico protein interaction screening uncovers DONSON’s role in replication initiation

1
1. scibot 29 Aug 2023
  
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  DOI: 10.1126/science.adi3448
  
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science.org/doi/10.1126/science.adi3448
Jul 2023
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.025
  
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sciencedirect.com/science/article/pii/S1097276523004720
Jun 2023
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Detection of endogenous translesion DNA synthesis in single mammalian cells

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.crmeth.2023.100501
  
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sciencedirect.com/science/article/pii/S2667237523001303
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PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors

1
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  DOI: 10.1016/j.isci.2023.106951
  
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sciencedirect.com/science/article/pii/S2589004223010283
May 2023
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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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1. scibot 17 May 2023
  
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  DOI: 10.1016/j.cell.2023.04.026
  
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sciencedirect.com/science/article/pii/S0092867423004221
www.nature.com www.nature.com

Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations

1
1. scibot 05 May 2023
  
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  DOI: 10.1038/s41419-022-05073-4
  
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nature.com/articles/s41419-022-05073-4
Jan 2023
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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks

1
1. scibot 26 Jan 2023
  
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  DOI: 10.1016/j.molcel.2022.12.034
  
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sciencedirect.com/science/article/pii/S1097276522012175
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

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1. scibot 12 Oct 2022
  
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  DOI: 10.1128/jvi.02028-21
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9044952/
Sep 2022
www.nature.com www.nature.com

A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

1
1. scibot 10 Sep 2022
  
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  DOI: 10.1038/s42003-022-03917-5
  
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nature.com/articles/s42003-022-03917-5
Apr 2022
aacrjournals.org aacrjournals.org

DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models

1
1. scibot 05 Apr 2022
  
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  DOI: 10.1158/1535-7163.MCT-21-0554
  
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aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
Mar 2022
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Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

1
1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.devcel.2022.02.013
  
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sciencedirect.com/science/article/pii/S153458072200079X
Oct 2021
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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

1
1. scibot 08 Oct 2021
  
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  DOI: 10.1016/j.molcel.2021.09.016
  
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sciencedirect.com/science/article/pii/S1097276521007504
Sep 2021
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

1
1. scibot 25 Sep 2021
  
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  DOI: 10.1016/j.xcrm.2021.100394
  
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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe

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Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells

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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

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TopBP1 assembles nuclear condensates to switch on ATR signaling

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

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CARM1 regulates replication fork speed and stress response by stimulating PARP1

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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DCAF14 promotes stalled fork stability to maintain genome integrity

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

1
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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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sciencedirect.com/science/article/pii/S2211124720316648
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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

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ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

1
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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

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SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

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Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

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ATR expands embryonic stem cell fate potential in response to replication stress

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C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

1
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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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Untitled document

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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

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ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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Untitled document

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SLFN11 Blocks Stressed Replication Forks Independently of ATR

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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells

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A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.

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Nov 2017
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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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  Mouse monoclonal anti-Chk1 (G-4)Santa CruzCat# sc-8408
  
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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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