83 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124726010752
  3. Aug 2026
  4. www.science.org www.science.org
    CDT1 acts with the replisome to remodel replication forks
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    science.org/doi/10.1126/sciadv.aee6914
  5. Jun 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC13270093/
  7. Apr 2026
  8. www.sciencedirect.com www.sciencedirect.com
    Efficacy, safety, and biomarker analysis of datopotamab deruxtecan in advanced non-small cell lung cancer: ICARUS-LUNG01 phase 2 study
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1535610826001716
  9. Dec 2025
  10. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com:5037/science/article/pii/S2211124725015177
  11. Nov 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12623888/
  13. www.sciencedirect.com www.sciencedirect.com
    CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124725012665
  14. Oct 2025
  15. 54.241.53.176 54.241.53.176
    2025.09.25.678487v1.full-html.html
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    54.241.53.176/6242d0964f3f11ac8334753a1121987506367c6b/2025.09.25.678487v1.full-html.html
  16. Feb 2025
  17. 52.53.155.43 52.53.155.43
    A non-catalytic function for Rad18 in sustaining glioblastoma proliferation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
  18. Dec 2024
  19. www.cell.com www.cell.com
    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    cell.com/current-biology/abstract/S0960-9822(24)01575-6
  20. www.sciencedirect.com www.sciencedirect.com
    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276524009894
  21. Aug 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
  23. Jun 2024
  24. www.cell.com www.cell.com
    CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    cell.com/iscience/abstract/S2589-0042(24)01200-8
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
  26. Apr 2024
  27. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  28. www.sciencedirect.com www.sciencedirect.com
    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124724003929
  29. www.sciencedirect.com www.sciencedirect.com
    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124724003528
  30. Feb 2024
  31. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  32. www.sciencedirect.com www.sciencedirect.com
    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124724001062
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  34. Jan 2024
  35. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276523010857
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  37. Dec 2023
  38. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
  39. Nov 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2589004223023556
  41. Aug 2023
  42. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    science.org/doi/10.1126/scisignal.ade6737
  43. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    science.org/doi/10.1126/science.adi3448
  44. Jul 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276523004720
  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Detection of endogenous translesion DNA synthesis in single mammalian cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2667237523001303
  48. www.sciencedirect.com www.sciencedirect.com
    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2589004223010283
  49. May 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S0092867423004221
  51. www.nature.com www.nature.com
    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    nature.com/articles/s41419-022-05073-4
  52. Jan 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276522012175
  54. Oct 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC9044952/
  56. Sep 2022
  57. www.nature.com www.nature.com
    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    nature.com/articles/s42003-022-03917-5
  58. Apr 2022
  59. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
  60. Mar 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S153458072200079X
  62. Oct 2021
  63. www.sciencedirect.com www.sciencedirect.com
    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276521007504
  64. Sep 2021
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC8484689/
  66. Aug 2021
  67. www.sciencedirect.com www.sciencedirect.com
    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276517302782
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6221544/
  70. www.embopress.org www.embopress.org
    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    embopress.org/doi/abs/10.15252/embj.2020107413
  71. europepmc.org europepmc.org
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    europepmc.org/articles/PMC6037479/
  72. Jul 2021
  73. www.jbc.org www.jbc.org
    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    jbc.org/content/294/6/1763.full
  74. elifesciences.org elifesciences.org
    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    elifesciences.org/articles/37868
  75. www.sciencedirect.com www.sciencedirect.com
    An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2666166721003841
  76. www.sciencedirect.com www.sciencedirect.com
    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1534580721005177
  77. May 2021
  78. www.sciencedirect.com www.sciencedirect.com
    TopBP1 assembles nuclear condensates to switch on ATR signaling
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276520309916
  79. www.sciencedirect.com www.sciencedirect.com
    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276520305815
  80. www.sciencedirect.com www.sciencedirect.com
    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276520302732
  81. Mar 2021
  82. www.sciencedirect.com www.sciencedirect.com
    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124721001224
  83. Feb 2021
  84. www.sciencedirect.com www.sciencedirect.com
    CARM1 regulates replication fork speed and stress response by stimulating PARP1
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276520309023
  85. www.sciencedirect.com www.sciencedirect.com
    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276521000046
  86. Jan 2021
  87. www.sciencedirect.com www.sciencedirect.com
    DCAF14 promotes stalled fork stability to maintain genome integrity
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720316582
  88. www.sciencedirect.com www.sciencedirect.com
    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720316697
  89. www.sciencedirect.com www.sciencedirect.com
    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720316648
  90. Oct 2020
  91. www.sciencedirect.com www.sciencedirect.com
    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1934590920304501
  92. Sep 2020
  93. www.sciencedirect.com www.sciencedirect.com
    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720310858
  94. www.sciencedirect.com www.sciencedirect.com
    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124719316821
  95. www.sciencedirect.com www.sciencedirect.com
    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720304332
  96. www.sciencedirect.com www.sciencedirect.com
    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124720311736
  97. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pubmed.ncbi.nlm.nih.gov/32966779/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATR expands embryonic stem cell fate potential in response to replication stress
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
  99. Jan 2020
  100. www.sciencedirect.com www.sciencedirect.com
    C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276519304794
  101. www.sciencedirect.com www.sciencedirect.com
    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1934590919302759
  102. www.sciencedirect.com www.sciencedirect.com
    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2451945619304015
  103. www.sciencedirect.com www.sciencedirect.com
    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276519307683
  104. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276519301042
  105. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S221112471930110X
  106. www.sciencedirect.com www.sciencedirect.com
    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276519302734
  107. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276519302801
  108. Nov 2018
  109. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276518307858
  110. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124718315055
  111. www.sciencedirect.com www.sciencedirect.com
    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124718312737
  112. www.sciencedirect.com www.sciencedirect.com
    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276518305586
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6037479/
  114. www.sciencedirect.com www.sciencedirect.com
    SLFN11 Blocks Stressed Replication Forks Independently of ATR
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276518300418
  115. www.sciencedirect.com www.sciencedirect.com
    The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276518300601
  116. europepmc.org europepmc.org
    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    europepmc.org/articles/PMC5764568/
  117. Nov 2017
  118. www.sciencedirect.com www.sciencedirect.com
    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276517301727
  119. www.sciencedirect.com www.sciencedirect.com
    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1097276517302782