82 Matching Annotations
  1. Last 7 days
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    CDT1 acts with the replisome to remodel replication forks
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    science.org/doi/10.1126/sciadv.aee6914
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability
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    pmc.ncbi.nlm.nih.gov/articles/PMC13270093/
  5. Apr 2026
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    Efficacy, safety, and biomarker analysis of datopotamab deruxtecan in advanced non-small cell lung cancer: ICARUS-LUNG01 phase 2 study
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    sciencedirect.com/science/article/pii/S1535610826001716
  7. Dec 2025
  8. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING
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    sciencedirect.com:5037/science/article/pii/S2211124725015177
  9. Nov 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623888/
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    CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
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    sciencedirect.com/science/article/pii/S2211124725012665
  12. Oct 2025
  13. 54.241.53.176 54.241.53.176
    2025.09.25.678487v1.full-html.html
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  14. Feb 2025
  15. 52.53.155.43 52.53.155.43
    A non-catalytic function for Rad18 in sustaining glioblastoma proliferation
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  16. Dec 2024
  17. www.cell.com www.cell.com
    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
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    cell.com/current-biology/abstract/S0960-9822(24)01575-6
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    sciencedirect.com/science/article/pii/S1097276524009894
  19. Aug 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
  21. Jun 2024
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    CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
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    cell.com/iscience/abstract/S2589-0042(24)01200-8
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
  24. Apr 2024
  25. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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  28. Feb 2024
  29. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  32. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    sciencedirect.com/science/article/pii/S1097276523010857
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  35. Dec 2023
  36. 52.53.155.43 52.53.155.43
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  37. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    sciencedirect.com/science/article/pii/S2589004223023556
  39. Aug 2023
  40. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    science.org/doi/10.1126/science.adi3448
  42. Jul 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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  44. Jun 2023
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    Detection of endogenous translesion DNA synthesis in single mammalian cells
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    sciencedirect.com/science/article/pii/S2667237523001303
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    sciencedirect.com/science/article/pii/S2589004223010283
  47. May 2023
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    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
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    sciencedirect.com/science/article/pii/S0092867423004221
  49. www.nature.com www.nature.com
    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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    nature.com/articles/s41419-022-05073-4
  50. Jan 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    sciencedirect.com/science/article/pii/S1097276522012175
  52. Oct 2022
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9044952/
  54. Sep 2022
  55. www.nature.com www.nature.com
    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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    nature.com/articles/s42003-022-03917-5
  56. Apr 2022
  57. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
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    aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
  58. Mar 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    sciencedirect.com/science/article/pii/S153458072200079X
  60. Oct 2021
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    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
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  62. Sep 2021
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
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    pmc.ncbi.nlm.nih.gov/articles/PMC8484689/
  64. Aug 2021
  65. www.sciencedirect.com www.sciencedirect.com
    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
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  68. www.embopress.org www.embopress.org
    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
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    embopress.org/doi/abs/10.15252/embj.2020107413
  69. europepmc.org europepmc.org
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  70. Jul 2021
  71. www.jbc.org www.jbc.org
    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
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    jbc.org/content/294/6/1763.full
  72. elifesciences.org elifesciences.org
    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
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    elifesciences.org/articles/37868
  73. www.sciencedirect.com www.sciencedirect.com
    An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells
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    sciencedirect.com/science/article/pii/S2666166721003841
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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    sciencedirect.com/science/article/pii/S1534580721005177
  75. May 2021
  76. www.sciencedirect.com www.sciencedirect.com
    TopBP1 assembles nuclear condensates to switch on ATR signaling
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    sciencedirect.com/science/article/pii/S1097276520305815
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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    sciencedirect.com/science/article/pii/S1097276520302732
  79. Mar 2021
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    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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    sciencedirect.com/science/article/pii/S2211124721001224
  81. Feb 2021
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    sciencedirect.com/science/article/pii/S1097276520309023
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    sciencedirect.com/science/article/pii/S1097276521000046
  84. Jan 2021
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    DCAF14 promotes stalled fork stability to maintain genome integrity
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    sciencedirect.com/science/article/pii/S2211124720316582
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    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
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    sciencedirect.com/science/article/pii/S2211124720316697
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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    sciencedirect.com/science/article/pii/S2211124720316648
  88. Oct 2020
  89. www.sciencedirect.com www.sciencedirect.com
    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
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  90. Sep 2020
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
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    sciencedirect.com/science/article/pii/S2211124720311736
  95. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
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    pubmed.ncbi.nlm.nih.gov/32966779/
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    ATR expands embryonic stem cell fate potential in response to replication stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
  97. Jan 2020
  98. www.sciencedirect.com www.sciencedirect.com
    C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex
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    sciencedirect.com/science/article/pii/S1097276519304794
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    sciencedirect.com/science/article/pii/S2451945619304015
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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
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    sciencedirect.com/science/article/pii/S1097276519307683
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    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
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  106. Nov 2018
  107. www.sciencedirect.com www.sciencedirect.com
    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    SLFN11 Blocks Stressed Replication Forks Independently of ATR
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  113. www.sciencedirect.com www.sciencedirect.com
    The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells
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  114. europepmc.org europepmc.org
    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.
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    europepmc.org/articles/PMC5764568/
  115. Nov 2017
  116. www.sciencedirect.com www.sciencedirect.com
    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
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    sciencedirect.com/science/article/pii/S1097276517301727
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    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
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