327 Matching Annotations
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    O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability
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  3. Apr 2024
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    Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
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    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
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  8. Mar 2024
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    Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
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    ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition
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    Eukaryotic release factor 1 from Euplotes promotes frameshifting at premature stop codons in human cells
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S0304416524000436
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    Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
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    AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway
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    Alternative splicing decouples local from global PRC2 activity
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8+ T cells
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  18. Feb 2024
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    PTBP3/IGF2BP3/HMGA1 axis promotes renal cancer growth and metastasis
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    The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    De novo variants in DENND5B cause a neurodevelopmental disorder
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    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    Metabolic rewiring and autophagy inhibition correct lysosomal storage disease in Mucopolysaccharidosis IIIB
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    Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia
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    Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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  28. Jan 2024
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    Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer
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    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
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  31. Dec 2023
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    Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition
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  33. Nov 2023
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    Postnatal Development and Maintenance of Functional Pituitary Gonadotrophs is Dependent on PI4-kinase A
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    MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology
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  36. Oct 2023
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    PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors
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    Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination
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    CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer
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    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
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      DOI: 10.1158/2767-9764.CRC-22-0521

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  44. Sep 2023
  45. www.sciencedirect.com www.sciencedirect.com
    An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis
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    Acetylation reprograms MITF target selectivity and residence time
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    Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway
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    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
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    Senescent cells form nuclear foci that contain the 26S proteasome
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    Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
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  53. Jul 2023
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    Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells
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    Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury
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    Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
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    Functional viromic screens uncover regulatory RNA elements
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    Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24
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    A chimeric human/dog-DNA vaccine against CSPG4 induces immunity with therapeutic potential in comparative preclinical models of osteosarcoma
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    Generation of two edited iPSCs lines by CRISPR/Cas9 with point mutations in PKP2 gene for Arrhythmogenic Cardiomyopathy in vitro modeling
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    SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma
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    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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    Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation
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    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
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    Exercise Improves Orofacial Pain and Modifies Neuropeptide Expression in a Rat Model of Parkinson’s Disease
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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  72. May 2023
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    eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance
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    Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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  77. Apr 2023
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    Molecular mechanisms of stress-induced reactivation in mumps virus condensates
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    Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism
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    Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators
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    An Overview of Alamadine/MrgD Signaling and Its Role in Cardiomyocytes
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    An overview of alamadine/MrgD signaling and its role in cardiomyocytes
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    Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis
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    The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
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    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
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    GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development
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  88. Feb 2023
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    Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes
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    Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
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  92. Jan 2023
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    Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment
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    Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
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  96. Dec 2022
  97. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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      DOI: 10.15252/embj.2022111961

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    Gain- and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
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  102. aacrjournals.org aacrjournals.org
    Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer
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  103. Nov 2022
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease
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    A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner
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  107. Oct 2022
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    Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice
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    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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    Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
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    Human-specific regulation of neural maturation identified by cross-primate transcriptomics
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    C9orf72 functions in the nucleus to regulate DNA damage repair
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
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  114. Sep 2022
  115. www.sciencedirect.com www.sciencedirect.com
    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
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    CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression
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  117. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Peripheral and respiratory muscle impairment during murine acute lung injury
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  118. Aug 2022
  119. www.sciencedirect.com www.sciencedirect.com
    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation
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    Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer
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  122. www.sciencedirect.com www.sciencedirect.com
    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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    Discovery of compounds that reactivate p53 mutants in vitro and in vivo
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  124. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T-cell dysfunction upon expression of MYC with altered phosphorylation at Threonine 58 and Serine 62
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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    Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
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    Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells
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  130. Jun 2022
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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    Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
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  134. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer
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    SETD4-mediated KU70 methylation suppresses apoptosis
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Excitation–Contraction Coupling: Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
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  140. Apr 2022
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    The role of PTEN in primary sensory neurons in processing itch and thermal information in mice
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    Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex
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    Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid
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    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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  146. Mar 2022
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    The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs
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    Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation
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    Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis
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    Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling
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    Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway
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  152. Feb 2022
  153. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV-1 neuropathogenesis
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    Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
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    Growth hormone-induced STAT5B regulates Star gene expression through a cooperation with cJUN in mouse MA-10 Leydig cells
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  156. Jan 2022
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency
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  158. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation
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    Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
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    Identification of a dihydropyridine scaffold that blocks ryanodine receptors
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    Lipid droplet dynamics regulate adult muscle stem cell fate
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  162. Dec 2021
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    Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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    Methods to separate nuclear soluble fractions reflecting localizations in living cells
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  166. Nov 2021
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    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
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    SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase
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  169. Oct 2021
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    Homeostatic plasticity induced by increased acetylcholine release at the mouse neuromuscular junction.
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    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
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    ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells
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    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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    Cancer cell immune mimicry delineates onco-immunologic modulation
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  175. Sep 2021
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    FKBP51 Affects TNF-Related Apoptosis Inducing Ligand Response in Melanoma
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    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species
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    Activating a collaborative innate-adaptive immune response to control metastasis
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    FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease
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  182. Aug 2021
  183. www.sciencedirect.com www.sciencedirect.com
    Metabolic plasticity drives development during mammalian embryogenesis
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    Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma
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    Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†
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    Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Fisetin provides antidepressant effects by activating the TrkB signal pathway in mice
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    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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  192. Jul 2021
  193. elifesciences.org elifesciences.org
    KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia
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    Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay
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    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins
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    Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells
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      Mouse GAPDH

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    Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current
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    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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      GAPDH

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    Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury
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  205. Jun 2021
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    The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury
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    Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
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    Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment
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  210. May 2021
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    Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation
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    Noise-induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence
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    Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
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  217. journals.physiology.org journals.physiology.org
    Increased cholinergic activity under conditions of low estrogen leads to adverse cardiac remodeling
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    Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells
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    A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
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  221. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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    A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form
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    Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11
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    Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190
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    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
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  227. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endoplasmic reticulum oxidoreductase 1 alpha modulates prostate cancer hallmarks
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    A selective p53 activator and anticancer agent to improve colorectal cancer therapy
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    Optogenetic activation of spinal microglia triggers chronic pain in mice
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    GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer
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      DOI: 10.1126/sciadv.abe2470

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