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  1. Last 7 days
  2. www.cell.com www.cell.com
    Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
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    cell.com/cell-reports/abstract/S2211-1247(24)00738-1
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  4. Jul 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11214290/
  6. Apr 2024
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    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    sciencedirect.com/science/article/pii/S1550413124001232
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    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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    sciencedirect.com/science/article/pii/S0092867424003970
  9. Feb 2024
  10. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    sciencedirect.com/science/article/pii/S2666379124000570
  12. Jan 2024
  13. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  14. Oct 2023
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    sciencedirect.com/science/article/pii/S1097276523007037
  16. Sep 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
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    sciencedirect.com/science/article/pii/S0002944023003152
  18. Aug 2023
  19. 52.53.155.43 52.53.155.43
    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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      DOI: 10.3390/ijms241411821

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  22. Jul 2023
  23. anatomypubs.onlinelibrary.wiley.com anatomypubs.onlinelibrary.wiley.com
    Patterns of senescence and apoptosis during development of branchial arches, epibranchial placodes, and pharyngeal pouches
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      DOI: 10.1002/dvdy.637

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    anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.637
  24. Jun 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
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    sciencedirect.com/science/article/pii/S0092867423005329
  27. May 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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    sciencedirect.com/science/article/pii/S2211124723005314
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10173299/
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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      DOI: 10.1016/j.celrep.2023.112479

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    sciencedirect.com/science/article/pii/S2211124723004904
  31. Feb 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
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      DOI: 10.1158/2159-8290.CD-22-0528

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    ncbi.nlm.nih.gov/pmc/articles/PMC9901536/
  33. Nov 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Biosensor Cell-Fit-HD4D for correlation of single-cell fate and microscale energy deposition in complex ion beams
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    sciencedirect.com/science/article/pii/S2666166722006785
  35. Sep 2022
  36. www.sciencedirect.com www.sciencedirect.com
    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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      DOI: 10.1016/j.jbc.2022.102532

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    sciencedirect.com/science/article/pii/S0021925822009759
  37. www.sciencedirect.com www.sciencedirect.com
    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    sciencedirect.com/science/article/pii/S2211124722012335
  38. Aug 2022
  39. www.sciencedirect.com www.sciencedirect.com
    Increasing cell size remodels the proteome and promotes senescence
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      DOI: 10.1016/j.molcel.2022.07.017

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    sciencedirect.com/science/article/pii/S1097276522007134
  40. Jun 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  42. Apr 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
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    sciencedirect.com/science/article/pii/S2211124722004454
  44. Mar 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    sciencedirect.com/science/article/pii/S153458072200079X
  46. link.springer.com link.springer.com
    Partial p53 reactivation is sufficient to induce cancer regression
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      DOI: 10.1186/s13046-022-02269-6

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    link.springer.com/article/10.1186/s13046-022-02269-6
  47. Feb 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Biosensor for deconvolution of individual cell fate in response to ion beam irradiation
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    sciencedirect.com/science/article/pii/S2667237522000212
  49. Nov 2021
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
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      DOI: 10.7554/eLife.70153

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    ncbi.nlm.nih.gov/pmc/articles/PMC8592571/
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    Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S2589004221012967
  52. Aug 2021
  53. www.sciencedirect.com www.sciencedirect.com
    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
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    sciencedirect.com/science/article/pii/S2211124721010020
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.stem.2017.09.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC5658514/
  55. www.ebiomedicine.com www.ebiomedicine.com
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      DOI: 10.1016/j.ebiom.2016.11.021

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    ebiomedicine.com/article/S2352-3964(16)30525-4/abstract
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.12.071

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    ncbi.nlm.nih.gov/pmc/articles/PMC6334229/
  57. Jul 2021
  58. www.nature.com www.nature.com
    α-Ketoglutarate links p53 to cell fate during tumour suppression
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      DOI: 10.1038/s41586-019-1577-5

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    nature.com/articles/s41586-019-1577-5
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
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    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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      DOI: 10.1016/j.ebiom.2016.11.021

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    sciencedirect.com/science/article/pii/S2352396416305254
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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  62. Jun 2021
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    Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
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    Bacterial genotoxins induce T cell senescence
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    ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells
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  66. May 2021
  67. mcr.aacrjournals.org mcr.aacrjournals.org
    Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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  69. Mar 2021
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    On the role of p53 in the cellular response to aneuploidy
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    PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
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  72. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
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  73. Feb 2021
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    Unique signatures of stress-induced senescent human astrocytes
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  75. Oct 2020
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    Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
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  77. Sep 2020
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    TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages
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  79. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
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    Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites
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  82. Jan 2020
  83. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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  85. www.sciencedirect.com www.sciencedirect.com
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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      RRID:AB_628073

      DOI: 10.1016/j.ccell.2019.02.004

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    Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
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      DOI: 10.1016/j.cmet.2019.01.021

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  89. Nov 2018
  90. www.sciencedirect.com www.sciencedirect.com
    The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression
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    Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging
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  93. europepmc.org europepmc.org
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
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    Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency
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  97. Nov 2017
  98. www.nature.com www.nature.com
    Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism
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    Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
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    Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
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    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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