98 Matching Annotations
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    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
  3. Oct 2025
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    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
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    Isoformic PD-1 impedes B cell activation and function in HIV-1 infection
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    sciencedirect.com/science/article/pii/S221112472501112X
  6. Sep 2025
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    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    sciencedirect.com/science/article/pii/S2211124725010484
  8. Aug 2025
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    Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322803/
  10. Jul 2025
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    Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
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    sciencedirect.com/science/article/pii/S2211124725008617
  12. Jun 2025
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    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
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    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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  15. May 2025
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    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    A lncRNA-mediated metabolic rewiring of cell senescence
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  18. Apr 2025
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  20. Mar 2025
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    The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2
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    Vagal pathway activation links chronic stress to decline in intestinal stem cell function
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  23. Feb 2025
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    Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
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    sciencedirect.com/science/article/pii/S2666379125000370
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    A non-catalytic function for Rad18 in sustaining glioblastoma proliferation
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  26. Jan 2025
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    Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
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    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control
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    Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer
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  31. Dec 2024
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    Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo
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    Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate
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  34. Nov 2024
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    Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats
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    p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
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    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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  38. Sep 2024
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    The Role of MFN2 in Regulating Endothelial Cell Senescence: Implications for Vascular Aging
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  40. Aug 2024
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    On the role of p53 in the cellular response to aneuploidy
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    Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice
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  43. Jul 2024
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    Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11214290/
  47. Apr 2024
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    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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  50. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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  53. Jan 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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  55. Oct 2023
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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  57. Sep 2023
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    Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
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    sciencedirect.com/science/article/pii/S0002944023003152
  59. Aug 2023
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis
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    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  63. Jul 2023
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    Patterns of senescence and apoptosis during development of branchial arches, epibranchial placodes, and pharyngeal pouches
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    anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.637
  65. Jun 2023
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
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    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
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  68. May 2023
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    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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    Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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  72. Feb 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
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  74. Nov 2022
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    Biosensor Cell-Fit-HD4D for correlation of single-cell fate and microscale energy deposition in complex ion beams
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    sciencedirect.com/science/article/pii/S2666166722006785
  76. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    sciencedirect.com/science/article/pii/S2211124722012335
  79. Aug 2022
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    Increasing cell size remodels the proteome and promotes senescence
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  81. Jun 2022
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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  83. Apr 2022
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    Functional elements of the cis-regulatory lincRNA-p21
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  85. Mar 2022
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    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    Partial p53 reactivation is sufficient to induce cancer regression
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  88. Feb 2022
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    Biosensor for deconvolution of individual cell fate in response to ion beam irradiation
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  90. Nov 2021
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    Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8592571/
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    Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
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  93. Aug 2021
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    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
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  98. Jul 2021
  99. www.nature.com www.nature.com
    α-Ketoglutarate links p53 to cell fate during tumour suppression
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    nature.com/articles/s41586-019-1577-5
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    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  103. Jun 2021
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    Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
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    Bacterial genotoxins induce T cell senescence
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    ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells
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    sciencedirect.com/science/article/pii/S0301472X21001995
  107. May 2021
  108. mcr.aacrjournals.org mcr.aacrjournals.org
    Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
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    mcr.aacrjournals.org/content/19/5/874
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  110. Mar 2021
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    On the role of p53 in the cellular response to aneuploidy
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    PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
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    Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001855RR
  114. Feb 2021
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    Unique signatures of stress-induced senescent human astrocytes
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  116. Oct 2020
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    Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
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  118. Sep 2020
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    TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
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    Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites
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  123. Jan 2020
  124. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    elifesciences.org/articles/47327
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    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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