107 Matching Annotations
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    Erk inhibitors intercept Erk-mediated negative feedback while imposing cell-cycle arrest and activating p38
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    A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal
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    Andrographolide attenuates microglial senescence in Alzheimer’s disease mice by suppressing the STAT3 signaling
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  10. Apr 2026
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    Chemotherapy-Induced Oral Mucosal Injury Is Defined by p53 Activation, Cell Cycle Arrest and Diverse Epithelial Progenitor Dynamics
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    Fatty acids modulate the colorectal cancer immune microenvironment via regulating the interaction and transactivation of PPARα/δ and P53
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    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes
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    Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
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    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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  44. Dec 2024
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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  76. Jul 2023
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  94. Jun 2022
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  96. Apr 2022
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  103. Nov 2021
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  106. Aug 2021
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    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
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  111. Jul 2021
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    α-Ketoglutarate links p53 to cell fate during tumour suppression
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    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  116. Jun 2021
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    Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
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    Bacterial genotoxins induce T cell senescence
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    ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells
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  120. May 2021
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    Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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  123. Mar 2021
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    On the role of p53 in the cellular response to aneuploidy
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    PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
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    Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
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  127. Feb 2021
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    Unique signatures of stress-induced senescent human astrocytes
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  129. Oct 2020
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    Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
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    Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
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  136. Jan 2020
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    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
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  143. Nov 2018
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    The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression
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    Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging
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    A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
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    Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency
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    Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism
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