270 Matching Annotations
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    Pharmacologic interrogation of USP28 cellular function in p53 signaling
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    Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia
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  4. Aug 2025
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    A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
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    Cannabichromene: integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy
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    Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers | EMBO reports
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  8. Jul 2025
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    Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence
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    Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers
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  11. Jun 2025
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    Potential Probiotic Lacticaseibacillus rhamnosus NKU FL1-11 Prevents Aging-Related Oxidative Stress and Inflammation via mTOR and FoxO Signaling Pathways in Zebrafish
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    Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer
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  15. May 2025
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    A lncRNA-mediated metabolic rewiring of cell senescence
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    Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo
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    IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma
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    ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
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  20. Apr 2025
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    Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma
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    p53 regulates DREAM complex-mediated repression in a p21-independent manner
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    A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells
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    Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
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    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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  26. Mar 2025
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    Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma
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    p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
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  30. Feb 2025
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    Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality
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    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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  37. Dec 2024
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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  44. Nov 2024
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    Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats
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    Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies
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  49. Aug 2024
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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  58. Jun 2024
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    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
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    ESR1 and p53 Interactome Alteration Defines Mechanisms of Tamoxifen Response in Luminal Breast Cancer
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    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
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  63. May 2024
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    Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells
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    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  67. Apr 2024
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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  72. Mar 2024
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53
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  75. Feb 2024
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    Apoptosis due to after-effects of acute ethanol exposure in brain cortex: Intrinsic and extrinsic signaling pathways
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    PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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  81. Jan 2024
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    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
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  85. Dec 2023
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    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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    Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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  90. Nov 2023
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    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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  96. Oct 2023
  97. www.nature.com www.nature.com
    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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    nature.com/articles/s41416-023-02465-x
  98. Sep 2023
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    circELMOD3 increases and stabilizes TRIM13 by sponging miR-6864-5p and direct binding to inhibit HCC progression
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    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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    The interplay of TARG1 and PARG protects against genomic instability
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    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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  103. Jul 2023
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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    Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism
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    A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling
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    Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation
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  109. Jun 2023
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  218. Jun 2021
  219. www.cell.com www.cell.com
    p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1
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    cell.com/iscience/abstract/S2589-0042(21)00669-6
  220. www.sciencedirect.com www.sciencedirect.com
    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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    sciencedirect.com/science/article/pii/S2451945621002543
  221. May 2021
  222. rupress.org rupress.org
    Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
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    rupress.org/jem/article/218/3/e20200662/211733/Loss-of-tRNA-modifying-enzyme-Elp3-activates-a-p53
  223. www.sciencedirect.com www.sciencedirect.com
    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    sciencedirect.com/science/article/pii/S1097276521003154
  224. www.sciencedirect.com www.sciencedirect.com
    POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
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    sciencedirect.com/science/article/pii/S1097276520303130
  225. www.cell.com www.cell.com
    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
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    cell.com/iscience/abstract/S2589-0042(21)00403-X
  226. www.sciencedirect.com www.sciencedirect.com
    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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    sciencedirect.com/science/article/pii/S1534580720308881
  227. Apr 2021
  228. www.sciencedirect.com www.sciencedirect.com
    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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    sciencedirect.com/science/article/pii/S1550413120305350
  229. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S1535610821000416
  230. www.sciencedirect.com www.sciencedirect.com
    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610820302609
  231. www.sciencedirect.com www.sciencedirect.com
    A selective p53 activator and anticancer agent to improve colorectal cancer therapy
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    sciencedirect.com/science/article/pii/S2211124721002965
  232. www.nature.com www.nature.com
    MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity
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    nature.com/articles/s41419-021-03647-2
  233. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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    sciencedirect.com/science/article/pii/S0092867421000842
  234. aasldpubs.onlinelibrary.wiley.com aasldpubs.onlinelibrary.wiley.com
    Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma
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    aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31594
  235. www.sciencedirect.com www.sciencedirect.com
    Modeling human retinoblastoma using embryonic stem cell-derived retinal organoids
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    sciencedirect.com/science/article/pii/S2666166721001519
  236. Mar 2021
  237. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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    sciencedirect.com/science/article/pii/S2451945621000076
  238. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001909R
  239. www.sciencedirect.com www.sciencedirect.com
    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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    sciencedirect.com/science/article/pii/S0021925821002490
  240. Feb 2021
  241. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15350
  242. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7697391/
  243. www.nature.com www.nature.com
    Altered Adhesion and Migration of Human Mesenchymal Stromal Cells under Febrile Temperature Stress Involves NF-κβ Pathway
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    nature.com/articles/s41598-020-61361-z