216 Matching Annotations
  1. Last 7 days
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    sciencedirect.com/science/article/pii/S2211124724004443
  3. Apr 2024
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    sciencedirect.com/science/article/pii/S2211124724003723
  5. Mar 2024
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S0304416524000436
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    A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53
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    sciencedirect.com/science/article/pii/S1097276524001370
  8. Feb 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Apoptosis due to after-effects of acute ethanol exposure in brain cortex: Intrinsic and extrinsic signaling pathways
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    sciencedirect.com/science/article/pii/S0306452224000861
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    PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879691/
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    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    sciencedirect.com/science/article/pii/S2666379124000570
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    1. scibot 16 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
  14. Jan 2024
  15. www.cell.com www.cell.com
    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    1. scibot 25 Jan 2024
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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
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      DOI: 10.1158/1078-0432.CCR-23-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  18. Dec 2023
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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      DOI: 10.1002/advs.202305620

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
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    Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
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    sciencedirect.com/science/article/pii/S2666379123005529
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    sciencedirect.com/science/article/pii/S2211124723015358
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  23. Nov 2023
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    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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    sciencedirect.com/science/article/abs/pii/S2451945623003720
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    sciencedirect.com/science/article/pii/S2211124723014961
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
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      DOI: 10.1158/2767-9764.CRC-23-0239

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
  29. Oct 2023
  30. www.nature.com www.nature.com
    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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      DOI: 10.1038/s41416-023-02465-x

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    nature.com/articles/s41416-023-02465-x
  31. Sep 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    circELMOD3 increases and stabilizes TRIM13 by sponging miR-6864-5p and direct binding to inhibit HCC progression
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      DOI: 10.1016/j.isci.2023.107818

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    ncbi.nlm.nih.gov/pmc/articles/PMC10518715/
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    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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      DOI: 10.1038/s41422-023-00874-4

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    nature.com/articles/s41422-023-00874-4
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    The interplay of TARG1 and PARG protects against genomic instability
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    sciencedirect.com/science/article/pii/S2211124723011245
  35. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  36. Jul 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
    1
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      DOI: 10.1158/2767-9764.CRC-23-0111

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    ncbi.nlm.nih.gov/pmc/articles/PMC10373600/
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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      DOI: 10.1016/j.celrep.2023.112833

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    sciencedirect.com/science/article/pii/S2211124723008446
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    Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism
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      DOI: 10.1016/j.cmet.2023.06.014

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    sciencedirect.com/science/article/abs/pii/S1550413123002243
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    A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling
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      DOI: 10.1016/j.molcel.2023.06.024

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    sciencedirect.com/science/article/pii/S1097276523004719
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    Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation
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    sciencedirect.com/science/article/pii/S258900422301297X
  42. Jun 2023
  43. 52.53.155.43 52.53.155.43
    can-22-3464-html.html
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      DOI: 10.1158/0008-5472.CAN-22-3464

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    52.53.155.43/8f4ba7cf674bbb2f5b6878f674808aab8499538e/can-22-3464-html.html
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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      DOI: 10.1016/j.celrep.2023.112693

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    sciencedirect.com/science/article/pii/S2211124723007040
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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      DOI: 10.1111/jne.13187

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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  46. May 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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    sciencedirect.com/science/article/pii/S2211124723005314
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    sciencedirect.com/science/article/pii/S2211124723005077
  49. www.nature.com www.nature.com
    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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  50. Apr 2023
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    Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells
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    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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    DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites
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    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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  57. Mar 2023
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    Novel Paired Normal Prostate and Prostate Cancer Model Cell Systems Derived from African American Patients
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  63. Feb 2023
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    Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma
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    Distinct dosage compensations of ploidy-sensitive and -insensitive X chromosome genes during development and in diseases
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  67. Jan 2023
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    Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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  73. Nov 2022
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    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
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    Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue
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    Metabolic regulation by p53 prevents R-loop-associated genomic instability
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  79. Oct 2022
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    m6A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress
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    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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    SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis
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    Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism
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    Oncogenic gain of function due to p53 amyloids by aberrant alteration of cell cycle and proliferation
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  92. Jul 2022
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    Self-assembly of pericentriolar material in interphase cells lacking centrioles
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  94. Jun 2022
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    MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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  99. May 2022
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    Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells
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  101. Apr 2022
  102. www.nature.com www.nature.com
    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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  103. www.sciencedirect.com www.sciencedirect.com
    Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide
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  104. Mar 2022
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    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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  107. Feb 2022
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion
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  109. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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  110. www.sciencedirect.com www.sciencedirect.com
    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
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  111. Dec 2021
  112. www.sciencedirect.com www.sciencedirect.com
    Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
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  113. Nov 2021
  114. www.sciencedirect.com www.sciencedirect.com
    LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells
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  116. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Non-genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease
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  117. Oct 2021
  118. link.springer.com link.springer.com
    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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      DOI: 10.1186/s13046-021-02124-0

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  119. www.sciencedirect.com www.sciencedirect.com
    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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  120. www.sciencedirect.com www.sciencedirect.com
    USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork
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  121. Sep 2021
  122. www.sciencedirect.com www.sciencedirect.com
    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
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  126. Aug 2021
  127. www.sciencedirect.com www.sciencedirect.com
    Serine/threonine ligation-assisted chemical synthesis of HMGA1a protein with site-specific post-translational modifications
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    Entosis is induced by UV radiation.
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  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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  130. link.springer.com link.springer.com
    Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  132. www.sciencedirect.com www.sciencedirect.com
    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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    Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  138. journals.biologists.com journals.biologists.com
    Direct evidence of cellular transformation by prion-like p53 amyloid infection
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    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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  140. Jul 2021
  141. onlinelibrary.wiley.com onlinelibrary.wiley.com
    CBX4 promotes the proliferation and metastasis via regulating BMI‐1 in lung cancer
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      anti‐P53

      DOI: 10.1111/jcmm.14771

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  142. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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      mouse anti‐p53

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  143. www.sciencedirect.com www.sciencedirect.com
    A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation
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      anti-human p53 Alexa Fluor 647 clone DO-1

      DOI: 10.1016/j.immuni.2019.08.009

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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  145. www.sciencedirect.com www.sciencedirect.com
    The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
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  146. elifesciences.org elifesciences.org
    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
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      DO-1

      DOI: 10.7554/eLife.28482

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  147. www.sciencedirect.com www.sciencedirect.com
    Selective Anti-tumor Activity of wogonin targeting the Warburg Effect through stablizing p53
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      DOI: 10.1016/j.phrs.2018.07.011

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    CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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      sc-126

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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  151. Jun 2021
  152. www.cell.com www.cell.com
    p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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  154. May 2021
  155. rupress.org rupress.org
    Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
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  156. www.sciencedirect.com www.sciencedirect.com
    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
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    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
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    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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  160. Apr 2021
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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  169. Mar 2021
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    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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  171. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner
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      anti‐p53

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    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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  173. Feb 2021
  174. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells
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    Altered Adhesion and Migration of Human Mesenchymal Stromal Cells under Febrile Temperature Stress Involves NF-κβ Pathway
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      DOI: 10.1038/s41598-020-61361-z

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  177. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype
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  178. Jan 2021
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4-mediated repression of p53 is a target for combination therapy in AML
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      DOI: 10.1038/s41467-020-20378-8

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  180. Oct 2020
  181. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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  182. Sep 2020
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    Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30
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    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
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      DOI: 10.7554/eLife.52570

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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis
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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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    WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion
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    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress
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    A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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  194. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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