127 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy
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    1. scibot 14 Dec 2024
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      DOI: 10.1016/j.isci.2024.111384

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    pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
  3. www.science.org www.science.org
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
    1
    1. scibot 06 Dec 2024
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      DOI: 10.1126/science.adq8587

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    science.org/doi/10.1126/science.adq8587
  4. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
    1
    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.cmet.2024.10.021

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    sciencedirect.com/science/article/pii/S1550413124004170
  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
    1
    1. scibot 26 Nov 2024
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      DOI: 10.1126/science.adq8587

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    pmc.ncbi.nlm.nih.gov/articles/PMC11583848/
  7. Oct 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CALHM2 is a mitochondrial protein import channel that regulates fatty acid metabolism
    1
    1. scibot 05 Oct 2024
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      DOI: 10.21203/rs.3.rs-4985689/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419264/
  9. www.sciencedirect.com www.sciencedirect.com
    Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.celrep.2024.114794

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    sciencedirect.com/science/article/pii/S2211124724011458
  10. Aug 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
    1
    1. scibot 18 Aug 2024
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      DOI: 10.1083/jcb.202305087

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    ncbi.nlm.nih.gov/pmc/articles/PMC10818064/
  12. Jul 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1080/15548627.2024.2333717

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    ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
  14. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1111/bph.16489

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16489
  15. www.medrxiv.org www.medrxiv.org
    The MFN2 Q367H variant from a patient with late-onset distal myopathy reveals a novel pathomechanism connected to mtDNA-mediated inflammation
    1
    1. scibot 04 Jul 2024
      RRID:AB_628381

      DOI: 10.1101/2024.06.20.24309123

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    medrxiv.org/content/10.1101/2024.06.20.24309123v1
  16. Jun 2024
  17. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
    1
    1. scibot 30 Jun 2024
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      DOI: 10.1016/j.isci.2024.110132

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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  18. www.sciencedirect.com www.sciencedirect.com
    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.017

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    sciencedirect.com/science/article/pii/S0092867424005269
  19. www.sciencedirect.com www.sciencedirect.com
    TRABD modulates mitochondrial homeostasis and tissue integrity
    1
    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114304

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    sciencedirect.com/science/article/pii/S2211124724006326
  20. May 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy
    1
    1. scibot 25 May 2024
      RRID:AB_628381

      DOI: 10.1038/s41598-024-60602-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11111795/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
    1
    1. scibot 24 May 2024
      RRID:AB_628381

      DOI: 10.1016/j.isci.2024.109860

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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease
    1
    1. scibot 23 May 2024
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      DOI: 10.1126/sciadv.adl2036

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    ncbi.nlm.nih.gov/pmc/articles/PMC11100560/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC
    1
    1. scibot 22 May 2024
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      DOI: 10.1038/s41467-024-48695-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11102494/
  25. www.sciencedirect.com www.sciencedirect.com
    Acyl-CoA synthetase 4 modulates mitochondrial function in breast cancer cells
    1
    1. scibot 07 May 2024
      RRID:AB_628381

      DOI: 10.1016/j.heliyon.2024.e30639

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    sciencedirect.com/science/article/pii/S2405844024066702
  26. Apr 2024
  27. www.nature.com www.nature.com
    Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies
    1
    1. scibot 18 Apr 2024
      RRID:AB_628381

      DOI: 10.1038/s41467-024-47569-x

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    nature.com/articles/s41467-024-47569-x
  28. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
    1
    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.013

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    sciencedirect.com/science/article/pii/S1934590924000948
  29. Mar 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis
    1
    1. scibot 28 Mar 2024
      RRID:AB_628381

      DOI: 10.1016/j.isci.2024.109288

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    ncbi.nlm.nih.gov/pmc/articles/PMC10963253/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease
    1
    1. scibot 27 Mar 2024
      RRID:AB_628381

      DOI: 10.4103/1673-5374.389356

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    ncbi.nlm.nih.gov/pmc/articles/PMC10960274/
  32. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
    2
    1. scibot 15 Mar 2024
      RRID:AB_628381

      DOI: 10.1016/j.cmet.2024.02.009

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    2. scibot 15 Mar 2024
      RRID:AB_628381

      DOI: 10.1016/j.cmet.2024.02.009

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    sciencedirect.com/science/article/pii/S155041312400055X
  33. Feb 2024
  34. www.sciencedirect.com www.sciencedirect.com
    NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113860

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    sciencedirect.com/science/article/pii/S2211124724001888
  35. 52.53.155.43 52.53.155.43
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
    2
    1. scibot 22 Feb 2024
      RRID:AB_628381

      DOI: 10.1152/ajpcell.00293.2023

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    2. scibot 22 Feb 2024
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      DOI: 10.1152/ajpcell.00293.2023

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    52.53.155.43/d532629e4f1cf755a6f5c302a21018f2c97350c4/reisbeck-et-al-2023-the-iron-chelator-and-oxphos-inhibitor-vlx600-induces-mitophagy-and-an-autophagy-dependent-type-of (1)-html.html
  36. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
    3
    1. scibot 16 Feb 2024
      RRID:AB_628381

      DOI: 10.1152/ajpcell.00293.2023

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    2. scibot 16 Feb 2024
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      DOI: 10.1152/ajpcell.00293.2023

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    3. scibot 16 Feb 2024
      RRID:AB_628381

      DOI: 10.1152/ajpcell.00293.2023

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    journals.physiology.org/doi/10.1152/ajpcell.00293.2023
  37. www.sciencedirect.com www.sciencedirect.com
    The HRI branch of the integrated stress response selectively triggers mitophagy
    2
    1. scibot 14 Feb 2024
      AB_628381

      DOI: 10.1016/j.molcel.2024.01.016

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      AB_628381

      DOI: 10.1016/j.molcel.2024.01.016

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    sciencedirect.com/science/article/pii/S1097276524000522
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss
    1
    1. scibot 01 Feb 2024
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      DOI: 10.12688/f1000research.53230.2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10808857/
  39. Jan 2024
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia
    1
    1. scibot 10 Jan 2024
      RRID:AB_628381

      DOI: 10.1158/2159-8290.CD-22-0601

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    pmc.ncbi.nlm.nih.gov/articles/PMC10330144/
  41. Nov 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis
    1
    1. scibot 30 Nov 2023
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      DOI: 10.1038/s41467-023-43175-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10673935/
  43. Oct 2023
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    STAT3 modulates CD4+ T mitochondrial dynamics and function in aging
    1
    1. scibot 17 Oct 2023
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      DOI: 10.1111/acel.13996

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    onlinelibrary.wiley.com/doi/10.1111/acel.13996
  45. Sep 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos
    1
    1. scibot 23 Sep 2023
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      DOI: 10.1016/j.xpro.2023.102569

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
    1
    1. scibot 22 Sep 2023
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      DOI: 10.1111/acel.13954

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    onlinelibrary.wiley.com/doi/10.1111/acel.13954
  48. link.springer.com link.springer.com
    Melatonin Prevents Non-image-Forming Visual System Alterations Induced by Experimental Glaucoma in Rats
    1
    1. scibot 17 Sep 2023
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      DOI: 10.1007/s12035-021-02374-1

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    link.springer.com/article/10.1007/s12035-021-02374-1
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain-derived neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A
    1
    1. scibot 13 Sep 2023
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      DOI: 10.1111/jnc.15945

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15945
  50. www.sciencedirect.com www.sciencedirect.com
    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
    1
    1. scibot 08 Sep 2023
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      DOI: 10.1016/j.molcel.2023.08.005

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    sciencedirect.com/science/article/pii/S109727652300641X
  51. Aug 2023
  52. www.biorxiv.org www.biorxiv.org
    KAT8 compound inhibition inhibits PINK1/Parkin-dependent mitophagy and initiates mitochondrial delivery to lysosomes
    1
    1. scibot 12 Aug 2023
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      DOI: 10.1101/2023.08.03.551835

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  53. Jul 2023
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    PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics
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    A Proximity Labeling Strategy Enables Proteomic Analysis of Inter-organelle Membrane Contacts
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  57. Jun 2023
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    A mitochondrial iron-responsive pathway regulated by DELE1
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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  62. May 2023
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    The ultrastructural function of MLN64 in the late endosome–mitochondria membrane contact sites in placental cells
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    The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice
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  65. Apr 2023
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    NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
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    Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis
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    Optineurin provides a mitophagy contact site for TBK1 activation
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  69. Mar 2023
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    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
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  71. Feb 2023
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    Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis
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  74. Jan 2023
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    VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites
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  76. Dec 2022
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    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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  78. Nov 2022
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    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon
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  82. Aug 2022
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    Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms
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  84. May 2022
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    Integrative analysis of mitochondrial metabolic dynamics in reprogramming human fibroblast cells
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons
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    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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  93. Jan 2022
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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  97. Dec 2021
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    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules
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  101. Aug 2021
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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  108. Jul 2021
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    SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
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    Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
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    Global mapping of Salmonella enterica-host protein-protein interactions during infection
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    Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
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  113. Jun 2021
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    Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity
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    Super-resolution imaging reveals cytoskeleton-dependent organelle rearrangement within platelets at intermediate stages of maturation
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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  117. May 2021
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    A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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  121. Apr 2021
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    Melatonin Prevents Non-image-Forming Visual System Alterations Induced by Experimental Glaucoma in Rats
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  124. Mar 2021
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    Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy
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  126. Feb 2021
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    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation
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  129. Jan 2021
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    Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content
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  131. Dec 2020
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    Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation
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  133. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  135. Oct 2020
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    Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity
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    Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma
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  138. Sep 2020
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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  141. rupress.org rupress.org
    Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy
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    Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
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    Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits
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    Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling
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    SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation
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    Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
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    Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
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      DOI: 10.1093/hmg/ddaa066

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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      mouse anti-TOM20

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  149. Aug 2020
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    Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
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  151. academic.oup.com academic.oup.com
    Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations
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  152. Jan 2020
  153. advances.sciencemag.org advances.sciencemag.org
    Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress
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    TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion
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    Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
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    The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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    sciencedirect.com/science/article/pii/S2211124718312348
  163. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
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    1. scibot 05 Nov 2018
      RRID:AB_628381

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    sciencedirect.com/science/article/pii/S1550413118303140
  164. www.sciencedirect.com www.sciencedirect.com
    TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
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    1. scibot 05 Nov 2018
      RRID:AB_628381

      Curator: @Jmenke

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      (Santa Cruz Biotechnology Cat# sc-17764, RRID:AB_628381)

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      RRID:AB_628381 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0960982217316809
  165. www.sciencedirect.com www.sciencedirect.com
    Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway
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    1. scibot 05 Nov 2018
      RRID:AB_628381

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      (Santa Cruz Biotechnology Cat# sc-17764, RRID:AB_628381)

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    sciencedirect.com/science/article/pii/S1097276517308067
  166. Nov 2017
  167. www.sciencedirect.com www.sciencedirect.com
    Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor
    1
    1. scibot 08 Nov 2017
      sc-17764

      Curator: @Jmenke

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      (Santa Cruz Biotechnology Cat# sc-17764, RRID:AB_628381)

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      RRID:AB_628381 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S009286741631652X
  168. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial mechanisms of neuronal rescue by F-68, a hydrophilic Pluronic block co-polymer, following acute substrate deprivation
    1
    1. scibot 08 Nov 2017
      AB_628381

      Curator: @gabimpine

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      (Santa Cruz Biotechnology Cat# sc-17764, RRID:AB_628381)

      SciCrunch record: RRID:AB_628381

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      RRID:AB_628381 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0197018617300906