46 Matching Annotations
  1. Jul 2025
  2. www.nature.com www.nature.com
    Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases
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    nature.com/articles/s41419-025-07812-9
  3. Jun 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
  5. www.sciencedirect.com www.sciencedirect.com
    Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket
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    sciencedirect.com/science/article/pii/S258900422400124X
  6. Apr 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p53 regulates DREAM complex-mediated repression in a p21-independent manner
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000331/
  8. Dec 2024
  9. www.science.org www.science.org
    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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    science.org/doi/10.1126/scisignal.adp1375
  10. Sep 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Conserved cysteine-switches for redox sensing operate in the Cyclin-Dependent Kinase Inhibitor p21(CIP/KIP) Protein Family.
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    sciencedirect.com/science/article/pii/S0891584924006609
  12. Jul 2024
  13. www.sciencedirect.com www.sciencedirect.com
    Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers
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    sciencedirect.com/science/article/pii/S2211124724008258
  14. Apr 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  16. Feb 2024
  17. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  18. Jan 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    sciencedirect.com/science/article/pii/S1534580724000029
  20. Dec 2023
  21. www.sciencedirect.com www.sciencedirect.com
    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    sciencedirect.com/science/article/pii/S2211124723015358
  22. Jun 2023
  23. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  24. May 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  26. Feb 2023
  27. www.sciencedirect.com www.sciencedirect.com
    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    sciencedirect.com/science/article/pii/S2211124723001407
  28. Apr 2022
  29. www.science.org www.science.org
    p53 directs leader cell behavior, migration, and clearance during epithelial repair
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    science.org/doi/full/10.1126/science.abl8876
  30. Feb 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
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    sciencedirect.com/science/article/pii/S153561082200006X
  32. Jan 2022
  33. www.sciencedirect.com www.sciencedirect.com
    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    sciencedirect.com/science/article/pii/S2211124721017733
  34. Nov 2021
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia
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    ncbi.nlm.nih.gov/pmc/articles/PMC8593568/
  36. Sep 2021
  37. www.sciencedirect.com www.sciencedirect.com
    Oncogene-dependent sloppiness in mRNA translation
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    sciencedirect.com/science/article/pii/S109727652100736X
  38. Aug 2021
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6221544/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6224545/
  41. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718317704
  42. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S0092867418315034
  43. Jul 2021
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32709
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6324198/
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SARNP, a participant in mRNA splicing and export, negatively regulates E‐cadherin expression via interaction with pinin
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.29073
  47. www.sciencedirect.com www.sciencedirect.com
    The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
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    sciencedirect.com/science/article/pii/S1097276518307901
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC3635462/
  49. elifesciences.org elifesciences.org
    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
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    elifesciences.org/articles/37868
  50. www.sciencedirect.com www.sciencedirect.com
    Targeting senescent cells improves functional recovery after spinal cord injury
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    sciencedirect.com/science/article/pii/S2211124721007105
  51. Apr 2021
  52. www.sciencedirect.com www.sciencedirect.com
    A selective p53 activator and anticancer agent to improve colorectal cancer therapy
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    sciencedirect.com/science/article/pii/S2211124721002965
  53. Jan 2021
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4-mediated repression of p53 is a target for combination therapy in AML
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    ncbi.nlm.nih.gov/pmc/articles/PMC7801601/
  55. Jan 2020
  56. www.sciencedirect.com www.sciencedirect.com
    BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
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    sciencedirect.com/science/article/pii/S0092867419306336
  57. www.sciencedirect.com www.sciencedirect.com
    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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    sciencedirect.com/science/article/pii/S1097276519301029
  58. Nov 2018
  59. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718314116
  60. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1550413118304480
  61. www.sciencedirect.com www.sciencedirect.com
    BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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    sciencedirect.com/science/article/pii/S1535610818302204
  62. www.sciencedirect.com www.sciencedirect.com
    Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
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    sciencedirect.com/science/article/pii/S1535610818300023
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC5926201/
  64. www.sciencedirect.com www.sciencedirect.com
    NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
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    sciencedirect.com/science/article/pii/S1097276517306573
  65. academic.oup.com academic.oup.com
    Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
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    academic.oup.com/endo/article/158/11/4000/4093568
  66. Nov 2017
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  68. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082