64 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
  3. Jul 2025
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
  5. Jun 2025
  6. journals.sagepub.com journals.sagepub.com
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    journals.sagepub.com/doi/full/10.1177/15347354251344592
  7. www.sciencedirect.com www.sciencedirect.com
    Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells
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    sciencedirect.com/science/article/pii/S0048357525001993
  8. May 2025
  9. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225007874-main-html.html
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    Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
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    sciencedirect.com/science/article/pii/S1534580725002072
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
  12. Apr 2025
  13. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225007199-main-html.html
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  14. www.jneurosci.org www.jneurosci.org
    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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    jneurosci.org/content/45/10/e0967242025
  15. Feb 2025
  16. aacrjournals.org aacrjournals.org
    Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling
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    aacrjournals.org/mct/article/21/7/1160/705294/Peptide-PDHPS1-Inhibits-Ovarian-Cancer-Growth
  17. aacrjournals.org aacrjournals.org
    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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    aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
  18. Jan 2025
  19. www.sciencedirect.com www.sciencedirect.com
    Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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    sciencedirect.com/science/article/pii/S1550413124004911
  20. Dec 2024
  21. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  22. Sep 2024
  23. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286715
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    sciencedirect.com/science/article/pii/S2211124724011136
  25. Aug 2024
  26. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    link.springer.com/article/10.1007/s12035-024-04425-9
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11317932/
  28. www.sciencedirect.com www.sciencedirect.com
    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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  29. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    sciencedirect.com/science/article/pii/S1535610824002708
  30. Jul 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  32. May 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
  34. Mar 2024
  35. www.sciencedirect.com www.sciencedirect.com
    MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2405844024042038
  36. Feb 2024
  37. link.springer.com link.springer.com
    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    link.springer.com/article/10.1007/s12010-024-04887-6
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
  39. Jan 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  41. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
  42. Aug 2023
  43. link.springer.com link.springer.com
    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
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    link.springer.com/article/10.1007/s10967-023-09067-0
  44. Jul 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    sciencedirect.com/science/article/pii/S221112472300880X
  46. www.sciencedirect.com www.sciencedirect.com
    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    sciencedirect.com/science/article/pii/S2589004223014189
  47. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    sciencedirect.com/science/article/pii/S2211124723008057
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
  49. Jun 2023
  50. 52.53.155.43 52.53.155.43
    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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  51. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  52. Mar 2023
  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla
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    onlinelibrary.wiley.com/doi/10.1111/cns.14142
  54. Dec 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    sciencedirect.com/science/article/pii/S1550413122005034
  56. Nov 2022
  57. link.springer.com link.springer.com
    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    link.springer.com/article/10.1007/s13402-022-00737-x
  58. Sep 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
  60. Jul 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell
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    ncbi.nlm.nih.gov/pmc/articles/PMC9316729/
  62. Jun 2022
  63. 52.53.155.43 52.53.155.43
    mct-21-0848-html.html
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    52.53.155.43/12e7b7b771463d8107a4061a3543e1c33fbd2829/mct-21-0848-html.html
  64. journals.lww.com journals.lww.com
    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
  65. May 2022
  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    HDAC inhibition prevents hypobaric hypoxia‐induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.30337
  67. Mar 2022
  68. www.sciencedirect.com www.sciencedirect.com
    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    sciencedirect.com/science/article/pii/S2211124722002893
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC8899187/
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15733
  71. Dec 2021
  72. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15693
  73. Jul 2021
  74. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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    jcs.biologists.org/content/132/20/jcs233221
  75. May 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    sciencedirect.com/science/article/pii/S0896627321001562
  77. Feb 2021
  78. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15047
  79. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  80. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  81. Dec 2020
  82. link.springer.com link.springer.com
    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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    link.springer.com/article/10.1007/s10495-020-01645-x
  83. Sep 2020
  84. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  85. www.sciencedirect.com www.sciencedirect.com
    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    sciencedirect.com/science/article/pii/S0006295220301775
  86. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14918
  87. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15042
  88. www.mdpi.com www.mdpi.com
    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
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    mdpi.com/2077-0383/9/2/353
  89. Jan 2020
  90. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    sciencedirect.com/science/article/pii/S1074761319304960
  91. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcb.29123
  92. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14626
  93. Nov 2018
  94. link.springer.com link.springer.com
    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
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    link.springer.com/article/10.1007/s10571-018-0616-3
  95. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/159/9/3132/5050928
  96. www.sciencedirect.com www.sciencedirect.com
    Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity
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    sciencedirect.com/science/article/pii/S1074761317304879
  97. Nov 2017
  98. academic.oup.com academic.oup.com
    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
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    academic.oup.com/endo/article/158/10/3661/4049499/Aldose-Reductase-Mediates-NLRP3-Inflammasome
  99. academic.oup.com academic.oup.com
    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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    academic.oup.com/endo/article/158/3/560/2930939/Dual-Role-of-Insulin-in-Spexin-Regulation