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    Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity
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  3. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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  7. Jun 2025
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    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells
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    Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
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    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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  17. Feb 2025
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    Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling
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    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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  20. Jan 2025
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    Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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  22. Dec 2024
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  24. Sep 2024
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    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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  27. Aug 2024
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    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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  32. Jul 2024
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    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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  34. May 2024
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    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
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  36. Mar 2024
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    MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
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  38. Feb 2024
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    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
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  41. Jan 2024
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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  44. Aug 2023
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    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
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  46. Jul 2023
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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  51. Jun 2023
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    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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  54. Mar 2023
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    LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla
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  56. Dec 2022
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    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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  58. Nov 2022
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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  60. Sep 2022
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    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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  62. Jul 2022
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    Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell
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  64. Jun 2022
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    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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  67. May 2022
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    HDAC inhibition prevents hypobaric hypoxia‐induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway
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  69. Mar 2022
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
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  73. Dec 2021
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  75. Jul 2021
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    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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  77. May 2021
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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  79. Feb 2021
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    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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  83. Dec 2020
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    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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  85. Sep 2020
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    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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  91. Jan 2020
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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  95. Nov 2018
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    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
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    Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity
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  99. Nov 2017
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    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
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    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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