154 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
    1
    1. scibot 13 Dec 2024
      RRID:AB_731658

      DOI: 10.1038/s44321-024-00161-8

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    pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell competition drives bronchiolization and pulmonary fibrosis
    1
    1. scibot 11 Dec 2024
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      DOI: 10.1038/s41467-024-54997-2

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    pmc.ncbi.nlm.nih.gov/articles/PMC11621346/
  4. Nov 2024
  5. www.sciencedirect.com www.sciencedirect.com
    ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
    1
    1. scibot 24 Nov 2024
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      DOI: 10.1016/j.cmet.2024.10.015

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    sciencedirect.com/science/article/pii/S155041312400411X
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis
    1
    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.isci.2024.111178

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    pmc.ncbi.nlm.nih.gov/articles/PMC11549989/
  7. link.springer.com link.springer.com
    Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma
    1
    1. scibot 07 Nov 2024
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      DOI: 10.1007/s10495-024-02039-z

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    link.springer.com/article/10.1007/s10495-024-02039-z
  8. Oct 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/2767-9764.CRC-24-0144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11425777/
  10. Aug 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II
    1
    1. scibot 26 Aug 2024
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      DOI: 10.7554/eLife.94407

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    ncbi.nlm.nih.gov/pmc/articles/PMC11343564/
  12. www.sciencedirect.com www.sciencedirect.com
    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114589

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    sciencedirect.com/science/article/pii/S2211124724009185
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    Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis
    1
    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S1550413124002808
  14. Jul 2024
  15. 52.53.155.43 52.53.155.43
    1-s2.0-S1535610824002319-mmc1-html.html
    1
    1. scibot 25 Jul 2024
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    52.53.155.43/fa631816ea536ebd5d77bd5edcecb27537053850/1-s2.0-S1535610824002319-mmc1-html.html
  16. www.sciencedirect.com www.sciencedirect.com
    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
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    1. scibot 25 Jul 2024
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  17. Jun 2024
  18. aacrjournals.org aacrjournals.org
    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1158/0008-5472.CAN-23-0519

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    aacrjournals.org/cancerres/article/84/11/1834/745520/Obesogenic-High-Fat-Diet-and-MYC-Cooperate-to
  19. May 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.ccell.2024.05.002

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    sciencedirect.com/science/article/pii/S1535610824001636
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell competition drives bronchiolization and pulmonary fibrosis
    1
    1. scibot 23 May 2024
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      DOI: 10.21203/rs.3.rs-4177351/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092845/
  22. journals.biologists.com journals.biologists.com
    Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
    1
    1. scibot 22 May 2024
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      DOI: 10.1242/dev.201581

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    journals.biologists.com/dev/article/150/11/dev201581/316006/Myc-promotes-polyploidy-in-murine-trophoblast
  23. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
    1. scibot 09 May 2024
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      DOI: 10.1016/j.celrep.2024.114211

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    sciencedirect.com/science/article/pii/S2211124724005394
  24. www.sciencedirect.com www.sciencedirect.com
    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
    1
    1. scibot 07 May 2024
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      DOI: 10.1016/j.molcel.2024.04.007

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    sciencedirect.com/science/article/pii/S1097276524002855
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
    1
    1. scibot 03 May 2024
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      DOI: 10.1158/1078-0432.CCR-23-2975

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    ncbi.nlm.nih.gov/pmc/articles/PMC11061603/
  26. Apr 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation
    1
    1. scibot 25 Apr 2024
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      DOI: 10.1016/j.devcel.2024.04.009

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    sciencedirect.com/science/article/pii/S153458072400234X
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
    1
    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114111

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    sciencedirect.com/science/article/pii/S221112472400439X
  29. www.sciencedirect.com www.sciencedirect.com
    Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
    2
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101484

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      DOI: 10.1016/j.xcrm.2024.101484

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    sciencedirect.com/science/article/pii/S2666379124001307
  30. Feb 2024
  31. www.sciencedirect.com www.sciencedirect.com
    ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.026

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    sciencedirect.com/science/article/pii/S1534580724000467
  32. www.sciencedirect.com www.sciencedirect.com
    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113810

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    sciencedirect.com/science/article/pii/S2211124724001384
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.isci.2023.108706

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    ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
  35. Dec 2023
  36. aacrjournals.org aacrjournals.org
    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
    1
    1. scibot 30 Dec 2023
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      DOI: 10.1158/0008-5472.CAN-22-2108

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    aacrjournals.org/cancerres/article/82/24/4586/711513/Dormant-SOX9-Positive-Cells-Facilitate-MYC-Driven
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1158/0008-5472.CAN-22-2948

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    ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
  38. 52.53.155.43 52.53.155.43
    Exosome-mediated delivery of miR-519e-5p promotes malignant tumor phenotype and CD8+ T-cell exhaustion in metastatic PTC
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1210/clinem/dgad725

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    52.53.155.43/49084488a43379eb61e571ff51a5cf6b7356b0d7/dgad725-html.html
  39. www.sciencedirect.com www.sciencedirect.com
    Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.020

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    sciencedirect.com/science/article/pii/S1534580723006184
  40. Nov 2023
  41. www.sciencedirect.com www.sciencedirect.com
    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101286

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    sciencedirect.com/science/article/pii/S2666379123004809
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    LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation
    1
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      DOI: 10.1016/j.celrep.2023.113479

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    sciencedirect.com/science/article/pii/S2211124723014912
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    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
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      DOI: 10.1016/j.chembiol.2023.10.023

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    sciencedirect.com/science/article/pii/S2451945623003847
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10616323/
  45. www.sciencedirect.com www.sciencedirect.com
    The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing
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      DOI: 10.1016/j.celrep.2023.113347

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    sciencedirect.com/science/article/pii/S2211124723013591
  46. Oct 2023
  47. www.sciencedirect.com www.sciencedirect.com
    ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells
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      DOI: 10.1016/j.celrep.2023.113280

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    sciencedirect.com/science/article/pii/S2211124723012925
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113270

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    sciencedirect.com/science/article/pii/S2211124723012822
  49. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  50. www.sciencedirect.com www.sciencedirect.com
    MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113221

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    sciencedirect.com/science/article/pii/S2211124723012330
  51. Sep 2023
  52. www.sciencedirect.com www.sciencedirect.com
    ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
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    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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  58. Jun 2023
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    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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  83. Apr 2022
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    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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  115. Jul 2021
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    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
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      Anti-c-Myc antibody [Y69]

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    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
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    Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
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    Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  122. Jun 2021
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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  124. May 2021
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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  127. Apr 2021
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    Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
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  129. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
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  132. Feb 2021
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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  134. Jan 2021
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    Impact of WIN site inhibitor on the WDR5 interactome
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    HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies
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    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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  139. Nov 2020
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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  141. Oct 2020
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  143. Sep 2020
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer
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    MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities
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    p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis
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  153. Jan 2020
  154. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
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    Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice
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    The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
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  180. Nov 2018
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    Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import
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    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
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    R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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  190. continuumtest--journal.elifesciences.org continuumtest--journal.elifesciences.org
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    Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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