139 Matching Annotations
  1. May 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
    1. scibot 09 May 2024
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      DOI: 10.1016/j.celrep.2024.114211

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    sciencedirect.com/science/article/pii/S2211124724005394
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
    1
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      DOI: 10.1016/j.molcel.2024.04.007

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    sciencedirect.com/science/article/pii/S1097276524002855
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
    1
    1. scibot 03 May 2024
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      DOI: 10.1158/1078-0432.CCR-23-2975

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    ncbi.nlm.nih.gov/pmc/articles/PMC11061603/
  5. Apr 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation
    1
    1. scibot 25 Apr 2024
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      DOI: 10.1016/j.devcel.2024.04.009

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    sciencedirect.com/science/article/pii/S153458072400234X
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
    1
    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114111

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    sciencedirect.com/science/article/pii/S221112472400439X
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    Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
    2
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101484

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      DOI: 10.1016/j.xcrm.2024.101484

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    sciencedirect.com/science/article/pii/S2666379124001307
  9. Feb 2024
  10. www.sciencedirect.com www.sciencedirect.com
    ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.026

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    sciencedirect.com/science/article/pii/S1534580724000467
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    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
    1
    1. scibot 21 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001384
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.isci.2023.108706

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    ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
  14. Dec 2023
  15. dx.doi.org dx.doi.org
    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
    1
    1. scibot 30 Dec 2023
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      DOI: 10.1158/0008-5472.CAN-22-2108

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    dx.doi.org/10.1158/0008-5472.CAN-22-2108
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
    1
    1. scibot 20 Dec 2023
      RRID:AB_731658

      DOI: 10.1158/0008-5472.CAN-22-2948

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    ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
  17. 52.53.155.43 52.53.155.43
    Exosome-mediated delivery of miR-519e-5p promotes malignant tumor phenotype and CD8+ T-cell exhaustion in metastatic PTC
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1210/clinem/dgad725

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    52.53.155.43/49084488a43379eb61e571ff51a5cf6b7356b0d7/dgad725-html.html
  18. www.sciencedirect.com www.sciencedirect.com
    Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.020

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    sciencedirect.com/science/article/pii/S1534580723006184
  19. Nov 2023
  20. www.sciencedirect.com www.sciencedirect.com
    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101286

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    sciencedirect.com/science/article/pii/S2666379123004809
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    LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113479

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    sciencedirect.com/science/article/pii/S2211124723014912
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    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.023

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    sciencedirect.com/science/article/pii/S2451945623003847
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS
    1
    1. scibot 04 Nov 2023
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      DOI: 10.1016/j.isci.2023.108168

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    ncbi.nlm.nih.gov/pmc/articles/PMC10616323/
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    The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing
    1
    1. scibot 03 Nov 2023
      RRID:AB_731658

      DOI: 10.1016/j.celrep.2023.113347

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    sciencedirect.com/science/article/pii/S2211124723013591
  25. Oct 2023
  26. www.sciencedirect.com www.sciencedirect.com
    ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells
    1
    1. scibot 27 Oct 2023
      RRID:AB_731658

      DOI: 10.1016/j.celrep.2023.113280

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    sciencedirect.com/science/article/pii/S2211124723012925
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
    1
    1. scibot 27 Oct 2023
      RRID:AB_731658

      DOI: 10.1016/j.celrep.2023.113270

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    sciencedirect.com/science/article/pii/S2211124723012822
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
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    MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113221

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    sciencedirect.com/science/article/pii/S2211124723012330
  30. Sep 2023
  31. www.sciencedirect.com www.sciencedirect.com
    ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113163

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    sciencedirect.com/science/article/pii/S2211124723011750
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Subtypes of Head and Neck Cancer in Patients of African Ancestry
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1158/1078-0432.CCR-22-2258

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    ncbi.nlm.nih.gov/pmc/articles/PMC9991972/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1158/2643-3230.BCD-22-0082

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    ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
  34. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
    1
    1. scibot 01 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113079

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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  35. Aug 2023
  36. 52.53.155.43 52.53.155.43
    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
    2
    1. scibot 16 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112979

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      DOI: 10.1016/j.celrep.2023.112979

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    52.53.155.43/491f3628ae56ca418965e7c0fc6856d1761b345d/PIIS2211124723009907-html.html
  37. Jun 2023
  38. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.ccell.2023.06.001

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    sciencedirect.com/science/article/pii/S1535610823002088
  39. www.sciencedirect.com www.sciencedirect.com
    Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.molcel.2023.05.022

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    sciencedirect.com/science/article/pii/S1097276523003787
  40. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
    1
    1. scibot 03 Jun 2023
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      DOI: 10.1158/0008-5472.CAN-22-1549

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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
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    The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
    1
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      DOI: 10.1016/j.celrep.2023.112590

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    sciencedirect.com/science/article/pii/S2211124723006010
  42. Apr 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Cell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells
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      DOI: 10.1016/j.celrep.2023.112401

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    sciencedirect.com/science/article/pii/S2211124723004126
  44. Mar 2023
  45. www.sciencedirect.com www.sciencedirect.com
    m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
    1
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      DOI: 10.1016/j.molcel.2023.02.024

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    sciencedirect.com/science/article/pii/S109727652300151X
  46. Feb 2023
  47. 52.53.155.43 52.53.155.43
    bcd-22-0082-html.html
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      DOI: 10.1158/2643-3230.bcd-22-0082

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  48. Jan 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    1. scibot 19 Jan 2023
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      DOI: 10.1016/j.ccell.2022.12.008

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    sciencedirect.com/science/article/pii/S1535610822005943
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
    1
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      DOI: 10.1016/j.cmet.2022.12.003

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    sciencedirect.com/science/article/pii/S155041312200540X
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    ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
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      DOI: 10.1016/j.celrep.2022.111909

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    sciencedirect.com/science/article/pii/S2211124722018083
  52. Nov 2022
  53. www.sciencedirect.com www.sciencedirect.com
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    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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  56. Sep 2022
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  58. Aug 2022
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  60. May 2022
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  62. Apr 2022
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  65. Mar 2022
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    Neddylation is essential for β-catenin degradation in Wnt signaling pathway
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  67. Feb 2022
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    EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells
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    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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    Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  72. Jan 2022
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    MYC amplifies gene expression through global changes in transcription factor dynamics
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    Impact of intravesical instillation of a novel biological response modifier (P-MAPA) on progress of non-muscle invasive bladder cancer treatment in a rat model
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  75. Dec 2021
  76. www.cell.com www.cell.com
    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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  77. Nov 2021
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    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation
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    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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  81. Oct 2021
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    Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
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  83. Sep 2021
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    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
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  86. Aug 2021
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    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
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      Anti-c-Myc antibody [Y69]

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    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
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    Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
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    Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11
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    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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  101. Jun 2021
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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  103. May 2021
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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  106. Apr 2021
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    Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
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  108. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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  113. Jan 2021
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    HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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  120. Oct 2020
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
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    Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice
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    The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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  159. Nov 2018
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    Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import
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    Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities
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    Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
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    Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
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    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
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    R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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  169. continuumtest--journal.elifesciences.org continuumtest--journal.elifesciences.org
    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc.
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  170. Nov 2017
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    Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response
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    Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
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    Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma
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    Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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      AB_731658

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    In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
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