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Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

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1. scibot 16 Sep 2026
  
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  DOI: 10.1016/j.cell.2016.09.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5039111/
Sep 2026
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Mitochondrial Fis1 tunes Rab7A activity via TBC1D15 modulating STING degradation

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117994
  
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sciencedirect.com/science/article/pii/S2211124726010727
Aug 2026
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Genome-wide mapping reveals increased R-loops in topoisomerase III-beta-deficient human cells

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1. scibot 15 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117168
  
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sciencedirect.com/science/article/pii/S2589004226025460
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UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes

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1. scibot 15 Aug 2026
  
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  DOI: 10.1016/j.immuni.2026.07.018
  
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sciencedirect.com/science/article/pii/S1074761326003171
Jul 2026
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Genome-wide rotational and translational phasing of nucleosomes with human transcription factors

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1. scibot 05 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.019
  
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sciencedirect.com/science/article/pii/S1097276526003904
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Phospholipid flippases ATP8A1 and ATP8A2 regulate GABAA receptor trafficking through distinct mechanisms in hippocampal neurons

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1. scibot 01 Jul 2026
  
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sciencedirect.com/science/article/pii/S258900422602002X
Jun 2026
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Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.05.026
  
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sciencedirect.com/science/article/pii/S1097276526003503
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Neuronal differentiation of neuroblastoma cell lines for neurological disease modeling

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1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116469
  
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sciencedirect.com/science/article/pii/S2589004226018444
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Combined Inhibition of HRAS and MEK Induces Tumor Regression and Restores Myogenic Differentiation in HRAS-Mutant Rhabdomyosarcoma

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-2985
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13176821/
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Proteogenomic detection of tumor-specific somatic mutant proteins in urinary extracellular vesicles for non-invasive monitoring of bladder cancer

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1. scibot 01 May 2026
  
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  DOI: 10.3389/fonc.2026.1808671
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13124499/
Apr 2026
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Proximity-based activation of AURORA A by MPS1 potentiates error correction

1
1. scibot 22 Apr 2026
  
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  DOI: 10.1016/j.cub.2025.03.018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12014372/
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A Novel Mouse Model of Sympathoadrenal Catecholamine Deficiency by Ablation of the Tyrosine Hydroxylase Gene With Slc6a4-Cre

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1. scibot 07 Apr 2026
  
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  DOI: 10.1111/jnc.70427
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70427
Feb 2026
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The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cub.2026.01.006
  
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sciencedirect.com/science/article/pii/S0960982226000060
Jan 2026
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A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration

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1. scibot 05 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.003
  
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sciencedirect.com/science/article/pii/S0092867425013790
Sep 2025
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RAD51 is chromatin enriched and targetable in BRCA1-deficient cells

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.017
  
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sciencedirect.com/science/article/pii/S1097276525007026
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Reelin Increases the Sphingomyelin Content of the Plasma Membrane and Affects the Surface Expression of GPI‐Anchored Proteins in Hippocampal Neurons

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1. scibot 05 Sep 2025
  
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  DOI: 10.1111/jnc.70225
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12406644/
Jul 2025
www.thelancet.com www.thelancet.com

GWAS meta-analysis identifies five susceptibility loci for endometrial cancer

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ebiom.2025.105830
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00274-9/abstract
52.53.155.43 52.53.155.43

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html

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1. scibot 08 Jul 2025
  
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  RRID:AB_772193
  
  DOI: 10.1016/j.isci.2025.113054
  
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52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
Jun 2025
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Enhancement of cigarette smoke extract-induced goblet cell metaplasia and hyperplasia exerted through IL-13 receptor α1 expression

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.toxlet.2025.06.010
  
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sciencedirect.com/science/article/pii/S0378427425001183
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Protocol for using MYOD1-transduced human urine-derived cells as a predictive platform for exon skipping therapy in Duchenne muscular dystrophy

1
1. scibot 13 Jun 2025
  
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  RRID:AB_772193
  
  DOI: 10.1016/j.xpro.2025.103856
  
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sciencedirect.com/science/article/pii/S266616672500262X
Apr 2025
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Reprogramming liver metastasis-associated macrophages toward an anti-tumoral phenotype through enforced miR-342 expression

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115592
  
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sciencedirect.com/science/article/pii/S2211124725003638
Mar 2025
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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115470
  
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sciencedirect.com/science/article/pii/S2211124725002414
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Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover

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1. scibot 20 Mar 2025
  
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  DOI: 10.1038/s44318-025-00366-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914266/
Feb 2025
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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.031
  
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sciencedirect.com/science/article/pii/S109727652500098X
Jan 2025
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Generation and heterozygous repair of human iPSC lines from two individuals with the neurodevelopmental disorder, TRAPPC4 deficiency

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.scr.2024.103640
  
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sciencedirect.com/science/article/pii/S1873506124003386
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO2-Stimulated Breathing

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1. scibot 12 Sep 2024
  
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  DOI: 10.1523/JNEUROSCI.0799-24.2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11376338/
Aug 2024
www.cell.com www.cell.com

Calcineurin is an adaptor required for assembly of the TCR signaling complex

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114568
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00897-0
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Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

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  sheep anti-mouse IgG ECL
  
  DOI: 10.3390/app11010110
  
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mdpi.com/2076-3417/11/1/110/htm
Jul 2024
www.cell.com www.cell.com

PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

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1. scibot 23 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114522
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00851-9
May 2024
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The Neurog2-Tbr2 axis forms a continuous transition to the neurogenic gene expression state in neural stem cells

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.devcel.2024.04.019
  
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sciencedirect.com/science/article/pii/S1534580724002946
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD

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1. scibot 31 Mar 2024
  
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  DOI: 10.1038/s42003-024-06071-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10978903/
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Caldendrin is a repressor of PIEZO2 channels and touch sensation in mice

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1. scibot 13 Mar 2024
  
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  DOI: 10.1523/JNEUROSCI.1402-23.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10919251/
52.53.155.43 52.53.155.43

JNEUROSCI.1402-23.2023.full-html.html

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  DOI: 10.1523/jneurosci.1402-23.2023
  
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52.53.155.43/7f223cea940290f3204f1037d8b12b16a7f6df0f/JNEUROSCI.1402-23.2023.full-html.html
Feb 2024
aacrjournals.org aacrjournals.org

Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

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1. scibot 27 Feb 2024
  
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  RRID:AB_772193
  
  DOI: 10.1158/2326-6066.CIR-23-0440
  
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2. scibot 27 Feb 2024
  
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  RRID:AB_772193
  
  DOI: 10.1158/2326-6066.CIR-23-0440
  
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3. scibot 06 Feb 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-0440
  
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52.53.155.43 52.53.155.43

JNEUROSCI.1402-23.2023.full-html.html

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Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice

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52.53.155.43 52.53.155.43

JNEUROSCI.1402-23.2023.full-html.html

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O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK

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A quantitative model for virus uncoating predicts influenza A infectivity

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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

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Determining the structure of protein-bound ceramides, essential lipids for skin barrier function

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DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

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C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

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Compartmentalization of soluble endocytic proteins in synaptic vesicle clusters by phase separation

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Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21

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A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans

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Mar 2023
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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

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Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement

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Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes

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Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

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JMJD1C-regulated lipid synthesis contributes to the maintenance of MLL-rearranged acute myeloid leukemia

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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

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Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

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RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair

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Untitled document

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An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation

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Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

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Light-Activated ROS Production Induces Synaptic Autophagy

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Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

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Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests

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Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

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Feb 2021
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Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

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MAPS integrates regulation of actin-targeting effector SteC into the virulence control network of Salmonella small RNA PinT

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Cross-compartment signal propagation in the mitotic exit network

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TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner

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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

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Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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BRCA1 Mutational Complementation Induces Synthetic Viability

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DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1

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Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

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Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice

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AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions

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Single amino acid mutations in the S. cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology

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Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

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Illuminating G-Protein-Coupling Selectivity of GPCRs

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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

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Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion

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Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

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A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

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Untitled document

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Untitled document

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Untitled document

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

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Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

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Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

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Elevated (Pro)renin Receptor Expression Contributes to Maintaining Aerobic Metabolism in Growth Hormone Deficiency

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Defective trafficking of Kv2.1 channels in MPTP‐induced nigrostriatal degeneration

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Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX‐2 involvement

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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Derivation of the Duchenne muscular dystrophy patient-derived induced pluripotent stem cell line lacking DMD exons 49 and 50 (CCMi001DMD-A-3, ∆ 49, ∆ 50)

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An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation

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Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

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sciencedirect.com/science/article/pii/S0092867416312363

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