102 Matching Annotations
  1. Feb 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Mouse oocytes sequester aggregated proteins in degradative super-organelles
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    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.031

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    sciencedirect.com/science/article/pii/S0092867424000680
  3. Jan 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.isci.2024.108801

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    sciencedirect.com/science/article/pii/S2589004224000221
  5. Dec 2023
  6. www.sciencedirect.com www.sciencedirect.com
    Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113573

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    sciencedirect.com/science/article/pii/S2211124723015851
  7. www.sciencedirect.com www.sciencedirect.com
    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1016/j.isci.2023.108485

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    sciencedirect.com/science/article/pii/S2589004223025622
  8. Nov 2023
  9. www.sciencedirect.com www.sciencedirect.com
    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113484

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    sciencedirect.com/science/article/pii/S2211124723014961
  10. www.sciencedirect.com www.sciencedirect.com
    Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy
    1
    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.isci.2023.108330

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    sciencedirect.com/science/article/pii/S2589004223024070
  11. Oct 2023
  12. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion
    1
    1. scibot 20 Oct 2023
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      DOI: 10.1111/jnc.15987

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15987
  13. www.cell.com www.cell.com
    Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.isci.2023.108061

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    cell.com/iscience/abstract/S2589-0042(23)02138-7
  14. www.biorxiv.org www.biorxiv.org
    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1101/2023.10.06.560832

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    biorxiv.org/content/10.1101/2023.10.06.560832v1
  15. Sep 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos
    1
    1. scibot 23 Sep 2023
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      DOI: 10.1016/j.xpro.2023.102569

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
  17. www.sciencedirect.com www.sciencedirect.com
    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
    1
    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.omtn.2023.08.024

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    sciencedirect.com/science/article/pii/S2162253123002354
  18. Aug 2023
  19. www.sciencedirect.com www.sciencedirect.com
    The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes
    1
    1. scibot 23 Aug 2023
      RRID:AB_775978

      DOI: 10.1016/j.celrep.2023.113012

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    sciencedirect.com/science/article/pii/S2211124723010239
  20. Jun 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.molcel.2023.06.004

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    sciencedirect.com/science/article/pii/S1097276523004264
  22. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
    1
    1. scibot 29 Jun 2023
      RRID:AB_775978

      DOI: 10.1016/j.isci.2023.107118

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    sciencedirect.com/science/article/pii/S2589004223011951
  23. 52.53.155.43 52.53.155.43
    Apolipoprotein E intersects with amyloid-β within neurons
    2
    1. scibot 24 Jun 2023
      RRID:AB_775978

      DOI: 10.26508/lsa.202201887

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    2. scibot 12 Jun 2023
      RRID:AB_775978

      DOI: 10.26508/lsa.202201887

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    52.53.155.43/d79c74abbe0299455dfcf8568ff6bf527c1e5b68/e202201887.full-html.html
  24. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1158/2159-8290.CD-22-0376

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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  25. www.thelancet.com www.thelancet.com
    Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1016/j.ebiom.2023.104628

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    thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00193-7/abstract
  26. May 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons
    1
    1. scibot 16 May 2023
      RRID:AB_775978

      DOI: 10.1523/JNEUROSCI.1356-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10175236/
  28. www.mdpi.com www.mdpi.com
    Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
    1
    1. scibot 06 May 2023
      AB_775978

      DOI: 10.3390/cells10020413

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    mdpi.com/2073-4409/10/2/413/htm
  29. Mar 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Large neutral amino acid levels tune perinatal neuronal excitability and survival
    1
    1. scibot 30 Mar 2023
      RRID:AB_775978

      DOI: 10.1016/j.cell.2023.02.037

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    sciencedirect.com/science/article/pii/S0092867423002155
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization
    1
    1. scibot 18 Mar 2023
      RRID: AB_775978

      DOI: 10.1016/j.isci.2023.106274

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    ncbi.nlm.nih.gov/pmc/articles/PMC9957656/
  32. www.sciencedirect.com www.sciencedirect.com
    Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis
    1
    1. scibot 08 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112202

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    sciencedirect.com/science/article/pii/S2211124723002139
  33. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation
    1
    1. scibot 04 Mar 2023
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      DOI: 10.1096/fj.202201469R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201469R
  34. Feb 2023
  35. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
    1
    1. scibot 17 Feb 2023
      RRID:AB_775978

      DOI: 10.1158/2159-8290.cd-22-0376

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    52.53.155.43/a051cdc9b66cfe47aeb3f39770c1ce7cd380afb2/cd-22-0376-html.html
  36. www.sciencedirect.com www.sciencedirect.com
    PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.005

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    sciencedirect.com/science/article/pii/S0092867423000053
  37. Jan 2023
  38. www.sciencedirect.com www.sciencedirect.com
    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
    2
    1. scibot 27 Jan 2023
      RRID: AB_775978

      DOI: 10.1016/j.celrep.2023.112037

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    2. scibot 27 Jan 2023
      AB_775978

      DOI: 10.1016/j.celrep.2023.112037

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    sciencedirect.com/science/article/pii/S2211124723000487
  39. www.sciencedirect.com www.sciencedirect.com
    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
    1
    1. scibot 21 Jan 2023
      RRID:AB_775978

      DOI: 10.1016/j.celrep.2023.112002

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    sciencedirect.com/science/article/pii/S221112472300013X
  40. Dec 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Protocol to purify and detect ubiquitinated phospholipids in budding yeast and human cell lines
    1
    1. scibot 18 Dec 2022
      RRID:AB_775978

      DOI: 10.1016/j.xpro.2022.101935

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    sciencedirect.com/science/article/pii/S2666166722008152
  42. Sep 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
    1
    1. scibot 30 Sep 2022
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      DOI: 10.3389/fimmu.2022.931087

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
  44. www.sciencedirect.com www.sciencedirect.com
    Microglial control of neuronal development via somatic purinergic junctions
    1
    1. scibot 21 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111369

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    sciencedirect.com/science/article/pii/S2211124722012013
  45. www.sciencedirect.com www.sciencedirect.com
    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
    1
    1. scibot 16 Sep 2022
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      DOI: 10.1016/j.ccell.2022.08.014

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    sciencedirect.com/science/article/pii/S1535610822003786
  46. www.sciencedirect.com www.sciencedirect.com
    Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance
    1
    1. scibot 11 Sep 2022
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      DOI: 10.1016/j.ccell.2022.08.012

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    sciencedirect.com/science/article/pii/S1535610822003762
  47. Aug 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination of phosphatidylethanolamine in organellar membranes
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    1. scibot 31 Aug 2022
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      DOI: 10.1016/j.molcel.2022.08.008

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    sciencedirect.com/science/article/pii/S1097276522007614
  49. www.sciencedirect.com www.sciencedirect.com
    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
    1
    1. scibot 30 Aug 2022
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      DOI: 10.1016/j.isci.2022.104923

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    sciencedirect.com/science/article/pii/S2589004222011956
  50. Jun 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
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    1. scibot 24 Jun 2022
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      DOI: 10.1016/j.cell.2022.05.017

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    sciencedirect.com/science/article/pii/S0092867422006481
  52. www.sciencedirect.com www.sciencedirect.com
    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
    1
    1. scibot 15 Jun 2022
      RRID:AB_775978

      DOI: 10.1016/j.celrep.2022.110943

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    sciencedirect.com/science/article/pii/S2211124722007252
  53. Apr 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis
    1
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      AB_24170

      DOI: 10.1016/j.omtm.2022.03.011

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    sciencedirect.com/science/article/pii/S2329050122000419
  55. Mar 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
    1
    1. scibot 27 Mar 2022
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      DOI: 10.1016/j.cmet.2022.02.013

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    sciencedirect.com/science/article/pii/S1550413122000857
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    Mitochondrial Dysfunction in Rabies Virus-Infected Human and Canine Brains
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  60. Feb 2022
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    Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes
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    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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    Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C
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  101. Jan 2021
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  103. Nov 2020
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    Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
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  114. academic.oup.com academic.oup.com
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  116. www.cell.com www.cell.com
    Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation
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  117. journals.physiology.org journals.physiology.org
    A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics | American Journal of Physiology-Cell Physiology
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  118. Jan 2020
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    Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity
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    Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles
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  122. www.jneurosci.org www.jneurosci.org
    PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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  126. Nov 2018
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    Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
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    Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway
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  129. Nov 2017
  130. www.jneurosci.org www.jneurosci.org
    Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway
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    Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors
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    Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
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    A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection
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