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Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

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1. scibot 05 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.01.034
  
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sciencedirect.com/science/article/pii/S0092867426001625
Feb 2026
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Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.crmeth.2025.101295
  
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sciencedirect.com/science/article/pii/S2667237525003315
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

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1. scibot 03 Feb 2026
  
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  AB_24170
  
  DOI: 10.1016/j.neuron.2025.10.040
  
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  Curator: @dhovakimyan1
  
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sciencedirect.com:5037/science/article/pii/S0896627325008475
Dec 2025
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Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

1
1. scibot 03 Dec 2025
  
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  DOI: 10.1016/j.neuron.2025.10.040
  
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sciencedirect.com:5037/science/article/pii/S0896627325008475
Nov 2025
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Attenuating α-synuclein pathology in mice with in situ engineered astrocytes

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1. scibot 25 Nov 2025
  
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  DOI: 10.1186/s40035-025-00518-0
  
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link.springer.com/article/10.1186/s40035-025-00518-0
Oct 2025
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

1
1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
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Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival

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1. scibot 09 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116421
  
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sciencedirect.com/science/article/pii/S2211124725011921
Sep 2025
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Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros

1
1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116296
  
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sciencedirect.com/science/article/pii/S2211124725010678
Aug 2025
52.53.155.43 52.53.155.43

2025.08.17.670564v1.full-html.html

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1. scibot 22 Aug 2025
  
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  AB_775978
  
  DOI: 10.1101/2025.08.17.670564
  
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52.53.155.43/5faff91dc4a1d4c7cd6e1fe4e1a4aa5aa8538a5d/2025.08.17.670564v1.full-html.html
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Altered translation elongation contributes to key hallmarks of aging in the killifish brain

1
1. scibot 05 Aug 2025
  
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  DOI: 10.1126/science.adk3079
  
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science.org/doi/10.1126/science.adk3079
52.53.155.43 52.53.155.43

2025.07.29.667421v1.full-html.html

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1. scibot 05 Aug 2025
  
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  RRID:AB_775978
  
  DOI: 10.1101/2025.07.29.667421
  
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52.53.155.43/b596bd38105568fb5cf99ba7e532b5190556003c/2025.07.29.667421v1.full-html.html
Jul 2025
www.cell.com www.cell.com

Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip

1
1. scibot 30 Jul 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.xcrm.2025.102244
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00317-9
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Direct interaction of HMGB1 with SARS-CoV-2 facilitates its infection via RAGE-dependent endocytosis

1
1. scibot 24 Jul 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.isci.2025.113063
  
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sciencedirect.com/science/article/pii/S2589004225013240
Jun 2025
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Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

1
1. scibot 18 Jun 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.str.2025.05.015
  
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sciencedirect.com/science/article/pii/S0969212625001935
elifesciences.org elifesciences.org

Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

1
1. scibot 11 Jun 2025
  
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  Abcam, ab24170
  
  DOI: 10.7554/eLife.103137.2
  
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  Curator: @areedewitt04
  
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elifesciences.org/reviewed-preprints/103137v2
May 2025
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Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease

1
1. scibot 17 May 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.immuni.2025.04.018
  
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sciencedirect.com/science/article/pii/S1074761325001815
Apr 2025
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ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

1
1. scibot 15 Apr 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.cell.2025.03.019
  
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sciencedirect.com/science/article/pii/S0092867425002922
Mar 2025
www.biorxiv.org www.biorxiv.org

Protective ApoE variants support neuronal function by extracting peroxidated lipids

1
1. scibot 14 Mar 2025
  
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  RRID:AB_775978
  
  DOI: 10.1101/2025.03.05.641722
  
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biorxiv.org/content/10.1101/2025.03.05.641722v1
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KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids

1
1. scibot 06 Mar 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.neuron.2025.02.001
  
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sciencedirect.com/science/article/pii/S089662732500114X
Feb 2025
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Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers

1
1. scibot 25 Feb 2025
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.isci.2025.111814
  
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sciencedirect.com/science/article/pii/S2589004225000744
Jan 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Actions of dexmedetomidine in regulating NLRP3 in postoperative cognitive dysfunction in aged mice via the autophagy–lysosome pathway

1
1. scibot 17 Jan 2025
  
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  RRID:AB_775978
  
  DOI: 10.1111/bph.17378
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17378
Dec 2024
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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

1
1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115101
  
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sciencedirect.com/science/article/pii/S2211124724014529
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Human iPSC-derived neural stem cells engraft and improve pathophysiology of MPS I mice

1
1. scibot 18 Dec 2024
  
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  AB_775978
  
  DOI: 10.1016/j.omtm.2024.101367
  
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sciencedirect.com/science/article/pii/S2329050124001839
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

1
1. scibot 11 Dec 2024
  
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  AB_775978
  
  DOI: 10.1371/journal.pone.0314858
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
52.53.155.43 52.53.155.43

TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neurons

1
1. scibot 05 Dec 2024
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.isci.2024.111515
  
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52.53.155.43/a78570202c237c34caff8d9dcc5ffd9013c3700f/1-s2.0-S2589004224027421-main-html.html
Nov 2024
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Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis

1
1. scibot 16 Nov 2024
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.cmet.2024.10.006
  
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sciencedirect.com/science/article/pii/S1550413124004029
Sep 2024
52.53.155.43 52.53.155.43

Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

1
1. scibot 05 Sep 2024
  
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  AB_775978
  
  DOI: 10.1101/2024.07.19.604372
  
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52.53.155.43/094bf1894e7037610818c8319cb16bd0730a5b11/2024.07.19.604372v1.full-html.html
Aug 2024
www.embopress.org www.embopress.org

The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization

1
1. scibot 02 Aug 2024
  
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  ab24170
  
  DOI: 10.15252/embj.2020107158
  
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  RRID:AB_775978 RRIDCUR:Missing
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embopress.org/doi/full/10.15252/embj.2020107158
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Sestrin2 drives ER-phagy in response to protein misfolding

1
1. scibot 02 Aug 2024
  
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  RRID:AB_775978_775978
  
  DOI: 10.1016/j.devcel.2024.07.004
  
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  RRID:AB_775978 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S1534580724004416
Jun 2024
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Interactions between genistein and Wnt pathway in colon adenocarcinoma and early embryos

1
1. scibot 04 Jun 2024
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.heliyon.2024.e32243
  
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sciencedirect.com/science/article/pii/S2405844024082744
May 2024
www.biorxiv.org www.biorxiv.org

Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

1
1. scibot 10 May 2024
  
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  ab24170; Abcam
  
  DOI: 10.1101/2024.01.25.577280
  
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  Curator: @abever99
  
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biorxiv.org/content/10.1101/2024.01.25.577280v1
link.springer.com link.springer.com

Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules

1
1. scibot 09 May 2024
  
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  RRID:AB_775978
  
  DOI: 10.1007/s00018-024-05247-7
  
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link.springer.com/article/10.1007/s00018-024-05247-7
Feb 2024
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Mouse oocytes sequester aggregated proteins in degradative super-organelles

1
1. scibot 21 Feb 2024
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.cell.2024.01.031
  
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sciencedirect.com/science/article/pii/S0092867424000680
Jan 2024
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Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection

1
1. scibot 19 Jan 2024
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.isci.2024.108801
  
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sciencedirect.com/science/article/pii/S2589004224000221
Dec 2023
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Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease

1
1. scibot 17 Dec 2023
  
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  RRID:AB_775978
  
  DOI: 10.1016/j.celrep.2023.113573
  
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  Curator: @scibot
  
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Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

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Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy

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Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion

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Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury

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Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

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Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos

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Base editing corrects the common Salla disease SLC17A5 c.115C>T variant

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The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

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Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

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SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux

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Apolipoprotein E intersects with amyloid-β within neurons

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LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL

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Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease

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Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons

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Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization

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Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis

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Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation

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cd-22-0376-html.html

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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Protocol to purify and detect ubiquitinated phospholipids in budding yeast and human cell lines

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Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

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Microglial control of neuronal development via somatic purinergic junctions

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Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation

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Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis

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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

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Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense

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Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation

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Mitochondrial Dysfunction in Rabies Virus-Infected Human and Canine Brains

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Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes

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ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis inactivated Δ6-fatty acid desaturase deficient mouse

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Use of dual-electron probes reveals the role of ferritin as an iron depot in ex vivo erythropoiesis

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Axon terminals control endolysosome diffusion to support synaptic remodelling

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Untitled document

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Untitled document

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Untitled document

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Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

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Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

1
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  anti-lysosomal-associated membrane protein (LAMP)1
  
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A convenient protocol for establishing a human cell culture model of the outer retina.

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Intrinsically Disordered Protein TEX264 Mediates ER-phagy

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  Rabbit polyclonal anti-LAMP-1
  
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A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

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High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

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LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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EBI2 Is Temporarily Upregulated in MO3.13 Oligodendrocytes during Maturation and Regulates Remyelination in the Organotypic Cerebellar Slice Model

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

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Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection

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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface

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cell.com/current-biology/abstract/S0960-9822(21)00283-9
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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

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Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity

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A common genetic variant in ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics

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  DOI: 10.1152/ajpcell.00383.2019
  
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A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics

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Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

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Astrocytes in stress accumulate lipid droplets

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OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

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β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

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Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

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Synaptotagmin‐7 enhances calcium‐sensing of chromaffin cell granules and slows discharge of granule cargos

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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

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Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction

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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

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Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice

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A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2

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Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

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A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics | American Journal of Physiology-Cell Physiology

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Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

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Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

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Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles

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PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Untitled document

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Untitled document

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Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

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Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

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Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway

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Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

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A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection

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