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Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis

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  DOI: 10.1126/sciadv.aee0517
  
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Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis

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science.org/doi/10.1126/sciadv.aee0517
Jun 2026
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STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy

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A role for CASM in the repair of damaged Golgi architecture

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pmc.ncbi.nlm.nih.gov/articles/PMC13217580/
May 2026
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High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice

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An optimized method to visualize lipid droplets in mouse brain tissue

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sciencedirect.com/science/article/pii/S2667237526001554
Mar 2026
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Human neuromuscular organoids mimic cancer-induced muscle cachexia

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pmc.ncbi.nlm.nih.gov/articles/PMC12946742/
Feb 2026
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Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

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  DOI: 10.1016/j.cell.2025.11.002
  
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sciencedirect.com/science/article/pii/S0092867425012516
Jan 2026
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RNF216 Variants Found in Patients With Dementia, Hypogonadotropic Hypogonadism, and Severe Ataxia Deregulate Autophagy

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  DOI: 10.1210/clinem/dgaf640
  
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Dec 2025
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1-s2.0-S0014488625004583-main-html.html

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BPS Publications

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  DOI: 10.1111/bph.70261
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70261
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Rhythmic patterns in microglial cells within the circadian pineal gland from male rats

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  DOI: 10.1002/ar.70099
  
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anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.70099
Nov 2025
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Identification of ATG7 as a protein ATG8ylation substrate

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  DOI: 10.1016/j.celrep.2025.116485
  
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sciencedirect.com/science/article/pii/S2211124725012562
Oct 2025
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O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries

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sciencedirect.com/science/article/pii/S0009279725004181
Sep 2025
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A role for CASM in the repair of damaged Golgi architecture

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  DOI: 10.1101/2025.09.04.674289
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424704/
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Histone demethylase LSD1 regulates lipid homeostasis during Cryptococcus neoformans infection

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sciencedirect.com/science/article/pii/S2589004225016669
Aug 2025
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dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html

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  DOI: 10.1038/s44318-025-00540-y
  
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52.53.155.43/6e1a51ae3d978e6c74ed455dd826dbf65caf9c68/dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html
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NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy

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pmc.ncbi.nlm.nih.gov/articles/PMC12335005/
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Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

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FEBS Press

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  DOI: 10.1002/1878-0261.70089
  
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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70089
Jul 2025
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Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition

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sciencedirect.com/science/article/pii/S2352396423003754
Jun 2025
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PDF-html.html

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  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
May 2025
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Metabolic and Structural Consequences of GM3 Synthase Deficiency: Insights from an HEK293-T Knockout Model

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  DOI: 10.3390/biomedicines13040843
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12024672/
Apr 2025
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Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis

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  DOI: 10.21203/rs.3.rs-6010379/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957193/
Mar 2025
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Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists

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  DOI: 10.3389/fvets.2025.1512343
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11891193/
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1-s2.0-S2589004225004043-main-html.html

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52.53.155.43/a54d23b2534862197be3e5d5ad98a8cc187610fd/1-s2.0-S2589004225004043-main-html.html
Feb 2025
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Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice

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  DOI: 10.1113/JP287592
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP287592
Jan 2025
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An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11733533/
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Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17

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  DOI: 10.1038/s41467-025-55906-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718230/
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14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity

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  DOI: 10.1016/j.nbd.2025.106801
  
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sciencedirect.com/science/article/pii/S0969996125000178
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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator

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  DOI: 10.1016/j.chembiol.2024.12.002
  
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sciencedirect.com/science/article/pii/S2451945624004914
Dec 2024
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

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  DOI: 10.1016/j.celrep.2024.115094
  
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TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neurons

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  DOI: 10.1016/j.isci.2024.111515
  
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52.53.155.43/a78570202c237c34caff8d9dcc5ffd9013c3700f/1-s2.0-S2589004224027421-main-html.html
Nov 2024
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Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

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1. scibot 26 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11570319/
Aug 2024
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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

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  DOI: 10.1080/15548627.2021.1938912
  
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tandfonline.com/doi/full/10.1080/15548627.2021.1938912
Jul 2024
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Lipid-associated macrophages reshape BAT cell identity in obesity

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May 2024
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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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Autophagy preferentially degrades non-fibrillar polyQ aggregates

1
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Apr 2024
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Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis

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The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan

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Mar 2024
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Rab32 family proteins regulate autophagosomal components recycling

2
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Feb 2024
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Sorafenib extends the lifespan of C. elegans through mitochondrial uncoupling mechanism

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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

3
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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

2
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Jan 2024
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Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival

1
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ULK phosphorylation of STX17 controls autophagosome maturation via FLNA

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Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis

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Dec 2023
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Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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Nov 2023
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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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Oct 2023
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Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway

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Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy

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Aug 2023
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Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

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Staphylococcus aureus phagocytosis is affected by senescence

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O-GlcNAcylation of Raptor transduces glucose signals to mTORC1

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Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome

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British J Pharmacology - 2023 - Chen - Anthelmintics nitazoxanide protects against experimental pulmonary fibrosis-html.html

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Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity

1
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ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

1
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Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis

1
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May 2023
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A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy

1
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MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis

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Apr 2023
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Optineurin provides a mitophagy contact site for TBK1 activation

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Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

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Mar 2023
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Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells

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Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes

1
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Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease

1
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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

1
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Feb 2023
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The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis

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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways

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The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

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Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

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Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication

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The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

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Autophagy activation attenuates the circadian clock oscillators in U2OS cells via the ATG5 pathway

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Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms

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Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy

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Acetylation of p62 regulates base excision repair through interaction with APE1

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Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

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Recycling of autophagosomal components from autolysosomes by the recycler complex

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Mar 2022
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Poly (ADP-ribose) polymerase 1-mediated defective mitophagy contributes to painful diabetic neuropathy in the db/db model

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Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy

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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

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The endoplasmic reticulum stress-mediated unfolded protein response protects against infection of goat endometrial epithelial cells by Trueperella pyogenes via autophagy

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

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Research Paper - By Targeting Atg7 MicroRNA-143 Mediates Oxidative Stress-Induced Autophagy of c-Kit+ Mouse Cardiac Progenitor Cells

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Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

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Delivering progranulin to neuronal lysosomes protects against excitotoxicity

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Neuronal VCP loss of function recapitulates FTLD-TDP pathology

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

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Mammalian cells use the autophagy process to restrict avian influenza virus replication

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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

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FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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BPS Publications

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SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12

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Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth

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Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

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TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

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Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling

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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules

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Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

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Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

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Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma

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Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

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Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

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Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

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Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy

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LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway

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Untitled document

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Untitled document

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Light-Activated ROS Production Induces Synaptic Autophagy

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Untitled document

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ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

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Untitled document

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Untitled document

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Complement Component C3 Is Highly Expressed in Human Pancreatic Islets and Prevents β Cell Death via ATG16L1 Interaction and Autophagy Regulation

1
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Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury

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Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

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ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules

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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC5957528/
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Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_796155
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_796155
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RRID:AB_796155

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sciencedirect.com/science/article/pii/S2451945618301247
www.sciencedirect.com www.sciencedirect.com

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_796155
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_796155
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RRID:AB_796155

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sciencedirect.com/science/article/pii/S0896627317309054
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Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_796155
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_796155
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URL

sciencedirect.com/science/article/pii/S153458071730953X
Nov 2017
www.sciencedirect.com www.sciencedirect.com

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_796155
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_796155 RRIDCUR:Validated
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RRID:AB_796155

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1534580717304598
www.sciencedirect.com www.sciencedirect.com

Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_796155
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_796155 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S1931312817302457
www.sciencedirect.com www.sciencedirect.com

Bassoon Controls Presynaptic Autophagy through Atg5

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_796155
  
  Curator: @kaitlinsung
  
  Resource used:
  
  (Sigma-Aldrich Cat# L7543, RRID:AB_796155)
  
  SciCrunch record: RRID:AB_796155
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_796155 RRIDCUR:Validated
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RRID:AB_796155

RRIDCUR:Validated

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URL

sciencedirect.com/science/article/pii/S0896627317300508

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