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Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117520
  
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sciencedirect.com/science/article/pii/S221112472600598X
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Chronic stress antagonizes formation of stress granules

1
1. scibot 28 Jan 2026
  
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  DOI: 10.1016/j.isci.2025.114556
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12828549/
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Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102531
  
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sciencedirect.com/science/article/pii/S2666379125006044
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Nov 2025
  
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  RRID:AB_823488
  
  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
Aug 2025
www.biorxiv.org www.biorxiv.org

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
Jun 2024
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

1
1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cmet.2024.05.015
  
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sciencedirect.com/science/article/pii/S1550413124001918
Apr 2024
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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114134
  
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sciencedirect.com/science/article/pii/S2211124724004625
Mar 2024
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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

2
1. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113935
  
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2. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113935
  
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sciencedirect.com/science/article/pii/S2211124724002638
Feb 2024
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Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

1
1. scibot 27 Feb 2024
  
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  Cell Signaling Technology#9742
  
  DOI: 10.1016/j.isci.2024.109121
  
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sciencedirect.com/science/article/pii/S2589004224003420
Jan 2024
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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

1
1. scibot 19 Jan 2024
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.isci.2024.108808
  
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sciencedirect.com/science/article/pii/S2589004224000294
Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

1
1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112868
  
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sciencedirect.com/science/article/pii/S2211124723008793
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

1
1. scibot 04 Jul 2023
  
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  RRID:AB_823488
  
  DOI: 10.1101/2023.06.03.543579
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
May 2023
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eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance

1
1. scibot 13 May 2023
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.isci.2023.106649
  
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sciencedirect.com/science/article/pii/S2589004223007265
Feb 2023
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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

1
1. scibot 11 Feb 2023
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.isci.2023.105965
  
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sciencedirect.com/science/article/pii/S2589004223000421
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model

1
1. scibot 11 Mar 2022
  
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  RRID:AB_823488
  
  DOI: 10.1152/ajpendo.00236.2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
Jul 2021
www.nature.com www.nature.com

Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

1
1. scibot 30 Jul 2021
  
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  total eIF4E
  
  DOI: 10.1038/s41386-019-0537-y
  
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  RRID:AB_823488 RRIDCUR:Missing
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nature.com/articles/s41386-019-0537-y
onlinelibrary.wiley.com onlinelibrary.wiley.com

Akt3-mTOR regulates hippocampal neurogenesis in adult mouse

1
1. scibot 29 Jul 2021
  
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  RRID:AB_823488
  
  DOI: 10.1111/jnc.15441
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15441
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Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

1
1. scibot 27 Jul 2021
  
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  RRID:AB_330955
  
  DOI: 10.1016/j.cell.2018.03.008
  
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  RRID:AB_823488 RRIDCUR:Unresolved RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S0092867418302885
www.cell.com www.cell.com

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

1
1. scibot 03 Jul 2021
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.molcel.2021.06.014
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
Apr 2021
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Coordinate regulation of the senescent state by selective autophagy

1
1. scibot 29 Apr 2021
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.devcel.2021.04.008
  
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sciencedirect.com/science/article/pii/S1534580721003178
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

1
1. scibot 11 Apr 2021
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.molcel.2021.01.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8384339/
Nov 2020
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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

1
1. scibot 24 Nov 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.xcrm.2020.100131
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2666379120301737
Sep 2020
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The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation

1
1. scibot 26 Sep 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.molcel.2019.12.024
  
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  RRIDCUR:Validated RRID:AB_823488
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sciencedirect.com/science/article/pii/S1097276519309542
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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

1
1. scibot 23 Sep 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.stem.2019.12.006
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1934590919305247
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

1
1. scibot 23 Sep 2020
  
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  RRID:AB_823488
  
  DOI: 10.1096/fj.201902305R
  
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  RRID:AB_823488 RRIDCUR:Validated
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

1
1. scibot 06 Sep 2020
  
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  AB_823488
  
  DOI: 10.1016/j.celrep.2020.107571
  
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sciencedirect.com/science/article/pii/S2211124720305209
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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

1
1. scibot 03 Sep 2020
  
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  eIF4E
  
  DOI: 10.1016/j.celrep.2020.02.002
  
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sciencedirect.com/science/article/pii/S221112472030156X
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Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions

1
1. scibot 03 Sep 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.molcel.2020.01.006
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S109727652030006X
Jan 2020
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HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.celrep.2019.09.023
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719312008
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Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.molcel.2019.07.030
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519305854
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_823488
  
  DOI: 10.1016/j.chembiol.2019.03.012
  
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sciencedirect.com/science/article/pii/S2451945619301084
Nov 2018
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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

1
1. scibot 05 Nov 2018
  
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  RRID:AB_823488
  
  Curator: @Jmenke
  
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  RRID:AB_823488 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518306051
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Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

1
1. scibot 05 Nov 2018
  
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  RRID:AB_823488
  
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sciencedirect.com/science/article/pii/S0092867417315180
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Systematic Functional Annotation of Somatic Mutations in Cancer

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1. scibot 05 Nov 2018
  
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  RRID:AB_823488
  
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  (Cell Signaling Technology Cat# 9742, RRID:AB_823488)
  
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sciencedirect.com/science/article/pii/S1535610818300217
Nov 2017
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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

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1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S153561081730363X
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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  RRID:AB_823488
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_823488
  
  Resource used:
  
  (Cell Signaling Technology Cat# 9742, RRID:AB_823488)
  
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sciencedirect.com/science/article/pii/S2405471216304082