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BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes

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  DOI: 10.1016/j.molcel.2026.01.012
  
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sciencedirect.com/science/article/pii/S1097276526000328
Feb 2026
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Triglycerides induce endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116976
  
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sciencedirect.com/science/article/pii/S2211124726000549
Jan 2026
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Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

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1. scibot 23 Jan 2026
  
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  DOI: 10.1172/JCI187341
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12807472/
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IRE1 signaling in osteoprogenitors augments β-catenin activity and physiologic bone accrual

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1. scibot 23 Jan 2026
  
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  DOI: 10.1093/jbmr/zjag001
  
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54.241.53.176/8609f087e24f454e84a0b566240b0a325314ae9e/zjag001-html.html
Dec 2025
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FEBS Press

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1. scibot 16 Dec 2025
  
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  DOI: 10.1111/febs.70365
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70365
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circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116659
  
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sciencedirect.com:5037/science/article/pii/S2211124725014317
Nov 2025
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Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality

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1. scibot 19 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113770
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12616019/
Aug 2025
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Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.023
  
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sciencedirect.com/science/article/pii/S1074761325003322
Jul 2025
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1-s2.0-S2589004225013823-main-html.html

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113121
  
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52.53.155.43/400079ec7a4701049bea5a65a822f5cc79d84f7b/1-s2.0-S2589004225013823-main-html.html
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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sciencedirect.com/science/article/pii/S0092867425007287
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RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation

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1. scibot 12 Jul 2025
  
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  DOI: 10.1101/2025.06.20.660705
  
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biorxiv.org/content/10.1101/2025.06.20.660705v1
Jun 2025
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Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.jpet.2025.103634
  
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sciencedirect.com/science/article/pii/S0022356525398472
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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.isci.2022.104050
  
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sciencedirect.com/science/article/pii/S2589004222003200
May 2025
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Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway

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1. scibot 29 May 2025
  
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  DOI: 10.1111/imm.13949
  
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onlinelibrary.wiley.com/doi/10.1111/imm.13949
www.cell.com www.cell.com

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115694
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00465-6
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Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115632
  
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sciencedirect.com/science/article/pii/S2211124725004036
Mar 2025
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Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

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1. scibot 28 Mar 2025
  
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  DOI: 10.1371/journal.pone.0320157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11940610/
Feb 2025
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

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1. scibot 08 Feb 2025
  
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  DOI: 10.7554/eLife.96798
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11785375/
Jan 2025
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
Sep 2024
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PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders

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1. scibot 25 Sep 2024
  
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  AB_823545
  
  DOI: 10.1016/j.cmet.2024.08.009
  
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sciencedirect.com/science/article/pii/S1550413124003619
Aug 2024
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E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress

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1. scibot 02 Aug 2024
  
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  DOI: 10.1111/jnc.15567
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.15567
cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com

Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

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1. scibot 02 Aug 2024
  
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  DOI: 10.1186/s13578-021-00640-2
  
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cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
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Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent Mice

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1. scibot 02 Aug 2024
  
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  IRE-1α
  
  DOI: 10.3390/cells10050996
  
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mdpi.com/2073-4409/10/5/996
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Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress | Molecular Biology of the Cell

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1. scibot 02 Aug 2024
  
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  DOI: 10.1091/mbc.E17-10-0594
  
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molbiolcell.org/doi/abs/10.1091/mbc.E17-10-0594
Jul 2024
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c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD

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1. scibot 19 Jul 2024
  
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  DOI: 10.1523/JNEUROSCI.1799-22.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10146492/
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BPS Publications

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1. scibot 12 Jul 2024
  
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  DOI: 10.1111/bph.16485
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16485
Jun 2024
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The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110196
  
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BPS Publications

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  DOI: 10.1111/bph.16436
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16436
May 2024
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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  DOI: 10.1016/j.cmet.2024.04.014
  
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sciencedirect.com/science/article/pii/S1550413124001347
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114149
  
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sciencedirect.com/science/article/pii/S2211124724004777
Mar 2024
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A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages

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1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113981
  
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  DOI: 10.1016/j.celrep.2024.113981
  
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sciencedirect.com/science/article/pii/S2211124724003097
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Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

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1. scibot 01 Mar 2024
  
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  AB_82354594
  
  DOI: 10.1016/j.isci.2024.109100
  
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52.53.155.43/d3d22b34dc913e3c2adad8dc51a7839208721c99/PIIS2589004224003213-html.html
Feb 2024
52.53.155.43 52.53.155.43

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

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1. scibot 22 Feb 2024
  
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  RRID:AB_82
  
  DOI: 10.1101/2023.10.02.560521
  
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52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
Dec 2023
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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

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  DOI: 10.1016/j.molmet.2023.101851
  
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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Oct 2023
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EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway

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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2

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Jun 2023
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ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

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May 2023
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Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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Mar 2023
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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

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Feb 2023
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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

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Jan 2023
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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation

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The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria

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Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells

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Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma

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BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

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Nov 2022
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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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ABCC10-mediated Oxaliplatin resistance in colorectal cancer cells was alleviated by intense endoplasmic reticulum stress (ERS) / IRE1α

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Sep 2022
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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

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Aug 2022
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

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Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity

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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells

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Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway

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BPS Publications

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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15744
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The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

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  DOI: 10.7554/eLife.73215
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8635982/
Nov 2021
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TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells

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academic.oup.com/endo/article/163/1/bqab212/6382455
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Differential ER Stress as a Driver of Cell Fate following Ricin Toxin Exposure

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faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2021-00005
Oct 2021
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Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2

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Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival

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Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity

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Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma

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Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

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Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

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Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus

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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

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Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

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A role for the ribosome-associated complex in activation of the IRE1 branch of UPR

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Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

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Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

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Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance

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TNFα selectively activates the IRE1α/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells

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TNFα Selectively Activates the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Airway Smooth Muscle Cells | American Journal of Physiology-Lung Cellular and Molecular Physiology

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A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress

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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

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Quantitative microscopy reveals dynamics and fate of clustered IRE1α

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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TNFα selectively activates the IRE1α/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells | American Journal of Physiology-Lung Cellular and Molecular Physiology

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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

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Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

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Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

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Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress

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Acute Deletion of METTL14 in β-cells of adult mice results in glucose intolerance

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Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

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Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

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  AB_823545
  
  DOI: 10.1016/j.cellsig.2016.08.012
  
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  DOI: 10.1016/j.cell.2019.04.010
  
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Untitled document

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  DOI: 10.7554/eLife.44161
  
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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  DOI: 10.1016/j.ccell.2019.01.006
  
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Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation

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  DOI: 10.1016/j.celrep.2019.03.017
  
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  DOI: 10.1016/j.cell.2018.12.012
  
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Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures

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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

1
1. scibot 08 Nov 2017
  
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The Sec61 translocon limits IRE1α signaling during the unfolded protein response

1
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Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes

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1. scibot 08 Nov 2017
  
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