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  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
    1
    1. scibot 30 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11055870/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
    1
    1. scibot 30 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052719/
  4. Apr 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
    1
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  6. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    nature.com/articles/s41419-024-06534-8
  7. Feb 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
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      DOI: 10.1093/brain/awad388

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834249/
  9. Dec 2023
  10. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
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    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  12. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration
    2
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    onlinelibrary.wiley.com/doi/10.1111/ejn.16196
  13. Oct 2023
  14. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    sciencedirect.com/science/article/pii/S2211124723012561
  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15967
  16. www.cell.com www.cell.com
    Impaired pre-synaptic plasticity and visual responses in Auxilin knockout mice
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    cell.com/iscience/abstract/S2589-0042(23)01919-3
  17. www.cell.com www.cell.com
    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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    cell.com/cell-reports/abstract/S2211-1247(23)01082-3
  18. Aug 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
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  20. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
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  22. Jul 2023
  23. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
    1
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      DOI: 10.1101/2023.06.05.543428

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  24. Jun 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  26. Mar 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
    1
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    sciencedirect.com/science/article/pii/S2211124723002425
  28. Jan 2023
  29. www.jneurosci.org www.jneurosci.org
    Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions
    1
    1. scibot 19 Jan 2023
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      DOI: 10.1523/JNEUROSCI.0680-22.2022

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  30. Nov 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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      DOI: 10.1016/j.crmeth.2022.100338

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    sciencedirect.com/science/article/pii/S2667237522002351
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy
    1
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      DOI: 10.1111/bpa.13131

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    onlinelibrary.wiley.com/doi/10.1111/bpa.13131
  33. www.sciencedirect.com www.sciencedirect.com
    Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics
    1
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    sciencedirect.com/science/article/pii/S2211124722015029
  34. journals.lww.com journals.lww.com
    Neuroprotective effects of insulin-like growth factor-2 in... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.355815

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    journals.lww.com/nrronline/Fulltext/2023/05000/Neuroprotective_effects_of_insulin_like_growth.29.aspx
  35. Sep 2022
  36. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    1. scibot 20 Sep 2022
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      DOI: 10.1007/s00401-022-02491-8

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    link.springer.com/article/10.1007/s00401-022-02491-8
  37. Jun 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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      DOI: 10.1016/j.cell.2022.05.021

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    sciencedirect.com/science/article/pii/S0092867422006523
  39. www.sciencedirect.com www.sciencedirect.com
    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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      DOI: 10.1016/j.neuron.2022.05.009

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    sciencedirect.com/science/article/pii/S0896627322004500
  40. May 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
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    1. scibot 27 May 2022
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      DOI: 10.1016/j.ebiom.2022.104076

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    sciencedirect.com/science/article/pii/S2352396422002572
  42. Mar 2022
  43. link.springer.com link.springer.com
    Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
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    link.springer.com/article/10.1186/s40478-022-01342-7
  44. Feb 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
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      DOI: 10.1016/j.neuropharm.2022.108977

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    sciencedirect.com/science/article/pii/S0028390822000363
  46. Dec 2021
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease
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      DOI: 10.4103/1673-5374.327353

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    ncbi.nlm.nih.gov/pmc/articles/PMC8643066/
  48. Sep 2021
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy
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      DOI: 10.1111/jcmm.16910

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    onlinelibrary.wiley.com/doi/10.1111/jcmm.16910
  50. Aug 2021
  51. www.physiology.org www.physiology.org
    Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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      DOI: 10.1152/ajpgi.00076.2019

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    physiology.org/doi/abs/10.1152/ajpgi.00076.2019
  52. link.springer.com link.springer.com
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    link.springer.com/article/10.1186/s40478-019-0679-5
  53. Jul 2021
  54. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0679-5
  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
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      DOI: 10.1002/cne.24468

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24468
  56. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
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    1. scibot 23 Jul 2021
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      DOI: 10.1002/jnr.24927

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24927
  57. www.sciencedirect.com www.sciencedirect.com
    Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
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      DOI: 10.1016/j.celrep.2021.109333

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    sciencedirect.com/science/article/pii/S2211124721007099
  58. Jun 2021
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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      DOI: 10.1523/ENEURO.0458-20.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8213444/
  60. May 2021
  61. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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      DOI: 10.1016/j.celrep.2021.109099

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    sciencedirect.com/science/article/pii/S2211124721004332
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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      DOI: 10.1038/s41467-021-22108-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  63. Apr 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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      DOI: 10.1016/j.brainres.2021.147383

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    sciencedirect.com/science/article/pii/S0006899321001086
  65. Mar 2021
  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease
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      DOI: 10.1111/jnc.15257

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15257
  67. Feb 2021
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain-Gut Interactions: Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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      DOI: 10.1152/ajpgi.00076.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6689734/
  69. Nov 2020
  70. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
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      DOI: 10.1111/jnc.15174

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15174
  71. Oct 2020
  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
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      DOI: 10.1111/jnc.15199

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  73. Sep 2020
  74. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
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      DOI: 10.1111/jnc.15107

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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
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      DOI: 10.1523/ENEURO.0453-18.2019

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  76. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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      DOI: 10.1523/JNEUROSCI.1076-19.2019

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  77. Jan 2020
  78. link.springer.com link.springer.com
    Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
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      DOI: 10.1186/s40478-019-0836-x

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  79. www.frontiersin.org www.frontiersin.org
    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
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      DOI: 10.3389/fncel.2019.00399

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  80. www.sciencedirect.com www.sciencedirect.com
    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
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      DOI: 10.1016/j.neuron.2019.12.004

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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.7554/eLife.42746

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    ncbi.nlm.nih.gov/pmc/articles/PMC6402832/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1186/s40478-019-0679-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
  83. Nov 2017
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    “Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14139/full
  85. link.springer.com link.springer.com
    Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
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      AB_869973

      Curator: @chewbeccax

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    link.springer.com/article/10.1007/s12035-017-0624-1