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  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
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      DOI: 10.1016/j.nbd.2024.106595

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    sciencedirect.com/science/article/pii/S0969996124001955
  3. Jun 2024
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    1. scibot 06 Jun 2024
      Figure S3Figure S3. List of the antibodies used in this study (related to Figures 1 to 9)A. Antibodies used for the detection of total aSyn.B. Antibodies used for the detection of α-syn phosphorylated at residue S129.C. Other antibodies used in the study.

      DOI: 10.1101/2022.03.30.486322

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    Alpha-synuclein aggregates are phosphatase resistant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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    ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
  7. May 2024
  8. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
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    biorxiv.org/content/10.1101/2024.05.24.595642v1
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11109094/
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    Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
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    biorxiv.org/content/10.1101/2024.05.09.593334v1
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    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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      ab51253; Abcam

      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  12. www.biorxiv.org www.biorxiv.org
    Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson’s Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
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  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030248/
  14. Apr 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11055870/
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    Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052719/
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    Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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  19. Feb 2024
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    Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10834249/
  21. Dec 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
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    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration
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    onlinelibrary.wiley.com/doi/10.1111/ejn.16196
  25. Oct 2023
  26. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    sciencedirect.com/science/article/pii/S2211124723012561
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15967
  28. www.cell.com www.cell.com
    Impaired pre-synaptic plasticity and visual responses in Auxilin knockout mice
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    cell.com/iscience/abstract/S2589-0042(23)01919-3
  29. www.cell.com www.cell.com
    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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    cell.com/cell-reports/abstract/S2211-1247(23)01082-3
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10462645/
  32. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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      DOI: 10.1016/j.brainres.2021.147383

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    sciencedirect.com/science/article/pii/S0006899321001086
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
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  34. Jul 2023
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    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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  36. Jun 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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    sciencedirect.com/science/article/pii/S1934590923002114
  38. Mar 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2211124723002425
  40. Jan 2023
  41. www.jneurosci.org www.jneurosci.org
    Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions
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      DOI: 10.1523/JNEUROSCI.0680-22.2022

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  42. Nov 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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    sciencedirect.com/science/article/pii/S2667237522002351
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy
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    onlinelibrary.wiley.com/doi/10.1111/bpa.13131
  45. www.sciencedirect.com www.sciencedirect.com
    Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics
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    sciencedirect.com/science/article/pii/S2211124722015029
  46. journals.lww.com journals.lww.com
    Neuroprotective effects of insulin-like growth factor-2 in... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.355815

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    journals.lww.com/nrronline/Fulltext/2023/05000/Neuroprotective_effects_of_insulin_like_growth.29.aspx
  47. Sep 2022
  48. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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      DOI: 10.1007/s00401-022-02491-8

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    link.springer.com/article/10.1007/s00401-022-02491-8
  49. Jun 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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      DOI: 10.1016/j.cell.2022.05.021

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    sciencedirect.com/science/article/pii/S0092867422006523
  51. www.sciencedirect.com www.sciencedirect.com
    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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      DOI: 10.1016/j.neuron.2022.05.009

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    sciencedirect.com/science/article/pii/S0896627322004500
  52. May 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
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      DOI: 10.1016/j.ebiom.2022.104076

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    sciencedirect.com/science/article/pii/S2352396422002572
  54. Mar 2022
  55. link.springer.com link.springer.com
    Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
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  56. Feb 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
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  58. Dec 2021
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease
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  60. Sep 2021
  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy
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  62. Aug 2021
  63. www.physiology.org www.physiology.org
    Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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  64. link.springer.com link.springer.com
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  65. Jul 2021
  66. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
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  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
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  69. www.sciencedirect.com www.sciencedirect.com
    Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
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  70. Jun 2021
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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  72. May 2021
  73. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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  75. Apr 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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      DOI: 10.1016/j.brainres.2021.147383

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  77. Mar 2021
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease
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      DOI: 10.1111/jnc.15257

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  79. Feb 2021
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain-Gut Interactions: Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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      DOI: 10.1152/ajpgi.00076.2019

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  81. Nov 2020
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
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      DOI: 10.1111/jnc.15174

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  83. Oct 2020
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
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      DOI: 10.1111/jnc.15199

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  85. Sep 2020
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
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      DOI: 10.1111/jnc.15107

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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
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      DOI: 10.1523/ENEURO.0453-18.2019

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  88. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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      DOI: 10.1523/JNEUROSCI.1076-19.2019

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  89. Jan 2020
  90. link.springer.com link.springer.com
    Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
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      DOI: 10.1186/s40478-019-0836-x

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  91. www.frontiersin.org www.frontiersin.org
    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
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      RRID:AB_869973

      DOI: 10.3389/fncel.2019.00399

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    frontiersin.org/article/10.3389/fncel.2019.00399/full
  92. www.sciencedirect.com www.sciencedirect.com
    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
    1
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      DOI: 10.1016/j.neuron.2019.12.004

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    sciencedirect.com/science/article/pii/S0896627319310463
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_869973

      DOI: 10.7554/eLife.42746

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    ncbi.nlm.nih.gov/pmc/articles/PMC6402832/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  95. Nov 2017
  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
    “Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
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  97. link.springer.com link.springer.com
    Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
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