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152 Matching Annotations

Oct 2025
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TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson’s disease models

1
1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.neuint.2025.106068
  
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sciencedirect.com/science/article/pii/S019701862500141X
Sep 2025
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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy

1
1. scibot 13 Sep 2025
  
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  DOI: 10.1016/j.neuron.2025.08.018
  
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sciencedirect.com/science/article/pii/S0896627325006245
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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.022
  
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sciencedirect.com/science/article/pii/S1097276525007075
Aug 2025
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Structural insights into the activation of TMEM175 by small molecule

1
1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.neuron.2025.07.029
  
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sciencedirect.com/science/article/pii/S0896627325005562
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CD11b Activation Reduces Myeloid Brain Infiltration and Mitigates Synucleinopathy in a Model of Parkinson’s Disease

1
1. scibot 19 Aug 2025
  
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  DOI: 10.1101/2025.08.11.669712
  
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biorxiv.org/content/10.1101/2025.08.11.669712v1
Jul 2025
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Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease

1
1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115636
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258067/
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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

1
1. scibot 01 Jul 2025
  
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  ab51253
  
  DOI: 10.1523/ENEURO.0166-21.2021
  
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eneuro.org/content/8/4/ENEURO.0166-21.2021
Jun 2025
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Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization

1
1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112823
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12221657/
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Low-grade chronic inflammatory stimulation alleviates α‑syn accumulation in Parkinson's disease by activating autophagy to promote neuronal survival in the Thy1-h[A30P]α-syn mouse model

1
1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.bbr.2025.115703
  
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sciencedirect.com/science/article/pii/S0166432825002906
52.53.155.43 52.53.155.43

PDF-html.html

2
1. scibot 14 Jun 2025
  
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  RRID:AB_869973
  
  DOI: 10.1093/braincomms/fcaf224
  
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2. scibot 12 Jun 2025
  
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  RRID:AB_869973
  
  DOI: 10.1093/braincomms/fcaf224
  
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52.53.155.43/4a6a966e38c69c020e4968e09e6c8a3a036414fb/fcaf224-html.html
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

1
1. scibot 19 May 2025
  
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  DOI: 10.1038/s41467-025-59441-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046008/
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Microglia-driven inflammation induces progressive tauopathies and synucleinopathies

1
1. scibot 19 May 2025
  
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  RRID:AB_869973
  
  DOI: 10.1038/s12276-025-01450-z
  
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link.springer.com/article/10.1038/s12276-025-01450-z
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SLC7A11 is an unconventional H+ transporter in lysosomes

1
1. scibot 16 May 2025
  
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  RRID:AB_869973
  
  DOI: 10.1016/j.cell.2025.04.004
  
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sciencedirect.com/science/article/pii/S0092867425004064
Apr 2025
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Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits

1
1. scibot 19 Apr 2025
  
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  DOI: 10.1523/ENEURO.0357-24.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998964/
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Early A-synuclein aggregation decreases corticostriatal glutamate drive and synapse density

1
1. scibot 17 Apr 2025
  
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  RRID:AB_869973
  
  DOI: 10.1016/j.nbd.2025.106918
  
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sciencedirect.com/science/article/pii/S0969996125001342
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Fibril fuzzy coat is important for α-synuclein pathological transmission activity

1
1. scibot 11 Apr 2025
  
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  DOI: 10.1016/j.neuron.2025.03.019
  
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sciencedirect.com/science/article/pii/S0896627325002193
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 03 Apr 2025
  
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  RRID:AB_869973
  
  DOI: 10.1523/eneuro.0357-24.2025
  
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52.53.155.43/6343470ab662b00750e766dae62c29226c242386/PDF-html.html
Mar 2025
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Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease

1
1. scibot 25 Mar 2025
  
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  DOI: 10.1186/s40478-025-01958-5
  
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link.springer.com/article/10.1186/s40478-025-01958-5
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Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

1
1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.101999
  
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sciencedirect.com/science/article/pii/S2666379125000722
Feb 2025
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Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils

1
1. scibot 26 Feb 2025
  
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  DOI: 10.1038/s42003-025-07680-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11846974/
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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

1
1. scibot 14 Feb 2025
  
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  RRID:AB_869973
  
  DOI: 10.4103/NRR.NRR-D-23-01348
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11801306/
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Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

1
1. scibot 07 Feb 2025
  
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  RRID: AB_869973
  
  DOI: 10.1101/2024.10.22.619411
  
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biorxiv.org/content/10.1101/2024.10.22.619411v1
academic.oup.com academic.oup.com

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

7
1. scibot 07 Feb 2025
  
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  RRID: AB_869973
  
  DOI: 10.1093/hmg/ddae113
  
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  Curator: @inessasarian
  
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2. scibot 06 Feb 2025
  
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  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
3. scibot 05 Feb 2025
  
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  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
4. scibot 04 Feb 2025
  
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  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
5. scibot 03 Feb 2025
  
  in Public
  
  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
6. scibot 02 Feb 2025
  
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  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
7. scibot 01 Feb 2025
  
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  RRID: AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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academic.oup.com/hmg/article-abstract/33/20/1771/7727363
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies

7
1. scibot 07 Feb 2025
  
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  AB_869973
  
  DOI: 10.21203/rs.3.rs-5649173/v1
  
  Resource: (Abcam Cat# ab51253, RRID:AB_869973)
  
  Curator: @scibot
  
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2. scibot 06 Feb 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
3. scibot 05 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
4. scibot 04 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
5. scibot 03 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
6. scibot 02 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
7. scibot 01 Feb 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11703330/
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Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies

7
1. scibot 07 Feb 2025
  
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  AB_869973
  
  DOI: 10.1101/2024.10.23.619548
  
  Resource: (Abcam Cat# ab51253, RRID:AB_869973)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_869973
  
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  RRID:AB_869973
2. scibot 06 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
3. scibot 05 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
4. scibot 04 Feb 2025
  
  in Public
  
  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
5. scibot 03 Feb 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
6. scibot 02 Feb 2025
  
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awaf051-html.html

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52.53.155.43 52.53.155.43

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation

1
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Jan 2025
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Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

1
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Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies

8
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2. scibot 30 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
3. scibot 29 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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4. scibot 28 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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5. scibot 27 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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6. scibot 26 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
7. scibot 25 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies

16
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  RRID:AB_869973
2. scibot 30 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
3. scibot 29 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
4. scibot 28 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
5. scibot 27 Jan 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
6. scibot 26 Jan 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
7. scibot 25 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
8. scibot 24 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
9. scibot 23 Jan 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
10. scibot 22 Jan 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
11. scibot 21 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
13. scibot 19 Jan 2025
  
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  AB_869973
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
14. scibot 18 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
15. scibot 17 Jan 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_869973
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease

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Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation

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14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity

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G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis

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Protocol for generation of PD-modeling-induced neurons and detection of α-synuclein forms

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Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model

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Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein

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Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy

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Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features

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CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism

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Neuromodulation modifies α-synuclein spreading dynamics in vivo and the pattern is predicted by changes in whole-brain function

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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

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Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala

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  Figure S3Figure S3. List of the antibodies used in this study (related to Figures 1 to 9)A. Antibodies used for the detection of total aSyn.B. Antibodies used for the detection of α-syn phosphorylated at residue S129.C. Other antibodies used in the study.
  
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Alpha-synuclein aggregates are phosphatase resistant

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Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

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Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study

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Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy

2
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Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

1
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Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

1
1. scibot 10 May 2024
  
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Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson’s Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder

1
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Alpha-synuclein aggregates are phosphatase resistant

1
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Apr 2024
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In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression

1
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Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex

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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

1
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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

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Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease

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Dec 2023
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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

1
1. scibot 22 Dec 2023
  
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NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62

1
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Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration

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α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity

1
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Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms

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Impaired pre-synaptic plasticity and visual responses in Auxilin knockout mice

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cell.com/iscience/abstract/S2589-0042(23)01919-3
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Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

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cell.com/cell-reports/abstract/S2211-1247(23)01082-3
Aug 2023
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α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies

1
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Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice

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Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins

1
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Jul 2023
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NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

1
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Jun 2023
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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease

1
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Jan 2023
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Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions

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Nov 2022
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Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier

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Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy

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Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics

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Neuroprotective effects of insulin-like growth factor-2 in... : Neural Regeneration Research

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journals.lww.com/nrronline/Fulltext/2023/05000/Neuroprotective_effects_of_insulin_like_growth.29.aspx
Sep 2022
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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

1
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  DOI: 10.1007/s00401-022-02491-8
  
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Jun 2022
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Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

1
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  DOI: 10.1016/j.cell.2022.05.021
  
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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

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  DOI: 10.1016/j.neuron.2022.05.009
  
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May 2022
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Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes

1
1. scibot 27 May 2022
  
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  DOI: 10.1016/j.ebiom.2022.104076
  
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Mar 2022
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Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies

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Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation

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Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease

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Sep 2021
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Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy

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Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism

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Untitled document

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Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies

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Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model

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Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

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Templated α-synuclein inclusion formation is independent of endogenous tau

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May 2021
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α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology

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In situ architecture of neuronal α-Synuclein inclusions

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Apr 2021
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Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice

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Mar 2021
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α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease

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Brain-Gut Interactions: Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism

1
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ncbi.nlm.nih.gov/pmc/articles/PMC6689734/
Nov 2020
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Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

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  DOI: 10.1111/jnc.15174
  
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Oct 2020
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Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain

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onlinelibrary.wiley.com/doi/10.1111/jnc.15199
Sep 2020
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H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity

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Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications

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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

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Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

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Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

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Untitled document

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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
Nov 2017
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“Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum

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Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC

1
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