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Vitamin D3 Prevents Epileptic Seizures by Modulating the Ras Signalling Pathway via Gnb1 and Casr in Acute Epilepsy Mouse Models

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1. scibot 15 May 2026
  
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  DOI: 10.1016/j.eplepsyres.2026.107820
  
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sciencedirect.com/science/article/pii/S0920121126000902
May 2026
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Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117338
  
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sciencedirect.com/science/article/pii/S221112472600416X
Apr 2026
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IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes

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1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.005
  
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sciencedirect.com/science/article/pii/S2451945626000759
Mar 2026
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Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.001
  
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sciencedirect.com/science/article/pii/S2451945626000711
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers

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1. scibot 18 Mar 2026
  
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  DOI: 10.1126/scisignal.adx5186
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors

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1. scibot 24 Feb 2026
  
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  DOI: 10.1126/sciadv.aea2511
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12922744/
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KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors

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1. scibot 24 Feb 2026
  
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  DOI: 10.1126/sciadv.aea2511
  
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science.org/doi/10.1126/sciadv.aea2511
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RAS mutation–specific responses to paralog- and state-selective RAS inhibitors

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1. scibot 20 Dec 2025
  
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  DOI: 10.1158/1541-7786.MCR-25-0319
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
Nov 2025
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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116588
  
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sciencedirect.com/science/article/pii/S2211124725013609
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
Jun 2025
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115774
  
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sciencedirect.com/science/article/pii/S2211124725005455
Apr 2025
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RAF1 kinase contributes to autophagic lysosome reformation

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115490
  
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sciencedirect.com/science/article/pii/S221112472500261X
Feb 2025
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SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.canlet.2025.217586
  
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sciencedirect.com/science/article/pii/S0304383525001508
Mar 2024
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A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice

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1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.019
  
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sciencedirect.com/science/article/pii/S1097276524001382
Jul 2023
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112794
  
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sciencedirect.com/science/article/pii/S2211124723008057
Jun 2023
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HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

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1. scibot 16 Jun 2023
  
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  DOI: 10.1126/sciadv.ade1155
  
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2. scibot 12 Jun 2023
  
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  RRID:AB_878040
  
  DOI: 10.1126/sciadv.ade1155
  
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  RRID:AB_878040 RRIDCUR:Validated
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science.org/doi/10.1126/sciadv.ade1155
dx.doi.org dx.doi.org

LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL

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1. scibot 08 Jun 2023
  
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  RRID:AB_878040
  
  DOI: 10.1158/2159-8290.CD-22-0376
  
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dx.doi.org/10.1158/2159-8290.CD-22-0376
Feb 2023
52.53.155.43 52.53.155.43

cd-22-0376-html.html

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1. scibot 17 Feb 2023
  
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  DOI: 10.1158/2159-8290.cd-22-0376
  
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52.53.155.43/a051cdc9b66cfe47aeb3f39770c1ce7cd380afb2/cd-22-0376-html.html
Jan 2023
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Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112003
  
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sciencedirect.com/science/article/pii/S2211124723000141
Mar 2022
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Regulation of GTPase function by autophosphorylation

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1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.02.011
  
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sciencedirect.com/science/article/pii/S1097276522001162
Jan 2022
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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia

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1. scibot 06 Jan 2022
  
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  DOI: 10.1016/j.isci.2021.103647
  
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sciencedirect.com/science/article/pii/S2589004221016175
Sep 2021
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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

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1. scibot 23 Sep 2021
  
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  DOI: 10.1016/j.molcel.2021.08.033
  
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sciencedirect.com/science/article/pii/S1097276521007139
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2018.11.011
  
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  RRID:AB_878040 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945618304331