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Lewy pathology accumulates in swollen corticostriatal synapses in α-synucleinopathies

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1. scibot 06 Sep 2025
  
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  DOI: 10.1101/2025.08.27.672679
  
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biorxiv.org/content/10.1101/2025.08.27.672679v1
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Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer’s disease

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116203
  
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sciencedirect.com/science/article/pii/S221112472500974X
Aug 2025
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1-s2.0-S2589004225016967-main-html.html

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1. scibot 28 Aug 2025
  
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  AB_887875
  
  DOI: 10.1016/j.isci.2025.113435
  
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52.53.155.43/b3f84da895cc36df97322da0dfda604a5cad7552/1-s2.0-S2589004225016967-main-html.html
Jul 2025
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Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xpro.2025.103945
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
Jun 2025
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CXCL12 engages cortical inhibitory neurons to enhance dendritic spine plasticity and structured network activity

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  DOI: 10.1523/JNEUROSCI.2213-24.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12160403/
Apr 2025
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Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.cell.2018.07.002
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6173057/
Mar 2025
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Protocol for SUM-PAINT spatial proteomic imaging generating neuronal architecture maps in rat hippocampal neurons

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sciencedirect.com/science/article/pii/S2666166725000437
Nov 2024
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Regulation of synapse density by Pumilio RNA-binding proteins

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114747
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11544588/
Oct 2024
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The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

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  DOI: 10.1016/j.cell.2024.09.006
  
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sciencedirect.com/science/article/pii/S0092867424010249
Sep 2024
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Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice

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1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16215
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16215
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Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.cell.2019.03.019
  
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sciencedirect.com/science/article/pii/S0092867419302818
Jul 2024
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.neuron.2024.06.002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
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Observing isolated synaptic vesicle association and fusion ex vivo

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1. scibot 16 Jul 2024
  
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  DOI: 10.1038/s41596-024-01014-x
  
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nature.com/articles/s41596-024-01014-x
Feb 2024
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3D bioprinting of human neural tissues with functional connectivity

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.stem.2023.12.009
  
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sciencedirect.com/science/article/pii/S1934590923004393
Dec 2023
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Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113576
  
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sciencedirect.com/science/article/pii/S2211124723015887
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Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.cell.2023.11.016
  
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sciencedirect.com/science/article/pii/S0092867423012333
Nov 2023
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The proteomic landscape of synaptic diversity across brain regions and cell types

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1. scibot 03 Nov 2023
  
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  DOI: 10.1016/j.cell.2023.09.028
  
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sciencedirect.com/science/article/pii/S0092867423010826
Sep 2023
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Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses

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1. scibot 29 Sep 2023
  
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  DOI: 10.1002/glia.24470
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24470
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Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113137
  
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sciencedirect.com/science/article/pii/S221112472301149X
Aug 2023
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Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses

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1. scibot 23 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113004
  
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sciencedirect.com/science/article/pii/S221112472301015X
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An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission

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1. scibot 03 Aug 2023
  
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  DOI: 10.3389/fnmol.2023.1115880
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10393139/
Jul 2023
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Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells

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  DOI: 10.1016/j.xpro.2023.102413
  
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sciencedirect.com/science/article/pii/S2666166723003805
Jun 2023
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Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.neuron.2023.05.016
  
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sciencedirect.com/science/article/pii/S0896627323003896
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Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality

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1. scibot 08 Jun 2023
  
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  DOI: 10.3389/fnins.2023.1198154
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10234422/
May 2023
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Immunohistochemical analysis of glutamatergic and serotonergic signaling pathways in chemosensory cell clusters in the pharynx and larynx of rats

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1. scibot 31 May 2023
  
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  DOI: 10.1016/j.tice.2023.102122
  
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sciencedirect.com/science/article/pii/S0040816623001106
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Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans

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1. scibot 11 May 2023
  
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  DOI: 10.1172/jci.insight.168448
  
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insight.jci.org/articles/view/168448
Apr 2023
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Multi-synaptic boutons are a feature of CA1 hippocampal connections in the stratum oriens

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1. scibot 19 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112397
  
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sciencedirect.com/science/article/pii/S2211124723004084
Jan 2023
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Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization

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1. scibot 27 Jan 2023
  
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  DOI: 10.1007/s10571-023-01317-9
  
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link.springer.com/article/10.1007/s10571-023-01317-9
Jul 2022
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Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation

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1. scibot 06 Jul 2022
  
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  DOI: 10.1016/j.isci.2022.104604
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9250022/
Jun 2022
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3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy

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1. scibot 28 Jun 2022
  
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  DOI: 10.1111/jnc.15653
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15653
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Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks

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1. scibot 22 Jun 2022
  
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  DOI: 10.1016/j.nbd.2022.105795
  
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sciencedirect.com/science/article/pii/S0969996122001875
Mar 2022
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Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

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1. scibot 09 Mar 2022
  
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  DOI: 10.1016/j.neuron.2022.02.008
  
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sciencedirect.com/science/article/pii/S0896627322001465
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Decoding the temporal and regional specification of microglia in the developing human brain

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1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.stem.2022.02.004
  
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sciencedirect.com/science/article/pii/S1934590922000558
Feb 2022
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LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants

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1. scibot 08 Feb 2022
  
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  RRID:AB_887875
  
  DOI: 10.1186/s11689-022-09421-5
  
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link.springer.com/article/10.1186/s11689-022-09421-5
Jan 2022
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Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey

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1. scibot 28 Jan 2022
  
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  DOI: 10.3389/fncir.2021.795325
  
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Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

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Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity

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Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling

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Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors

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NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

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TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering

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A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons

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VGLUT1 synapses and P‐boutons on regenerating motoneurons after nerve crush

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Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

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Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus

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Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1

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Transmitter and ion channel profiles of neurons in the primate abducens and trochlear nuclei

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Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

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Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable

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Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

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Nanoscale 3D EM reconstructions reveal intrinsic mechanisms of structural diversity of chemical synapses

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Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment

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Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

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Astrocytes in stress accumulate lipid droplets

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Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors

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Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus

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Nov 2020
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Missense mutations in CASK interfere with neurexin binding and neurexin‐induced oligomerization.

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Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke

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Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

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A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

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A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons

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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ

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Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants

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Microglia Dynamics and Interactions with Motoneurons Axotomized After Nerve Injuries Revealed By Two-Photon Imaging

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VMHvl-Projecting Vglut1+ Neurons in the Posterior Amygdala Gate Territorial Aggression

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Inputs from Sequentially Developed Parallel Fibers Are Required for Cerebellar Organization

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Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

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Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response

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Selective rab11 transport and the intrinsic regenerative ability of CNS axons

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Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism

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Untitled document

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Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity

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Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia

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Untitled document

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Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

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Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

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Combining mGRASP and Optogenetics Enables High-Resolution Functional Mapping of Descending Cortical Projections

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Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement

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A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration

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Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats

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Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories

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Untitled document

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Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus)

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Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission

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Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

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