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AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling

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1. scibot 03 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117394
  
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sciencedirect.com/science/article/pii/S2211124726004729
Feb 2026
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism

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1. scibot 06 Feb 2026
  
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  DOI: 10.1113/JP289036
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP289036
Jan 2026
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The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

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1. scibot 23 Jan 2026
  
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  DOI: 10.1038/s41467-026-68492-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820292/
Oct 2025
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Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113552
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12508894/
Sep 2025
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Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116300
  
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sciencedirect.com/science/article/pii/S221112472501071X
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1-s2.0-S2589004225018139-main-html.html

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1. scibot 13 Sep 2025
  
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  DOI: 10.1016
  
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52.53.155.43/253550384e171aeac03650972660e6e19e7d73f6/1-s2.0-S2589004225018139-main-html.html
Aug 2025
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.012
  
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sciencedirect.com/science/article/pii/S1535610825003186
Jun 2025
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Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115831
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
May 2025
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Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115625
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
Apr 2025
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Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle

1
1. scibot 19 Apr 2025
  
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  DOI: 10.21203/rs.3.rs-5968078/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
Feb 2025
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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

1
1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115339
  
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sciencedirect.com/science/article/pii/S221112472500110X
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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.22.614256
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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1. scibot 04 Sep 2024
  
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  AB_915788
  
  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Feb 2024
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DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling

2
1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113713
  
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  DOI: 10.1016/j.celrep.2024.113713
  
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sciencedirect.com/science/article/pii/S221112472400041X
www.cell.com www.cell.com

Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.cell.2024.01.004
  
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cell.com/cell/fulltext/S0092-8674(24)00006-0
Jan 2024
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Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model

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1. scibot 06 Jan 2024
  
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  RRID:AB_915788
  
  DOI: 10.1016/j.jbc.2023.105619
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
Dec 2023
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Epinephrine inhibits PI3Kα via the Hippo kinases

1
1. scibot 20 Dec 2023
  
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  RRID:AB_915788
  
  DOI: 10.1016/j.celrep.2023.113535
  
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sciencedirect.com/science/article/pii/S2211124723015474
Aug 2023
52.53.155.43 52.53.155.43

L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

2
1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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2. scibot 10 Aug 2023
  
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  RRID:AB_915788
  
  DOI: 10.1016/j.xcrm.2023.101142
  
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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
Jun 2023
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Identification of XAF1 as an endogenous AKT inhibitor

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1. scibot 29 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112690
  
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sciencedirect.com/science/article/pii/S2211124723007015
May 2023
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Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

1
1. scibot 19 May 2023
  
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  DOI: 10.1016/j.chom.2023.04.018
  
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sciencedirect.com/science/article/pii/S1931312823001671
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VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

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1. scibot 12 May 2023
  
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  RRID: AB_915788
  
  DOI: 10.1016/j.celrep.2023.112489
  
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sciencedirect.com/science/article/pii/S2211124723005004
Apr 2023
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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

1
1. scibot 21 Apr 2023
  
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  RRID:AB_915788
  
  DOI: 10.1016/j.cmet.2023.03.021
  
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sciencedirect.com/science/article/pii/S1550413123001262
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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

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1. scibot 18 Apr 2023
  
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  DOI: 10.1038/s41398-023-02411-8
  
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nature.com/articles/s41398-023-02411-8
Nov 2022
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Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells

1
1. scibot 03 Nov 2022
  
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  AB_915788
  
  DOI: 10.1210/endocr/bqac170
  
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academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
Aug 2022
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EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

1
1. scibot 12 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104827
  
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sciencedirect.com/science/article/pii/S2589004222010999
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

1
1. scibot 31 Jul 2022
  
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  DOI: 10.3390/ijms23147774
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
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AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

1
1. scibot 27 Jul 2022
  
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  RRID:AB_915788
  
  DOI: 10.1111/febs.16375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
May 2022
www.nature.com www.nature.com

Convergent somatic mutations in metabolism genes in chronic liver disease

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1. scibot 05 May 2022
  
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  DOI: 10.1038/s41586-021-03974-6
  
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nature.com/articles/s41586-021-03974-6
Dec 2021
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TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

1
1. scibot 11 Dec 2021
  
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  2938S
  
  DOI: 10.1016/j.jcmgh.2021.11.007
  
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sciencedirect.com/science/article/pii/S2352345X21002411
Oct 2021
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A role for AKT1 in nonsense-mediated mRNA decay

1
1. scibot 15 Oct 2021
  
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  2938
  
  DOI: 10.1093/nar/gkab882
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab882/6389627
Jul 2021
jcs.biologists.org jcs.biologists.org

The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3

1
1. scibot 31 Jul 2021
  
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  Akt 1
  
  DOI: 10.1242/jcs.233221
  
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jcs.biologists.org/content/132/20/jcs233221
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Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

1
1. scibot 27 Jul 2021
  
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  RRID:AB_10829158
  
  DOI: 10.1016/j.stem.2019.09.009
  
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  RRID:AB_915788 RRIDCUR:Unresolved RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S1934590919304205
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Untitled document

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1. scibot 27 Jul 2021
  
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  RRID:AB_10829158
  
  DOI: 10.1016/j.neuron.2018.10.051
  
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  Curator: @Jmenke
  
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  RRID:AB_915788 RRIDCUR:Unresolved RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S0896627318309590
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Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability

1
1. scibot 09 Jul 2021
  
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  RRID:AB_10829158
  
  DOI: 10.1016/j.celrep.2021.109327
  
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sciencedirect.com/science/article/pii/S2211124721007038
May 2021
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Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

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1. scibot 19 May 2021
  
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  RRID:AB_915788
  
  DOI: 10.1016/j.celrep.2021.109128
  
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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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  DOI: 10.1016/j.neuron.2021.03.008
  
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The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

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  DOI: 10.7554/eLife.61313
  
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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

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1. scibot 28 Feb 2021
  
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Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells

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1. scibot 27 Feb 2021
  
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  DOI: 10.1007/s10637-020-01050-w
  
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Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

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  DOI: 10.7554/eLife.56630
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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  DOI: 10.7554/eLife.58941
  
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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  DOI: 10.1016/j.celrep.2020.108223
  
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BPS Publications

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  DOI: 10.1111/bph.15236
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7520443/
Jan 2020
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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

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  DOI: 10.1016/j.chembiol.2019.11.014
  
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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  DOI: 10.1016/j.molcel.2019.07.023
  
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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  DOI: 10.1016/j.immuni.2019.11.015
  
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Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

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  RRID:AB_915788
  
  DOI: 10.1016/j.celrep.2019.02.096
  
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Nov 2018
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Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β

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The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

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Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

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Untitled document

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europepmc.org/articles/PMC5722612/
Nov 2017
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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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1. scibot 08 Nov 2017
  
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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

1
1. scibot 08 Nov 2017
  
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  AB_915788
  
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