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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

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  DOI: 10.1080/15548627.2025.2552905
  
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Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic islets

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  DOI: 10.1016/j.celrep.2025.116211
  
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sciencedirect.com/science/article/pii/S2211124725009829
Aug 2025
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

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1. scibot 21 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.041
  
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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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1. scibot 14 Aug 2025
  
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  DOI: 10.1126/sciadv.abf9141
  
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Jul 2025
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Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling

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  DOI: 10.1016/j.phymed.2025.157110
  
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BPS Publications

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1. scibot 11 Jul 2025
  
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  DOI: 10.1111/bph.70094
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70094
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Brain miR-137 governs growth and development via GH/IGF-1 signaling

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  DOI: 10.1186/s12915-025-02306-8
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-025-02306-8
Jun 2025
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Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease

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1. scibot 28 Jun 2025
  
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  DOI: 10.4103/1673-5374.324854
  
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journals.lww.com/nrronline/fulltext/2022/05000/angiotensin__1_7__reduces___synuclein_aggregation.42.aspx
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Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

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1. scibot 11 Jun 2025
  
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May 2025
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Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

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1. scibot 20 May 2025
  
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  DOI: 10.1111/eci.70051
  
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1-s2.0-S2589004225009095-main-html.html

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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cmet.2025.04.015
  
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OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115681
  
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sciencedirect.com/science/article/pii/S2211124725004528
Apr 2025
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Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle

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1. scibot 19 Apr 2025
  
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  DOI: 10.21203/rs.3.rs-5968078/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
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RAF1 kinase contributes to autophagic lysosome reformation

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  DOI: 10.1016/j.celrep.2025.115490
  
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sciencedirect.com/science/article/pii/S221112472500261X
Mar 2025
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115462
  
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Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma

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1. scibot 20 Mar 2025
  
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  DOI: 10.1038/s41420-025-02355-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914149/
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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11970383/
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7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

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1. scibot 06 Mar 2025
  
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  DOI: 10.1111/bph.17464
  
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  DOI: 10.1111/bph.17464
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Feb 2025
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kenny-et-al-2024-the-effect-of-high-intensity-exercise-in-temperate-and-hot-ambient-conditions-on-autophagy-and-the-html.html

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  DOI: 10.1152/ajpregu.00178.2024
  
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52.53.155.43/0fe8f54535c196dd58c3b00db0a77abec614600b/kenny-et-al-2024-the-effect-of-high-intensity-exercise-in-temperate-and-hot-ambient-conditions-on-autophagy-and-the-html.html
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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Jan 2025
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Lysosomal activity in response to the incubation of pristine and functionalized carbon nanodots

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  DOI: 10.1016/j.isci.2024.111654
  
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PDF-html.html

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  DOI: 10.1074/mcp.m113.031591
  
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Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation

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1. scibot 03 Jan 2025
  
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  RRID:AB_915
  
  DOI: 10.1016/j.molcel.2024.12.005
  
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sciencedirect.com/science/article/pii/S1097276524010001
Dec 2024
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PDF-html.html

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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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  DOI: 10.1016/j.celrep.2024.115115
  
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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

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pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

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  DOI: 10.1016/j.cels.2024.11.004
  
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Nov 2024
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AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

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  DOI: 10.1016/j.celrep.2024.115001
  
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Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis

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  DOI: 10.1016/j.isci.2024.111372
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11625362/
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Autophagy-dependent splicing control directs translation toward inflammation during senescence

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  DOI: 10.1016/j.devcel.2024.10.008
  
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sciencedirect.com/science/article/pii/S1534580724006270
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VPS4A is the selective receptor for lipophagy in mice and humans

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  DOI: 10.1016/j.molcel.2024.10.022
  
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sciencedirect.com/science/article/pii/S1097276524008621
Oct 2024
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Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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1. scibot 02 Oct 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01592
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11433901/
Sep 2024
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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.molcel.2019.07.021
  
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

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Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells

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BPS Publications

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer

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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization

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TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis

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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice

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The HRI branch of the integrated stress response selectively triggers mitophagy

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Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy

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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo

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PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site

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Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

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The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells

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Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects

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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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PIIS2589004223017029-html.html

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Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome

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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production

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SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux

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Apolipoprotein E intersects with amyloid-β within neurons

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PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

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BPS Publications

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Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

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ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL

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Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex

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Common Markers and Small Molecule Inhibitors in Golgi Studies

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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

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NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

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The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations

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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites

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The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells

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Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis

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Autophagy modulates cell fate decisions during lineage commitment

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Glutamine metabolism modulates chondrocyte inflammatory response

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling

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Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice

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The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats

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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

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The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

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Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction

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Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter

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Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells

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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line

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Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

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Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1‐dependent autophagy

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Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

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The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy

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Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

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Lipophagy Contributes to Testosterone Biosynthesis in Male Rat Leydig Cells

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Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury

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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

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Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

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Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

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Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

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MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease

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Missense mutations in small muscle protein X-linked ( SMPX ) cause distal myopathy with protein inclusions

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Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

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Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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Autophagosome content profiling using proximity biotinylation proteomics coupled to protease digestion in mammalian cells

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Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin

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Tau seeds are subject to aberrant modifications resulting in distinct signatures

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

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Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

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Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

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Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

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Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle

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Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor

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Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice

2
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ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

1
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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

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Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

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Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle

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Mitochondrial dysfunction in skeletal muscle of fukutin deficient mice is resistant to exercise‐ and AICAR‐induced rescue

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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

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Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles

1
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  DOI: 10.1096/fj.201901815R
  
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Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

2
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The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

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Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

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Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

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HUNK Phosphorylates Rubicon to Support Autophagy

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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

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Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

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Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress

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Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

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Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity

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BPS Publications

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  DOI: 10.1111/bph.14718
  
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ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

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PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux

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The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1

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BPS Publications

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  DOI: 10.1111/bph.14706
  
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Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

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Untitled document

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sciencedirect.com/science/article/pii/S2211124719302311

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