205 Matching Annotations
  1. Last 7 days
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    Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014669
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    sciencedirect.com/science/article/pii/S2405471224003375
  6. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11625362/
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    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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    sciencedirect.com/science/article/pii/S1534580724006270
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    VPS4A is the selective receptor for lipophagy in mice and humans
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  11. Oct 2024
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    Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy
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  13. Sep 2024
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    cell.com/cell/fulltext/S0092-8674(24)00911-5
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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  17. 52.53.155.43 52.53.155.43
    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease
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    1. scibot 05 Sep 2024
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  18. Aug 2024
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    sciencedirect.com/science/article/pii/S2211124724009379
  20. Jul 2024
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  24. Jun 2024
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    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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    sciencedirect.com/science/article/pii/S0092867424005269
  26. May 2024
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    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
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  29. 52.53.155.43 52.53.155.43
    TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis
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  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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  32. Feb 2024
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    UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis
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    sciencedirect.com/science/article/pii/S2211124724001360
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
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      DOI: 10.1007/s00018-024-05115-4

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    The HRI branch of the integrated stress response selectively triggers mitophagy
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    sciencedirect.com/science/article/pii/S1097276524000522
  38. Jan 2024
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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    sciencedirect.com/science/article/pii/S1535610823004476
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
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    sciencedirect.com/science/article/pii/S1934590923004332
  42. Dec 2023
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    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
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    sciencedirect.com/science/article/pii/S0969996123003868
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    Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
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    sciencedirect.com/science/article/pii/S2211124723015413
  45. Nov 2023
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    sciencedirect.com/science/article/pii/S2211124723014961
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    sciencedirect.com/science/article/pii/S1550413123003868
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    Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
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    sciencedirect.com/science/article/pii/S2211124723014481
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    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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      DOI: 10.1016/j.celrep.2023.113381

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    sciencedirect.com/science/article/pii/S2211124723013931
  50. Oct 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells
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      DOI: 10.3390/biology12091225

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    ncbi.nlm.nih.gov/pmc/articles/PMC10525791/
  52. Sep 2023
  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
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      DOI: 10.1111/acel.13954

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    onlinelibrary.wiley.com/doi/10.1111/acel.13954
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    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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  56. Aug 2023
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    Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
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  59. Jul 2023
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    Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
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  61. Jun 2023
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    SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
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    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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  68. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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  75. Apr 2023
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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  77. Mar 2023
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    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
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    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
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  80. Feb 2023
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    EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins
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  84. Dec 2022
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    The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations
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  86. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
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  90. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis
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  94. Aug 2022
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  96. Jul 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  98. Jun 2022
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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  101. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  104. Apr 2022
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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  106. Mar 2022
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    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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  108. Jan 2022
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    ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice
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  110. Dec 2021
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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  112. Nov 2021
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  114. Oct 2021
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    Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase
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    Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
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  119. Sep 2021
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    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
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    Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells
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    Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line
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  136. Jul 2021
  137. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1‐dependent autophagy
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    Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
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      Rabbit polyclonal Anti-LC3B

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    The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy
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    Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock
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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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  151. Jun 2021
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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  154. May 2021
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    Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
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    Missense mutations in small muscle protein X-linked ( SMPX ) cause distal myopathy with protein inclusions
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    Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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  163. Apr 2021
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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  172. Mar 2021
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    Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling
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    Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease
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    Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness
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  176. Feb 2021
  177. bmcpulmmed.biomedcentral.com bmcpulmmed.biomedcentral.com
    Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle
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    Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor
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    Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice
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  180. Jan 2021
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    ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
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    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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    Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
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    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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  185. Dec 2020
  186. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Mitochondrial dysfunction in skeletal muscle of fukutin deficient mice is resistant to exercise‐ and AICAR‐induced rescue
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  187. Sep 2020
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    HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
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  189. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles
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    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells
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    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
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  192. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
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    Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
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  196. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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  197. www.mdpi.com www.mdpi.com
    HUNK Phosphorylates Rubicon to Support Autophagy
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    AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
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  199. Jan 2020
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    Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model
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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
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