54 Matching Annotations
  1. Jun 2024
  2. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations
    1
    1. scibot 06 Jun 2024
      RRID:AB_94882

      DOI: 10.1002/alz.13904

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    alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13904
  3. May 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
    1
    1. scibot 30 May 2024
      RRID:AB_94882

      DOI: 10.1016/j.neuron.2024.05.002

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    sciencedirect.com/science/article/pii/S0896627324003295
  5. Feb 2024
  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptic adhesion molecule protocadherin-γC5 mediates β-amyloid-induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease
    1
    1. scibot 15 Feb 2024
      RRID:AB_94882

      DOI: 10.1111/jnc.16066

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16066
  7. Aug 2023
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses
    1
    1. scibot 29 Aug 2023
      AB_94882

      DOI: 10.3390/cells12162085

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    ncbi.nlm.nih.gov/pmc/articles/PMC10453064/
  9. Jul 2023
  10. www.sciencedirect.com www.sciencedirect.com
    Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment
    1
    1. scibot 13 Jul 2023
      RRID:AB_94882

      DOI: 10.1016/j.celrep.2023.112774

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    sciencedirect.com/science/article/pii/S2211124723007854
  11. May 2023
  12. link.springer.com link.springer.com
    Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
    1
    1. scibot 02 May 2023
      RRID:AB_94882

      DOI: 10.1186/s12974-023-02784-z

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    link.springer.com/article/10.1186/s12974-023-02784-z
  13. Mar 2023
  14. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex
    1
    1. scibot 03 Mar 2023
      AB_94882

      DOI: 10.1111/jnc.15750

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15750
  15. Oct 2022
  16. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
    1
    1. scibot 28 Oct 2022
      RRID:AB_94882

      DOI: 10.1016/j.cell.2022.09.033

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    sciencedirect.com/science/article/pii/S0092867422012521
  17. Sep 2022
  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endoplasmic reticulum stress induces Alzheimer's disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein
    1
    1. scibot 17 Sep 2022
      RRID:AB_94882

      DOI: 10.1111/jnc.15687

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15687
  19. Aug 2022
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk
    1
    1. scibot 26 Aug 2022
      RRID:AB_94882

      DOI: 10.3389/fnagi.2022.896522

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    ncbi.nlm.nih.gov/pmc/articles/PMC9395645/
  21. Jul 2022
  22. www.sciencedirect.com www.sciencedirect.com
    Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice
    1
    1. scibot 13 Jul 2022
      RRID:AB_94882

      DOI: 10.1016/j.celrep.2022.111062

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    sciencedirect.com/science/article/pii/S2211124722008609
  23. Jun 2022
  24. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination
    1
    1. scibot 17 Jun 2022
      RRID:AB_94882

      DOI: 10.1111/jnc.15650

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15650
  25. www.sciencedirect.com www.sciencedirect.com
    Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease
    1
    1. scibot 03 Jun 2022
      RRID:AB_94882

      DOI: 10.1016/j.celrep.2022.110883

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    sciencedirect.com/science/article/pii/S2211124722006581
  26. Mar 2022
  27. www.nature.com www.nature.com
    White matter integrity in mice requires continuous myelin synthesis at the inner tongue
    1
    1. scibot 10 Mar 2022
      RRID:AB_94882

      DOI: 10.1038/s41467-022-28720-y

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    nature.com/articles/s41467-022-28720-y
  28. Oct 2021
  29. www.sciencedirect.com www.sciencedirect.com
    Cold exposure protects from neuroinflammation through immunologic reprogramming
    1
    1. scibot 23 Oct 2021
      RRID:AB_94882

      DOI: 10.1016/j.cmet.2021.10.002

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    sciencedirect.com/science/article/pii/S1550413121004800
  30. Aug 2021
  31. link.springer.com link.springer.com
    Untitled document
    1
    1. scibot 13 Aug 2021
      AB_94882

      DOI: 10.1007/s00418-019-01786-4

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    link.springer.com/article/10.1007/s00418-019-01786-4
  32. www.nature.com www.nature.com
    Untitled document
    1
    1. scibot 01 Aug 2021
      RRID:AB_94882

      DOI: 10.1038/s41598-018-31957-7

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    nature.com/articles/s41598-018-31957-7
  33. Jul 2021
  34. www.sciencedirect.com www.sciencedirect.com
    Transient increase in sAPPα secretion in response to Aβ1–42 oligomers: an attempt of neuronal self-defense?
    2
    1. scibot 28 Jul 2021
      RRID:AB_94882

      DOI: 10.1016/j.neurobiolaging.2017.09.008

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      Curator: @evieth

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      RRID:AB_94882 RRIDCUR:Duplicate RRIDCUR:Validated
    2. scibot 28 Jul 2021
      RRID:AB_94882

      DOI: 10.1016/j.neurobiolaging.2017.09.008

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    sciencedirect.com/science/article/pii/S0197458017303019
  35. link.springer.com link.springer.com
    Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
    1
    1. scibot 27 Jul 2021
      94,882

      DOI: 10.1007/s11011-019-00488-z

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    link.springer.com/article/10.1007/s11011-019-00488-z
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
    1
    1. scibot 01 Jul 2021
      RRID:AB_9488

      DOI: 10.1016/j.immuni.2021.06.002

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC8188302/
  37. Feb 2021
  38. www.nature.com www.nature.com
    MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
    1
    1. scibot 25 Feb 2021
      RRID:AB_94882

      DOI: 10.1038/s41380-020-0824-3

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    nature.com/articles/s41380-020-0824-3
  39. portlandpress.com portlandpress.com
    The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
    1
    1. scibot 25 Feb 2021
      AB_94882

      DOI: 10.1042/BSR20200435

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    portlandpress.com/bioscirep/article/40/4/BSR20200435/222674/The-cellular-expression-and-proteolytic-processing
  40. Jan 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
    1
    1. scibot 07 Jan 2021
      RRID:AB_94882

      DOI: 10.1016/j.celrep.2020.108588

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    sciencedirect.com/science/article/pii/S2211124720315771
  42. Dec 2020
  43. www.cell.com www.cell.com
    Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury
    1
    1. scibot 11 Dec 2020
      RRID:AB_94882

      DOI: 10.1016/j.neuron.2020.09.033

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    cell.com/neuron/abstract/S0896-6273(20)30757-1
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment
    1
    1. scibot 07 Dec 2020
      AB_94882

      DOI: 10.1002/glia.23937

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    onlinelibrary.wiley.com/doi/10.1002/glia.23937
  45. Nov 2020
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Absence of R‐Ras1 and R‐Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model
    1
    1. scibot 20 Nov 2020
      RRID:AB_94882

      DOI: 10.1002/glia.23917

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    onlinelibrary.wiley.com/doi/10.1002/glia.23917
  47. Sep 2020
  48. www.sciencedirect.com www.sciencedirect.com
    NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation
    1
    1. scibot 17 Sep 2020
      RRID:AB_94882

      DOI: 10.1016/j.celrep.2020.02.059

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      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S2211124720302278
  49. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
    1
    1. scibot 13 Sep 2020
      RRID:AB_94882

      DOI: 10.1523/JNEUROSCI.1076-19.2019

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      RRIDCUR:Validated RRID:AB_94882
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    jneurosci.org/content/40/2/459
  50. www.eneuro.org www.eneuro.org
    Traumatic Brain Injury Preserves Firing Rates but Disrupts Laminar Oscillatory Coupling and Neuronal Entrainment in Hippocampal CA1
    1
    1. scibot 11 Sep 2020
      RRID: AB_94882

      DOI: 10.1523/ENEURO.0495-19.2020

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      Curator comments: Mouse Anti-Alzheimer Precursor Protein A4, aa66-81 of APP Monoclonal antibody, Unconjugated, Clone 22c11 Millipore Cat# MAB348

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    eneuro.org/content/7/5/ENEURO.0495-19.2020
  51. elifesciences.org elifesciences.org
    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21
    1
    1. scibot 05 Sep 2020
      RRID:AB_94882

      DOI: 10.7554/eLife.56223

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    elifesciences.org/articles/56223
  52. Jan 2020
  53. jcb.rupress.org jcb.rupress.org
    A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1083/jcb.201806205

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    jcb.rupress.org/content/218/2/644
  54. www.sciencedirect.com www.sciencedirect.com
    Laquinimod ameliorates secondary brain inflammation
    1
    1. scibot 13 Jan 2020
      AB_94882

      DOI: 10.1016/j.nbd.2019.104675

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    sciencedirect.com/science/article/pii/S096999611930350X
  55. www.mdpi.com www.mdpi.com
    Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.3390/cells8091024

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    mdpi.com/2073-4409/8/9/1024/htm
  56. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1016/j.neuron.2019.10.010

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      RRID:AB_94882 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627319308839
  57. www.sciencedirect.com www.sciencedirect.com
    Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1016/j.cell.2019.07.043

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    sciencedirect.com/science/article/pii/S0092867419308438
  58. www.sciencedirect.com www.sciencedirect.com
    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1016/j.neuron.2019.12.004

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      RRID:AB_94882 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627319310463
  59. www.sciencedirect.com www.sciencedirect.com
    Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1016/j.immuni.2019.12.004

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      RRID:AB_94882 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761319305230
  60. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
    1
    1. scibot 13 Jan 2020
      RRID:AB_94882

      DOI: 10.1016/j.stem.2018.12.013

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    sciencedirect.com/science/article/pii/S1934590918306039
  61. Nov 2018
  62. link.springer.com link.springer.com
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:AB_94882

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus
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    Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression
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    Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
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  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Calmodulin‐like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease
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  68. Nov 2017
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    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
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    TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
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  71. elifesciences.org elifesciences.org
    NPTX2 and cognitive dysfunction in Alzheimer’s Disease
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    Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport
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    Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins
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    Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
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  75. bmcneurosci.biomedcentral.com bmcneurosci.biomedcentral.com
    PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons
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