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41 Matching Annotations

Oct 2025
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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.stem.2025.09.011
  
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sciencedirect.com/science/article/pii/S1934590925003674
Jun 2025
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Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112843
  
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sciencedirect.com/science/article/pii/S2589004225011046
May 2025
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Generation of a human embryonic stem cell line (WAe009-A-3B) carrying homozygous TNNT2 gene knockout by CRISPR/Cas9 editing

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1. scibot 18 May 2025
  
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sciencedirect.com/science/article/pii/S1873506125000790
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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115687
  
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sciencedirect.com/science/article/pii/S2211124725004589
Feb 2025
52.53.155.43 52.53.155.43

Maturation of human cardiac organoids enables complex disease modelling and drug discovery

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.05.611336
  
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52.53.155.43/2a3cc686934257c062697951b2a037bb697f8dd7/2024.09.05.611336v1.full-html.html
Nov 2024
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CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity

1
1. scibot 11 Nov 2024
  
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sciencedirect.com/science/article/pii/S1934590924003692
Sep 2024
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Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids

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1. scibot 11 Sep 2024
  
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  DOI: 10.1016/j.stem.2024.08.008
  
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sciencedirect.com/science/article/pii/S1934590924002947
Aug 2024
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Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate small molecule induction of human iPSC-derived cardiomyocyte proliferation

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110485
  
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sciencedirect.com/science/article/pii/S2589004224017103
Jul 2024
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Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

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1. scibot 23 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110395
  
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sciencedirect.com/science/article/pii/S2589004224016201
Jun 2024
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Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114302
  
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sciencedirect.com/science/article/pii/S2211124724006302
Feb 2024
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Generation of CRISPR/Cas9 edited human induced pluripotent stem cell line carrying the heterozygous p.H695VfsX5 frameshift mutation in the exon 10 of the PKP2 gene

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.scr.2024.103341
  
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sciencedirect.com/science/article/pii/S1873506124000394
Dec 2023
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Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells

1
1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.scr.2023.103295
  
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sciencedirect.com/science/article/pii/S1873506123002817
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Scalable production of homogeneous cardiac organoids derived from human pluripotent stem cells

1
1. scibot 23 Dec 2023
  
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  DOI: 10.1016/j.crmeth.2023.100666
  
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sciencedirect.com/science/article/pii/S2667237523003454
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Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing

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1. scibot 14 Dec 2023
  
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  DOI: 10.1016/j.scr.2023.103276
  
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sciencedirect.com/science/article/pii/S1873506123002623
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Multi-chamber cardioids unravel human heart development and cardiac defects

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.cell.2023.10.030
  
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sciencedirect.com/science/article/pii/S0092867423011819
Nov 2023
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Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113340
  
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sciencedirect.com/science/article/pii/S2211124723013529
Jul 2023
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Generation of vascularized human cardiac organoids for 3D in vitro modeling

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1. scibot 05 Jul 2023
  
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  DOI: 10.1016/j.xpro.2023.102371
  
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sciencedirect.com/science/article/pii/S2666166723003386
Apr 2023
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Vascular cells improve functionality of human cardiac organoids

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112322
  
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sciencedirect.com/science/article/pii/S2211124723003339
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Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy

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1. scibot 07 Apr 2023
  
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  DOI: 10.1016/j.stem.2023.03.010
  
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sciencedirect.com/science/article/pii/S1934590923000814
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

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1. scibot 18 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105414
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9646950/
Sep 2022
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Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome

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1. scibot 27 Sep 2022
  
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  DOI: 10.1016/j.cels.2022.09.001
  
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sciencedirect.com/science/article/pii/S2405471222003532
Mar 2022
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PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem-cell-derived cardiomyocytes

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1. scibot 27 Mar 2022
  
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  DOI: 10.1016/j.stem.2022.02.011
  
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sciencedirect.com/science/article/pii/S1934590922000972
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

1
1. scibot 22 Jan 2022
  
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  DOI: 10.7554/eLife.60311
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8763402/
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Generation of SCN5A heterozygous knock-out human induced pluripotent stem cell line by CRISPR/Cas9-mediated genome editing

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1. scibot 21 Jan 2022
  
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  DOI: 10.1016/j.scr.2022.102680
  
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sciencedirect.com/science/article/pii/S1873506122000290
Dec 2021
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Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids

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1. scibot 03 Dec 2021
  
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  DOI: 10.1016/j.stem.2021.11.007
  
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sciencedirect.com/science/article/pii/S1934590921004550
Sep 2021
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RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy

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1. scibot 16 Sep 2021
  
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  DOI: 10.1016/j.stem.2021.08.006
  
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sciencedirect.com/science/article/pii/S193459092100343X
Aug 2021
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Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation

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1. scibot 27 Aug 2021
  
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  DOI: 10.1016/j.scr.2021.102518
  
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sciencedirect.com/science/article/pii/S1873506121003652
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Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

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1. scibot 06 Aug 2021
  
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  DOI: 10.1016/j.cels.2021.07.003
  
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sciencedirect.com/science/article/pii/S2405471221002817
Jul 2021
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Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression

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1. scibot 28 Jul 2021
  
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  DOI: 10.1016/j.scr.2021.102473
  
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sciencedirect.com/science/article/pii/S1873506121003202
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A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

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1. scibot 27 Jul 2021
  
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  DOI: 10.1016/j.stem.2019.02.015
  
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sciencedirect.com/science/article/pii/S1934590919300670
Jun 2021
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Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation

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1. scibot 08 Jun 2021
  
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  DOI: 10.1016/j.scr.2021.102418
  
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sciencedirect.com/science/article/pii/S1873506121002646
May 2021
www.cell.com www.cell.com

Cell states beyond transcriptomics: Integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

1
1. scibot 27 May 2021
  
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  DOI: 10.1016/j.cels.2021.05.001
  
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cell.com/cell-systems/fulltext/S2405-4712(21)00156-3
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Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome

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1. scibot 09 May 2021
  
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  DOI: 10.1016/j.stem.2020.07.015
  
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sciencedirect.com/science/article/pii/S1934590920303532
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Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.devcel.2020.07.006
  
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sciencedirect.com/science/article/pii/S1534580720305803
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection

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1. scibot 06 Apr 2021
  
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  DOI: 10.1016/j.cell.2021.03.026
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7962543/
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human iPSC-Derived Cardiomyocytes , are Susceptible to SARS-CoV-2 Infection

1
1. scibot 26 Feb 2021
  
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  DOI: 10.1016/j.xcrm.2020.100052
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7323681/
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Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

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1. scibot 12 Feb 2021
  
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  RRID:AB_956386
  
  DOI: 10.3389/fphar.2020.553852
  
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  Curator: @ethanbadger
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7874215/
Sep 2020
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Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation

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1. scibot 26 Sep 2020
  
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  RRID:AB_956386
  
  DOI: 10.1016/j.scr.2020.101944
  
  Resource: (Abcam Cat# ab45932, RRID:AB_956386)
  
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sciencedirect.com/science/article/pii/S1873506120302452
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Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

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1. scibot 11 Sep 2020
  
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  RRID:AB_956386
  
  DOI: 10.1016/j.celrep.2020.107886
  
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sciencedirect.com/science/article/pii/S2211124720308676
Nov 2018
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Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase

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1. scibot 05 Nov 2018
  
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  RRID:AB_956386
  
  Curator: @Jmenke
  
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  RRID:AB_956386 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S109727651830741X
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SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation

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1. scibot 05 Nov 2018
  
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  RRID:AB_956386
  
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  (Abcam Cat# ab45932, RRID:AB_956386)
  
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sciencedirect.com/science/article/pii/S1934590918300675