99 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12542347/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel–Kreienkamp syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12529666/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12559333/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12486091/
  6. www.nature.com www.nature.com
    Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
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    nature.com/articles/s41467-025-65487-4
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12588532/
  8. Oct 2025
  9. www.biorxiv.org www.biorxiv.org
    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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    biorxiv.org/content/10.1101/2025.10.14.682478v1
  10. Aug 2025
  11. www.nature.com www.nature.com
    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    nature.com/articles/s41593-025-02043-9
  12. www.biorxiv.org www.biorxiv.org
    Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses
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    biorxiv.org/content/10.1101/2025.08.19.671016v1
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11780352/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225013811-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329260/
  15. www.biorxiv.org www.biorxiv.org
    A sensitive orange fluorescent calcium ion indicator for imaging neural activity
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    biorxiv.org/content/10.1101/2025.07.28.667269v1
  16. Jul 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PP2Acα regulates sleep amount and sleep homeostasis in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238387/
  19. elifesciences.org elifesciences.org
    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
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    elifesciences.org/reviewed-preprints/107556
  20. www.biorxiv.org www.biorxiv.org
    Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity
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    biorxiv.org/content/10.1101/2025.06.20.660790v1
  21. Jun 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185343/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132946/
  24. May 2025
  25. www.sciencedirect.com www.sciencedirect.com
    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627325003459
  26. www.sciencedirect.com www.sciencedirect.com
    Machine learning identification of enhancers in the rhesus macaque genome
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    sciencedirect.com/science/article/pii/S0896627325003137
  27. www.sciencedirect.com www.sciencedirect.com
    Specific targeting of brain endothelial cells using enhancer AAV vectors
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    sciencedirect.com/science/article/pii/S089662732500251X
  28. www.sciencedirect.com www.sciencedirect.com
    A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
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    sciencedirect.com/science/article/pii/S0092867425005136
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050299/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  31. Apr 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Staufen2 dysregulation in neurodegenerative disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11938042/
  33. Mar 2025
  34. www.nature.com www.nature.com
    Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
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    nature.com/articles/s41587-025-02565-4
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766445/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extensive length and homology dependent chimerism in pool-packaged AAV libraries
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761685/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760745/
  38. Feb 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842818/
  40. www.sciencedirect.com www.sciencedirect.com
    IL-16 exerts anti-rabies virus effects through CD9 on the surface of viral particles
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    sciencedirect.com/science/article/pii/S0141813025015910
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789068/
  42. Jan 2025
  43. www.sciencedirect.com www.sciencedirect.com
    An engineered adeno-associated virus mediates efficient blood-brain barrier penetration with enhanced neurotropism and reduced hepatotropism
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    sciencedirect.com/science/article/pii/S0168365925000240
  44. Dec 2024
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668525/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11264692/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11603655/
  48. Sep 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11258272/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343251/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple and highly specific targeting of resident microglia with adeno-associated virus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407971/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of KDM6B mosaic brain knockout on synaptic function and behavior
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369245/
  53. Aug 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316102/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell discovery of m6A RNA modifications in the hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293556/
  56. rupress.org rupress.org
    An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels
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    rupress.org/jcb/article/223/10/e202401140/276880/An-evolutionarily-conserved-AnkyrinG-dependent
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269569/
  58. www.cell.com www.cell.com
    Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
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    cell.com/cell-reports/fulltext/S2211-1247(24)00756-3
  59. Jun 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering viral vectors for acoustically targeted gene delivery
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    ncbi.nlm.nih.gov/pmc/articles/PMC11164914/
  61. May 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A multicolor suite for deciphering population coding of calcium and cAMP in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC11093745/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070337/
  64. www.sciencedirect.com www.sciencedirect.com
    Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
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    sciencedirect.com/science/article/pii/S2666379124002386
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042220/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno‐associated virus vectors expressing human P301L tau
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    ncbi.nlm.nih.gov/pmc/articles/PMC11058624/
  67. Apr 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034579/
  69. Mar 2024
  70. www.biorxiv.org www.biorxiv.org
    Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
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    biorxiv.org/content/10.1101/2024.03.20.585910v1
  71. www.sciencedirect.com www.sciencedirect.com
    Type-I-interferon-responsive microglia shape cortical development and behavior
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    sciencedirect.com/science/article/pii/S0092867424001867
  72. Feb 2024
  73. link.springer.com link.springer.com
    Oxidized SOD1 accelerates cellular senescence in neural stem cells
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    link.springer.com/article/10.1186/s13287-024-03669-5
  74. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    biorxiv.org/content/10.1101/2023.12.21.572751v1
  75. www.sciencedirect.com www.sciencedirect.com
    Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves
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    sciencedirect.com/science/article/pii/S2211124724000810
  76. Dec 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
  78. www.biorxiv.org www.biorxiv.org
    Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
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    biorxiv.org/content/10.1101/2020.03.31.016972v2
  79. www.biorxiv.org www.biorxiv.org
    Creation of de novo cryptic splicing for ALS/FTD precision medicine
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    biorxiv.org/content/10.1101/2023.11.15.565967v1
  80. Nov 2023
  81. www.sciencedirect.com www.sciencedirect.com
    ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging
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    sciencedirect.com/science/article/pii/S2213231723003737
  82. www.nature.com www.nature.com
    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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    nature.com/articles/s41467-023-42746-w
  83. www.sciencedirect.com www.sciencedirect.com
    Dopamine pathways mediating affective state transitions after sleep loss
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    sciencedirect.com/science/article/pii/S0896627323007584
  84. www.sciencedirect.com www.sciencedirect.com
    An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains
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    sciencedirect.com/science/article/pii/S2211124723013608
  85. Aug 2023
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KMT2C knockout generates ASD-like behaviors in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10394233/
  87. Jul 2023
  88. cmbl.biomedcentral.com cmbl.biomedcentral.com
    Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
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    cmbl.biomedcentral.com/articles/10.1186/s11658-023-00472-7
  89. www.nature.com www.nature.com
    Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
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    nature.com/articles/s41565-023-01419-x
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10332811/
  91. 52.53.155.43 52.53.155.43
    Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
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    52.53.155.43/2945eba83e58c4a88c16c49d9e3b61762240780a/awad222-html.html
  92. Jun 2023
  93. www.biorxiv.org www.biorxiv.org
    Scalable, cell type-selective in vivo AAV-based CRISPR screens in mice
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    biorxiv.org/content/10.1101/2023.06.13.544831v1
  94. www.biorxiv.org www.biorxiv.org
    KMT2C knockout generates ASD-like behaviors in mice
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    biorxiv.org/content/10.1101/2023.05.26.542423v1
  95. May 2023
  96. www.mdpi.com www.mdpi.com
    Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome
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    mdpi.com/2218-273X/13/5/763
  97. Mar 2023
  98. europepmc.org europepmc.org
    ER proteostasis regulators cell-non-autonomously control sleep
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    europepmc.org/article/med/36924492
  99. www.biorxiv.org www.biorxiv.org
    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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    biorxiv.org/content/10.1101/2023.02.21.529451v1
  100. Feb 2023
  101. www.nature.com www.nature.com
    An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice
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    nature.com/articles/s41467-023-36324-3
  102. Jan 2023
  103. www.biorxiv.org www.biorxiv.org
    Neuronal expression of herpes simplex virus type-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation by activating Jun
    1
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    biorxiv.org/content/10.1101/2023.01.13.524029v1
  104. Jun 2022
  105. www.sciencedirect.com www.sciencedirect.com
    Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina
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    sciencedirect.com/science/article/pii/S2211124722007422
  106. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Single-Cell Quantification of Triple-AAV Vector Genomes Coexpressed in Neurons
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    currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.430
  107. Nov 2021
  108. www.sciencedirect.com www.sciencedirect.com
    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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    sciencedirect.com/science/article/pii/S0166432821005611
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8549541/
  110. Oct 2021
  111. www.nature.com www.nature.com
    Comparative cellular analysis of motor cortex in human, marmoset and mouse
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    nature.com/articles/s41586-021-03465-8
  112. Sep 2021
  113. www.sciencedirect.com www.sciencedirect.com
    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    sciencedirect.com/science/article/pii/S0092867421010527
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8426581/
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8417311/
  116. Aug 2021
  117. www.sciencedirect.com www.sciencedirect.com
    Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
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    sciencedirect.com/science/article/pii/S2211124721009220
  118. Jul 2021
  119. www.sciencedirect.com www.sciencedirect.com
    GABA-receptive microglia selectively sculpt developing inhibitory circuits
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    sciencedirect.com/science/article/pii/S0092867421007534
  120. May 2021
  121. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
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    pubmed.ncbi.nlm.nih.gov/33960685/
  122. www.sciencedirect.com www.sciencedirect.com
    Enhancer viruses for combinatorial cell-subclass-specific labeling
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    sciencedirect.com/science/article/pii/S0896627321001598
  123. Feb 2021
  124. www.frontiersin.org www.frontiersin.org
    Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness
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    frontiersin.org/article/10.3389/fnmol.2020.600051/full
  125. www.nature.com www.nature.com
    Viral rhodopsins 1 are an unique family of light-gated cation channels
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    nature.com/articles/s41467-020-19457-7
  126. Dec 2020
  127. www.jneurosci.org www.jneurosci.org
    Cell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice
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    jneurosci.org/content/40/50/9772
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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    ncbi.nlm.nih.gov/pmc/articles/PMC7683292/
  129. Sep 2020
  130. www.sciencedirect.com www.sciencedirect.com
    Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
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  131. Jan 2020
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6819083/