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CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element

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1. scibot 07 Nov 2026
  
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  plasmid_108100
  
  DOI: 10.1016/j.cell.2026.10.002
  
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sciencedirect.com/science/article/pii/S0092867426012134
Sep 2026
www.nature.com www.nature.com

PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia

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1. scibot 03 Sep 2026
  
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  plasmid_108100
  
  DOI: 10.1038/s41375-026-03098-8
  
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nature.com/articles/s41375-026-03098-8
Feb 2026
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CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples

1
1. scibot 27 Feb 2026
  
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  Addgene_108100
  
  DOI: 10.1016/j.molcel.2026.02.003
  
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sciencedirect.com/science/article/pii/S1097276526000985
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens

1
1. scibot 01 Feb 2026
  
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  plasmid_108100
  
  DOI: 10.64898/2026.01.08.698516
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12803220/
Jan 2026
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Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

1
1. scibot 30 Jan 2026
  
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  RRID:Addgene_108100
  
  DOI: 10.1158/2159-8290.CD-25-0919
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12848863/
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Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies

1
1. scibot 26 Jan 2026
  
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  108100
  
  DOI: 10.1158/2159-8290.CD-25-0299
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
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Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia

1
1. scibot 23 Jan 2026
  
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  plasmid_108100
  
  DOI: 10.1016/j.celrep.2025.116875
  
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sciencedirect.com/science/article/pii/S221112472501647X
Nov 2025
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Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration

1
1. scibot 23 Nov 2025
  
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  108100
  
  DOI: 10.1016/j.isci.2025.113552
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12508894/
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Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3

1
1. scibot 22 Nov 2025
  
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  Addgene_108100
  
  DOI: 10.1016/j.celrep.2025.116572
  
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sciencedirect.com/science/article/pii/S2211124725013440
Sep 2025
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Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression

1
1. scibot 25 Sep 2025
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.cmet.2025.08.012
  
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sciencedirect.com/science/article/pii/S1550413125003857
Aug 2025
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On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

1
1. scibot 11 Aug 2025
  
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  Addgene_108100
  
  DOI: 10.1101/2025.08.03.668359
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12324462/
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

1
1. scibot 08 Aug 2025
  
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  Addgene_108100
  
  DOI: 10.1016/j.ccell.2025.07.012
  
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sciencedirect.com/science/article/pii/S1535610825003186
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Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer

1
1. scibot 06 Aug 2025
  
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  Addgene_108100
  
  DOI: 10.1158/1541-7786.MCR-24-0672
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12319404/
Jun 2025
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FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

1
1. scibot 18 Jun 2025
  
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  RRID:Addgene_108100
  
  DOI: 10.1158/0008-5472.CAN-24-4576
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
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CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells

1
1. scibot 15 Jun 2025
  
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  108100
  
  DOI: 10.3390/ijms26104907
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12112730/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis

1
1. scibot 15 Jun 2025
  
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  Addgene_108100
  
  DOI: 10.3390/ijms26104585
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12111665/
Apr 2025
www.biorxiv.org www.biorxiv.org

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

1
1. scibot 13 Apr 2025
  
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  RRID:Addgene_108100
  
  DOI: 10.1101/2025.04.07.647605
  
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biorxiv.org/content/10.1101/2025.04.07.647605v1
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 04 Apr 2025
  
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  RRID:Addgene_108100
  
  DOI: 10.1158/0008-5472.can-24-4576
  
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52.53.155.43/d82b50f0340a265ea39586fdf6016ce1aa48cfa1/PDF-html.html
www.cell.com www.cell.com

SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity

1
1. scibot 02 Apr 2025
  
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  Addgene108100
  
  DOI: 10.1016/j.celrep.2025.115476
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells

1
1. scibot 18 Aug 2024
  
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  108100
  
  DOI: 10.1126/sciadv.adl4043
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11305386/
Jul 2024
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Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

1
1. scibot 25 Jul 2024
  
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  Plasmid_108100
  
  DOI: 10.1016/j.ccell.2024.06.006
  
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sciencedirect.com/science/article/pii/S1535610824002319
May 2024
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
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  AddgeneCat#108100
  
  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
Mar 2024
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IκBζ is a dual-use coactivator of NF-κB and POU transcription factors

2
1. scibot 08 Mar 2024
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.molcel.2024.01.007
  
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2. scibot 08 Mar 2024
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.molcel.2024.01.007
  
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sciencedirect.com/science/article/pii/S109727652400008X
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

1
1. scibot 16 Feb 2024
  
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  108100
  
  DOI: 10.1101/2024.01.22.576669
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10849552/
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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

1
1. scibot 02 Feb 2024
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.cell.2024.01.004
  
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cell.com/cell/fulltext/S0092-8674(24)00006-0
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma

1
1. scibot 01 Feb 2024
  
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  108100
  
  DOI: 10.1007/s11060-023-04531-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10824881/
Dec 2023
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B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling

1
1. scibot 17 Dec 2023
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.ccell.2023.11.008
  
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sciencedirect.com/science/article/pii/S1535610823003999
Jun 2022
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

1
1. scibot 25 Jun 2022
  
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  Addgene_108100
  
  DOI: 10.1016/j.molcel.2022.06.005
  
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sciencedirect.com/science/article/pii/S109727652200541X
Apr 2022
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

1
1. scibot 13 Apr 2022
  
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  RRID:Addgene_108100
  
  DOI: 10.1016/j.immuni.2022.03.007
  
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sciencedirect.com/science/article/pii/S1074761322001303
Feb 2022
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

1
1. scibot 23 Feb 2022
  
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  Addgene Cat# 108100
  
  DOI: 10.1016/j.molcel.2022.01.015
  
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sciencedirect.com/science/article/pii/S1097276522000582
Jan 2022
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SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
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  plasmid_108100
  
  DOI: 10.1016/j.celrep.2021.110233
  
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sciencedirect.com/science/article/pii/S2211124721017423
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 11 Aug 2021
  
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  plasmid_108100
  
  DOI: 10.1016/j.celrep.2018.10.051
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
Jul 2021
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Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

1
1. scibot 28 Jul 2021
  
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  LentiV_Cas9_puro
  
  DOI: 10.1016/j.molcel.2019.01.006
  
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sciencedirect.com/science/article/pii/S1097276519300061
Mar 2021
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

1
1. scibot 02 Mar 2021
  
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  RRID:Addgene_108100
  
  DOI: 10.7554/eLife.65905
  
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  RRID:Addgene_108100 RRIDCUR:Validated
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pmc.ncbi.nlm.nih.gov/articles/PMC7886351/
Feb 2021
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 25 Feb 2021
  
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  RRID:Addgene_108100
  
  DOI: 10.1038/s41467-020-17209-1
  
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nature.com/articles/s41467-020-17209-1
elifesciences.org elifesciences.org

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_108100
  
  DOI: 10.7554/eLife.61797
  
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  RRID:Addgene_108100 RRIDCUR:Validated
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elifesciences.org/articles/61797
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

1
1. scibot 05 Sep 2020
  
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  addgene_108100
  
  DOI: 10.7554/eLife.53381
  
  Resource: RRID:Addgene_108100
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_108100
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_108100
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RRID:Addgene_108100

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7200154/
Aug 2020
www.nature.com www.nature.com

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

1
1. scibot 24 Aug 2020
  
  in Public
  
  RRID:Addgene_108100
  
  DOI: 10.1038/s41467-020-17209-1
  
  Resource: RRID:Addgene_108100
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_108100
  
  What is this?
  
  RRID:Addgene_108100
Visit annotations in context

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RRID:Addgene_108100

Annotators

scibot

URL

nature.com/articles/s41467-020-17209-1