60 Matching Annotations
  1. Last 7 days
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    HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma
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    aacrjournals.org/cancerres/article/85/20/3875/766093/HPV-E5-Mediates-Resistance-to-Chemotherapy-and
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteasome dysfunction underlies HERC2-linked neurodevelopmental disorder with Angelman-like clinical features
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    pmc.ncbi.nlm.nih.gov/articles/PMC13187139/
  5. May 2026
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    Human Immunodeficiency Virus Type 2 Vpx-mediated Degradation of TASOR Activates Innate Immune Sensing of Nucleic Acids in Infected Cells
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    sciencedirect.com/science/article/pii/S0022283626002524
  7. Apr 2026
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice
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    onlinelibrary.wiley.com/doi/10.1002/glia.70155
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12849445/
  10. Mar 2026
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    Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo
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    sciencedirect.com/science/article/pii/S1934590926001165
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    DCPS modulates TDP-43-linked neurodegeneration through P-body-mediated RNA decay
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    sciencedirect.com/science/article/pii/S0896627326000449
  13. Nov 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF-κB pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594511/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The key role of acss1 in mammary gland development and lactation: a study based on gene co-expression network analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12523080/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12537947/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting SQLE-mediated cholesterol metabolism to enhance CD8+ T cell activation and immunotherapy efficacy in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12481379/
  18. Oct 2025
  19. www.biorxiv.org www.biorxiv.org
    AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis
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    biorxiv.org/content/10.1101/2025.10.01.679670v1
  20. Sep 2025
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    Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state
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    sciencedirect.com/science/article/pii/S2211124725009568
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    Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways
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    sciencedirect.com/science/article/pii/S2589004225017699
  23. Aug 2025
  24. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225017006-main-html.html
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278642/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262666/
  27. Jul 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227071/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DSG2 promotes pancreatic cancer stem cell maintenance via support of tumour and macrophage cellular cross-talk
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227620/
  30. www.science.org www.science.org
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    science.org/doi/10.1126/sciadv.adu2339
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    Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma
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    nature.com/articles/s41598-025-07215-y
  32. Jun 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167931/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
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    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
  36. Apr 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11926012/
  38. Mar 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    REDD1-dependent GSK3β signaling in podocytes promotes canonical NF-κB activation in diabetic nephropathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904504/
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    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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    sciencedirect.com/science/article/pii/S0896627325001187
  41. Sep 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358006/
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    SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364541/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD+ as Limiting Factors for Hair Cell Reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC11425867/
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    Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1097276524007317
  46. Aug 2024
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    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    sciencedirect.com/science/article/pii/S1097276524006609
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    Compression-dependent microtubule reinforcement enables cells to navigate confined environments
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    nature.com/articles/s41556-024-01476-x
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    PRPS2‐mediated modulation of the antitumor immune response in lung cancer through CCL2‐mediated tumor‐associated macrophages and myeloid‐derived suppressor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11320087/
  50. Jun 2024
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    FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161053/
  52. May 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour‐derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13–CCR2–M2 macrophage axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11056704/
  54. Apr 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10954767/
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    Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959923/
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    NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β
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    ncbi.nlm.nih.gov/pmc/articles/PMC10981446/
  58. Mar 2024
  59. www.sciencedirect.com www.sciencedirect.com
    A gut-derived hormone regulates cholesterol metabolism
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    sciencedirect.com/science/article/pii/S0092867424002265
  60. Feb 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10869360/
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    Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10761817/
  63. Jan 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10803816/
  65. Oct 2023
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    Fibroblast activation protein drives tumor metastasis via a protease-independent role in invadopodia stabilization
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    sciencedirect.com/science/article/pii/S2211124723013141
  67. Sep 2023
  68. www.nature.com www.nature.com
    HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling
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    nature.com/articles/s41419-023-05549-x
  69. Aug 2023
  70. www.biorxiv.org www.biorxiv.org
    The endosomal sorting complex Retromer has a central role in systemic cholesterol homeostasis by controlling endo-lysosomal cholesterol transport in hepatocytes
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    biorxiv.org/content/10.1101/2023.08.09.552611v2
  71. Jul 2023
  72. www.sciencedirect.com www.sciencedirect.com
    mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
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    sciencedirect.com/science/article/pii/S1097276523004689
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    REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice
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    sciencedirect.com/science/article/pii/S0021925823020197
  74. Feb 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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    sciencedirect.com/science/article/pii/S0960982223001525
  76. Jan 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    sciencedirect.com/science/article/pii/S1535610822005943
  78. Oct 2022
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    Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling
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    sciencedirect.com/science/article/pii/S002192582201081X
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    HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress
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    link.springer.com/article/10.1007/s00018-022-04586-7
  81. Jun 2022
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SAMM50 Regulates Thermogenesis of Beige Adipocytes Differentiated from Human Adipose-Derived Stem Cells by Balancing Mitochondrial Dynamics
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    ncbi.nlm.nih.gov/pmc/articles/PMC9224253/
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    Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity
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    sciencedirect.com/science/article/pii/S221112472200763X
  84. Jun 2021
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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    ncbi.nlm.nih.gov/pmc/articles/PMC8216717/
  86. May 2021
  87. www.sciencedirect.com www.sciencedirect.com
    Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development
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    sciencedirect.com/science/article/pii/S193459092100206X
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    sciencedirect.com/science/article/pii/S009286742100502X
  89. Sep 2020
  90. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems
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    pubmed.ncbi.nlm.nih.gov/32810208/
  91. Jan 2020
  92. www.sciencedirect.com www.sciencedirect.com
    Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming
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    sciencedirect.com/science/article/pii/S1934590919303406