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23 Matching Annotations

Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers

1
1. scibot 11 Aug 2025
  
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  111906
  
  DOI: 10.1038/s41467-025-62309-5
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
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  RRID:Addgene_111906
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pmc.ncbi.nlm.nih.gov/articles/PMC12307730/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Interferon-dependent R-loop induction by Zika virus contributes to growth attenuation

1
1. scibot 15 Jun 2025
  
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  111906
  
  DOI: 10.1093/pnasnexus/pgaf147
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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pmc.ncbi.nlm.nih.gov/articles/PMC12082298/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer

1
1. scibot 15 Jun 2025
  
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  111906
  
  DOI: 10.1038/s41467-025-59804-0
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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pmc.ncbi.nlm.nih.gov/articles/PMC12085574/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Comprehensive interrogation of synthetic lethality in the DNA damage response

1
1. scibot 16 May 2025
  
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  111906
  
  DOI: 10.1038/s41586-025-08815-4
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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pmc.ncbi.nlm.nih.gov/articles/PMC12018271/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

1
1. scibot 16 Feb 2025
  
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  Addgene_111
  
  DOI: 10.1093/nar/gkaf061
  
  Resource: None
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRIDCUR:Unresolved RRID:Addgene_111906
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RRIDCUR:Unresolved

RRID:Addgene_111906

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC11806356/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA-mediated double-strand break repair by end-joining mechanisms

1
1. scibot 27 Sep 2024
  
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  Addgene_111906
  
  DOI: 10.1038/s41467-024-51457-9
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC11390984/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AKT1 interacts with DHX9 to mitigate R-loop-induced replication stress in ovarian cancer

1
1. scibot 25 Sep 2024
  
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  111906
  
  DOI: 10.1158/0008-5472.CAN-23-1908
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC10947874/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression

1
1. scibot 30 Jun 2024
  
  in Public
  
  plasmid_111906
  
  DOI: 10.1093/nar/gkae239
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC11194065/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AAV-mediated genome editing is influenced by the formation of R-loops

1
1. scibot 21 Jun 2024
  
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  plasmid_111906
  
  DOI: 10.1101/2024.05.07.592855
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC11100726/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency

1
1. scibot 09 Jun 2024
  
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  Addgene_111906
  
  DOI: 10.1038/s41467-024-48286-1
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC11148086/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS

1
1. scibot 07 Jun 2024
  
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  111906
  
  DOI: 10.1126/sciadv.adm8196
  
  Resource: RRID:Addgene_111906
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC11122683/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 06 Mar 2024
  
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  RRID:Addgene_111906
  
  DOI: 10.1038/s41467-024-45947-z
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis

1
1. scibot 11 Jan 2024
  
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  RRID:Addgene_111906
  
  DOI: 10.1016/j.celrep.2023.113644
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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sciencedirect.com/science/article/pii/S2211124723016558
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

1
1. scibot 20 Dec 2023
  
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  RRID:Addgene_111906
  
  DOI: 10.1158/0008-5472.CAN-22-2948
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
Oct 2023
dx.doi.org dx.doi.org

Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics

1
1. scibot 13 Oct 2023
  
  in Public
  
  plasmid_111906
  
  DOI: 10.1093/nar/gkad812
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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dx.doi.org/10.1093/nar/gkad812
May 2023
www.sciencedirect.com www.sciencedirect.com

EWSR1 maintains centromere identity

1
1. scibot 27 May 2023
  
  in Public
  
  Plasmid_111906
  
  DOI: 10.1016/j.celrep.2023.112568
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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sciencedirect.com/science/article/pii/S221112472300579X
Apr 2023
www.sciencedirect.com www.sciencedirect.com

TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner

1
1. scibot 15 Apr 2023
  
  in Public
  
  Addgene_111906
  
  DOI: 10.1016/j.celrep.2023.112406
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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RRID:Addgene_111906

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URL

sciencedirect.com/science/article/pii/S2211124723004175
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 12 Apr 2023
  
  in Public
  
  RRID:Addgene_111906
  
  DOI: 10.1101/2023.03.13.532415
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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RRID:Addgene_111906

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ncbi.nlm.nih.gov/pmc/articles/PMC10054921/
Oct 2022
www.sciencedirect.com www.sciencedirect.com

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

1
1. scibot 26 Oct 2022
  
  in Public
  
  111906
  
  DOI: 10.1016/j.celrep.2022.111526
  
  Resource: RRID:Addgene_111906
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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RRID:Addgene_111906

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scibot

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sciencedirect.com/science/article/pii/S2211124722013821
Oct 2021
www.sciencedirect.com www.sciencedirect.com

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

1
1. scibot 08 Oct 2021
  
  in Public
  
  addgene_111906
  
  DOI: 10.1016/j.molcel.2021.09.016
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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RRID:Addgene_111906

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sciencedirect.com/science/article/pii/S1097276521007504
Aug 2021
academic.oup.com academic.oup.com

Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1

1
1. scibot 17 Aug 2021
  
  in Public
  
  RRID:Addgene_111906
  
  DOI: 10.1093/narcan/zcab033
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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academic.oup.com/narcancer/article/3/3/zcab033/6352433
Feb 2021
mcb.asm.org mcb.asm.org

Mutual balance of histone deacetylases HDAC1, HDAC2, and the acetyl reader ATAD2 regulates the level of acetylation of histone H4 on nascent chromatin of human cells

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:Addgene_111906
  
  DOI: 10.1128/MCB.00421-19
  
  Resource: RRID:Addgene_111906
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_111906
  
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  RRID:Addgene_111906
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mcb.asm.org/content/40/9/e00421-19
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

1
1. scibot 25 Sep 2020
  
  in Public
  
  RRID:Addgene_111906
  
  DOI: 10.1016/j.celrep.2020.108166
  
  Resource: RRID:Addgene_111906
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_111906
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_111906
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RRIDCUR:Validated

RRID:Addgene_111906

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scibot

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pubmed.ncbi.nlm.nih.gov/32966794/