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Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genome editing strategies to generate working models of polycystic kidney disease

1
1. scibot 23 Nov 2025
  
  in Public
  
  pCMV_AncBE4max_P2A_GFP
  
  DOI: 10.1038/s41598-025-18343-w
  
  Resource: RRID:Addgene_112100
  
  Curator: @olekpark
  
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  RRID:Addgene_112100
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pmc.ncbi.nlm.nih.gov/articles/PMC12480119/
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

1
1. scibot 27 Sep 2025
  
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  Addgene_112100
  
  DOI: 10.1016/j.xcrm.2025.102376
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666379125004495
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants

1
1. scibot 02 Apr 2025
  
  in Public
  
  plasmid_112100
  
  DOI: 10.1093/nar/gkaf037
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
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  RRID:Addgene_112100
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pmc.ncbi.nlm.nih.gov/articles/PMC11952967/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Interferon-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins

1
1. scibot 27 Feb 2025
  
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  plasmid_112100
  
  DOI: 10.1016/j.stem.2025.02.003
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1934590925000426
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Enhanced genome editing with a Streptococcus equinus Cas9

1
1. scibot 16 Feb 2025
  
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  Addgene_112100
  
  DOI: 10.1038/s42003-025-07593-z
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11806022/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools

1
1. scibot 22 Aug 2024
  
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  plasmid_112100
  
  DOI: 10.1016/j.xpro.2024.103189
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100
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ncbi.nlm.nih.gov/pmc/articles/PMC11298932/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

1
1. scibot 06 Jan 2024
  
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  RRID:Addgene_112100
  
  DOI: 10.1186/s13287-023-03619-7
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100
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ncbi.nlm.nih.gov/pmc/articles/PMC10763022/
Aug 2023
52.53.155.43 52.53.155.43

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

2
1. scibot 24 Aug 2023
  
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  plasmid_112100
  
  DOI: 10.1038/s41467-023-40701-3
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100
2. scibot 24 Aug 2023
  
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  plasmid_112100
  
  DOI: 10.1038/s41467-023-40701-3
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100
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52.53.155.43/6be832dffc5b1bbf8ca7ed6df051bba72a6ab6af/s41467-023-40701-3-html.html
May 2023
www.sciencedirect.com www.sciencedirect.com

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification

1
1. scibot 13 May 2023
  
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  Addgene_112100
  
  DOI: 10.1016/j.medj.2023.04.003
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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sciencedirect.com/science/article/pii/S2666634023001356
Apr 2023
link.springer.com link.springer.com

Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones

1
1. scibot 29 Apr 2023
  
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  RRID:Addgene_112100
  
  DOI: 10.1186/s13287-023-03327-2
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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link.springer.com/article/10.1186/s13287-023-03327-2
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetically Edited Hepatic Cells Expressing the NTCP-S267F Variant are Resistant to Hepatitis B Virus Infection

1
1. scibot 02 Dec 2021
  
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  RRID:Addgene_112100
  
  DOI: 10.1016/j.omtm.2021.11.002
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100
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ncbi.nlm.nih.gov/pmc/articles/PMC8608598/
May 2021
www.sciencedirect.com www.sciencedirect.com

Cas9 deactivation with photocleavable guide RNAs

1
1. scibot 08 May 2021
  
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  Addgene_112100
  
  DOI: 10.1016/j.molcel.2021.02.007
  
  Resource: RRID:Addgene_112100
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_112100
  
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sciencedirect.com/science/article/pii/S1097276521000939
Jan 2020
www.nature.com www.nature.com

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_112100
  
  DOI: 10.1038/s41467-019-13342-8
  
  Resource: RRID:Addgene_112100
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_112100
  
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  RRID:Addgene_112100 RRIDCUR:Validated
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RRIDCUR:Validated

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scibot

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nature.com/articles/s41467-019-13342-8