171 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acsl4-mediated Lipid Homeostasis Orchestrates Synaptic and Cognitive Plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142639/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell type-specific barcoding reveals the projectional architecture of the mouse midbrain dopaminergic system
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    pmc.ncbi.nlm.nih.gov/articles/PMC13075453/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226660/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection
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    pmc.ncbi.nlm.nih.gov/articles/PMC13183376/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo CRISPR-mediated activation of cardiogenic genes to reprogram cardiac fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC13143979/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-destructive transcriptomics via vesicular export
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    pmc.ncbi.nlm.nih.gov/articles/PMC13121718/
  8. May 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modelling kidney cystogenesis using human kidney tubuloid cultures
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    pmc.ncbi.nlm.nih.gov/articles/PMC13162504/
  10. www.sciencedirect.com www.sciencedirect.com
    Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics
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    sciencedirect.com/science/article/pii/S266637912600217X
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13148380/
  12. Apr 2026
  13. www.biorxiv.org www.biorxiv.org
    Controlled linking of AAV capsids enables coordinated multi-vector delivery
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    biorxiv.org/content/10.64898/2026.04.13.716639v1
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for differentiation and efficient AAV-mediated gene delivery to hiPSC-derived microglia for functional studies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13068558/
  15. www.biorxiv.org www.biorxiv.org
    Sphingosine-1-Phosphate Receptor 1 regulates competition dependent astrocyte morphogenesis and tiling in murine cortex
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    biorxiv.org/content/10.64898/2026.03.28.714989v2
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo interrogation of transcriptional and epigenetic regulators of lung epithelial regeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015491/
  17. www.nature.com www.nature.com
    UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration
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    nature.com/articles/s41593-026-02226-y
  18. Mar 2026
  19. www.biorxiv.org www.biorxiv.org
    Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy
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    biorxiv.org/content/10.64898/2026.02.26.707014v1
  20. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226005560-main-html.html
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    54.241.53.176/3f9deeebafbe98264959bc85c646f95d599d5b8f/1-s2.0-S2589004226005560-main-html.html
  21. Feb 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905377/
  23. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement
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    sciencedirect.com/science/article/pii/S0896627325009845
  24. www.sciencedirect.com www.sciencedirect.com
    Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
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    sciencedirect.com/science/article/pii/S009286742600111X
  25. www.sciencedirect.com www.sciencedirect.com
    An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation and osteoporotic fracture repair
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    sciencedirect.com/science/article/pii/S2667237525003352
  26. Jan 2026
  27. www.sciencedirect.com www.sciencedirect.com
    AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy
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    sciencedirect.com/science/article/pii/S0092867425014886
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Engineered Small Extracellular Vesicles Targeting Tumor-Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202518490
  29. www.biorxiv.org www.biorxiv.org
    Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy
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    biorxiv.org/content/10.64898/2026.01.09.698633v1
  30. Nov 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12560573/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12542959/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554105/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-22 Exacerbates Coxsackievirus Type B3-Induced Pancreatitis by Elevating Viral Replication Through STAT3 Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12599472/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rat somatic genome editing enables ER+ breast cancer modeling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12458290/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12450567/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Modeling of Human Dorsal Root Ganglion Neurons for GCaMP6-Based Calcium Imaging of Sensory Responses to HSV-1 Infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12513575/
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    Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex
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    sciencedirect.com/science/article/pii/S2589004225022199
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623870/
  40. Oct 2025
  41. www.biorxiv.org www.biorxiv.org
    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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    biorxiv.org/content/10.1101/2025.10.14.682478v1
  42. 54.241.53.176 54.241.53.176
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  43. Sep 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12441120/
  45. www.biorxiv.org www.biorxiv.org
    Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation
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    biorxiv.org/content/10.1101/2025.09.15.676326v1
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    GephyrinΔ199-233 - an epileptogenic microdeletion
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    biorxiv.org/content/10.1101/2025.08.26.672322v1
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410343/
  49. Aug 2025
  50. www.sciencedirect.com www.sciencedirect.com
    Hepatocyte metabolic adaptations during pregnancy and lactation
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    sciencedirect.com/science/article/pii/S0092867425009213
  51. www.nature.com www.nature.com
    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    nature.com/articles/s41593-025-02043-9
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11780352/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265543/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272419/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained high expression of human FVII following AAV8-mediated gene delivery in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282199/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unveiling Small Non‐Coding RNA Dynamics During Recombinant Adeno‐Associated Virus Production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329270/
  57. Jul 2025
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236521/
  59. 52.53.155.43 52.53.155.43
    matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
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  60. www.journal-of-hepatology.eu www.journal-of-hepatology.eu
    Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
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    journal-of-hepatology.eu/article/S0168-8278(25)02320-7/fulltext
  61. elifesciences.org elifesciences.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    elifesciences.org/reviewed-preprints/106778
  62. Jun 2025
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185343/
  64. www.sciencedirect.com www.sciencedirect.com
    Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice
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    sciencedirect.com/science/article/pii/S2666166725003132
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162853/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of hydrophilic interaction liquid chromatography and top-down mass spectrometry for characterisation of adeno-associated virus capsid proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122587/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclophilin J Reprograms Tumor-associated Macrophages to Exert an Anti-tumor Effect in Liver Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160919/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137126/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12152525/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCL12 engages cortical inhibitory neurons to enhance dendritic spine plasticity and structured network activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160403/
  71. 52.53.155.43 52.53.155.43
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  72. May 2025
  73. www.sciencedirect.com www.sciencedirect.com
    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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  74. link.springer.com link.springer.com
    SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes
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    link.springer.com/article/10.1007/s12035-025-05036-8
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024971/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050299/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986041/
  78. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice
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    sciencedirect.com/science/article/pii/S1525001625002965
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11987650/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060515/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A humanized Gs-coupled DREADD for circuit and behavior modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015759/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The G protein modifier KCTD5 tunes the decoding of neuromodulatory signals necessary for motor function in striatal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021292/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predicting adenine base editing efficiencies in different cellular contexts by deep learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049829/
  86. Apr 2025
  87. 52.53.155.43 52.53.155.43
    1-s2.0-S1525001625002795-main-html.html
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  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225003700-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951025/
  90. www.biorxiv.org www.biorxiv.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    biorxiv.org/content/10.1101/2025.03.24.645101v1
  91. Mar 2025
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cardiac-Specific Gene Editing via an AAV9-Tnnt2-SaCas9-miR122TS Vector
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    pmc.ncbi.nlm.nih.gov/articles/PMC11896767/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Use of an oversized AAV8 vector for CPS1 deficiency results in long-term survival and ammonia control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11905892/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766445/
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839100/
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761689/
  97. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876347/
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
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  111. Dec 2024
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  116. Nov 2024
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  118. Sep 2024
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  128. Aug 2024
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  136. Jun 2024
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  141. May 2024
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  148. Apr 2024
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  150. Mar 2024
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  159. Feb 2024
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  162. Jan 2024
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  164. Dec 2023
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  166. Nov 2023
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  169. Aug 2023
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  171. Jul 2023
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  174. Jun 2023
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  177. May 2023
  178. www.authorea.com www.authorea.com
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  179. Apr 2023
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  182. Mar 2023
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  184. Feb 2023
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  186. Jan 2023
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  189. Dec 2022
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  191. Nov 2022
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  193. Jul 2022
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  195. Jun 2022
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  198. May 2022
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  200. Mar 2022
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  202. Jan 2022
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  204. Nov 2021
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    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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  207. Oct 2021
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    A Fast, Aqueous, Reversible Three-Day Tissue Clearing Method for Adult and Embryonic Mouse Brain and Whole Body
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  209. Sep 2021
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    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    Compact RNA editors with small Cas13 proteins
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  212. Jul 2021
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    Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models
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  214. Apr 2021
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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  216. Feb 2021
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    A simple adeno-associated virus-based approach for the generation of cardiac genetic models in rats
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  218. Dec 2020
  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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    ncbi.nlm.nih.gov/pmc/articles/PMC7683292/
  220. Jan 2020
  221. www.sciencedirect.com www.sciencedirect.com
    Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
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    sciencedirect.com/science/article/pii/S0092867419306208