146 Matching Annotations
  1. Aug 2025
  2. www.biorxiv.org www.biorxiv.org
    A Phosphoinositide Interacting Protein Coordinates Stress Precursor Activities
    2
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    biorxiv.org/content/10.1101/2025.08.18.670812v1
  3. www.sciencedirect.com www.sciencedirect.com
    Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity
    1
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    sciencedirect.com/science/article/pii/S2666379125003805
  4. www.sciencedirect.com www.sciencedirect.com
    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
    1
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    sciencedirect.com/science/article/pii/S1074761325003267
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early methionine availability attenuates T cell exhaustion
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307228/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EF1α, rather than CMV promoter, is suitable for luciferase tag expression in target cells for in vitro cytotoxicity assays of CAR-T cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329255/
  7. www.sciencedirect.com www.sciencedirect.com
    Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
    1
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    sciencedirect.com/science/article/pii/S155041312500333X
  8. Jul 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208539/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLIMP1 negatively regulates IL-2 signaling in T cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273773/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
  12. Jun 2025
  13. rupress.org rupress.org
    BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
    1
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    rupress.org/jem/article/222/8/e20241133/277913/BCOR-and-ZC3H12A-suppress-a-core-stemness-program
  14. www.sciencedirect.com www.sciencedirect.com
    Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease
    1
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    sciencedirect.com/science/article/pii/S2211124725005698
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12083649/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12092595/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12143136/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076078/
  19. May 2025
  20. www.science.org www.science.org
    An engineered viral protein activates STAT5 to prevent T cell suppression
    1
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    science.org/doi/10.1126/sciimmunol.adn9633
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12018455/
  22. Apr 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD34 serves as an intrinsic innate immune guardrail protecting stem cells from replicating retroviruses
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11956995/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nucleosome Engagement Regulates RORγt Structure and Dynamics
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952427/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11937441/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957990/
  28. Mar 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11903307/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11920272/
  31. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti-Tumor Effector Cytotoxic T Cells
    1
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202410241
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immunomodulatory role of the stem cell circadian clock in muscle repair
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11881903/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642886/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
  35. Feb 2025
  36. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
    1
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    sciencedirect.com/science/article/pii/S1934590925000104
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11803149/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11815418/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805920/
  40. www.sciencedirect.com www.sciencedirect.com
    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
    1
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    sciencedirect.com/science/article/pii/S221112472500052X
  41. 52.53.155.43 52.53.155.43
    Different signaling interpretations by PKC eta and theta control T cell function and exhaustion
    1
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    52.53.155.43/9f90de74dc5bf358748b9367775e021d8c3b69fa/2024.09.26.615103v1.full-html.html
  42. Jan 2025
  43. 52.53.155.43 52.53.155.43
    Acidity-induced dysfunction of CD8+ T cells is characterized by impaired IL-2 responsiveness and perturbations to mTORC1 signaling and c-Myc levels
    1
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    52.53.155.43/714b3a4b4f102fbda2f7d4eb1d71fcddef5e6e60/2023.12.15.571931v2.full-html.html
  44. www.sciencedirect.com www.sciencedirect.com
    Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer
    1
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    sciencedirect.com/science/article/pii/S1535610825000194
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729897/
  46. www.science.org www.science.org
    Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis
    1
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    science.org/doi/10.1126/sciimmunol.adl4909
  47. www.sciencedirect.com www.sciencedirect.com
    IL-21 shapes the B cell response in a context-dependent manner
    1
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    sciencedirect.com/science/article/pii/S2211124724015419
  48. Dec 2024
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665559/
  50. www.sciencedirect.com www.sciencedirect.com
    Lnc-RAINY Regulates Genes Involved in Radiation Susceptibility Through DNA:DNA:RNA triplex-forming Interactions and has Tumor Therapeutic Potential in Lung Cancers
    1
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    sciencedirect.com/science/article/pii/S2468054024001689
  51. www.sciencedirect.com www.sciencedirect.com
    YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
    1
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    sciencedirect.com/science/article/pii/S0092867424013242
  52. www.sciencedirect.com www.sciencedirect.com
    Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
    1
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    sciencedirect.com/science/article/pii/S1535610824004380
  53. Nov 2024
  54. www.sciencedirect.com www.sciencedirect.com
    A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis
    1
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    sciencedirect.com/science/article/pii/S2211124724013032
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11535206/
  56. Sep 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reversible control of kinase signaling through chemical-induced dephosphorylation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366001/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LILRB3 supports immunosuppressive activity of myeloid cells and tumor development
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10932818/
  59. www.embopress.org www.embopress.org
    Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling
    1
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    embopress.org/doi/10.1038/s44318-024-00235-w
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating mutations remodel the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A‐rearranged acute leukemia
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426354/
  61. www.biorxiv.org www.biorxiv.org
    DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells
    1
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    biorxiv.org/content/10.1101/2024.09.15.613155v1
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of immortal-like and functional CAR T cells by defined factors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10965394/
  63. www.biorxiv.org www.biorxiv.org
    Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells
    1
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    biorxiv.org/content/10.1101/2024.09.18.613594v1
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10922727/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of an antigen-based approach to noninvasively image CAR T cells in real time and as a predictive tool
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11409975/
  67. www.sciencedirect.com www.sciencedirect.com
    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
    1
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    sciencedirect.com/science/article/pii/S2211124724010416
  68. Aug 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pathologically expanded, clonal lineage of IL-21–producing CD4+ T cells drives inflammatory neuropathy
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11290969/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fructose vs. glucose: modulating stem cell growth and function through sugar supplementation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301265/
  72. Jul 2024
  73. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
    1
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    sciencedirect.com/science/article/pii/S2211124724008945
  74. www.sciencedirect.com www.sciencedirect.com
    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
    1
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    sciencedirect.com/science/article/pii/S1097276524004775
  75. rupress.org rupress.org
    PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway
    1
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    rupress.org/jem/article/221/7/e20221721/276807/PD-L1-promotes-oncolytic-virus-infection-via-a
  76. Jun 2024
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD52/FLAG and CD52/HA Fusion Proteins as Novel Magnetic Cell Selection Markers
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11203882/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11188874/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11178498/
  80. May 2024
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell of origin epigenetic priming determines susceptibility to Tet2 mutation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11109152/
  82. www.sciencedirect.com www.sciencedirect.com
    T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells
    1
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    sciencedirect.com/science/article/pii/S2211124724005862
  83. www.sciencedirect.com www.sciencedirect.com
    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
    1
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    sciencedirect.com/science/article/pii/S2211124724005898
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T cell help shapes B cell tolerance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11095409/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11095456/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting senescent cells with NKG2D-CAR T cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11069534/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11078192/
  88. Apr 2024
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10990278/
  90. Mar 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959178/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for self-discrimination by neoantigen-specific TCRs
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924104/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10928157/
  94. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
    3
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    sciencedirect.com/science/article/pii/S1535610824000606
  95. www.sciencedirect.com www.sciencedirect.com
    NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment
    2
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    sciencedirect.com/science/article/pii/S2211124724002262
  96. Feb 2024
  97. www.sciencedirect.com www.sciencedirect.com
    Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity
    2
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    sciencedirect.com/science/article/pii/S2211124724001244
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802410/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798966/
  100. Jan 2024
  101. www.nature.com www.nature.com
    CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
    1
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    nature.com/articles/s41423-024-01124-2
  102. Dec 2023
  103. www.sciencedirect.com www.sciencedirect.com
    Highly cooperative chimeric super-SOX induces naive pluripotency across species
    1
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    sciencedirect.com/science/article/pii/S1934590923004022
  104. www.sciencedirect.com www.sciencedirect.com
    MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy
    1
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    sciencedirect.com/science/article/pii/S221112472301464X
  105. Nov 2023
  106. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
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