190 Matching Annotations
  1. Last 7 days
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    Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis
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    nature.com/articles/s41418-026-01846-y
  3. Aug 2026
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    Preclinical evaluation of nitrated α-synuclein-specific CAR-Treg therapy in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2666379126004003
  5. Jul 2026
  6. aacrjournals.org aacrjournals.org
    Engineering T Cells with a Tumor-Reactive Chimeric T Cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses
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    aacrjournals.org/cancerres/article/86/11/2688/785304/Engineering-T-Cells-with-a-Tumor-Reactive-Chimeric
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13335422/
  8. Jun 2026
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    Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors
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    sciencedirect.com/science/article/pii/S2666379126003022
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    ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development
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    sciencedirect.com/science/article/pii/S266637912600296X
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    Targeting TYRO3 attenuates apoptotic cell–driven cancer stemness in triple negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237900/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Age-related reduction of pyruvate dehydrogenase kinase 1 impairs T cell responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13200556/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sequential in vivo CRISPR screens identify the clonal dominance of Nf1 loss in long-term hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13221118/
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    A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1097276526003114
  15. May 2026
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    An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior
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    sciencedirect.com/science/article/pii/S2451945626001418
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ionizing radiation enhances CAR T-cell infiltration and efficacy in solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13125132/
  18. Apr 2026
  19. aacrjournals.org aacrjournals.org
    Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages
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    aacrjournals.org/cancerimmunolres/article/13/12/2054/768330/Functional-Genetic-Screens-Reveal-Key-Pathways
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    A universal boosting strategy for adoptive T cell therapy using a paired vaccine/chimeric antigen receptor
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    aacrjournals.org/cancerimmunolres/article/14/2/261/771969/A-Universal-Boosting-Strategy-for-Adoptive-T-cell
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    A stress-induced PI3P complex controls autophagy in erythroid precursors
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    sciencedirect.com/science/article/pii/S2589004226005572
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomic analysis of clonal development reveals new regulators of leukemic cell growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC13041715/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA binding protein Sam68 promotes germinal center reaction and IgG response through regulation of miR29
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    pmc.ncbi.nlm.nih.gov/articles/PMC13013783/
  24. aacrjournals.org aacrjournals.org
    STAT5 activation enhances adoptive therapy combined with peptide vaccination by preventing PD-1 inhibition
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    aacrjournals.org/mct/article/24/3/419/752080/STAT5-Activation-Enhances-Adoptive-Therapy
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    Sulfur partitioning from cysteine controls T cell proliferation and effector function
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    sciencedirect.com/science/article/pii/S0092867426002795
  26. Mar 2026
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    Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration
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    sciencedirect.com/science/article/pii/S1074761326000919
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    Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma
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    sciencedirect.com/science/article/pii/S1931312826000879
  29. dx.doi.org dx.doi.org
    Gamma-retrovirus design for efficacious microRNA-mediated gene knock-down and protein co-expression without compromising titers
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    dx.doi.org/10.1093/narmme/ugaf030
  30. www.sciencedirect.com www.sciencedirect.com
    Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia
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    sciencedirect.com/science/article/pii/S2666379126001047
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    Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
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    sciencedirect.com/science/article/pii/S2211124726001403
  32. 54.241.53.176 54.241.53.176
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  33. Feb 2026
  34. www.sciencedirect.com www.sciencedirect.com
    Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection
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    sciencedirect.com/science/article/pii/S1074761326000270
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    Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma
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    link.springer.com/article/10.1007/s10456-026-10031-1
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    ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124726000884
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    Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes
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  38. Jan 2026
  39. www.sciencedirect.com www.sciencedirect.com
    Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells
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    sciencedirect.com/science/article/pii/S1535610825005021
  40. 54.241.53.176 54.241.53.176
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12794186/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-Treatment with Dacarbazine Sensitizes B16 Melanoma to CAR T Cell Therapy in Syngeneic Mouse Model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12785862/
  43. Dec 2025
  44. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration
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    sciencedirect.com:5037/science/article/pii/S1074761325005114
  45. Nov 2025
  46. www.sciencedirect.com www.sciencedirect.com
    Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Peptide-MHC–targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594172/
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    IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
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    sciencedirect.com/science/article/pii/S1074761325004789
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    Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S0092867425012334
  50. Sep 2025
  51. www.sciencedirect.com www.sciencedirect.com
    IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation
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    sciencedirect.com/science/article/pii/S2211124725011015
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    Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12420363/
  53. www.biorxiv.org www.biorxiv.org
    Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.09.04.673818v1
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    Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation
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    sciencedirect.com/science/article/pii/S2211124725010575
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade
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    pmc.ncbi.nlm.nih.gov/articles/PMC12412523/
  56. Aug 2025
  57. www.biorxiv.org www.biorxiv.org
    A Phosphoinositide Interacting Protein Coordinates Stress Precursor Activities
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    biorxiv.org/content/10.1101/2025.08.18.670812v1
  58. www.sciencedirect.com www.sciencedirect.com
    Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379125003805
  59. www.sciencedirect.com www.sciencedirect.com
    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
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    sciencedirect.com/science/article/pii/S1074761325003267
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early methionine availability attenuates T cell exhaustion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307228/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EF1α, rather than CMV promoter, is suitable for luciferase tag expression in target cells for in vitro cytotoxicity assays of CAR-T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329255/
  62. www.sciencedirect.com www.sciencedirect.com
    Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
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    sciencedirect.com/science/article/pii/S155041312500333X
  63. Jul 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208539/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLIMP1 negatively regulates IL-2 signaling in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273773/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
  67. Jun 2025
  68. rupress.org rupress.org
    BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
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    rupress.org/jem/article/222/8/e20241133/277913/BCOR-and-ZC3H12A-suppress-a-core-stemness-program
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    Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease
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  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT
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    pmc.ncbi.nlm.nih.gov/articles/PMC12083649/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12092595/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12143136/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12076078/
  74. May 2025
  75. www.science.org www.science.org
    An engineered viral protein activates STAT5 to prevent T cell suppression
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    science.org/doi/10.1126/sciimmunol.adn9633
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12018455/
  77. Apr 2025
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD34 serves as an intrinsic innate immune guardrail protecting stem cells from replicating retroviruses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11956995/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nucleosome Engagement Regulates RORγt Structure and Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952427/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay
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    pmc.ncbi.nlm.nih.gov/articles/PMC11937441/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957990/
  83. Mar 2025
  84. www.nature.com www.nature.com
    Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
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    nature.com/articles/s41586-024-08466-x
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC11920272/
  86. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti-Tumor Effector Cytotoxic T Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202410241
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immunomodulatory role of the stem cell circadian clock in muscle repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11881903/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dnmt3a-dependent de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642886/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760969/
  90. Feb 2025
  91. www.sciencedirect.com www.sciencedirect.com
    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    sciencedirect.com/science/article/pii/S1934590925000104
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11803149/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11815418/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805920/
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    sciencedirect.com/science/article/pii/S221112472500052X
  96. 52.53.155.43 52.53.155.43
    Different signaling interpretations by PKC eta and theta control T cell function and exhaustion
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    52.53.155.43/9f90de74dc5bf358748b9367775e021d8c3b69fa/2024.09.26.615103v1.full-html.html
  97. Jan 2025
  98. 52.53.155.43 52.53.155.43
    Acidity-induced dysfunction of CD8+ T cells is characterized by impaired IL-2 responsiveness and perturbations to mTORC1 signaling and c-Myc levels
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    52.53.155.43/714b3a4b4f102fbda2f7d4eb1d71fcddef5e6e60/2023.12.15.571931v2.full-html.html
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    Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer
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    sciencedirect.com/science/article/pii/S1535610825000194
  100. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729897/
  101. www.science.org www.science.org
    Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis
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    science.org/doi/10.1126/sciimmunol.adl4909
  102. www.sciencedirect.com www.sciencedirect.com
    IL-21 shapes the B cell response in a context-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724015419
  103. Dec 2024
  104. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11665559/
  105. www.sciencedirect.com www.sciencedirect.com
    Lnc-RAINY Regulates Genes Involved in Radiation Susceptibility Through DNA:DNA:RNA triplex-forming Interactions and has Tumor Therapeutic Potential in Lung Cancers
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  210. Dec 2021
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  222. May 2021
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  225. Mar 2021
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    Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity
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  227. Feb 2021
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    The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation
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  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
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  230. Oct 2020
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    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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  232. Sep 2020
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    Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
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  234. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia
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    Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL‑AF9 translocation
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    Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
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  237. Jan 2020
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    53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
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