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Sep 2025
www.biorxiv.org www.biorxiv.org

The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

2
1. scibot 18 Sep 2025
  
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  Addgene plasmid # 14883
  
  DOI: 10.1101/2025.09.09.674816
  
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  DOI: 10.1101/2025.09.09.674816
  
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biorxiv.org/content/10.1101/2025.09.09.674816v1
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Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1

2
1. scibot 11 Sep 2025
  
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  AddgeneCat#(14883)
  
  DOI: 10.1016/j.celrep.2025.116266
  
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2. scibot 11 Sep 2025
  
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  Addgene_14883
  
  DOI: 10.1016/j.celrep.2025.116266
  
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sciencedirect.com/science/article/pii/S221112472501037X
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Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer

1
1. scibot 11 Sep 2025
  
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  Cat# 14883
  
  DOI: 10.1016/j.celrep.2025.116235
  
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sciencedirect.com/science/article/pii/S221112472501006X
Jul 2025
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A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

1
1. scibot 30 Jul 2025
  
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  Addgene_14883
  
  DOI: 10.1101/2025.07.22.666069
  
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biorxiv.org/content/10.1101/2025.07.22.666069v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

1
1. scibot 20 Jul 2025
  
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  Addgene_14883
  
  DOI: 10.1038/s41467-025-61216-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12238573/
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

1
1. scibot 18 Jun 2025
  
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  RRID:Addgene_14883
  
  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
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Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal

1
1. scibot 14 Jun 2025
  
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  Addgene_14883
  
  DOI: 10.1242/jcs.263695
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12148026/
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Harnessing endogenous miRNA targeting ZIKV: A cutting-edge strategy to inhibit virus infection

1
1. scibot 14 Jun 2025
  
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  Addgene_14883
  
  DOI: 10.1016/j.omtn.2025.102562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12155756/
May 2025
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Two waves of adipogenesis in developing avian skin and dermal plasticity

1
1. scibot 29 May 2025
  
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  RRID:Addgene_14883
  
  DOI: 10.1016/j.ydbio.2025.05.019
  
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sciencedirect.com/science/article/pii/S0012160625001423
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Lineage-specific CDK activity dynamics characterize early mammalian development

1
1. scibot 16 May 2025
  
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  Addgene_14883
  
  DOI: 10.1016/j.celrep.2025.115558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12070373/
Mar 2025
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m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

1
1. scibot 20 Mar 2025
  
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  RRID: Addgene_14883
  
  DOI: 10.1016/j.stem.2025.02.011
  
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sciencedirect.com/science/article/pii/S1934590925000797
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The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain

1
1. scibot 11 Mar 2025
  
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  14883
  
  DOI: 10.1101/2025.01.10.632395
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

1
1. scibot 11 Mar 2025
  
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  14883
  
  DOI: 10.1038/s41586-024-08532-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
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The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo

1
1. scibot 11 Mar 2025
  
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  RRID:Addgene_14883
  
  DOI: 10.1038/s41467-025-57521-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11885535/
Feb 2025
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GEVSod2 Powder: A Modified Product Based on Biovesicles Functioned in Air Pollution PM2.5-Induced Cardiopulmonary Injury

1
1. scibot 15 Feb 2025
  
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  plasmid_14883
  
  DOI: 10.34133/research.0609
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11822167/
Jan 2025
www.nature.com www.nature.com

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

1
1. scibot 31 Jan 2025
  
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  Addgene_14883
  
  DOI: 10.1038/s41467-025-56282-2
  
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nature.com/articles/s41467-025-56282-2
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling

1
1. scibot 27 Jan 2025
  
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  14883
  
  DOI: 10.1101/2025.01.06.631593
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11741329/
www.sciencedirect.com www.sciencedirect.com

OSMOTIC STRESS INFLUENCES MICROTUBULE DRUG RESPONSE VIA WNK1 KINASE SIGNALING

1
1. scibot 23 Jan 2025
  
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  Addgene_14883
  
  DOI: 10.1016/j.drup.2025.101203
  
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sciencedirect.com/science/article/pii/S1368764625000032
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 28 Dec 2024
  
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  RRID:Addgene_14883
  
  DOI: 10.1111/j.1469-7580.2009.01173.x
  
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52.53.155.43/e965e8c267bcac477ace8b0fa7455c4f20806539/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

1
1. scibot 27 Dec 2024
  
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  14883
  
  DOI: 10.1016/j.isci.2024.111425
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648915/
Nov 2024
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Regulation of synapse density by Pumilio RNA-binding proteins

1
1. scibot 15 Nov 2024
  
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  RRID:Addgene_14883
  
  DOI: 10.1016/j.celrep.2024.114747
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11544588/
www.biorxiv.org www.biorxiv.org

Human adipose-derived mesenchymal stromal cells improved wound healing in enterocutaneous fistulizing disease mouse model

1
1. scibot 14 Nov 2024
  
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  RRID:Addgene_14883
  
  DOI: 10.1101/2024.11.07.622127
  
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biorxiv.org/content/10.1101/2024.11.07.622127v1
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Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons

2
1. scibot 07 Nov 2024
  
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  RRID:Addgene_14883
  
  DOI: 10.3389/fncel.2024.1465011
  
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2. scibot 07 Nov 2024
  
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  RRID:Addgene_14
  
  DOI: 10.3389/fncel.2024.1465011
  
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  Curator: @evieth
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513877/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Light-gated integrator for highlighting kinase activity in living cells

1
1. scibot 28 Sep 2024
  
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  Addgene_14883
  
  DOI: 10.1038/s41467-024-51270-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11379911/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

New ZNHIT3 Variants Disrupting snoRNP Assembly Cause Prenatal PEHO Syndrome with Isolated Hydrops

1
1. scibot 28 Sep 2024
  
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  Addgene_14883
  
  DOI: 10.1101/2024.08.26.24312490
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11383450/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Deafness causing neuroplastin missense variants fail to promote plasma membrane Ca2+-ATPase levels and Ca2+ transient regulation in brain neurons

1
1. scibot 26 Aug 2024
  
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  FUGW
  
  DOI: 10.1016/j.jbc.2024.107474
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11264175/
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The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling

1
1. scibot 26 Aug 2024
  
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  14883
  
  DOI: 10.1172/JCI170550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11324312/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization

1
1. scibot 22 Aug 2024
  
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  plasmid_14883
  
  DOI: 10.1371/journal.pbio.3002751
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11321591/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

1
1. scibot 20 Jul 2024
  
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  plasmid_14883
  
  DOI: 10.1038/s41467-020-16411-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7260201/
www.biorxiv.org www.biorxiv.org

Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling

1
1. scibot 16 Jul 2024
  
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  Addgene_14883
  
  DOI: 10.1101/2024.07.08.602030
  
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biorxiv.org/content/10.1101/2024.07.08.602030v1
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYCT1 controls environmental sensing in human haematopoietic stem cells

1
1. scibot 15 Jun 2024
  
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  14883
  
  DOI: 10.1038/s41586-024-07478-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11168926/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction

1
1. scibot 09 Jun 2024
  
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  plasmid_14883
  
  DOI: 10.1126/sciadv.adj0385
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11160455/
www.biorxiv.org www.biorxiv.org

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

1
1. scibot 07 Jun 2024
  
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  Addgene_14883
  
  DOI: 10.1101/2024.05.30.596755
  
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biorxiv.org/content/10.1101/2024.05.30.596755v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

1
1. scibot 03 Jun 2024
  
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  RRID:Addgene_14883
  
  DOI: 10.1038/s41467-024-49016-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
May 2024
www.biorxiv.org www.biorxiv.org

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons

1
1. scibot 23 May 2024
  
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  plasmid_14883
  
  DOI: 10.1101/2024.05.16.594502
  
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biorxiv.org/content/10.1101/2024.05.16.594502v1
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Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids

1
1. scibot 16 May 2024
  
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  Addgene_14883
  
  DOI: 10.1016/j.stem.2024.04.019
  
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Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut

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Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program

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The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism

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Light-gated Integrator for Highlighting Kinase Activity in Living Cells

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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation

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Viral Epitope Scanning Reveals Correlation between Seasonal HCoVs and SARS-CoV-2 Antibody Responses among Cancer and Non-Cancer Patients

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Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models

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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

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In vivo imaging in transgenic songbirds reveals superdiffusive neuron migration in the adult brain

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Glia trigger endocytic clearance of axonal proteins to promote rodent myelination

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Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion

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The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation

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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

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Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells

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Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation

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Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy

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2023.08.11.551903v1.full-html.html

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Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease

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May 2023
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Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons

1
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Feb 2023
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Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

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ncbi.nlm.nih.gov/pmc/articles/PMC9894587/
Nov 2022
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Niraparib-induced STAT3 inhibition increases its antitumor effects

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  DOI: 10.3389/fonc.2022.966492
  
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Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors

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May 2022
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Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke

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Feb 2022
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Characterization of the canine CD20 as a therapeutic target for comparative passive immunotherapy

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Nov 2021
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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

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Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

2
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  RRID:AB_14883
  
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RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

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Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment

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Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

1
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Aug 2021
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The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons

1
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  DOI: 10.1038/s42003-021-02512-4
  
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Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

1
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  DOI: 10.1091/mbc.E20-06-0382
  
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A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength

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Untitled document

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  DOI: 10.7554/eLife.41563
  
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Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability

1
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sciencedirect.com/science/article/pii/S2211124721009049
Jul 2021
europepmc.org europepmc.org

Untitled document

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  DOI: 10.1016/j.celrep.2018.11.066
  
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  DOI: 10.1016/j.cub.2018.08.060
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6224479/
May 2021
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Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism

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1. scibot 19 May 2021
  
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  plasmid_14883
  
  DOI: 10.1016/j.celrep.2021.109127
  
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An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

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1. scibot 12 May 2021
  
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  DOI: 10.1007/s12264-021-00685-w
  
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Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells

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1. scibot 09 May 2021
  
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  DOI: 10.1016/j.stem.2020.11.018
  
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Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuron.2021.01.007
  
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Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuron.2021.02.023
  
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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

1
1. scibot 08 May 2021
  
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  RRID:Addgene_14883
  
  DOI: 10.1016/j.neuron.2021.02.009
  
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sciencedirect.com/science/article/pii/S0896627321000830
Apr 2021
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Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

1
1. scibot 30 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.12.002
  
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sciencedirect.com/science/article/pii/S1550413120306574
Feb 2021
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Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

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1. scibot 26 Feb 2021
  
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  DOI: 10.1038/s41467-020-18956-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7560607/
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Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1

1
1. scibot 26 Feb 2021
  
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  Plasmid_14883
  
  DOI: 10.1016/j.celrep.2018.11.066
  
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cell.com/cell-reports/abstract/S2211-1247(18)31842-4
Jan 2021
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Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations

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1. scibot 15 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.107797
  
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sciencedirect.com/science/article/pii/S2211124720307786
Dec 2020
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The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

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1. scibot 07 Dec 2020
  
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  RRID:Addgene_14883
  
  DOI: 10.7554/eLife.56058
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7685708/
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Multiple Alternative Promoters and Alternative Splicing Enable Universal Transcription-Based Logic Computation in Mammalian Cells

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1. scibot 07 Dec 2020
  
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  Plasmid_14883
  
  DOI: 10.1016/j.celrep.2020.108437
  
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sciencedirect.com/science/article/pii/S2211124720314261
Nov 2020
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PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

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1. scibot 05 Nov 2020
  
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  Plasmid_14883
  
  DOI: 10.1016/j.celrep.2020.108312
  
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sciencedirect.com/science/article/pii/S2211124720313012
Oct 2020
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In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves

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1. scibot 08 Oct 2020
  
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  plasmid_14883
  
  DOI: 10.1007/s12035-020-02155-2
  
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link.springer.com/article/10.1007/s12035-020-02155-2
Sep 2020
elifesciences.org elifesciences.org

Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

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1. scibot 23 Sep 2020
  
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  RRID:Addgene_14883
  
  DOI: 10.7554/eLife.56469
  
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elifesciences.org/articles/56469
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Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

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1. scibot 07 Sep 2020
  
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  plasmid_14883
  
  DOI: 10.1523/JNEUROSCI.2994-18.2019
  
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jneurosci.org/content/39/37/7408
Jan 2020
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Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_14883
  
  DOI: 10.7554/eLife.47498
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6739868/
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Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_14883
  
  DOI: 10.1523/JNEUROSCI.0215-19.2019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6538862/
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Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_14883
  
  DOI: 10.1016/j.celrep.2019.08.102
  
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sciencedirect.com/science/article/pii/S2211124719311647
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Untitled document

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  Plasmid_14883
  
  DOI: 10.1016/j.celrep.2018.11.066
  
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sciencedirect.com/science/article/pii/S2211124718318424
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Untitled document

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  DOI: 10.1016/j.cub.2018.08.060
  
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sciencedirect.com/science/article/pii/S0960982218311448
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Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140

1
1. scibot 13 Jan 2020
  
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  Addgene_14883
  
  DOI: 10.1016/j.neuron.2018.10.008
  
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sciencedirect.com/science/article/pii/S0896627318308961
europepmc.org europepmc.org

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  DOI: 10.1016/j.celrep.2018.11.066
  
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europepmc.org/articles/PMC6302549/

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