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Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

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1. scibot 22 Sep 2025
  
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  174820
  
  DOI: 10.1038/s41586-025-09021-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12449813/
Aug 2025
www.mdpi.com www.mdpi.com

Prime Editing Modification with FEN1 Improves F508del Variant Editing in the CFTR Gene in Airway Basal Cells

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1. scibot 22 Aug 2025
  
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  RRID:Addgene_174820
  
  DOI: 10.3390/ijms26167943
  
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mdpi.com/1422-0067/26/16/7943
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AI-generated MLH1 small binder improves prime editing efficiency

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1. scibot 06 Aug 2025
  
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  Addgene plasmid #174820
  
  DOI: 10.1016/j.cell.2025.07.010
  
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sciencedirect.com/science/article/pii/S0092867425007998
Jul 2025
www.cell.com www.cell.com

In vivo prime editing rescues alternating hemiplegia of childhood in mice

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1. scibot 25 Jul 2025
  
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  #174820
  
  DOI: 10.1016/j.cell.2025.06.038
  
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cell.com/cell/fulltext/S0092-8674(25)00740-8
Jun 2025
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

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1. scibot 28 Jun 2025
  
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  Addgene, #174820
  
  DOI: 10.1002/1873-3468.70097
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70097
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

EXPERT expands prime editing efficiency and range of large fragment edits

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1. scibot 16 Feb 2025
  
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  DOI: 10.1038/s41467-025-56734-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11822059/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

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1. scibot 16 Feb 2025
  
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  DOI: 10.1038/s41467-025-56568-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11825950/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles

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1. scibot 08 Jan 2025
  
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  174820
  
  DOI: 10.1038/s41467-024-55604-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11700204/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Development and testing of a versatile genome editing application reporter (V-GEAR) system

1
1. scibot 21 Jun 2024
  
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  174820
  
  DOI: 10.1016/j.omtm.2024.101253
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11101715/
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Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor

1
1. scibot 15 Jun 2024
  
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  plasmid_174820
  
  DOI: 10.1093/nar/gkae310
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11162781/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Improving prime editing with an endogenous small RNA-binding protein

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1. scibot 23 Apr 2024
  
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  174820
  
  DOI: 10.1038/s41586-024-07259-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
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Chromatin context-dependent regulation and epigenetic manipulation of prime editing

1
1. scibot 12 Apr 2024
  
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  Addgene: 174820
  
  DOI: 10.1016/j.cell.2024.03.020
  
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  Curator: @abever99
  
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sciencedirect.com/science/article/pii/S0092867424003118
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Enhancing prime editor activity by directed protein evolution in yeast

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1. scibot 17 Mar 2024
  
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  Addgene #174820
  
  DOI: 10.1038/s41467-024-46107-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10920827/
Feb 2024
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One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics

1
1. scibot 07 Feb 2024
  
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  RRID:Addgene_174820
  
  DOI: 10.1016/j.crmeth.2024.100698
  
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sciencedirect.com/science/article/pii/S2667237524000043
Dec 2023
www.biorxiv.org www.biorxiv.org

Creation of de novo cryptic splicing for ALS/FTD precision medicine

1
1. scibot 02 Dec 2023
  
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  RRID:Addgene_174820
  
  DOI: 10.1101/2023.11.15.565967
  
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biorxiv.org/content/10.1101/2023.11.15.565967v1
Sep 2023
www.nature.com www.nature.com

Genotoxic effects of base and prime editing in human hematopoietic stem cells

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1. scibot 20 Sep 2023
  
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  RRID:Addgene_174820
  
  DOI: 10.1038/s41587-023-01915-4
  
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nature.com/articles/s41587-023-01915-4