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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

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1. scibot 22 Sep 2025
  
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  174828
  
  DOI: 10.1038/s41586-025-09021-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12449813/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools

1
1. scibot 20 Jul 2025
  
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  174828
  
  DOI: 10.34133/research.0770
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12220932/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Effects of heterozygous SMG1 mutations on nonsense-mediated mRNA decay in human pluripotent stem cell model

2
1. scibot 20 Jul 2025
  
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  174828
  
  DOI: 10.1016/j.mocell.2025.100225
  
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2. scibot 20 Jul 2025
  
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  174828
  
  DOI: 10.1016/j.mocell.2025.100225
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12173119/
Jun 2025
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

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1. scibot 28 Jun 2025
  
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  Addgene, #174828
  
  DOI: 10.1002/1873-3468.70097
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70097
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel

1
1. scibot 17 May 2025
  
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  pCMV-PEmax-P2A-hMLH1dn
  
  DOI: 10.3390/ijms26072835
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11988564/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types

1
1. scibot 17 May 2025
  
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  174828
  
  DOI: 10.3389/fcell.2025.1589034
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12069386/
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Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

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1. scibot 17 May 2025
  
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  174 828
  
  DOI: 10.1002/advs.202417790
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12061241/
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High-throughput screening of human genetic variants by pooled prime editing

1
1. scibot 16 May 2025
  
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  174828
  
  DOI: 10.1016/j.xgen.2025.100814
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12008803/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Precise Generation of Human Induced Pluripotent Stem Cell–derived Cell Lines Harboring Disease-relevant Single Nucleotide Variants Using a Prime Editing System

1
1. scibot 11 Mar 2025
  
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  174828
  
  DOI: 10.21769/BioProtoc.5191
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11865833/
Feb 2025
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A molecular proximity sensor based on an engineered, dual-component guide RNA

1
1. scibot 16 Feb 2025
  
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  174828
  
  DOI: 10.7554/eLife.98110
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11820115/
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EXPERT expands prime editing efficiency and range of large fragment edits

1
1. scibot 16 Feb 2025
  
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  174828
  
  DOI: 10.1038/s41467-025-56734-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11822059/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Engineering Oncogenic Hotspot Mutations on SF3B1 via CRISPR-Directed PRECIS Mutagenesis

2
1. scibot 27 Sep 2024
  
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  174828
  
  DOI: 10.1158/2767-9764.CRC-24-0145
  
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2. scibot 27 Sep 2024
  
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  174828
  
  DOI: 10.1158/2767-9764.CRC-24-0145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11421219/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A protocol for the detection of precision genome editing in human cells using One-pot DTECT

1
1. scibot 27 Sep 2024
  
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  plasmid_174828
  
  DOI: 10.1016/j.xpro.2024.103307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11422130/
Aug 2024
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Directed evolution of hyperactive integrases for site specific insertion of transgenes

1
1. scibot 22 Aug 2024
  
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  Addgene_174828
  
  DOI: 10.1093/nar/gkae534
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11317131/
May 2024
www.sciencedirect.com www.sciencedirect.com

Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells

1
1. scibot 02 May 2024
  
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  Addgene: 174828
  
  DOI: 10.1016/j.xcrm.2024.101544
  
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sciencedirect.com/science/article/pii/S2666379124002349
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Improving prime editing with an endogenous small RNA-binding protein

1
1. scibot 23 Apr 2024
  
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  174828
  
  DOI: 10.1038/s41586-024-07259-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes

1
1. scibot 23 Apr 2024
  
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  Plasmid_174828
  
  DOI: 10.1038/s41467-024-46795-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11026479/
www.sciencedirect.com www.sciencedirect.com

Chromatin context-dependent regulation and epigenetic manipulation of prime editing

1
1. scibot 12 Apr 2024
  
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  Addgene: 174828
  
  DOI: 10.1016/j.cell.2024.03.020
  
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  Curator: @abever99
  
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sciencedirect.com/science/article/pii/S0092867424003118
Jan 2024
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Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo

1
1. scibot 11 Jan 2024
  
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  Addgene_174828
  
  DOI: 10.1016/j.stem.2023.12.003
  
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sciencedirect.com/science/article/pii/S1934590923004332
Nov 2023
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Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need

1
1. scibot 04 Nov 2023
  
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  RRID:Addgene_174828
  
  DOI: 10.1016/j.ajhg.2023.10.005
  
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sciencedirect.com/science/article/pii/S0002929723003580
Sep 2023
www.nature.com www.nature.com

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

1
1. scibot 20 Sep 2023
  
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  plasmid_174828
  
  DOI: 10.1038/s42003-023-05052-1
  
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nature.com/articles/s42003-023-05052-1
Jun 2023
www.nature.com www.nature.com

Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing

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1. scibot 13 Jun 2023
  
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  RRID:Addgene_174828
  
  DOI: 10.1038/s41467-023-39246-2
  
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nature.com/articles/s41467-023-39246-2