87 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Caspase-5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13476857/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A mitochondria-driven quality control mechanism for peroxisomal membrane proteins
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402316/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13396389/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced HER2 internalization by clathrin-dependent endocytosis in non-small cell lung cancer positive for HER2 mutations
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12479963/
  6. www.sciencedirect.com www.sciencedirect.com
    Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation
    1
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    sciencedirect.com/science/article/pii/S0092867426008093
  7. Jun 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tripartite motif-containing 34 (TRIM34) protein interacts with the nucleocytoplasmic transport machinery and negatively modulates antiviral responses
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13189347/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13221179/
  10. Apr 2026
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13038753/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improved efficiency of protein aggregate removal using ubiquitin with a signal peptide
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13036567/
  13. Mar 2026
  14. www.sciencedirect.com www.sciencedirect.com
    STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels
    1
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    sciencedirect.com/science/article/pii/S2211124726002615
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13000003/
  16. www.sciencedirect.com www.sciencedirect.com
    Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes
    1
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    sciencedirect.com/science/article/pii/S0896627326000863
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Androgen receptor ubiquitination links KCTD13 to genitourinary tract defects
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12080724/
  18. Nov 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of PD-L1 Protein Expression by the E3 Ubiquitin Ligase GP78
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12563870/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554184/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614643/
  22. Sep 2025
  23. www.sciencedirect.com www.sciencedirect.com
    The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy
    1
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    sciencedirect.com/science/article/pii/S2211124725010289
  24. www.biorxiv.org www.biorxiv.org
    The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
    1
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    biorxiv.org/content/10.1101/2025.09.01.673523v1
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407064/
  26. Aug 2025
  27. www.mdpi.com www.mdpi.com
    Ubiquitination Regulates Reorganization of the Membrane System During Cytomegalovirus Infection
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    mdpi.com/2075-1729/15/8/1212
  28. Jul 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12283747/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224959/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12211564/
  32. Jun 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12126869/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCFFBXO22–BACH1 complex in triple-negative breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130529/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    cIAP2-mediated IGF2BP2 ubiquitination and degradation regulate cardiomyocyte apoptosis via stabilizing m6A-modified BAX mRNA in myocardial infarction
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12125055/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11572255/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC12155308/
  38. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial fumarate inhibits Parkin-mediated mitophagy
    1
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    sciencedirect.com/science/article/pii/S1097276525004605
  39. May 2025
  40. www.sciencedirect.com www.sciencedirect.com
    HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma
    1
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    sciencedirect.com/science/article/pii/S2211124725004917
  41. Apr 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11941746/
  43. www.biorxiv.org www.biorxiv.org
    The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters
    1
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    biorxiv.org/content/10.1101/2025.03.25.645338v1
  44. Mar 2025
  45. rupress.org rupress.org
    The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B
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    rupress.org/jcb/article/224/5/e202407014/277317/The-deubiquitinase-USP45-inhibits-autophagy
  46. Feb 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811033/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11825969/
  49. Jan 2025
  50. www.biorxiv.org www.biorxiv.org
    Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states
    1
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    biorxiv.org/content/10.1101/2025.01.26.634904v1
  51. Sep 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387738/
  53. www.sciencedirect.com www.sciencedirect.com
    HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma
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    sciencedirect.com/science/article/pii/S2211124724011070
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11300456/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405407/
  56. Aug 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11264351/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335248/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864110/
  60. Jul 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7862454/
  62. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    sciencedirect.com/science/article/pii/S1097276524004799
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8565315/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257679/
  65. Jun 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130243/
  67. May 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OTULIN-related conditions: Report of a new case and review of the literature using GenIA
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11071612/
  69. Apr 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11047997/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10949840/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10944491/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10994560/
  74. Mar 2024
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937711/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-monoubiquitylation controls VASP-mediated actin dynamics
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    ncbi.nlm.nih.gov/pmc/articles/PMC10917064/
  77. Feb 2024
  78. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
    1
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    sciencedirect.com/science/article/pii/S2589004224004024
  79. www.sciencedirect.com www.sciencedirect.com
    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
    1
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    sciencedirect.com/science/article/pii/S1097276524000480
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784524/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10795397/
  82. Jan 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10819186/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The unusual gene architecture of polyubiquitin is created by dual-specific splice sites
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10809524/
  85. Dec 2023
  86. www.sciencedirect.com www.sciencedirect.com
    FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression
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    sciencedirect.com/science/article/pii/S2589004223026573
  87. Aug 2023
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-monoubiquitination controls VASP-mediated actin dynamics
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    ncbi.nlm.nih.gov/pmc/articles/PMC10370145/
  89. Jul 2023
  90. www.sciencedirect.com www.sciencedirect.com
    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
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    sciencedirect.com/science/article/pii/S1931312823002238
  91. Apr 2023
  92. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    1
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    sciencedirect.com/science/article/pii/S2666379123001179
  93. Mar 2023
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9986520/
  95. www.sciencedirect.com www.sciencedirect.com
    Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates
    1
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    sciencedirect.com/science/article/pii/S1534580723000485
  96. Dec 2022
  97. www.sciencedirect.com www.sciencedirect.com
    Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis
    1
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    sciencedirect.com/science/article/pii/S0026049522002566
  98. Jul 2022
  99. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
    1
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    sciencedirect.com/science/article/pii/S2211124722008683
  100. Jun 2022
  101. www.sciencedirect.com www.sciencedirect.com
    Stub1 maintains proteostasis of master transcription factors in embryonic stem cells
    1
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    sciencedirect.com/science/article/pii/S2211124722006969
  102. Mar 2022
  103. rupress.org rupress.org
    The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
    1
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    rupress.org/jcb/article/221/4/e202010065/213061/The-E3-ligase-TRIM1-ubiquitinates-LRRK2-and
  104. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
    1
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    sciencedirect.com/science/article/pii/S2211124722000705
  105. Jan 2022
  106. www.sciencedirect.com www.sciencedirect.com
    Gentiopicroside targets PAQR3 to activate PI3K/AKT signaling pathway and ameliorate glucose and lipid metabolism
    1
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    sciencedirect.com/science/article/pii/S2211383521004949
  107. Oct 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
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    sciencedirect.com/science/article/pii/S2211124721013747
  109. www.sciencedirect.com www.sciencedirect.com
    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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    sciencedirect.com/science/article/pii/S2211124721013589
  110. Jul 2021
  111. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1074761319300378
  112. www.nature.com www.nature.com
    Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
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    nature.com/articles/s41467-019-09800-y
  113. Jun 2021
  114. www.sciencedirect.com www.sciencedirect.com
    TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity
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    sciencedirect.com/science/article/pii/S0092867421005821
  115. May 2021
  116. www.sciencedirect.com www.sciencedirect.com
    A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development
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    sciencedirect.com/science/article/pii/S1534580720306705
  117. Jan 2021
  118. www.sciencedirect.com www.sciencedirect.com
    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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    sciencedirect.com/science/article/pii/S2211124720315588
  119. Dec 2020
  120. www.mdpi.com www.mdpi.com
    Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination
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    mdpi.com/2073-4409/9/12/2547/htm
  121. Sep 2020
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance
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    ncbi.nlm.nih.gov/pmc/articles/PMC7039193/
  123. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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  125. Jan 2020
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    Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor
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