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Apr 2026
www.biorxiv.org www.biorxiv.org

Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

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1. scibot 21 Apr 2026
  
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  DOI: 10.64898/2026.04.14.718163
  
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biorxiv.org/content/10.64898/2026.04.14.718163v1
Mar 2026
www.sciencedirect.com www.sciencedirect.com

Cardiolipin disperses aquaporin Z tetramers to enhance water permeability

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1. scibot 24 Mar 2026
  
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  RRID:Addgene_20066
  
  DOI: 10.1016/j.ijbiomac.2026.151540
  
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sciencedirect.com/science/article/pii/S0141813026014662
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter

2
1. scibot 24 Nov 2025
  
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  MSP1E3D1
  
  DOI: 10.1038/s41467-025-65037-y
  
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2. scibot 24 Nov 2025
  
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  p1E3D1
  
  DOI: 10.1038/s41467-025-65037-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12606247/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments

1
1. scibot 23 Nov 2025
  
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  MSP1E3D1
  
  DOI: 10.1126/sciadv.adv0683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459404/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs

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1. scibot 26 Aug 2025
  
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  plasmid_20066
  
  DOI: 10.1016/j.str.2025.07.020
  
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sciencedirect.com/science/article/pii/S0969212625002680
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Broad-Spectrum Antiviral Styrene Maleic-Acid Copolymer Lipid Particle Nanodiscs for pH-Responsive Irreversible Virus Inactivation

1
1. scibot 20 Jul 2025
  
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  20066
  
  DOI: 10.1021/acs.biomac.5c00037
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12264959/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Narrowed pore conformations of aquaglyceroporins AQP3 and GlpF

1
1. scibot 07 Apr 2025
  
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  20,066
  
  DOI: 10.1038/s41467-025-57728-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11926279/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids

1
1. scibot 07 Apr 2025
  
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  plasmid_20066
  
  DOI: 10.1038/s41467-025-58334-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11947440/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants

1
1. scibot 11 Mar 2025
  
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  20,066
  
  DOI: 10.1186/s12951-025-03100-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11761773/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inner membrane components of the plasmid pKM101 type IV secretion system TraE and TraD are DNA-binding proteins

1
1. scibot 11 Mar 2025
  
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  20,066
  
  DOI: 10.1038/s41598-025-85446-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876611/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

1
1. scibot 04 Jan 2025
  
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  RRID:Addgene_20066
  
  DOI: 10.7554/eLife.96743
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695057/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM

1
1. scibot 21 Dec 2024
  
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  Plasmid_20066
  
  DOI: 10.1016/j.str.2024.11.018
  
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sciencedirect.com/science/article/pii/S0969212624005318
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structure and mechanism of a phosphotransferase system glucose transporter

1
1. scibot 27 Sep 2024
  
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  plasmid_20066
  
  DOI: 10.1038/s41467-024-52100-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11393339/
Aug 2024
pubs.acs.org pubs.acs.org

Unusual Vibrational Coupling of the Schiff Base in the Retinal Chromophore of Sodium Ion-Pumping Rhodopsins

2
1. scibot 18 Aug 2024
  
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  RRID:Addgene_20066
  
  DOI: 10.1021/acs.jpcb.4c04466
  
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2. scibot 14 Aug 2024
  
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  RRID:Addgene_20066
  
  DOI: 10.1021/acs.jpcb.4c04466
  
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  Curator: @dhovakimyan1
  
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  RRID:Addgene_20066 DOI:10.1021/acs.jpcb.4c04466
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DOI:10.1021/acs.jpcb.4c04466

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pubs.acs.org/doi/full/10.1021/acs.jpcb.4c04466
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

1
1. scibot 13 Aug 2024
  
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  20066
  
  DOI: 10.7554/eLife.90996
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11065425/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor

1
1. scibot 19 May 2024
  
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  pMSP1E3D1
  
  DOI: 10.1038/s41467-024-48292-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11096358/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment

1
1. scibot 13 Apr 2024
  
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  plasmid_20066
  
  DOI: 10.1038/s41467-024-47370-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10997623/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

1
1. scibot 17 Mar 2024
  
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  20066
  
  DOI: 10.7554/eLife.92462
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942615/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The co-receptor Tspan12 directly captures Norrin to promote ligand-specific β-catenin signaling

1
1. scibot 02 Mar 2024
  
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  20066
  
  DOI: 10.1101/2024.02.03.578714
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10862866/
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

1
1. scibot 01 Dec 2023
  
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  RRID:Addgene_20066
  
  DOI: 10.1038/s41467-023-42497-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10681989/
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Anomalous Oligomerization Behavior of E. coli Aquaporin Z in Detergent and in Nanodiscs

1
1. scibot 16 May 2023
  
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  RRID:Addgene_20066
  
  DOI: 10.3390/ijms24098098
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10178869/
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

1
1. scibot 05 Apr 2023
  
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  RRID:Addgene_20066
  
  DOI: 10.7554/eLife.82431
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10049205/
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

1
1. scibot 16 Mar 2023
  
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  RRID:Addgene_20066
  
  DOI: 10.3389/fmolb.2023.1141081
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9995911/
Sep 2021
link.springer.com link.springer.com

Evaluation of the tert-butyl group as a probe for NMR studies of macromolecular complexes

1
1. scibot 10 Sep 2021
  
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  RRID:Addgene_20066
  
  DOI: 10.1007/s10858-021-00380-y
  
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link.springer.com/article/10.1007/s10858-021-00380-y
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Point-localized and site-specific membrane potential optical recording by engineered single fluorescent nanodiscs

1
1. scibot 16 Aug 2021
  
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  plasmid_20066
  
  DOI: 10.1016/j.bpr.2021.100007
  
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sciencedirect.com/science/article/pii/S2667074721000070
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ca2+-dependent release of Synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

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1. scibot 23 Sep 2020
  
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  RRID:Addgene_20066
  
  DOI: 10.7554/eLife.57154
  
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  RRIDCUR:Validated RRID:Addgene_20066
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ncbi.nlm.nih.gov/pmc/articles/PMC7498268/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_20066
  
  DOI: 10.1016/j.jmb.2019.07.006
  
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  RRID:Addgene_20066 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0022283619304279