46 Matching Annotations
  1. Jul 2026
  2. www.biorxiv.org www.biorxiv.org
    Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.06.28.734981v1
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Divergent Role of ULK1 to Balance Mitochondrial Homeostasis and Bioenergetics in Ovarian Cancer Spheroids
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    pmc.ncbi.nlm.nih.gov/articles/PMC13255712/
  5. May 2026
  6. www.science.org www.science.org
    Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes
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    science.org/doi/10.1126/scitranslmed.adj4902
  7. Mar 2026
  8. www.nature.com www.nature.com
    ULK1 promotes metastatic progression in experimental models of epithelial ovarian cancer
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    nature.com/articles/s41388-026-03702-2
  9. Nov 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485954/
  11. Oct 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve is a Therapeutic Strategy for Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11999774/
  13. Sep 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
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    pmc.ncbi.nlm.nih.gov/articles/PMC12084873/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DIRAS3 Inhibits Ovarian Cancer Cell Growth by Blocking the Fibronectin-Mediated Integrin β1/FAK/AKT Signaling Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12384585/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cepharanthine Enhances MHC-I Antigen Presentation and Anti-Tumor Immunity in Melanoma via Autophagy Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12384187/
  17. Aug 2025
  18. 52.53.155.43 52.53.155.43
    preprints202508.0115.v1-html.html
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    52.53.155.43/404097c13a1856caf19c4b99d86ab0e9a3c47028/preprints202508.0115.v1-html.html
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC12271461/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12205077/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12246382/
  23. Jun 2025
  24. www.sciencedirect.com www.sciencedirect.com
    The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
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    sciencedirect.com/science/article/pii/S2211124725006412
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12153388/
  26. Oct 2024
  27. link.springer.com link.springer.com
    Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
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    link.springer.com/article/10.1007/s00018-024-05441-7
  28. Sep 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364435/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Autophagy by Berbamine Hydrochloride Mitigates Tumor Immune Escape by Elevating MHC-I in Melanoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11430705/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11381443/
  32. Jun 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11165123/
  34. May 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11116505/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE
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    ncbi.nlm.nih.gov/pmc/articles/PMC11089807/
  37. Apr 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
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    ncbi.nlm.nih.gov/pmc/articles/PMC11031965/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11040505/
  40. Mar 2024
  41. www-nature-com.vu-nl.idm.oclc.org www-nature-com.vu-nl.idm.oclc.org
    Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection
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    www-nature-com.vu-nl.idm.oclc.org/articles/s41467-024-46606-z
  42. Feb 2024
  43. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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    sciencedirect.com/science/article/pii/S2211124724001086
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10861597/
  45. Jul 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812941/
  47. Jun 2023
  48. www.sciencedirect.com www.sciencedirect.com
    LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy
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    sciencedirect.com/science/article/pii/S1534580723002423
  49. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  50. Mar 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
  52. Feb 2023
  53. www.nature.com www.nature.com
    CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells
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    nature.com/articles/s41598-023-29437-8
  54. Dec 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    sciencedirect.com/science/article/pii/S2211124722017260
  56. Aug 2022
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional and biological heterogeneity of KRASQ61 mutations
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    pmc.ncbi.nlm.nih.gov/articles/PMC9534304/
  58. Dec 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Undescribed polyether ionophores from Streptomyces cacaoi and their antibacterial and antiproliferative activities
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    sciencedirect.com/science/article/pii/S0031942221003873
  60. Oct 2021
  61. journals.biologists.com journals.biologists.com
    GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network
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    journals.biologists.com/bio/article/10/10/bio058736/272440/GRASP55-restricts-early-stage-autophagy-and
  62. Sep 2021
  63. www.sciencedirect.com www.sciencedirect.com
    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    sciencedirect.com/science/article/pii/S1097276521007292
  64. Aug 2021
  65. www.sciencedirect.com www.sciencedirect.com
    RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal
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    sciencedirect.com/science/article/pii/S2211124721008688
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC6484853/
  67. Jul 2021
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6389288/
  69. May 2021
  70. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma
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    clincancerres.aacrjournals.org/content/27/9/2624
  71. Apr 2021
  72. www.sciencedirect.com www.sciencedirect.com
    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    sciencedirect.com/science/article/pii/S1535610820302683
  73. Sep 2020
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7235646/
  75. Jan 2020
  76. www.sciencedirect.com www.sciencedirect.com
    Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
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    sciencedirect.com/science/article/pii/S235239641930430X
  77. www.nature.com www.nature.com
    Untitled document
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    nature.com/articles/s41591-019-0368-8
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6389288/