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Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes

1
1. scibot 05 Mar 2026
  
  in Public
  
  AddgeneCat# 24230
  
  DOI: 10.1016/j.molcel.2026.02.009
  
  Resource: RRID:Addgene_24230
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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sciencedirect.com/science/article/pii/S1097276526001048
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling

1
1. scibot 01 Feb 2026
  
  in Public
  
  24230
  
  DOI: 10.1038/s12276-025-01603-0
  
  Resource: RRID:Addgene_24230
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12800308/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis

1
1. scibot 17 May 2025
  
  in Public
  
  24230
  
  DOI: 10.1038/s41467-025-59003-x
  
  Resource: RRID:Addgene_24230
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12034783/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

1
1. scibot 18 Feb 2025
  
  in Public
  
  24230
  
  DOI: 10.20892/j.issn.2095-3941.2024.0459
  
  Resource: RRID:Addgene_24230
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC11795262/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

EZH2 specifically regulates ISL1 during embryonic urinary tract formation

1
1. scibot 05 Oct 2024
  
  in Public
  
  Plasmid_24230
  
  DOI: 10.1038/s41598-024-74303-w
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC11447050/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma

1
1. scibot 20 Jan 2024
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.1158/0008-5472.CAN-23-1148
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC10790128/
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

2
1. scibot 07 Sep 2023
  
  in Public
  
  RRID:Addgene_2423059
  
  DOI: 10.1016/j.isci.2023.107630
  
  Resource: RRID:Addgene_24230
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:Unresolved
2. scibot 06 Sep 2023
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.1016/j.isci.2023.107630
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRIDCUR:Unresolved

RRID:Addgene_24230

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
Aug 2023
www.biorxiv.org www.biorxiv.org

EZH2 specifically regulates ISL1 during embryonic urinary tract formation

1
1. scibot 27 Aug 2023
  
  in Public
  
  Plasmid_24230
  
  DOI: 10.1101/2023.08.21.554100
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

URL

biorxiv.org/content/10.1101/2023.08.21.554100v1
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

1
1. scibot 23 Jun 2023
  
  in Public
  
  plasmid_24230
  
  DOI: 10.1016/j.isci.2023.107035
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

URL

sciencedirect.com/science/article/pii/S2589004223011124
Mar 2023
www.biorxiv.org www.biorxiv.org

Activation of AKT induces EZH2-mediated beta-catenin trimethylation in colorectal cancer

1
1. scibot 03 Mar 2023
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.1101/2023.01.31.526429
  
  Resource: RRID:Addgene_24230
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_24230
  
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  RRID:Addgene_24230
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RRID:Addgene_24230

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scibot

URL

biorxiv.org/content/10.1101/2023.01.31.526429v2
Jul 2021
www.sciencedirect.com www.sciencedirect.com

The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins

1
1. scibot 27 Jul 2021
  
  in Public
  
  Addgene_24230
  
  DOI: 10.1016/j.molcel.2017.09.016
  
  Resource: RRID:Addgene_24230
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_24230
  
  Curator comments: PCMVHA HEZH2
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:NotRRID RRIDCUR:Unresolved
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RRIDCUR:Unresolved

RRIDCUR:NotRRID

RRID:Addgene_24230

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scibot

URL

sciencedirect.com/science/article/pii/S1097276517306676
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 27 Jul 2021
  
  in Public
  
  Addgene_24230
  
  DOI: 10.1016/j.molcel.2017.09.016
  
  Resource: RRID:Addgene_24230
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:NotRRID RRIDCUR:Unresolved
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RRIDCUR:Unresolved

RRIDCUR:NotRRID

RRID:Addgene_24230

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5659763/
Apr 2021
www.sciencedirect.com www.sciencedirect.com

SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

1
1. scibot 17 Apr 2021
  
  in Public
  
  Cat #24230
  
  DOI: 10.1016/j.ccell.2020.05.022
  
  Resource: RRID:Addgene_24230
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRIDCUR:Missing RRID:Addgene_24230
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RRIDCUR:Missing

RRID:Addgene_24230

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scibot

URL

sciencedirect.com/science/article/pii/S1535610820302725
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genistein represses HOTAIR/chromatin remodeling pathways to suppress kidney cancer

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.33594/000000205
  
  Resource: RRID:Addgene_24230
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_24230

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7382546/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.1016/j.chembiol.2019.11.006
  
  Resource: RRID:Addgene_24230
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_24230

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scibot

URL

sciencedirect.com/science/article/pii/S2451945619303642
www.sciencedirect.com www.sciencedirect.com

Unraveling the role of H3K4 trimethylation and lncRNA HOTAIR in SATB1 and DUSP4-dependent survival of virulent Mycobacterium tuberculosis in macrophages

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_24230
  
  DOI: 10.1016/j.tube.2019.101897
  
  Resource: RRID:Addgene_24230
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_24230
  
  What is this?
  
  RRID:Addgene_24230 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_24230

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scibot

URL

sciencedirect.com/science/article/pii/S1472979219302616