61 Matching Annotations
  1. Dec 2024
  2. www.cell.com www.cell.com
    UBA1 inhibition sensitizes cancer cells to PARP inhibitors
    1
    1. scibot 05 Dec 2024
      Addgene_26477

      DOI: 10.1016/j.xcrm.2024.101834

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00605-0
  3. Nov 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
    1
    1. scibot 15 Nov 2024
      AddgeneCat #26477

      DOI: 10.1016/j.isci.2024.111283

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    sciencedirect.com/science/article/pii/S2589004224025082
  5. Sep 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response
    1
    1. scibot 29 Sep 2024
      pCBASceI

      DOI: 10.1186/s13148-024-01719-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350970/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
    1
    1. scibot 28 Sep 2024
      26477

      DOI: 10.1038/s41467-024-51784-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377823/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
    1
    1. scibot 28 Sep 2024
      26477

      DOI: 10.2147/OTT.S463217

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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance
    1
    1. scibot 27 Sep 2024
      26477

      DOI: 10.1038/s41419-024-07045-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387829/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL inhibition prevents RPA2/CHK1-mediated homologous recombination to increase PARP inhibitor sensitivity in hepatocellular carcinoma
    1
    1. scibot 25 Sep 2024
      pCBA-I-SceI

      DOI: 10.1016/j.heliyon.2024.e36283

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    ncbi.nlm.nih.gov/pmc/articles/PMC11399589/
  11. www.sciencedirect.com www.sciencedirect.com
    Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches
    1
    1. scibot 17 Sep 2024
      RRID:Addgene_26477

      DOI: 10.1016/j.tranon.2024.102119

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    sciencedirect.com/science/article/pii/S1936523324002468
  12. Aug 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation
    1
    1. scibot 26 Aug 2024
      26477

      DOI: 10.1016/j.omtn.2024.102274

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    ncbi.nlm.nih.gov/pmc/articles/PMC11331969/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
    1
    1. scibot 22 Aug 2024
      Addgene_26477

      DOI: 10.1038/s41598-024-68926-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310344/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
    1
    1. scibot 13 Aug 2024
      26477

      DOI: 10.1016/j.ebiom.2024.105129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  16. Jul 2024
  17. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
    1. scibot 17 Jul 2024
      AddgeneCat #26477

      DOI: 10.1016/j.celrep.2024.114464

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    sciencedirect.com/science/article/pii/S2211124724007939
  18. www.nature.com www.nature.com
    PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
    4
    1. scibot 16 Jul 2024
      plasmid_26477

      DOI: 10.1038/s41467-024-50158-7

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    2. scibot 16 Jul 2024
      RRID:addgene_26477

      DOI: 10.1038/s41467-024-50158-7

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    3. scibot 14 Jul 2024
      plasmid_26477

      DOI: 10.1038/s41467-024-50158-7

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    4. scibot 14 Jul 2024
      RRID:addgene_26477

      DOI: 10.1038/s41467-024-50158-7

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    nature.com/articles/s41467-024-50158-7
  19. www.biorxiv.org www.biorxiv.org
    Homologous recombination promotes mitotic death to suppress the innate immune response
    1
    1. scibot 09 Jul 2024
      RRID:Addgene_26477

      DOI: 10.1101/2024.05.04.592546

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    biorxiv.org/content/10.1101/2024.05.04.592546v1
  20. Jun 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma
    1
    1. scibot 25 Jun 2024
      plasmid_26477

      DOI: 10.1038/s41467-024-49316-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11192742/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
    1
    1. scibot 21 Jun 2024
      26477

      DOI: 10.1007/s00018-024-05265-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC11149539/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response
    1
    1. scibot 15 Jun 2024
      26477

      DOI: 10.1093/nar/gkae233

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    ncbi.nlm.nih.gov/pmc/articles/PMC11162808/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance
    1
    1. scibot 03 Jun 2024
      26477

      DOI: 10.1186/s13046-024-03078-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11137994/
  25. Apr 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study
    1
    1. scibot 15 Apr 2024
      26477

      DOI: 10.1002/2056-4538.12367

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951049/
  27. www.sciencedirect.com www.sciencedirect.com
    DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
    2
    1. scibot 12 Apr 2024
      Addgene_26477

      DOI: 10.1016/j.cels.2024.03.003

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    2. scibot 12 Apr 2024
      Addgene_26477

      DOI: 10.1016/j.cels.2024.03.003

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    sciencedirect.com/science/article/pii/S2405471224000887
  28. Mar 2024
  29. 52.53.155.43 52.53.155.43
    The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling
    3
    1. scibot 19 Mar 2024
      Addgene_26477

      DOI: 10.1038/s44319-023-00035-z

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    2. scibot 19 Mar 2024
      Addgene_26477

      DOI: 10.1038/s44319-023-00035-z

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    3. scibot 01 Mar 2024
      Addgene_26477

      DOI: 10.1038/s44319-023-00035-z

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    52.53.155.43/85f3cfb5ea69a502f1e71c384533cb9dacfc2966/collin-et-al-2024-the-immediate-early-protein-1-of-human-herpesvirus-6b-interacts-with-nbs1-and-inhibits-atm-signaling-html.html
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
    1
    1. scibot 16 Mar 2024
      pCBASceI#26477

      DOI: 10.1080/15384047.2024.2323768

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    ncbi.nlm.nih.gov/pmc/articles/PMC10936631/
  31. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
    1
    1. scibot 14 Mar 2024
      RRID:Addgene_26477

      DOI: 10.1038/s41388-024-02982-w

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    nature.com/articles/s41388-024-02982-w
  32. Jan 2024
  33. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    2
    1. scibot 19 Jan 2024
      RRID:Addgene_26477

      DOI: 10.1016/j.xcrm.2023.101376

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      Curator: @evieth

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    2. scibot 19 Jan 2024
      plasmid_26477

      DOI: 10.1016/j.xcrm.2023.101376

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    sciencedirect.com/science/article/pii/S2666379123006055
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
    1. scibot 10 Jan 2024
      RRID:Addgene_26477

      DOI: 10.1158/1078-0432.CCR-23-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  35. Dec 2023
  36. link.springer.com link.springer.com
    PRAME induces genomic instability in uveal melanoma
    1
    1. scibot 02 Dec 2023
      plasmid_26477

      DOI: 10.1038/s41388-023-02887-0

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    link.springer.com/article/10.1038/s41388-023-02887-0
  37. Nov 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins
    1
    1. scibot 02 Nov 2023
      Addgene_26477

      DOI: 10.1016/j.xcrm.2023.101255

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    sciencedirect.com/science/article/pii/S2666379123004329
  39. Oct 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer
    1
    1. scibot 12 Oct 2023
      RRID:Addgene_26477

      DOI: 10.1158/2767-9764.CRC-23-0089

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    ncbi.nlm.nih.gov/pmc/articles/PMC10561629/
  41. Aug 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib
    1
    1. scibot 16 Aug 2023
      RRID:Addgene_26477

      DOI: 10.3390/cancers15153919

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    ncbi.nlm.nih.gov/pmc/articles/PMC10417836/
  43. Jul 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment
    1
    1. scibot 06 Jul 2023
      plasmid_26477

      DOI: 10.3389/fonc.2023.1117262

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    ncbi.nlm.nih.gov/pmc/articles/PMC10318356/
  45. Jun 2023
  46. 52.53.155.43 52.53.155.43
    Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild Type Ovarian Cancer Cells to Olaparib
    1
    1. scibot 29 Jun 2023
      RRID:Addgene_26477

      DOI: 10.20944/preprints202304.0327.v1

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    52.53.155.43/71ce6d131c64aa7fc9989cc74f4998f83ebdb128/preprints202304.0327.v1-html.html
  47. May 2023
  48. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
    2
    1. scibot 10 May 2023
      RRID: Addgene_26477

      DOI: 10.1016/j.celrep.2023.112484

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    2. scibot 10 May 2023
      RRID:Addgene_26477

      DOI: 10.1016/j.celrep.2023.112484

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    sciencedirect.com/science/article/pii/S2211124723004953
  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
    1
    1. scibot 29 Apr 2023
      plasmid_2647767

      DOI: 10.1016/j.molcel.2023.03.027

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    sciencedirect.com/science/article/pii/S109727652300240X
  51. Sep 2022
  52. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    1
    1. scibot 29 Sep 2022
      plasmid_26477

      DOI: 10.15252/embr.202154136

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    embopress.org/doi/10.15252/embr.202154136
  53. Apr 2022
  54. aacrjournals.org aacrjournals.org
    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
    1
    1. scibot 09 Apr 2022
      RRID:Addgene_26477

      DOI: 10.1158/1535-7163.MCT-21-0827

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    aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
  55. Dec 2021
  56. www.sciencedirect.com www.sciencedirect.com
    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    1
    1. scibot 15 Dec 2021
      RRID:Addgene_26477

      DOI: 10.1016/j.celrep.2021.110068

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    sciencedirect.com/science/article/pii/S2211124721015540
  57. Oct 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
    1
    1. scibot 13 Oct 2021
      Addgene_26477

      DOI: 10.1016/j.celrep.2021.109815

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    sciencedirect.com/science/article/pii/S2211124721012791
  59. Aug 2021
  60. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
    1
    1. scibot 16 Aug 2021
      RRID:Addgene_26477

      DOI: 10.1158/0008-5472.CAN-20-3738

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    cancerres.aacrjournals.org/content/81/12/3215
  61. www.embopress.org www.embopress.org
    Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes
    1
    1. scibot 15 Aug 2021
      RRID:Addgene_26477

      DOI: 10.15252/embr.202052190

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    embopress.org/doi/full/10.15252/embr.202052190
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
    1
    1. scibot 14 Aug 2021
      plasmid_26477

      DOI: 10.1093/nar/gkz076

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    ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
  63. Jul 2021
  64. academic.oup.com academic.oup.com
    Untitled document
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    1. scibot 31 Jul 2021
      plasmid_26477

      DOI: 10.1093/nar/gkz076

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135
  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
    1
    1. scibot 29 Jul 2021
      Addgene_26477

      DOI: 10.1002/ijc.32670

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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
  66. www.nature.com www.nature.com
    UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
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    1. scibot 01 Jul 2021
      RRID:Addgene_26477

      DOI: 10.1038/s41467-021-24201-w

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    nature.com/articles/s41467-021-24201-w
  67. Jun 2021
  68. www.sciencedirect.com www.sciencedirect.com
    The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
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    1. scibot 30 Jun 2021
      Addgene_26477

      DOI: 10.1016/j.celrep.2021.109306

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    sciencedirect.com/science/article/pii/S2211124721006823
  69. May 2021
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells
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    1. scibot 19 May 2021
      RRID:Addgene_26477

      DOI: 10.3390/ijms22094422

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    ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
  71. www.sciencedirect.com www.sciencedirect.com
    miR-1293, a candidate for miRNA-based cancer therapeutics, simultaneously targets BRD4 and the DNA repair pathway
    1
    1. scibot 09 May 2021
      RRID:Addgene_26477

      DOI: 10.1016/j.ymthe.2020.04.001

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    sciencedirect.com/science/article/pii/S1525001620301829
  72. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
    1
    1. scibot 07 May 2021
      RRID:Addgene_26477

      DOI: 10.1016/j.molcel.2020.06.028

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    sciencedirect.com/science/article/pii/S1097276520304305
  73. Apr 2021
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
    1
    1. scibot 22 Apr 2021
      RRID: Addgene_26477

      DOI: 10.1016/j.ccell.2020.10.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
  75. Feb 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
    1
    1. scibot 24 Feb 2021
      RRID:Addgene_26477

      DOI: 10.1128/MCB.00105-19

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    ncbi.nlm.nih.gov/pmc/articles/PMC6664603/
  77. Jan 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
    1
    1. scibot 27 Jan 2021
      RRID:Addgene_26477

      DOI: 10.1016/j.celrep.2020.108680

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    sciencedirect.com/science/article/pii/S2211124720316697
  79. Dec 2020
  80. www.mdpi.com www.mdpi.com
    Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells
    1
    1. scibot 30 Dec 2020
      RRID:Addgene_26477

      DOI: 10.3390/cancers13010021

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    mdpi.com/2072-6694/13/1/21
  81. Jan 2020
  82. www.sciencedirect.com www.sciencedirect.com
    53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
    1
    1. scibot 13 Jan 2020
      RRID:Addgene_26477

      DOI: 10.1016/j.molcel.2019.09.024

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      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1097276519307294
  83. academic.oup.com academic.oup.com
    Untitled document
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    1. scibot 12 Jan 2020
      plasmid_26477

      DOI: 10.1093/nar/gkz076

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135